{"id":"https://openalex.org/W4301372179","doi":"https://doi.org/10.1186/s40168-022-01342-8","title":"Alterations in the respiratory tract microbiome in COVID-19: current observations and potential significance","display_name":"Alterations in the respiratory tract microbiome in COVID-19: current observations and potential significance","publication_year":2022,"publication_date":"2022-10-04","ids":{"openalex":"https://openalex.org/W4301372179","doi":"https://doi.org/10.1186/s40168-022-01342-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/36195943","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9532226"},"language":"en","primary_location":{"id":"doi:10.1186/s40168-022-01342-8","doi":"https://doi.org/10.1186/s40168-022-01342-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40168-022-01342-8","pdf_url":"https://microbiomejournal.biomedcentral.com/counter/pdf/10.1186/s40168-022-01342-8","source":{"id":"https://openalex.org/S3004984423","display_name":"Microbiome","issn_l":"2049-2618","issn":["2049-2618"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiome","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://microbiomejournal.biomedcentral.com/counter/pdf/10.1186/s40168-022-01342-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016752451","display_name":"Carter Merenstein","orcid":"https://orcid.org/0000-0002-7628-1828","observed_orcids":["https://orcid.org/0000-0002-7628-1828"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carter Merenstein","raw_affiliation_strings":["Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016535188","display_name":"Frederic D. Bushman","orcid":"https://orcid.org/0000-0003-4740-4056","observed_orcids":["https://orcid.org/0000-0003-4740-4056"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederic D. Bushman","raw_affiliation_strings":["Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074582058","display_name":"Ronald G. Collman","orcid":"https://orcid.org/0000-0002-0508-3701","observed_orcids":["https://orcid.org/0000-0002-0508-3701"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ronald G. Collman","raw_affiliation_strings":["Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. collmanr@pennmedicine.upenn.edu","Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA. collmanr@pennmedicine.upenn.edu","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5074582058"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":6.8314,"has_fulltext":true,"cited_by_count":67,"citation_normalized_percentile":{"value":0.98044937,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"10","issue":"1","first_page":"165","last_page":"165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.45260000228881836,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.45260000228881836,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.23549999296665192,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.051600001752376556,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.968999981880188},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9779999852180481},{"id":"https://openalex.org/keywords/respiratory-microbiome","display_name":"airway microbiome","score":0.9909999966621399},{"id":"https://openalex.org/keywords/oropharyngeal-microbiota","display_name":"oropharyngeal microbiota","score":0.8450000286102295},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.8730000257492065},{"id":"https://openalex.org/keywords/haemophilus","display_name":"Haemophilus","score":0.9290000200271606},{"id":"https://openalex.org/keywords/neisseria","display_name":"Neisseria","score":1.0},{"id":"https://openalex.org/keywords/systemic-immune-response","display_name":"systemic immune response","score":0.8090000152587891},{"id":"https://openalex.org/keywords/bacterial-community-diversity","display_name":"bacterial community diversity","score":0.6460000276565552},{"id":"https://openalex.org/keywords/causality","display_name":"causality","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.822878360748291},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.7674241065979004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.762274444103241},{"id":"https://openalex.org/C190139176","wikidata":"https://www.wikidata.org/wiki/Q598976","display_name":"Medical microbiology","level":2,"score":0.6111342906951904},{"id":"https://openalex.org/C2779644171","wikidata":"https://www.wikidata.org/wiki/Q13400765","display_name":"Respiratory tract","level":3,"score":0.6038510799407959},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.5874441862106323},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.5532613396644592},{"id":"https://openalex.org/C2776012195","wikidata":"https://www.wikidata.org/wiki/Q754447","display_name":"Respiratory