{"id":"https://openalex.org/W4302010917","doi":"https://doi.org/10.1038/s41586-022-05260-5","title":"Antibiotic combinations reduce Staphylococcus aureus clearance","display_name":"Antibiotic combinations reduce Staphylococcus aureus clearance","publication_year":2022,"publication_date":"2022-10-05","ids":{"openalex":"https://openalex.org/W4302010917","doi":"https://doi.org/10.1038/s41586-022-05260-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/36198788","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9533972"},"language":"en","primary_location":{"id":"doi:10.1038/s41586-022-05260-5","doi":"https://doi.org/10.1038/s41586-022-05260-5","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41586-022-05260-5","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9533972","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083395715","display_name":"Vikt\u00f3ria L\u00e1z\u00e1r","orcid":"https://orcid.org/0000-0002-9778-941X","observed_orcids":["https://orcid.org/0000-0002-9778-941X"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]},{"id":"https://openalex.org/I2800351701","display_name":"HUN-REN Szegedi Biol\u00f3giai Kutat\u00f3k\u00f6zpont","ror":"https://ror.org/016gb1631","country_code":"HU","type":"facility","lineage":["https://openalex.org/I2800351701","https://openalex.org/I7597260"]},{"id":"https://openalex.org/I4210103004","display_name":"Institute of Biochemistry","ror":"https://ror.org/022dvs210","country_code":"HU","type":"facility","lineage":["https://openalex.org/I2800351701","https://openalex.org/I4210103004","https://openalex.org/I7597260"]}],"countries":["HU","IL"],"is_corresponding":false,"raw_author_name":"Vikt\u00f3ria L\u00e1z\u00e1r","raw_affiliation_strings":["Faculty of Biology, Technion-Israel Institute of Technology, Haifa, Israel","HCEMM-BRC Pharmacodinamic Drug Interaction Research Group, Szeged, Hungary","Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Szeged, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biology, Technion-Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]},{"raw_affiliation_string":"HCEMM-BRC Pharmacodinamic Drug Interaction Research Group, Szeged, Hungary","institution_ids":["https://openalex.org/I2800351701"]},{"raw_affiliation_string":"Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Szeged, Hungary","institution_ids":["https://openalex.org/I2800351701","https://openalex.org/I4210103004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017012599","display_name":"Olga Snitser","orcid":"https://orcid.org/0000-0001-6067-1912","observed_orcids":["https://orcid.org/0000-0001-6067-1912"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Olga Snitser","raw_affiliation_strings":["Faculty of Biology, Technion-Israel Institute of Technology, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biology, Technion-Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017021161","display_name":"Daniel Barkan","orcid":"https://orcid.org/0000-0002-5691-1757","observed_orcids":["https://orcid.org/0000-0002-5691-1757"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Daniel Barkan","raw_affiliation_strings":["Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agricultural, Food & Environment, The Hebrew University of Jerusalem, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agricultural, Food & Environment, The Hebrew University of Jerusalem, Jerusalem, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062737173","display_name":"Roy Kishony","orcid":"https://orcid.org/0000-0002-5013-5072","observed_orcids":["https://orcid.org/0000-0002-5013-5072"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Roy Kishony","raw_affiliation_strings":["Faculty of Biology, Technion-Israel Institute of Technology, Haifa, Israel. rkishony@technion.ac.il","Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel. rkishony@technion.ac.il","Faculty of Computer Science, Technion-Israel Institute of Technology, Haifa, Israel. rkishony@technion.ac.il","Faculty of Biology, Technion\u2013Israel Institute of Technology, Haifa, Israel"],"raw_orcid":"https://orcid.org/0000-0002-5013-5072","affiliations":[{"raw_affiliation_string":"Faculty of Biology, Technion-Israel Institute of Technology, Haifa, Israel. rkishony@technion.ac.il","institution_ids":["https://openalex.org/I174306211"]},{"raw_affiliation_string":"Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel. rkishony@technion.ac.il","institution_ids":["https://openalex.org/I174306211"]},{"raw_affiliation_string":"Faculty of Computer Science, Technion-Israel Institute of Technology, Haifa, Israel. rkishony@technion.ac.il","institution_ids":["https://openalex.org/I174306211"]},{"raw_affiliation_string":"Faculty of Biology, Technion\u2013Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5062737173"],"corresponding_institution_ids":["https://openalex.org/I174306211"],"apc_list":{"value":11390,"currency":"USD","value_usd":11390},"apc_paid":null,"fwci":11.8086,"has_fulltext":false,"cited_by_count":123,"citation_normalized_percentile":{"value":0.99185752,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"610","issue":"7932","first_page":"540","last_page":"546"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.8939999938011169,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.8939999938011169,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.023000000044703484,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibiotic-combinations","display_name":"antibiotic combinations","score":0.7720000147819519},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9850000143051147},{"id":"https://openalex.org/keywords/bacterial-clearance","display_name":"bacterial