{"id":"https://openalex.org/W4302013574","doi":"https://doi.org/10.1080/17425247.2022.2131768","title":"Synthetic biodegradable polyesters for implantable controlled-release devices","display_name":"Synthetic biodegradable polyesters for implantable controlled-release devices","publication_year":2022,"publication_date":"2022-10-03","ids":{"openalex":"https://openalex.org/W4302013574","doi":"https://doi.org/10.1080/17425247.2022.2131768","pmid":"https://pubmed.ncbi.nlm.nih.gov/36197839"},"language":"en","primary_location":{"id":"doi:10.1080/17425247.2022.2131768","doi":"https://doi.org/10.1080/17425247.2022.2131768","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17425247.2022.2131768","pdf_url":null,"source":{"id":"https://openalex.org/S51663496","display_name":"Expert Opinion on Drug Delivery","issn_l":"1742-5247","issn":["1742-5247","1744-7593"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Delivery","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026463009","display_name":"Jinal U. Pothupitiya","orcid":"https://orcid.org/0000-0002-6281-2683","observed_orcids":["https://orcid.org/0000-0002-6281-2683"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinal U. Pothupitiya","raw_affiliation_strings":["Department of Biomedical Engineering, Yale University, New Haven, CT, USA","Department of Cellular & Molecular Physiology, Yale University, New Haven, CT, USA","Department of Chemical & Environmental Engineering, Yale University, New Haven, CT, USA","Department of Dermatology, Yale University, New Haven, CT, USA"],"raw_orcid":"https://orcid.org/0000-0002-6281-2683","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Cellular & Molecular Physiology, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Chemical & Environmental Engineering, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Dermatology, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059436082","display_name":"Christy Zheng","orcid":"https://orcid.org/0000-0002-1748-7607","observed_orcids":["https://orcid.org/0000-0002-1748-7607"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christy Zheng","raw_affiliation_strings":["Department of Biomedical Engineering, Yale University, New Haven, CT, USA","Department of Cellular & Molecular Physiology, Yale University, New Haven, CT, USA","Department of Chemical & Environmental Engineering, Yale University, New Haven, CT, USA","Department of Dermatology, Yale University, New Haven, CT, USA"],"raw_orcid":"https://orcid.org/0000-0002-1748-7607","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Cellular & Molecular Physiology, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Chemical & Environmental Engineering, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Dermatology, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012106344","display_name":"W. Mark Saltzman","orcid":"https://orcid.org/0000-0002-2163-549X","observed_orcids":["https://orcid.org/0000-0002-2163-549X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"W. Mark Saltzman","raw_affiliation_strings":["Department of Biomedical Engineering, Yale University, New Haven, CT, USA","Department of Cellular & Molecular Physiology, Yale University, New Haven, CT, USA","Department of Chemical & Environmental Engineering, Yale University, New Haven, CT, USA","Department of Dermatology, Yale University, New Haven, CT, USA"],"raw_orcid":"https://orcid.org/0000-0002-2163-549X","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Cellular & Molecular Physiology, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Chemical & Environmental Engineering, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Dermatology, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012106344"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":0.4593,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.37845706,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"19","issue":"10","first_page":"1351","last_page":"1364"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.8925999999046326,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.8925999999046326,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10661","display_name":"biodegradable polymer synthesis and properties","score":0.09449999779462814,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biodegradable-polyesters","display_name":"biodegradable polyesters","score":0.9980000257492065},{"id":"https://openalex.org/keywords/implantable-drug-delivery-systems","display_name":"implantable drug delivery","score":0.890999972820282},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.8989999890327454},{"id":"https://openalex.org/keywords/drug-loaded-implants","display_name":"drug-loaded implants","score":0.8579999804496765},{"id":"https://openalex.org/keywords/drug-release-mechanism","display_name":"drug release mechanism","score":0.7049999833106995},{"id":"https://openalex.org/keywords/localized-drug-release","display_name":"localized drug release","score":0.7950000166893005},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.7400000095367432},{"id":"https://openalex.org/keywords/pain-management","display_name":"pain