tract infections","level":3,"score":0.5157390236854553},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.48886436223983765},{"id":"https://openalex.org/C69562835","wikidata":"https://www.wikidata.org/wiki/Q3054637","display_name":"Microbial ecology","level":3,"score":0.43559765815734863},{"id":"https://openalex.org/C2778137277","wikidata":"https://www.wikidata.org/wiki/Q16532287","display_name":"Betacoronavirus","level":5,"score":0.41337886452674866},{"id":"https://openalex.org/C148043351","wikidata":"https://www.wikidata.org/wiki/Q4456944","display_name":"Current (fluid)","level":2,"score":0.4101673662662506},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36747533082962036},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.32141467928886414},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3193129003047943},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.27488747239112854},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18163329362869263},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.17703798413276672},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.16550245881080627},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15891939401626587},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13340961933135986},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.12805116176605225},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012137","descriptor_name":"Respiratory System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s40168-022-01342-8","doi":"https://doi.org/10.1186/s40168-022-01342-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40168-022-01342-8","pdf_url":"https://microbiomejournal.biomedcentral.com/counter/pdf/10.1186/s40168-022-01342-8","source":{"id":"https://openalex.org/S3004984423","display_name":"Microbiome","issn_l":"2049-2618","issn":["2049-2618"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiome","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9532226","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9532226","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiome","raw_type":"Text"},{"id":"pmid:36195943","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36195943","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiome","raw_type":"Letter"},{"id":"pmh:oai:doaj.org/article:6cf50a1bb07e411ea711e08992a8e4a0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6cf50a1bb07e411ea711e08992a8e4a0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microbiome, Vol 10, Iss 1, Pp 1-14 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s40168-022-01342-8","doi":"https://doi.org/10.1186/s40168-022-01342-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40168-022-01342-8","pdf_url":"https://microbiomejournal.biomedcentral.com/counter/pdf/10.1186/s40168-022-01342-8","source":{"id":"https://openalex.org/S3004984423","display_name":"Microbiome","issn_l":"2049-2618","issn":["2049-2618"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiome","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6187618398","display_name":"The Lung DNA Virome in Health and Disease","funder_award_id":"R33HL137063","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4301372179.pdf","grobid_xml":"https://content.openalex.org/works/W4301372179.grobid-xml"},"referenced_works_count":100,"referenced_works":["https://openalex.org/W1793747226","https://openalex.org/W1969359874","https://openalex.org/W1981549976","https://openalex.org/W2033314496","https://openalex.org/W2037878492","https://openalex.org/W2077691383","https://openalex.org/W2085108411","https://openalex.org/W2141980700","https://openalex.org/W2154865352","https://openalex.org/W2159497758","https://openalex.org/W2272135501","https://openalex.org/W2272836689","https://openalex.org/W2343030398","https://openalex.org/W2402456610","https://openalex.org/W2496661162","https://openalex.org/W2561758149","https://openalex.org/W2577063957","https://openalex.org/W2718738457","https://openalex.org/W2766099743","https://openalex.org/W2790152383","https://openalex.org/W2791621421","https://openalex.org/W2884768618","https://openalex.org/W2896038997","https://openalex.org/W2898800746","https://openalex.org/W2903804358","https://openalex.org/W2936757566","https://openalex.org/W2947236490","https://openalex.org/W2951788718","https://openalex.org/W2968595581","https://openalex.org/W2985529221","https://openalex.org/W2993153957","https://openalex.org/W3001883374","https://openalex.org/W3010869838","https://openalex.org/W3011134208","https://openalex.org/W3011201358","https://openalex.org/W3027434935","https://openalex.org/W3030412499","https://openalex.org/W3035895802","https://openalex.org/W3037