{"id":"https://openalex.org/W4301906451","doi":null,"title":"NTP Toxicology and Carcinogenesis Studies of Nitromethane (CAS No. 75-52-5) in F344/N Rats and B6C3F1 Mice (Inhalation Studies).","display_name":"NTP Toxicology and Carcinogenesis Studies of Nitromethane (CAS No. 75-52-5) in F344/N Rats and B6C3F1 Mice (Inhalation Studies).","publication_year":1997,"publication_date":"1997-02-01","ids":{"openalex":"https://openalex.org/W4301906451","pmid":"https://pubmed.ncbi.nlm.nih.gov/12587015"},"language":"en","primary_location":{"id":"pmid:12587015","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12587015","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"National Toxicology Program technical report series","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"461","issue":null,"first_page":"1","last_page":"289"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11493","display_name":"Water Treatment and Disinfection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitromethane","display_name":"nitromethane","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inhalation-toxicity","display_name":"inhalation toxicity","score":0.7289999723434448},{"id":"https://openalex.org/keywords/carcinogenicity","display_name":"carcinogenicity","score":0.7749999761581421},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.7390000224113464},{"id":"https://openalex.org/keywords/f344-n-rats","display_name":"F344/N rats","score":0.847000002861023},{"id":"https://openalex.org/keywords/b6c3f1-mice","display_name":"B6C3F1 mice","score":1.0},{"id":"https://openalex.org/keywords/liver-weight","display_name":"liver weight","score":0.5220000147819519},{"id":"https://openalex.org/keywords/2-nitropropane","display_name":"2-nitropropane","score":0.6520000100135803},{"id":"https://openalex.org/keywords/tetranitromethane","display_name":"tetranitromethane","score":0.9819999933242798},{"id":"https://openalex.org/keywords/human-exposure","display_name":"human exposure","score":0.37299999594688416},{"id":"https://openalex.org/keywords/occupational-exposure","display_name":"occupational exposure","score":0.3499999940395355},{"id":"https://openalex.org/keywords/environmental-exposure","display_name":"environmental exposure","score":0.3230000138282776},{"id":"https://openalex.org/keywords/salmonella-typhimurium","display_name":"Salmonella typhimurium","score":0.675000011920929},{"id":"https://openalex.org/keywords/cho-cells","display_name":"CHO cells","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C2777327210","wikidata":"https://www.wikidata.org/wiki/Q407733","display_name":"Nitromethane","level":2,"score":0.7710453271865845},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.7525189518928528},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5988484025001526},{"id":"https://openalex.org/C2779777708","wikidata":"https://www.wikidata.org/wiki/Q6033622","display_name":"Inhalation exposure","level":3,"score":0.5732225775718689},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.4851427972316742},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4719254970550537},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.4550824761390686},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43937498331069946},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.32950359582901},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2933580279350281},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.23602887988090515},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17420563101768494},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16209730505943298},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.15123039484024048},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07168689370155334},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmid:12587015","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12587015","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"National Toxicology Program technical report