{"id":"https://openalex.org/W4302283239","doi":"https://doi.org/10.1136/bmjoq-2021-001797","title":"Reducing the costs of floor cleaning in a level III NICU of Bangalore rural: a quality","display_name":"Reducing the costs of floor cleaning in a level III NICU of Bangalore rural: a quality","publication_year":2022,"publication_date":"2022-10-01","ids":{"openalex":"https://openalex.org/W4302283239","doi":"https://doi.org/10.1136/bmjoq-2021-001797","pmid":"https://pubmed.ncbi.nlm.nih.gov/36202408","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9540838"},"language":"en","primary_location":{"id":"doi:10.1136/bmjoq-2021-001797","doi":"https://doi.org/10.1136/bmjoq-2021-001797","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjoq-2021-001797","pdf_url":"https://bmjopenquality.bmj.com/content/bmjqir/11/Suppl_1/e001797.full.pdf","source":{"id":"https://openalex.org/S4210206356","display_name":"BMJ Open Quality","issn_l":"2399-6641","issn":["2399-6641"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open Quality","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmjopenquality.bmj.com/content/bmjqir/11/Suppl_1/e001797.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004693170","display_name":"Abhishek Somasekhara Aradhya","orcid":"https://orcid.org/0000-0003-3524-0939","observed_orcids":["https://orcid.org/0000-0003-3524-0939"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Abhishek Somasekhara Aradhya","raw_affiliation_strings":["Department of Pediatrics, Ovum Hospitals, Bangalore, Karnataka, India"],"raw_orcid":"https://orcid.org/0000-0003-3524-0939","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Ovum Hospitals, Bangalore, Karnataka, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010318211","display_name":"Latha Mercy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Latha Mercy","raw_affiliation_strings":["Department of Pediatrics, Ovum Hospitals, Bangalore, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Ovum Hospitals, Bangalore, Karnataka, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092162604","display_name":"Venugopal Reddy Iragamreddy","orcid":"https://orcid.org/0000-0002-2272-0004","observed_orcids":["https://orcid.org/0000-0002-2272-0004"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Venugopal Reddy","raw_affiliation_strings":["Department of Pediatrics, Ovum Hospitals, Bangalore, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Ovum Hospitals, Bangalore, Karnataka, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035577071","display_name":"Praveen Venkatagiri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Praveen Venkatagiri","raw_affiliation_strings":["Department of Pediatrics, Ovum Hospitals, Bangalore, Karnataka, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Ovum Hospitals, Bangalore, Karnataka, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5004693170"],"corresponding_institution_ids":[],"apc_list":{"value":1500,"currency":"GBP","value_usd":1839},"apc_paid":{"value":1500,"currency":"GBP","value_usd":1839},"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"Suppl 1","first_page":"e001797","last_page":"e001797"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11000","display_name":"Infection Control in Healthcare","score":0.3379000127315521,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11000","display_name":"Infection Control in Healthcare","score":0.3379000127315521,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.18850000202655792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12871","display_name":"Healthcare Quality and Management","score":0.17309999465942383,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neonatal-intensive-care-unit","display_name":"neonatal intensive care unit","score":0.9240000247955322},{"id":"https://openalex.org/keywords/hospital-cost-reduction","display_name":"hospital cost savings","score":0.5220000147819519},{"id":"https://openalex.org/keywords/neonatal-care","display_name":"neonatal care","score":0.4129999876022339},{"id":"https://openalex.org/keywords/rural-hospitals","display_name":"rural hospitals","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C57236427","wikidata":"https://www.wikidata.org/wiki/Q5382987","display_name":"Epileptogenesis","level":3,"score":0.9757095575332642},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.78717041015625},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.5632320046424866},{"id":"https://openalex.org/C100691959","wikidata":"https://www.wikidata.org/wiki/Q6410625","display_name":"Kindling","level":3,"score":0.5491769313812256},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5443084836006165},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5288998484611511},{"id":"https://openalex.org/C2777865847","wikidata":"https://www.wikidata.org/wiki/Q425894","display_name":"Trichostatin A","level":5,"score":0.4530588388442993},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4519750773906708},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43675458431243896},{"id":"https://openalex.org/C2776819090","wikidata":"https://www.wikidata.org/wiki/Q412391","display_name":"Pentylenetetrazol","level":4,"score":0.43296387791633606},{"id":"https://openalex.org/C2778942008","wikidata":"https://www.wikidata.org/wiki/Q305004","display_name":"Sodium