822861","https://openalex.org/W3043040397","https://openalex.org/W3043975336","https://openalex.org/W3046496943","https://openalex.org/W3046718123","https://openalex.org/W3084842516","https://openalex.org/W3087332590","https://openalex.org/W3093379297","https://openalex.org/W3099001354","https://openalex.org/W3107994581","https://openalex.org/W3112865260","https://openalex.org/W3116855495","https://openalex.org/W3127825824","https://openalex.org/W3128287277","https://openalex.org/W3130940832","https://openalex.org/W3132124756","https://openalex.org/W3136680670","https://openalex.org/W3144819531","https://openalex.org/W3149683693","https://openalex.org/W3151130436","https://openalex.org/W3157703981","https://openalex.org/W3157756116","https://openalex.org/W3160295311","https://openalex.org/W3162132240","https://openalex.org/W3163596978","https://openalex.org/W3170560273","https://openalex.org/W3173603446","https://openalex.org/W3176728552","https://openalex.org/W3179477167","https://openalex.org/W3189670162","https://openalex.org/W3193495330","https://openalex.org/W3193623972","https://openalex.org/W3195257085","https://openalex.org/W3195488339","https://openalex.org/W3196235362","https://openalex.org/W3196674905","https://openalex.org/W3198200035","https://openalex.org/W3198947486","https://openalex.org/W3201109880","https://openalex.org/W3208935219","https://openalex.org/W3209084632","https://openalex.org/W3211195906","https://openalex.org/W3211228774","https://openalex.org/W3211580856","https://openalex.org/W3213277876","https://openalex.org/W3214255991","https://openalex.org/W3215123698","https://openalex.org/W4206916577","https://openalex.org/W4210475015","https://openalex.org/W4210795913","https://openalex.org/W4210854558","https://openalex.org/W4213050698","https://openalex.org/W4213163387","https://openalex.org/W4214855554","https://openalex.org/W4224293761","https://openalex.org/W4226086840","https://openalex.org/W4229004796","https://openalex.org/W4281561573","https://openalex.org/W4285588951","https://openalex.org/W4291036706","https://openalex.org/W4298144862","https://openalex.org/W4323044646"],"related_works":["https://openalex.org/W4313312789","https://openalex.org/W4378717751","https://openalex.org/W4284698857","https://openalex.org/W3119574730","https://openalex.org/W3211228774","https://openalex.org/W3209791419","https://openalex.org/W7203746890","https://openalex.org/W4306247768","https://openalex.org/W4385497394","https://openalex.org/W4381618277"],"abstract_inverted_index":{"SARS-CoV-2":[0],"infection":[1],"causes":[2],"COVID-19":[3,64],"disease,":[4],"which":[5],"can":[6,178],"result":[7,152],"in":[8,99,138,149,153],"consequences":[9],"ranging":[10],"from":[11],"undetectable":[12],"to":[13,28,46,76],"fatal,":[14],"focusing":[15],"attention":[16],"on":[17],"the":[18,30,44,50,58,66,71,83,100,135,141,150,161,168],"modulators":[19],"of":[20,32,60,96,111,125,134,143],"outcomes.":[21,131],"The":[22,94,108],"respiratory":[23,67],"tract":[24,68],"microbiome":[25,52,120,151],"is":[26,145],"thought":[27],"modulate":[29],"outcomes":[31],"infections":[33],"such":[34,171],"as":[35,37,39,172],"influenza":[36],"well":[38],"acute":[40],"lung":[41],"injury,":[42],"raising":[43],"question":[45],"what":[47],"degree":[48],"does":[49],"airway":[51],"influence":[53],"COVID-19?":[54],"Here,":[55],"we":[56],"review":[57],"results":[59,84],"56":[61],"studies":[62,177],"examining":[63],"and":[65,74,113,129],"microbiome,":[69,162],"summarize":[70],"main":[72],"generalizations,":[73],"point":[75],"useful":[77],"avenues":[78],"for":[79],"further":[80],"research.":[81],"Although":[82],"vary":[85],"among":[86],"studies,":[87,140],"a":[88],"few":[89],"consistent":[90],"findings":[91],"stand":[92],"out.":[93],"diversity":[95],"bacterial":[97],"communities":[98],"oropharynx":[101],"typically":[102],"declined":[103,116],"with":[104,117,123],"increasing":[105],"disease":[106],"severity.":[107,118],"relative":[109],"abundance":[110],"Haemophilus":[112],"Neisseria":[114],"also":[115],"Multiple":[119],"measures":[121,124],"tracked":[122],"systemic":[126],"immune":[127],"responses":[128],"COVID":[130,155,158],"For":[132],"many":[133],"conclusions":[136],"drawn":[137],"these":[139,181],"direction":[142],"causality":[144],"unknown-did":[146],"an":[147],"alteration":[148],"increased":[154],"severity,":[156],"did":[157],"severity":[159],"alter":[160],"or":[163],"was":[164],"some":[165],"third":[166],"factor":[167],"primary":[169],"driver,":[170],"medication":[173],"use.":[174],"Follow-up":[175],"mechanistic":[176],"help":[179],"answer":[180],"questions.":[182],"Video":[183],"Abstract.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2022-10-05T00:00:00"}