series","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4299141600","https://openalex.org/W2404425094","https://openalex.org/W2000636068","https://openalex.org/W4240082140","https://openalex.org/W4298446030","https://openalex.org/W2104453273","https://openalex.org/W1980217167","https://openalex.org/W4301019720","https://openalex.org/W2417769743","https://openalex.org/W4302438065"],"abstract_inverted_index":{"Nitromethane":[0,49],"is":[1,63],"used":[2],"as":[3,9,20,24,665,717,1281],"a":[4,10,21,623,648,1645],"rocket":[5],"and":[6,17,23,31,42,45,60,70,73,77,109,123,189,209,227,229,253,256,291,307,338,381,387,400,404,413,423,427,434,468,484,499,542,571,595,609,611,617,643,680,682,696,743,771,800,804,818,826,834,842,847,853,858,869,876,893,906,949,986,995,1007,1013,1037,1061,1072,1091,1100,1132,1147,1171,1200,1213,1308,1320,1360,1389,1473,1478,1496,1509,1515,1520,1537,1542,1560,1571,1591,1597,1621],"engine":[7],"fuel;":[8],"synthesis":[11],"intermediate":[12],"for":[13,56,88,149,364,525,636,932,1195,1384],"agricultural":[14],"fumigants,":[15],"biocides,":[16],"other":[18],"products;":[19],"solvent;":[22],"an":[25,583],"explosive":[26],"in":[27,38,40,46,101,169,206,212,224,233,286,304,402,407,420,430,441,465,482,489,548,566,568,582,593,634,676,687,729,736,749,768,794,797,805,815,824,835,851,855,867,1010,1032,1069,1084,1086,1095,1097,1116,1150,1208,1225,1270,1283,1285,1291,1296,1314,1317,1329,1339,1349,1396,1475,1501,1513,1517,1526,1535,1539,1552,1557,1594,1613,1616,1624,1634,1638],"mining,":[28],"oil-well":[29],"drilling,":[30],"seismic":[32],"exploration.":[33],"It":[34],"has":[35],"been":[36,655],"detected":[37],"air,":[39],"surface":[41],"drinking":[43],"water,":[44],"cigarette":[47],"smoke.":[48],"was":[50,174,284,302,462,478,590,626,706,791,871,1230,1289,1401],"studied":[51],"because":[52,61],"of":[53,113,120,158,166,181,194,201,231,239,246,250,260,273,280,289,335,373,384,393,417,439,451,455,459,479,496,534,545,558,577,605,661,667,722,726,747,759,766,787,864,889,903,941,952,960,974,977,987,1001,1004,1008,1022,1029,1042,1055,1107,1123,1135,1160,1168,1223,1235,1243,1254,1266,1304,1335,1357,1394,1406,1413,1425,1440,1446,1453,1460,1492,1531,1568,1582,1610,1649],"the":[54,67,156,159,170,182,184,202,213,225,234,237,240,254,274,281,287,371,374,394,408,421,435,442,452,456,460,532,535,549,559,569,637,641,658,668,713,720,750,760,769,780,788,798,856,862,890,894,939,942,961,982,996,1011,1023,1033,1038,1056,1087,1098,1108,1120,1133,1151,1161,1226,1236,1239,1250,1255,1258,1286,1297,1318,1330,1333,1340,1350,1397,1407,1421,1426,1429,1436,1441,1444,1447,1461,1464,1471,1518,1527,1540,1553,1558,1578,1592,1595,1605,1617,1625,1635,1639],"potential":[55],"widespread":[57],"human":[58],"exposure":[59,576,584,1507,1589],"it":[62],"structurally":[64],"related":[65],"to":[66,129,199,263,277,294,311,318,344,370,391,471,486,505,531,579,598,657,691,700,712,784,808,829,839,873,879,886,912,938,958,990,1045,1076,1114,1130,1143,1177,1249,1273,1366,1435,1458],"carcinogens":[68],"2-nitropropane":[69],"tetranitromethane.":[71],"Male":[72],"female":[74,125,210,308,340,405,428,501,697,837,908,1073,1173,1217,1294,1315,1362,1622],"F344/N":[75],"rats":[76,126,153,168,211,252,309,316,502,529,547,567,578,689,698,796,1174,1284,1295,1316],"B6C3F1":[78],"mice":[79,341,368,406,419,429,909,936,954,980,1031,1074,1363,1503,1556,1615,1623],"received":[80],"nitromethane":[81,138,353,514,580,921,1184,1373],"(purity":[82],"98%":[83],"or":[84,93,135,266,297,314,320,350,474,511,601,652,694,702,708,811,832,882,918,993,1048,1079,1181,1216,1275,1293,1311,1370,1498,1574,1652],"greater)":[85],"by":[86,139,354,515,719,922,1185,1374],"inhalation":[87],"16":[89,150,365],"days,":[90],"13":[91,526,933],"weeks,":[92],"2":[94],"years.":[95],"Genetic":[96],"toxicology":[97],"studies":[98],"were":[99,127,197,268,342,389,446,503,553,620,685,739,754,775,910,955,964,1017,1050,1066,1175,1204,1246,1262,1324,1344,1364,1416,1432,1456,1482,1510,1546,1601,1629],"conducted":[100],"Salmonella":[102],"typhimurium,":[103],"cultured":[104],"Chinese