clearance","score":0.9079999923706055},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.5130000114440918},{"id":"https://openalex.org/keywords/persister-cells","display_name":"persister cells","score":0.5680000185966492},{"id":"https://openalex.org/keywords/methicillin-resistant-staphylococcus-aureus","display_name":"methicillin-resistant Staphylococcus aureus","score":0.8899999856948853},{"id":"https://openalex.org/keywords/beta-lactamase-inhibitors","display_name":"beta-lactamase inhibitors","score":0.7870000004768372},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.546999990940094},{"id":"https://openalex.org/keywords/galleria-mellonella","display_name":"Galleria mellonella","score":0.7649999856948853},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.7581579089164734},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.7069888114929199},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.602084219455719},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.538964033126831},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5041793584823608},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.43452268838882446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41903677582740784},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38678833842277527},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3519681692123413},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2696438431739807},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D047090","descriptor_name":"beta-Lactams","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D055624","descriptor_name":"Methicillin-Resistant Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D065093","descriptor_name":"beta-Lactamase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41586-022-05260-5","doi":"https://doi.org/10.1038/s41586-022-05260-5","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41586-022-05260-5","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9533972","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9533972","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Text"},{"id":"pmid:36198788","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36198788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:nature:v:610:y:2022:i:7932:d:10.1038_s41586-022-05260-5","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41586-022-05260-5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9533972","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9533972","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3353436801","display_name":"The population genetics of antibiotic resistance in multi-drug environments","funder_award_id":"R01GM081617","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W1518907982","https://openalex.org/W1599551995","https://openalex.org/W1861965265","https://openalex.org/W1915534382","https://openalex.org/W1963603410","https://openalex.org/W1982836127","https://openalex.org/W2000120673","https://openalex.org/W2000860657","https://openalex.org/W2007296377","https://openalex.org/W2010912190","https://openalex.org/W2019096041","https://openalex.org/W2031932867","https://openalex.org/W2034561842","https://openalex.org/W2035896576","https://openalex.org/W2045701919","https://openalex.org/W2045825103","https://openalex.org/W2056695832","https://openalex.org/W2063951106","https://openalex.org/W2072727449","https://openalex.org/W2073828389","https://openalex.org/W2074221649","https://openalex.org/W2078567081","https://openalex.org/W2084464728","https://openalex.org/W2094637365","https://openalex.org/W2100817487","https://openalex.org/W2108433768","https://openalex.org/W2112396377","https://openalex.org/W2112833584","https://openalex.org/W2115076532","https://openalex.org/W2122710851","https://openalex.org/W2129765509","https://openalex.org/W2130825211","https://openalex.org/W2136008972","https://openalex.org/W2145744900","https://openalex.org/W2146370523","https://openalex.org/W2148134634","https://openalex.org/W2148323109","https://openalex.org/W2157265409","https://openalex.org/W2159536084","https://openalex.org/W2222642144","https://openalex.org/W2341166238","https://openalex.org/W2518086895","https://openalex.org/W2523333269","https://openalex.org/W2564499404","https://openalex.org/W2611046756","https://openalex.org/W2620525720","https://openalex.org/W2751830153","https://openalex.org/W2764287995","https://openalex.org/W2803219518","https://openalex.org/W2810727101","https://openalex.org/W2887752833","https://openalex.org/W2895309779","https://openalex.org/W2912247484","https://openalex.org/W2914639997","https://openalex.org/W2949806765","https://openalex.org/W2968932575","https://openalex.org/W2991248316","https://openalex.org/W2995568032","https://openalex.org/W2998807596","https://openalex.org/W3013942083","https://openalex.org/W3023088732","https://openalex.org/W3043975336","https://openalex.org/W3084015191","https://openalex.org/W3085167852","https://openalex.org/W3110538222","https://openalex.org/W3207744615","https://openalex.org/W4214754383","https://openalex.org/W6906749117"],"related_works":["https://openalex.org/W4307989605","https://openalex.org/W2944287196","https://openalex.org/W4210741336","https://openalex.org/W2009145134","https://openalex.org/W4245950221","https://openalex.org/W4312133059","https://openalex.org/W4387130436","https://openalex.org/W2953487048","https://openalex.org/W2734646424","https://openalex.org/W4411371309"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":29},{"year":2025,"cited_by_count":25},{"year":2024,"cited_by_count":37},{"year":2023,"cited_by_count":30},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-10-06T00:00:00"}