management","score":0.6190000176429749},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.9229999780654907},{"id":"https://openalex.org/keywords/contraception","display_name":"contraception","score":0.8500000238418579},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.9810000061988831}],"concepts":[{"id":"https://openalex.org/C119394753","wikidata":"https://www.wikidata.org/wiki/Q188245","display_name":"Polyester","level":2,"score":0.783578634262085},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6585140228271484},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.579567015171051},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5459633469581604},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5424826741218567},{"id":"https://openalex.org/C163588942","wikidata":"https://www.wikidata.org/wiki/Q5165929","display_name":"Controlled release","level":2,"score":0.5246713161468506},{"id":"https://openalex.org/C45211672","wikidata":"https://www.wikidata.org/wiki/Q4119016","display_name":"Biodegradable polymer","level":3,"score":0.5024557113647461},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.48677846789360046},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.468230664730072},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32063931226730347},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3066718280315399},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.25971636176109314},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.19066840410232544},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004343","descriptor_name":"Drug Implants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011091","descriptor_name":"Polyesters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D065546","descriptor_name":"Drug Liberation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/17425247.2022.2131768","doi":"https://doi.org/10.1080/17425247.2022.2131768","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17425247.2022.2131768","pdf_url":null,"source":{"id":"https://openalex.org/S51663496","display_name":"Expert Opinion on Drug Delivery","issn_l":"1742-5247","issn":["1742-5247","1744-7593"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Delivery","raw_type":"journal-article"},{"id":"pmid:36197839","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36197839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on drug delivery","raw_type":"Review"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1423435821","display_name":null,"funder_award_id":"OPP1200867","funder_id":"https://openalex.org/F4320306115","funder_display_name":"United States Agency for International Development"}],"funders":[{"id":"https://openalex.org/F4320306115","display_name":"United States Agency for International Development","ror":"https://ror.org/01n6e6j62"},{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":171,"referenced_works":["https://openalex.org/W343060647","https://openalex.org/W1509156154","https://openalex.org/W1509303906","https://openalex.org/W1946992674","https://openalex.org/W1964369590","https://openalex.org/W1964890096","https://openalex.org/W1967995141","https://openalex.org/W1968761716","https://openalex.org/W1971916284","https://openalex.org/W1972018012","https://openalex.org/W1972536063","https://openalex.org/W1975828910","https://openalex.org/W1976930786","https://openalex.org/W1977072597","https://openalex.org/W1984054252","https://openalex.org/W1985570466","https://openalex.org/W1985656444","https://openalex.org/W1985800624","https://openalex.org/W1992578749","https://openalex.org/W1993400409","https://openalex.org/W1993831258","https://openalex.org/W1995456522","https://openalex.org/W1999501080","https://openalex.org/W2003101514","https://openalex.org/W2006679764","https://openalex.org/W2007793290","https://openalex.org/W2008533076","https://openalex.org/W2009841111","https://openalex.org/W2010393253","https://openalex.org/W2010400795","https://openalex.org/W2013742329","https://openalex.org/W2016020566","https://openalex.org/W2016844038","https://openalex.org/W2017240002","https://openalex.org/W2019157513","https://openalex.org/W2024262973","https://openalex.org/W2024264816","https://openalex.org/W2025535896","https://openalex.org/W2028874982","https://openalex.org/W2033637395","https://openalex.org/W2034717191","https://openalex.org/W2047287124","https://openalex.org/W2047958475","https://openalex.org/W2048797437","https://openalex.org/W2049816550","https://openalex.org/W2049930363","https://openalex.org/W2051863890","https://openalex.org/W2054948075","https://openalex.org/W2056730157","https://openalex.org/W2056833999","https://openalex.org/W2058913110","https://openalex.org/W2064672899","https://openalex.org/W2071935288","https://openalex.org/W2075343185","https://openalex.org/W2077411228","https://openalex.org/W2077634623","https://openalex.org/W2085673277","https://openalex.org/W2086470645","https://openalex.org/W2087032263","https://openalex.org/W2092370428","https://openalex.org/W2092888419","https://openalex.org/W2099435753","https://openalex.org/W2101120946","https://openalex.org/W2106035984","https://openalex.org/W2108040669","https://openalex.org/W2108463100","https://openalex.org/W2118031005","https://openalex.org/W2131290715","https://openalex.org/W2133105213","https://openalex.org/W2138699545","https://openalex.org/W2139636274","https://openalex.org/W2144438594","https://openalex.org/W2145463329","https://openalex.org/W2145587477","https://openalex.org/W2151585742","https://openalex.org/W2157976579","https://openalex.org/W2163562411","https://openalex.org/W2170456951","https://openalex.org/W2186075428","https://openalex.org/W2208142751","https://openalex.org/W2229309228","https://openalex.org/W2258689661","https://openalex.org/W2277474039","https://openalex.org/W2289002238","https://openalex.org/W2303279577","https://openalex.org/W2321998