{"id":"https://openalex.org/W4302013403","doi":"https://doi.org/10.1002/cbdv.202200615","title":"Phytochemicals and Biological Activities of Burdock ( Arctium lappa L.) Extracts: A Review","display_name":"Phytochemicals and Biological Activities of Burdock ( Arctium lappa L.) Extracts: A Review","publication_year":2022,"publication_date":"2022-10-05","ids":{"openalex":"https://openalex.org/W4302013403","doi":"https://doi.org/10.1002/cbdv.202200615","pmid":"https://pubmed.ncbi.nlm.nih.gov/36198078"},"language":"en","primary_location":{"id":"doi:10.1002/cbdv.202200615","doi":"https://doi.org/10.1002/cbdv.202200615","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbdv.202200615","pdf_url":null,"source":{"id":"https://openalex.org/S206700086","display_name":"Chemistry & Biodiversity","issn_l":"1612-1872","issn":["1612-1872","1612-1880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biodiversity","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032067368","display_name":"Ari\u00e1dine Reder Cust\u00f3dio de Souza","orcid":"https://orcid.org/0000-0003-4306-2984","observed_orcids":["https://orcid.org/0000-0003-4306-2984"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ari\u00e1dine Reder Custodio de Souza","raw_affiliation_strings":["Department of Food Engineering State University of Midwest  Alameda \u00c9lio Antonio Dalla Vecchia, 838 85040-167 Guarapuava Paran\u00e1 Brazil"],"raw_orcid":"https://orcid.org/0000-0003-4306-2984","affiliations":[{"raw_affiliation_string":"Department of Food Engineering State University of Midwest  Alameda \u00c9lio Antonio Dalla Vecchia, 838 85040-167 Guarapuava Paran\u00e1 Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022953413","display_name":"Thais Latansio de Oliveira","orcid":"https://orcid.org/0000-0002-1294-2578","observed_orcids":["https://orcid.org/0000-0002-1294-2578"]},"institutions":[{"id":"https://openalex.org/I3018588415","display_name":"Centro Universit\u00e1rio Cesumar","ror":"https://ror.org/03byjr489","country_code":"BR","type":"education","lineage":["https://openalex.org/I3018588415"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Thais Latansio de Oliveira","raw_affiliation_strings":["Center for Biological and Health Sciences UniCesumar  Rua Desembargador Westphalen, 60 84036-350 Ponta Grossa Paran\u00e1 Brazil"],"raw_orcid":"https://orcid.org/0000-0002-1294-2578","affiliations":[{"raw_affiliation_string":"Center for Biological and Health Sciences UniCesumar  Rua Desembargador Westphalen, 60 84036-350 Ponta Grossa Paran\u00e1 Brazil","institution_ids":["https://openalex.org/I3018588415"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074822190","display_name":"P\u00e2mela Dias Fontana","orcid":"https://orcid.org/0000-0003-3489-5909","observed_orcids":["https://orcid.org/0000-0003-3489-5909","https://orcid.org/0000-0003-3031-6367"]},"institutions":[{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"P\u00e2mela Dias Fontana","raw_affiliation_strings":["Department of Medical Pathology Federal University of Paran\u00e1  Rua Gen. Carneiro, 181 80060-900 Curitiba Paran\u00e1 Brazil"],"raw_orcid":"https://orcid.org/0000-0003-3489-5909","affiliations":[{"raw_affiliation_string":"Department of Medical Pathology Federal University of Paran\u00e1  Rua Gen. Carneiro, 181 80060-900 Curitiba Paran\u00e1 Brazil","institution_ids":["https://openalex.org/I52418104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062584677","display_name":"Milena Carvalho Carneiro","orcid":"https://orcid.org/0000-0003-1077-1506","observed_orcids":["https://orcid.org/0000-0003-1077-1506"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Milena Carvalho Carneiro","raw_affiliation_strings":["Department of Immunology University of S\u00e3o Paulo  Avenida Prof. Lineu Prestes 05508-000 S\u00e3o Paulo Brazil"],"raw_orcid":"https://orcid.org/0000-0003-1077-1506","affiliations":[{"raw_affiliation_string":"Department of Immunology University of S\u00e3o Paulo  Avenida Prof. Lineu Prestes 05508-000 S\u00e3o Paulo Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008001412","display_name":"Marcos