{"id":"https://openalex.org/W4301912147","doi":"https://doi.org/10.1093/jnci/67.4.947","title":"Demonstration of Multiple Phenotypic Diversity in a Murine Melanoma of Recent Origin 2 3 4","display_name":"Demonstration of Multiple Phenotypic Diversity in a Murine Melanoma of Recent Origin 2 3 4","publication_year":1981,"publication_date":"1981-10-01","ids":{"openalex":"https://openalex.org/W4301912147","doi":"https://doi.org/10.1093/jnci/67.4.947","mag":"2257712216","pmid":"https://pubmed.ncbi.nlm.nih.gov/6944560"},"language":"en","primary_location":{"id":"doi:10.1093/jnci/67.4.947","doi":"https://doi.org/10.1093/jnci/67.4.947","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/67.4.947","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI: Journal of the National Cancer Institute","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110018505","display_name":"Isaiah J. Fidler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isaiah J. Fidler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108907600","display_name":"Eilene Gruys","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eilene Gruys","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103330210","display_name":"Maria A. Cifone","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria A. Cifone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108550037","display_name":"Zoa Barnes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zoa Barnes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110009456","display_name":"Corazon D. Bucana","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Corazon Bucana","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5436,"currency":"USD","value_usd":5436},"apc_paid":null,"fwci":12.1384,"has_fulltext":false,"cited_by_count":196,"citation_normalized_percentile":{"value":0.99025619,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"67","issue":"4","first_page":"947","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.7160000205039978},{"id":"https://openalex.org/keywords/metastatic-heterogeneity","display_name":"metastatic heterogeneity","score":0.9330000281333923},{"id":"https://openalex.org/keywords/tumor-cell-clones","display_name":"tumor cell clones","score":0.5659999847412109},{"id":"https://openalex.org/keywords/c3h-hen-mice","display_name":"C3H/HeN mice","score":0.7179999947547913},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.4909999966621399},{"id":"https://openalex.org/keywords/tumor-subpopulations","display_name":"tumor cell subpopulations","score":0.6480000019073486},{"id":"https://openalex.org/keywords/phenotypic-diversity","display_name":"phenotypic diversity","score":0.6959999799728394},{"id":"https://openalex.org/keywords/tumor-growth-rate","display_name":"tumor growth rate","score":0.5289999842643738},{"id":"https://openalex.org/keywords/karyotype","display_name":"karyotype","score":0.5180000066757202},{"id":"https://openalex.org/keywords/tumor-pigmentation","display_name":"tumor pigmentation","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6440777778625488},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5995897650718689},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5923071503639221},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5088479518890381},{"id":"https://openalex.org/C163005120","wikidata":"https://www.wikidata.org/wiki/Q4115252","display_name":"Subcloning","level":4,"score":0.5043736696243286},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39083296060562134},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38940298557281494},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37860357761383057},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32368046045303345},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20171478390693665},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14002257585525513},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0921330451965332}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/jnci/67.4.947","doi":"https://doi.org/10.1093/jnci/67.4.947","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/67.4.947","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI: Journal of the National Cancer Institute","raw_type":"journal-article"},{"id":"pmid:6944560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6944560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Cancer Institute","raw_type":"Journal Article"},{"id":"mag:2257712216","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6944560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2257712216","https://openalex.org/W1499083095","https://openalex.org/W1998811052","https://openalex.org/W2141379498","https://openalex.org/W2307303111","https://openalex.org/W2067176857","https://openalex.org/W1907082099","https://openalex.org/W1942671762","https://openalex.org/W1999349995","https://openalex.org/W1967203637"],"abstract_inverted_index":{"The":[0,30,70,112,193],"purpose":[1],"of":[2,27,94,114,129,139,157,180,230,239],"these":[3],"studies":[4],"was":[5,46,160,184],"to":[6,67,97,164],"examine":[7],"whether":[8],"the":[9,60,92,95,125,135,140,155,169,178,188,191,225],"metastatic":[10,221],"heterogeneity":[11],"that":[12,34,154,177],"is":[13,234],"frequently":[14],"found":[15],"in":[16,23,36,56,62,79,148,182,198,208,212],"serially":[17],"transplanted":[18,47],"neoplasms":[19],"could":[20],"be":[21],"observed":[22],"a":[24,227],"murine":[25,40,228],"melanoma":[26,33,229],"recent":[28,232],"origin.":[29],"primary":[31],"K-1735":[32,72],"arose":[35],"an":[37,50],"inbred":[38],"C3H/HeN":[39],"mammary":[41],"tumor":[42],"virus-negative":[43],"(C3H-)":[44],"mouse":[45],"once":[48],"into":[49,108],"immunosuppressed":[51],"recipient":[52],"and":[53,73,81,100,120,236],"then":[54],"established":[55],"culture.":[57],"Cells":[58],"from":[59,134],"fifth":[61],"vitro":[63,183],"passage":[64],"were":[65,77,88,105,132,145],"used":[66],"produce":[68,98],"clones.":[69,126,192],"parent":[71,136],"22":[74,130],"cloned":[75],"lines":[76],"tumorigenic":[78,143],"syngeneic":[80],"outbred":[82],"N:NIH(S)":[83],"nude":[84,150],"mice.":[85,111],"Metastatic":[86],"properties":[87],"assessed":[89],"by":[90,168],"observing":[91],"ability":[93],"cells":[96,240],"pulmonary":[99],"extrapulmonary":[101],"lesions":[102],"after":[103],"they":[104,205],"injected":[106],"iv":[107],"6-week-old":[109],"C3H-":[110,171],"number":[113],"metastases":[115],"produced,":[116],"their":[117,165,199,209],"relative":[118],"size,":[119,203],"pigmentation":[121],"varied":[122],"dramatically":[123],"among":[124,190],"Only":[127],"2":[128],"clones":[131,194],"indistinguishable":[133],"tumor.":[137],"Most":[138],"nonmetastatic":[141,147],"(but":[142],"clones)":[144],"also":[146],"3-week-old":[149],"mice,":[151],"which":[152],"suggests":[153],"absence":[156],"metastasis":[158],"formation":[159],"not":[161,185,196,218],"merely":[162],"due":[163],"immunologic":[166],"rejection":[167],"normal":[170],"mouse.":[172],"Control":[173],"subcloning":[174],"experiments":[175],"demonstrated":[176],"procedure":[179],"cloning":[181],"responsible":[186],"for":[187],"variability":[189],"did":[195,206,217],"differ":[197,207],"karyotype":[200],"or":[201],"cell":[202],"but":[204],"growth":[210],"rate":[211],"vitro.":[213],"These":[214],"phenotypes,":[215],"however,":[216],"correlate":[219],"with":[220,241],"propensity.":[222],"In":[223],"conclusion,":[224],"K-1735,":[226],"most":[231],"origin,":[233],"heterogeneous":[235],"contains":[237],"subpopulations":[238],"diverse":[242],"biologic":[243],"behavior.":[244]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-10-06T00:00:00"}