butyrate","level":3,"score":0.4269663989543915},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4133131802082062},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23760029673576355},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.1737474501132965},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09266394376754761},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003365","descriptor_name":"Costs and Cost Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007194","descriptor_name":"India","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007363","descriptor_name":"Intensive Care Units, Neonatal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012424","descriptor_name":"Rural Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1136/bmjoq-2021-001797","doi":"https://doi.org/10.1136/bmjoq-2021-001797","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjoq-2021-001797","pdf_url":"https://bmjopenquality.bmj.com/content/bmjqir/11/Suppl_1/e001797.full.pdf","source":{"id":"https://openalex.org/S4210206356","display_name":"BMJ Open Quality","issn_l":"2399-6641","issn":["2399-6641"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open Quality","raw_type":"journal-article"},{"id":"pmid:36202408","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36202408","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ open quality","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9540838","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9540838/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open Qual","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:fa9ddb2db2f34e518edd3f095f3536a2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fa9ddb2db2f34e518edd3f095f3536a2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMJ Open Quality, Vol 11, Iss Suppl 1 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/bmjoq-2021-001797","doi":"https://doi.org/10.1136/bmjoq-2021-001797","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjoq-2021-001797","pdf_url":"https://bmjopenquality.bmj.com/content/bmjqir/11/Suppl_1/e001797.full.pdf","source":{"id":"https://openalex.org/S4210206356","display_name":"BMJ Open Quality","issn_l":"2399-6641","issn":["2399-6641"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open Quality","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4302283239.pdf","grobid_xml":"https://content.openalex.org/works/W4302283239.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W2063672892","https://openalex.org/W2085332470","https://openalex.org/W3164021118"],"related_works":["https://openalex.org/W2766964874","https://openalex.org/W7162666875","https://openalex.org/W2594683118","https://openalex.org/W7131131869","https://openalex.org/W1969023129","https://openalex.org/W4404515118","https://openalex.org/W2766429477","https://openalex.org/W2966039191","https://openalex.org/W999295945","https://openalex.org/W2406242144"],"abstract_inverted_index":{"Epilepsy":[0],"is":[1],"a":[2,43,56,63,90,144,166,173,201],"chronic":[3],"brain":[4,45],"disease":[5,20],"characterized":[6],"by":[7,210],"repeated":[8],"unprovoked":[9],"seizures.":[10],"Currently,":[11],"no":[12],"drug":[13],"therapy":[14,204],"exists":[15],"for":[16,98,139,205],"curing":[17,208],"epilepsy":[18,88,133,209],"or":[19,207],"modification":[21],"in":[22,38,67,80,143,159,169,195],"people":[23],"at":[24],"risk.":[25],"Despite":[26],"several":[27],"emerging":[28],"mechanisms,":[29],"there":[30],"have":[31],"been":[32],"few":[33],"studies":[34],"of":[35,50,59,85,100,114,127,147,155,176,188],"epigenetic":[36,65,213],"signaling":[37,193],"epileptogenesis,":[39],"the":[40,73,81,112,125,156,186,212],"process":[41],"whereby":[42],"normal":[44],"becomes":[46],"progressively":[47],"epileptic":[48,160],"because":[49],"precipitating":[51],"factors.":[52],"Here,":[53],"we":[54],"report":[55],"novel":[57,203],"role":[58,194],"histone":[60,74],"deacetylation":[61],"as":[62],"critical":[64,192],"mechanism":[66],"epileptogenesis.":[68,148,177,196],"Experiments":[69],"were":[70],"conducted":[71],"using":[72],"deacetylase":[75],"(HDAC)":[76],"inhibitor":[77],"sodium":[78],"butyrate":[79,105],"hippocampus":[82],"kindling":[83],"model":[84,92],"temporal":[86],"lobe":[87],"(TLE),":[89],"classic":[91],"heavily":[93],"used":[94],"to":[95],"approve":[96],"drugs":[97],"treatment":[99,103],"epilepsy.":[101],"Daily":[102],"with":[104],"significantly":[106],"inhibited":[107],"HDAC":[108,121,137,149,183,214],"activity":[109],"and":[110],"retarded":[111],"development":[113,187],"limbic":[115],"epileptogenesis":[116],"without":[117],"affecting":[118],"after-discharge":[119],"signal.":[120],"inhibition":[122,138,184],"markedly":[123],"impaired":[124],"persistence":[126],"seizure":[128],"expression":[129],"many":[130],"weeks":[131,141],"after":[132],"development.":[134],"Moreover,":[135],"subchronic":[136],"2":[140],"resulted":[142],"striking":[145],"retardation":[146],"inhibition,":[150],"unexpectedly,":[151],"also":[152],"showed":[153],"erasure":[154],"epileptogenic":[157],"state":[158],"animals.":[161],"Finally,":[162],"butyrate-treated":[163],"animals":[164],"exhibited":[165],"powerful":[167],"reduction":[168],"mossy":[170],"fiber":[171],"sprouting,":[172],"morphologic":[174],"index":[175],"Together":[178],"these":[179],"results":[180],"underscore":[181],"that":[182],"prevents":[185],"TLE,":[189],"indicating":[190],"HDAC\u2019s":[191],"These":[197],"findings,":[198],"therefore,":[199],"envisage":[200],"unique":[202],"preventing":[206],"targeting":[211],"pathway.":[215]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-10-06T00:00:00"}