Lucio Corazza","orcid":"https://orcid.org/0000-0003-2305-1989","observed_orcids":["https://orcid.org/0000-0003-2305-1989"]},"institutions":[{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcos L\u00facio Corazza","raw_affiliation_strings":["Department of Chemical Engineering Federal University of Paran\u00e1  Avenida Coronel Francisco H. dos Santos 81531-990 Curitiba Paran\u00e1 Brazil"],"raw_orcid":"https://orcid.org/0000-0003-2305-1989","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering Federal University of Paran\u00e1  Avenida Coronel Francisco H. dos Santos 81531-990 Curitiba Paran\u00e1 Brazil","institution_ids":["https://openalex.org/I52418104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028857982","display_name":"Iara Messias-Reason","orcid":"https://orcid.org/0000-0002-5573-260X","observed_orcids":["https://orcid.org/0000-0002-5573-260X"]},"institutions":[{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Iara Jose de Messias Reason","raw_affiliation_strings":["Department of Medical Pathology Federal University of Paran\u00e1  Rua Gen. Carneiro, 181 80060-900 Curitiba Paran\u00e1 Brazil"],"raw_orcid":"https://orcid.org/0000-0002-5573-260X","affiliations":[{"raw_affiliation_string":"Department of Medical Pathology Federal University of Paran\u00e1  Rua Gen. Carneiro, 181 80060-900 Curitiba Paran\u00e1 Brazil","institution_ids":["https://openalex.org/I52418104"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035873821","display_name":"Lorena Bavia","orcid":"https://orcid.org/0000-0003-1702-2284","observed_orcids":["https://orcid.org/0000-0003-1702-2284"]},"institutions":[{"id":"https://openalex.org/I52418104","display_name":"Universidade Federal do Paran\u00e1","ror":"https://ror.org/05syd6y78","country_code":"BR","type":"education","lineage":["https://openalex.org/I52418104"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Lorena Bavia","raw_affiliation_strings":["Department of Cell Biology Federal University of Paran\u00e1  Avenida Coronel Francisco H. dos Santos, 100 19031, 81531-980 Curitiba Paran\u00e1 Brazil"],"raw_orcid":"https://orcid.org/0000-0003-1702-2284","affiliations":[{"raw_affiliation_string":"Department of Cell Biology Federal University of Paran\u00e1  Avenida Coronel Francisco H. dos Santos, 100 19031, 81531-980 Curitiba Paran\u00e1 Brazil","institution_ids":["https://openalex.org/I52418104"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035873821"],"corresponding_institution_ids":["https://openalex.org/I52418104"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":0.4533,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.36345089,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"19","issue":"11","first_page":"e202200615","last_page":"e202200615"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.6211000084877014,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.6211000084877014,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.17739999294281006,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11973","display_name":"Plant chemical constituents analysis","score":0.12389999628067017,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arctium-lappa","display_name":"Arctium lappa","score":0.9990000128746033},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.9810000061988831},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.9900000095367432},{"id":"https://openalex.org/keywords/terpenes","display_name":"terpenes","score":0.996999979019165},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9919999837875366},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9800000190734863},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":1.0},{"id":"https://openalex.org/keywords/wild-edible-plants","display_name":"wild edible plants","score":0.7689999938011169},{"id":"https://openalex.org/keywords/medicinal-plants","display_name":"medicinal plants","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C2909562583","wikidata":"https://www.wikidata.org/wiki/Q5575581","display_name":"Arctium