":[105],"hamster":[106],"ovary":[107],"cells,":[108],"peripheral":[110],"blood":[111],"erythrocytes":[112],"mice.":[114],"16-DAY":[115,330],"STUDY":[116,331,492,899,1164,1353],"IN":[117,332,493,900,1165,1354],"RATS:":[118,494,1166],"Groups":[119,334,495,902,1167,1356],"five":[121,124,336,339],"male":[122,167,208,251,306,337,403,418,498,546,688,795,905,979,1030,1071,1170,1215,1292,1359,1614],"exposed":[128,195,248,262,293,310,317,343,385,432,470,504,597,690,699,730,807,816,828,838,878,911,953,978,989,1005,1044,1075,1176,1212,1244,1272,1365,1414,1454,1476,1502],"0,":[130,345,506,913,1178,1367],"94,":[131,346,507,914,1179],"188,":[132,347,508,915,1180,1368],"375,":[133,348,509,916,1369],"750,":[134,349,510,917],"1,500":[136,171,214,321,351,409,424,512,550,572,703,751,772,801,859,919,983,1014,1152],"ppm":[137,172,215,265,296,313,322,352,410,425,444,473,513,551,573,600,693,752,773,802,810,831,841,860,881,920,984,992,1015,1035,1047,1078,1089,1102,1153,1183,1228,1322,1342,1372,1399,1522,1544,1562,1599,1619,1627,1641],"inhalation,":[140,355,516,923,1186,1375],"6":[141,356,517,924,1187,1376],"hours":[142,357,518,925,1188,1377],"per":[143,147,358,362,519,523,926,930,1189,1193,1378,1382],"day,":[144,359,520,927,1190,1379],"5":[145,360,521,928,1191,1380],"days":[146,361,522,929,1192,1381],"week,":[148,363,524,931,1194,1383],"days.":[151,366],"All":[152,367,528,935,1145],"survived":[154,369,530,937],"until":[155],"end":[157,238,372,533,940,1445],"study.":[160,241,375,536,943,1259,1299,1448,1465],"The":[161,242,376,537,603,741,762,944,969,1025,1104,1219,1302,1391,1409,1449,1490,1529,1580,1608],"mean":[162,186,190,378,539,613,946,1220,1240,1251,1410,1422,1437,1450],"body":[163,187,191,379,540,947,1221,1241,1252,1411,1423,1438,1451],"weight":[164,192,382,438,541,543,950,1028,1222,1253,1439],"gain":[165,544],"group":[173,445,552,753,985,1036,1229,1343,1400,1620,1628,1642],"slightly":[175,1231,1418,1548],"but":[176,1431],"significantly":[177,269,447,554,723,755,777,1018,1051,1325,1345,1511,1565,1602,1630,1646],"less":[178,555,756,778],"than":[179,271,449,556,757,779,1020,1053,1233,1327,1347,1404,1420,1524,1550,1577,1604,1632],"that":[180,622,1234,1405],"controls;":[183],"final":[185,377,538,945],"weights":[188,245,259,380,416,738,948,973,1000,1041,1242,1412,1424,1452],"gains":[193,383,951],"females":[196,261,292,388,469,596,767,806,819,827,854,870,877,988,1009,1085,1096,1149,1224,1271,1395,1415,1516,1538],"similar":[198,390,957,1248,1434,1457],"those":[200,272,392,450,557,758,959,1021,1054,1328,1348,1459,1525,1551,1633],"controls.":[203,275,395,453,560,761,962,1024,1057,1331,1351,1408,1528,1554,1579,1636],"Clinical":[204,396,561,1201,1260,1466],"findings":[205,397,562,1261,1467,1481],"all":[207,247,305,431,466,975,1002,1070],"groups":[216,249,426,433,774,803,976,1003,1016,1154,1323,1523,1545,1563,1600],"included":[217,398,563,820,1468],"increased":[218,612,724,1504,1586],"preening,":[219],"rapid":[220],"breathing,":[221],"hyperactivity":[222],"early":[223],"study,":[226,1288],"hypoactivity":[228,399],"loss":[230],"coordination":[232],"hindlimbs":[235],"near":[236],"relative":[243,257,414,436,997,1039],"liver":[244,258,415,437,1027,1040,1583],"absolute":[255,970,1026],"375":[264,295,312,443,472,599,692,830,880,1046,1077,1182,1227,1276,1321,1341,1519,1541,1596,1626],"greater":[267,270,448,695,833,883,994,1019,1049,1052,1232,1326,1346,1403,1419,1512,1549,1566,1603,1631,1647],"Minimal":[276,783],"mild":[278,487,785,887,1115,1131],"degeneration":[279,301,823,888,1060,1126],"olfactory":[282,457,821,1124],"epithelium":[283,458],"observed":[285,463,686,792,1067,1290],"nose":[288,461],"males":[290,386,440,467,483,594,748,817,825,852,868,1006,1043,1146,1245,1455,1477,1514,1536],"greater.":[298,602,812,1080],"Sciatic":[299],"nerve":[300,892],"present":[303],"greater;":[315,475],"750":[319,422,570,701,770,799,857,1012,1034,1371,1398,1521,1543,1561,1598,1618,1640],"also":[323,776,1082,1155,1547,1643],"had":[324,884,1156,1564,1644],"reduced":[325],"myelin":[326],"around":[327