191","https://openalex.org/W2330801783","https://openalex.org/W2370611650","https://openalex.org/W2470636241","https://openalex.org/W2472329501","https://openalex.org/W2505029629","https://openalex.org/W2554019942","https://openalex.org/W2558113089","https://openalex.org/W2577348619","https://openalex.org/W2593680118","https://openalex.org/W2610468247","https://openalex.org/W2611155692","https://openalex.org/W2619456193","https://openalex.org/W2747631593","https://openalex.org/W2757077157","https://openalex.org/W2765306627","https://openalex.org/W2770158960","https://openalex.org/W2781695025","https://openalex.org/W2785651857","https://openalex.org/W2790491770","https://openalex.org/W2790899697","https://openalex.org/W2791629423","https://openalex.org/W2792360188","https://openalex.org/W2792615048","https://openalex.org/W2793749008","https://openalex.org/W2800095283","https://openalex.org/W2883478827","https://openalex.org/W2885443429","https://openalex.org/W2892069689","https://openalex.org/W2903613218","https://openalex.org/W2911522931","https://openalex.org/W2912502989","https://openalex.org/W2921533698","https://openalex.org/W2941289539","https://openalex.org/W2946663771","https://openalex.org/W2948611734","https://openalex.org/W2948838573","https://openalex.org/W2967076325","https://openalex.org/W2970309842","https://openalex.org/W2974040532","https://openalex.org/W2979728016","https://openalex.org/W2982613471","https://openalex.org/W2986343050","https://openalex.org/W2987931197","https://openalex.org/W2991253675","https://openalex.org/W2991877203","https://openalex.org/W3004719946","https://openalex.org/W3013719332","https://openalex.org/W3015824084","https://openalex.org/W3042251649","https://openalex.org/W3047355133","https://openalex.org/W3095452147","https://openalex.org/W3096086014","https://openalex.org/W3111638484","https://openalex.org/W3112036251","https://openalex.org/W3120412421","https://openalex.org/W3120831601","https://openalex.org/W3121957226","https://openalex.org/W3129288808","https://openalex.org/W3135678215","https://openalex.org/W3135836510","https://openalex.org/W3135966249","https://openalex.org/W3148531641","https://openalex.org/W3159027057","https://openalex.org/W3165877104","https://openalex.org/W3166301720","https://openalex.org/W3176688087","https://openalex.org/W3177138598","https://openalex.org/W3194428327","https://openalex.org/W3194753014","https://openalex.org/W3196168773","https://openalex.org/W3203016969","https://openalex.org/W3207376694","https://openalex.org/W4200329047","https://openalex.org/W4205690004","https://openalex.org/W4205924698","https://openalex.org/W4212927278","https://openalex.org/W4213050961","https://openalex.org/W4221134582","https://openalex.org/W4224275506","https://openalex.org/W4225002709","https://openalex.org/W4226168218","https://openalex.org/W4243435236","https://openalex.org/W4255378812","https://openalex.org/W4281682194","https://openalex.org/W4286208795"],"related_works":["https://openalex.org/W7154008802","https://openalex.org/W7203608078","https://openalex.org/W7203588277","https://openalex.org/W2099774314","https://openalex.org/W22226093","https://openalex.org/W1971835699","https://openalex.org/W2484562721","https://openalex.org/W2037067627","https://openalex.org/W3128939164","https://openalex.org/W2055781205"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Implantable":[1],"devices":[2],"can":[3,132],"be":[4],"designed":[5],"to":[6,9,25,141,174],"release":[7,36,161],"drugs":[8],"localized":[10,135],"regions":[11],"of":[12,30,68,78,89,95,129,145,147,159,170,178],"tissue":[13,127],"at":[14],"sustained":[15,112],"and":[16,28,43,58,86,92,111,118,126],"reliable":[17],"rates.":[18],"Advances":[19],"in":[20,150,180],"polymer":[21],"engineering":[22],"have":[23],"led":[24],"the":[26,66,76,123,142,167,176],"design":[27,125],"development":[29],"drug-loaded":[31,72],"implants":[32,49,73,96,105,131,154,165,173],"with":[33],"predictable,":[34],"desirable":[35],"profiles.":[37],"Biodegradable":[38],"polyesters":[39,70,149],"exhibit":[40],"chemical,":[41],"physical,":[42],"biological":[44],"properties":[45,77],"suitable":[46],"for":[47,50,71,83,109,184],"developing":[48],"pain":[51],"management,":[52],"cancer":[53],"therapy,":[54,57],"contraception,":[55],"antiviral":[56],"other":[59],"applications.":[60],"AREAS":[61],"COVERED:":[62],"This":[63],"article":[64],"reviews":[65],"use":[67,146],"biodegradable":[69],"by":[74],"discussing":[75],"commonly":[79],"used":[80],"polymers,":[81],"techniques":[82],"implant":[84,124],"formulation":[85],"manufacturing,":[87],"mechanisms":[88],"drug":[90,98,113,138,171],"release,":[91,114],"clinical":[93],"applications":[94],"as":[97],"delivery":[99,104,172],"devices.":[100],"EXPERT":[101],"OPINION:":[102],"Drug":[103],"are":[106,166],"unique":[107],"systems":[108],"safe":[110],"providing":[115],"high":[116],"bioavailability":[117],"low":[119],"toxicity.":[120],"Depending":[121],"on":[122],"site":[128],"deployment,":[130],"offer":[133],"either":[134],"or":[136,182],"systemic":[137],"release.":[139],"Due":[140],"long":[143],"history":[144],"degradable":[148],"medical":[151],"devices,":[152],"polyester-based":[153,164],"represent":[155],"an":[156],"important":[157],"class":[158],"controlled":[160],"technologies.":[162],"Further,":[163],"largest":[168],"category":[169],"reach":[175],"point":[177],"testing":[179],"humans":[181],"approval":[183],"human":[185],"use.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-10-06T00:00:00"}