lappa","level":2,"score":0.965766429901123},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6915102005004883},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5882753133773804},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5686424970626831},{"id":"https://openalex.org/C44937612","wikidata":"https://www.wikidata.org/wiki/Q212364","display_name":"Terpene","level":2,"score":0.5487077236175537},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.532578706741333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19770163297653198},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10488271713256836},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D031170","descriptor_name":"Arctium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D064209","descriptor_name":"Phytochemicals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064209","descriptor_name":"Phytochemicals","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cbdv.202200615","doi":"https://doi.org/10.1002/cbdv.202200615","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbdv.202200615","pdf_url":null,"source":{"id":"https://openalex.org/S206700086","display_name":"Chemistry & Biodiversity","issn_l":"1612-1872","issn":["1612-1872","1612-1880"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & Biodiversity","raw_type":"journal-article"},{"id":"pmid:36198078","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36198078","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemistry & biodiversity","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":131,"referenced_works":["https://openalex.org/W97931933","https://openalex.org/W100277804","https://openalex.org/W852174574","https://openalex.org/W1462606079","https://openalex.org/W1552827566","https://openalex.org/W1568914582","https://openalex.org/W1587696181","https://openalex.org/W1961007623","https://openalex.org/W1963531920","https://openalex.org/W1974370294","https://openalex.org/W1976674928","https://openalex.org/W1979189704","https://openalex.org/W1981677485","https://openalex.org/W1983463696","https://openalex.org/W1984858728","https://openalex.org/W1987054296","https://openalex.org/W1987086586","https://openalex.org/W1988442419","https://openalex.org/W1988885276","https://openalex.org/W1993739340","https://openalex.org/W1994749378","https://openalex.org/W2000810398","https://openalex.org/W2001779548","https://openalex.org/W2006864838","https://openalex.org/W2007612032","https://openalex.org/W2012090110","https://openalex.org/W2014191744","https://openalex.org/W2019881147","https://openalex.org/W2021151992","https://openalex.org/W2024127721","https://openalex.org/W2032980460","https://openalex.org/W2035200958","https://openalex.org/W2038834120","https://openalex.org/W2039945137","https://openalex.org/W2048139696","https://openalex.org/W2056057030","https://openalex.org/W2056857495","https://openalex.org/W2062414332","https://openalex.org/W2068562671","https://openalex.org/W2075041427","https://openalex.org/W2076756701","https://openalex.org/W2078263231","https://openalex.org/W2080051804","https://openalex.org/W2080082188","https://openalex.org/W2082066304","https://openalex.org/W2083787857","https://openalex.org/W2085456846","https://openalex.org/W2090807054","https://openalex.org/W2095582845","https://openalex.org/W2100664574","https://openalex.org/W2103151997","https://openalex.org/W2106697064","https://openalex.org/W2111019180","https://openalex.org/W2111903453","https://openalex.org/W2117155382","https://openalex.org/W2122312251","https://openalex.org/W2125421419","https://openalex.org/W2127084057","https://openalex.org/W2136648677","https://openalex.org/W2143526245","https://openalex.org/W2147241039","https://openalex.org/W2148023247","https://openalex.org/W2149591934","https://openalex.org/W2157795406","https://openalex.org/W2165517945","https://openalex.org/W2168803878","https://openalex.org/W2168940291","https://openalex.org/W2172081792","https://openalex.org/W2210005574","https://openalex.org/W2226656930","https://openalex.org/W2278323210","https://openalex.org/W2287049166","https://openalex.org/W2314010529","https://openalex.org/W2315931145","https://openalex.org/W2339076098","https://openalex.org/W2397512299","https://openalex.org/W2432859710","https://openalex.org/W2443127266","https://openalex.org/W2492985291","https://openalex.org/W2496584440","https://openalex.org/W2519530122","https://openalex.org/W2548621528","https://openalex.org/W2555935710","https://openalex.org/W2565862006","https://openalex.org/W2582168232","https://openalex.org/W2599595495","https://openalex.org/W2743988619","https://openalex.org/W2763632197","https://openalex.org/W2767633468","https://openalex.org/W2776350836","https://openalex.org/W2780555838","https://openalex.org/W2786151405","https://openalex.org/W2794079111","https://openalex.org/W2802480494","https://openalex.org/W2804542874","https://openalex.org/W2807927144","https://openalex.org/W2901244515","https://openalex.org/W2901752441","https://openalex.org/W2903768251","https://openalex.org/W2914604561","https://openalex.org/W2915802636","https://openalex.org/W2919848985","https://openalex.org/W2920903673","https://openalex.org/W2946097000","https://openalex.org/W2951286232","https://openalex.org/W2959974167","https://openalex.org/W2963987042","https://openalex.org/W2976456616","https://openalex.org/W2981342933","https://openalex.org/W2991184047","https://openalex.org/W2991909196","https://openalex.org/W2999071824","https://openalex.org/W3000660226","https://openalex.org/W3010875254","https://openalex.org/W3010924828","https://openalex.org/W3032929430","https://openalex.org/W3033136106","https://openalex.org/W3091026034","https://openalex.org/W3093244269","https://openalex.org/W3100036981","https://openalex.org/W3117077698","https://openalex.org/W3127022435","https://openalex.org/W3130013558","https://openalex.org/W3145497580","https://openalex.org/W3158041746","https://openalex.org/W4200364303","https://openalex.org/W4214768268","https://openalex.org/W4226038181","https://openalex.org/W4249396442","https://openalex.org/W4253811102","https://openalex.org/W6910636632"],"related_works":["https://openalex.org/W2512312020","https://openalex.org/W2083787857","https://openalex.org/W2985548905","https://openalex.org/W7095653089","https://openalex.org/W2372853914","https://openalex.org/W4312188447","https://openalex.org/W4312085152","https://openalex.org/W4226038181","https://openalex.org/W7133750939","https://openalex.org/W4401715623"],"abstract_inverted_index":{"Arctium":[0],"lappa":[1,115],"L.,":[2],"also":[3],"known":[4],"as":[5,59],"burdock,":[6],"is":[7,22],"an":[8,81,91,118],"edible":[9],"wild":[10],"plant":[11],"which":[12,79],"has":[13,34],"the":[14,30,38,76,85,112],"ability":[15],"to":[16],"grow":[17],"in":[18,26,37,55,84],"distinct":[19],"environments":[20],"and":[21,40,51,63,123],"considered":[23],"a":[24,72],"weed":[25],"several":[27],"parts":[28],"of":[29,87],"world.":[31],"This":[32],"species":[33,113],"great":[35],"value":[36],"biological":[39,57],"medical":[41],"fields":[42],"with":[43,90,101],"its":[44],"major":[45],"secondary":[46],"components":[47],"being":[48],"phenolic":[49],"compounds":[50],"terpenes,":[52],"substances":[53],"rich":[54],"desired":[56],"activities":[58,104],"antioxidant,":[60],"antimicrobial,":[61],"antitumor":[62],"anti-inflammatory.":[64],"In":[65],"addition,":[66],"burdock":[67],"leaves":[68],"extracts":[69],"have":[70],"shown":[71],"modulatory":[73],"effect":[74,93],"on":[75,94],"complement":[77,96],"system,":[78],"plays":[80],"important":[82],"role":[83],"development":[86],"inflammatory":[88,128],"diseases,":[89],"inhibitory":[92],"all":[95],"pathways.":[97],"Thus,":[98],"natural":[99],"products":[100],"those":[102],"relevant":[103],"are":[105],"promising":[106],"agents":[107],"for":[108,121,127],"healthcare":[109],"applications.":[110],"Therefore,":[111],"A.":[114],"may":[116],"represent":[117],"interesting":[119],"asset":[120],"researching":[122],"developing":[124],"new":[125],"therapies":[126],"afflictions.":[129]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-10-06T00:00:00"}