,1470],"sciatic":[328,891],"axons.":[329],"MICE:":[333,901,1355],"tachypnea":[401],"groups.":[411,574,1103],"Absolute":[412],"Degeneration":[454,1081],"microscopically":[464,793,1068],"this":[476,628],"lesion":[477],"minimal":[480,485,872,885,1113,1129,1142,1157],"severity":[481,488,863,1106,1122,1134],"females.":[490],"13-WEEK":[491,898],"10":[497,500,904,907],"weeks.":[527,934,1197,1386],"hindlimb":[564,744,763,1279],"paralysis":[565],"Inhalation":[575],"resulted":[581],"concentration-dependent,":[585],"microcytic,":[586],"responsive":[587],"anemia;":[588],"anemia":[589,642],"most":[591],"pronounced":[592],"presence":[604],"schistocytes,":[606],"Heinz":[607],"bodies,":[608],"spherocytes":[610],"cell":[614,849],"hemoglobin":[615],"concentration":[616,619,1508],"methemoglobin":[618],"evidence":[621],"hemolytic":[624,629],"process":[625,630],"occurring;":[627],"could":[631,653],"have":[632,654],"accounted,":[633],"part,":[635],"anemia.":[638],"Thrombocytosis":[639],"accompanied":[640],"would":[644],"be":[645],"consistent":[646,1263],"with":[647,1264,1484,1505,1587],"reactive":[649],"bone":[650,789],"marrow":[651,790],"due":[656],"erroneous":[659],"inclusion":[660],"small":[662],"erythrocyte":[663],"fragments":[664],"part":[666],"platelet":[669],"count.":[670],"On":[671],"day":[672],"23,":[673],"transient":[674],"decreases":[675],"serum":[677],"triiodothyronine,":[678],"thyroxine,":[679],"fr":[681],"free":[683],"thyroxine":[684],"ppm.":[704],"There":[705,963,1203],"little":[707],"no":[709,965,1205,1278],"pituitary":[710],"response":[711],"thyroid":[714],"hormone":[715,728],"decreases,":[716],"evidenced":[718],"lack":[721],"concentrations":[725],"thyroid-stimulating":[727],"rats.":[731,1218],"No":[732],"biologically":[733],"significant":[734,1206],"differences":[735,1207],"organ":[737],"observed.":[740],"forelimb":[742],"grip":[745,764],"strengths":[746,765],"control":[781,1214,1237,1606],"value.":[782],"hyperplasia":[786,850],"188":[809,840,991,1088,1101,1274,1319,1559],"Nasal":[813],"lesions":[814,866,1110],"epithelial":[822,844,1059,1063,1125,1137],"one":[836],"respiratory":[843,1062,1136],"hyaline":[845,1064,1092,1138],"droplets":[846,1065,1093,1139],"goblet":[848],"groups;":[861],"nasal":[865,1109],"mild.":[874],"Males":[875],"lumbar":[895],"spinal":[896],"cord.":[897],"generally":[956,1247,1417,1433],"treatment-related":[966],"clinical":[967],"findings.":[968],"right":[971,998],"kidney":[972,999],"except":[981],"Olfactory":[1058],"occurred":[1083,1094,1282],"group,":[1090],"94":[1099],"average":[1105,1121],"ranged":[1111,1127,1140],"from":[1112,1128,1141],"males.":[1117],"In":[1118],"females,":[1119],"moderate.":[1144],"nine":[1148],"extramedullary":[1158],"hematopoiesis":[1159],"spleen.":[1162],"2-YEAR":[1163,1352],"50":[1169,1172,1358,1361],"103":[1196,1385],"Survival,Body":[1198,1387],"Weights,":[1199,1388],"Findings:":[1202,1301,1489],"survival":[1209,1392],"rates":[1210],"between":[1211],"group;":[1238],"controls":[1256,1427,1442,1462],"throughout":[1257,1463],"incidences":[1265,1303,1334,1491,1530,1567,1581,1593,1609],"mammary":[1267,1305,1336],"gland":[1268,1306,1337,1486,1494,1533],"neoplasms":[1269],"ppm;":[1277],"paralysis,":[1280],"13-week":[1287],"2-year":[1298],"Pathology":[1300,1488],"fibroadenoma":[1307],"fibroadenoma,":[1309],"adenoma,":[1310],"carcinoma":[1312,1338,1499,1534,1575,1612,1653],"(combined)":[1313,1500,1576],"Additionally,":[1332],"ClinicalFindings":[1390],"rate":[1393],"marginally":[1402],"during":[1428],"study":[1430],"at":[1443],"swelling":[1469],"eyes":[1472],"exophthalmos":[1474],"females;":[1479],"these":[1480],"coincident":[1483],"harderian":[1485,1493,1532],"neoplasms.":[1487],"adenoma":[1495,1497,1570,1573,1651],"increasing":[1506,1588],"Female":[1555],"hepatocellular":[1569,1572],"eosinophilic":[1584],"focus":[1585],"concentration,":[1590],"incidence.":[1607],"alveolar/bronchiolar":[1611,1650],"Females":[1637],"incidence":[1648]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2022-10-06T00:00:00"}
