{"id":"https://openalex.org/W4302362471","doi":"https://doi.org/10.1038/s41592-022-01633-w","title":"Advances in nanopore direct RNA sequencing","display_name":"Advances in nanopore direct RNA sequencing","publication_year":2022,"publication_date":"2022-10-01","ids":{"openalex":"https://openalex.org/W4302362471","doi":"https://doi.org/10.1038/s41592-022-01633-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/36203024","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11388133"},"language":"en","primary_location":{"id":"doi:10.1038/s41592-022-01633-w","doi":"https://doi.org/10.1038/s41592-022-01633-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41592-022-01633-w","pdf_url":"https://www.nature.com/articles/s41592-022-01633-w.pdf","source":{"id":"https://openalex.org/S127827428","display_name":"Nature Methods","issn_l":"1548-7091","issn":["1548-7091","1548-7105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Methods","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s41592-022-01633-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018121239","display_name":"Miten Jain","orcid":"https://orcid.org/0000-0002-4571-3982","observed_orcids":["https://orcid.org/0000-0002-4571-3982"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Miten Jain","raw_affiliation_strings":["Northeastern University, Boston, MA, USA. mi.jain@northeastern.edu","Northeastern University, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northeastern University, Boston, MA, USA. mi.jain@northeastern.edu","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Northeastern University, Boston, MA, USA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029537657","display_name":"Robin L. Abu-Shumays","orcid":"https://orcid.org/0000-0003-1485-080X","observed_orcids":["https://orcid.org/0000-0003-1485-080X"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robin Abu-Shumays","raw_affiliation_strings":["University of California, Santa Cruz, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Santa Cruz, CA, USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086203077","display_name":"Hugh E. Olsen","orcid":"https://orcid.org/0000-0002-7293-8853","observed_orcids":["https://orcid.org/0000-0002-7293-8853"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hugh E. Olsen","raw_affiliation_strings":["University of California, Santa Cruz, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Santa Cruz, CA, USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012942178","display_name":"Mark A. Akeson","orcid":"https://orcid.org/0000-0001-9392-8075","observed_orcids":["https://orcid.org/0000-0001-9392-8075"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark Akeson","raw_affiliation_strings":["University of California, Santa Cruz, CA, USA. makeson@soe.ucsc.edu","University of California, Santa Cruz, CA, USA"],"raw_orcid":"https://orcid.org/0000-0001-9392-8075","affiliations":[{"raw_affiliation_string":"University of California, Santa Cruz, CA, USA. makeson@soe.ucsc.edu","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"University of California, Santa Cruz, CA, USA","institution_ids":["https://openalex.org/I185103710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012942178","https://openalex.org/A5018121239"],"corresponding_institution_ids":["https://openalex.org/I12912129","https://openalex.org/I185103710"],"apc_list":{"value":11390,"currency":"USD","value_usd":11390},"apc_paid":{"value":11390,"currency":"USD","value_usd":11390},"fwci":10.7991,"has_fulltext":true,"cited_by_count":204,"citation_normalized_percentile":{"value":0.995016,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"19","issue":"10","first_page":"1160","last_page":"1164"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.5054000020027161,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.5054000020027161,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.41499999165534973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanopore-direct-rna-sequencing","display_name":"nanopore direct RNA sequencing","score":0.9520000219345093},{"id":"https://openalex.org/keywords/single-molecule-rna-sequencing","display_name":"single-molecule RNA sequencing","score":0.8309999704360962},{"id":"https://openalex.org/keywords/rna-modification","display_name":"RNA modification","score":0.49300000071525574},{"id":"https://openalex.org/keywords/base-calling-accuracy","display_name":"base calling accuracy","score":0.7459999918937683}],"concepts":[{"id":"https://openalex.org/C141795571","wikidata":"https://www.wikidata.org/wiki/Q580942","display_name":"Nanopore","level":2,"score":0.8290764093399048},{"id":"https://openalex.org/C126513998","wikidata":"https://www.wikidata.org/wiki/Q8973627","display_name":"Nanopore sequencing","level":4,"score":0.822809100151062},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.7989464402198792},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6026598215103149},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.5674572587013245},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4633268713951111},{"id":"https://openalex.org/C2991743866","wikidata":"https://www.wikidata.org/wiki/Q417379","display_name":"Rna processing","level":4,"score":0.4492265284061432},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.35526707768440247},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32562315464019775},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.28484517335891724},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2843981981277466},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.09615501761436462}],"mesh":[{"descriptor_ui":"D000081414","descriptor_name":"Nanopore Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058608","descriptor_name":"Nanopores","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41592-022-01633-w","doi":"https://doi.org/10.1038/s41592-022-01633-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41592-022-01633-w","pdf_url":"https://www.nature.com/articles/s41592-022-01633-w.pdf","source":{"id":"https://openalex.org/S127827428","display_name":"Nature Methods","issn_l":"1548-7091","issn":["1548-7091","1548-7105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Methods","raw_type":"journal-article"},{"id":"pmid:36203024","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36203024","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature methods","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11388133","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11388133","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nat Methods","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41592-022-01633-w","doi":"https://doi.org/10.1038/s41592-022-01633-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41592-022-01633-w","pdf_url":"https://www.nature.com/articles/s41592-022-01633-w.pdf","source":{"id":"https://openalex.org/S127827428","display_name":"Nature Methods","issn_l":"1548-7091","issn":["1548-7091","1548-7105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Methods","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6369178755","display_name":"A Unified Nanopore Platform for Direct Sequencing of Individual Full Length RNA Strands Bearing Modified Nucleotides","funder_award_id":"R01HG010053","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4302362471.pdf","grobid_xml":"https://content.openalex.org/works/W4302362471.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1519765314","https://openalex.org/W2148890861","https://openalex.org/W2789843538","https://openalex.org/W2949707636","https://openalex.org/W2950063384","https://openalex.org/W2953309432","https://openalex.org/W2969431118","https://openalex.org/W2989499631","https://openalex.org/W2999689892","https://openalex.org/W3004933912","https://openalex.org/W3017680297","https://openalex.org/W3106255275","https://openalex.org/W3111806715","https://openalex.org/W3119738125","https://openalex.org/W3122118726","https://openalex.org/W3162353597","https://openalex.org/W3170979065","https://openalex.org/W3184504420","https://openalex.org/W3186264726","https://openalex.org/W3193727621","https://openalex.org/W3195224616","https://openalex.org/W3199440159","https://openalex.org/W3200750092","https://openalex.org/W3202467862","https://openalex.org/W3209837036","https://openalex.org/W3213079002","https://openalex.org/W4200167258","https://openalex.org/W4200342639","https://openalex.org/W4213273432","https://openalex.org/W4214912285","https://openalex.org/W4225514458","https://openalex.org/W4225743429","https://openalex.org/W4280519358","https://openalex.org/W4282585897","https://openalex.org/W4283809266","https://openalex.org/W4286471979","https://openalex.org/W4317498469","https://openalex.org/W4322624413"],"related_works":["https://openalex.org/W7166848587","https://openalex.org/W4414057255","https://openalex.org/W7125122090","https://openalex.org/W4402549043","https://openalex.org/W4389108763","https://openalex.org/W6964519051","https://openalex.org/W4416823254","https://openalex.org/W4410070483","https://openalex.org/W4285279805","https://openalex.org/W7168150768"],"abstract_inverted_index":{"Nanopore":[0],"direct":[1],"RNA":[2,8,25,67],"sequencing":[3],"(DRS)":[4],"reads":[5],"continuous":[6],"native":[7],"strands.":[9],"Early":[10],"adopters":[11],"have":[12,41],"used":[13],"this":[14],"technology":[15],"to":[16,38],"document":[17],"nucleotide":[18],"modifications":[19],"and":[20,55,65],"3\u2032":[21],"polyadenosine":[22],"tails":[23],"on":[24],"strands":[26,32],"without":[27],"added":[28],"chemistry":[29],"steps.":[30],"Individual":[31],"ranging":[33],"in":[34],"length":[35],"from":[36],"70":[37],"26,000":[39],"nucleotides":[40],"been":[42],"sequenced.":[43],"In":[44],"our":[45],"opinion,":[46],"broader":[47],"acceptance":[48],"of":[49],"nanopore":[50],"DRS":[51],"by":[52,61],"molecular":[53],"biologists":[54,57],"cell":[56],"will":[58],"be":[59],"accelerated":[60],"higher":[62],"basecall":[63],"accuracy":[64],"lower":[66],"input":[68],"requirements.":[69]},"counts_by_year":[{"year":2026,"cited_by_count":42},{"year":2025,"cited_by_count":74},{"year":2024,"cited_by_count":59},{"year":2023,"cited_by_count":29}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2022-10-06T00:00:00"}
