{"id":"https://openalex.org/W4301366336","doi":"https://doi.org/10.1016/j.xpro.2022.101750","title":"Protocol for intranasal chemoprevention delivery in a urethane mouse lung cancer model","display_name":"Protocol for intranasal chemoprevention delivery in a urethane mouse lung cancer model","publication_year":2022,"publication_date":"2022-10-04","ids":{"openalex":"https://openalex.org/W4301366336","doi":"https://doi.org/10.1016/j.xpro.2022.101750","pmid":"https://pubmed.ncbi.nlm.nih.gov/36201319","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9535317"},"language":"en","primary_location":{"id":"doi:10.1016/j.xpro.2022.101750","doi":"https://doi.org/10.1016/j.xpro.2022.101750","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xpro.2022.101750","pdf_url":"https://www.sciencedirect.com/science/article/pii/S266616672200630X/pdf","source":{"id":"https://openalex.org/S4210212477","display_name":"STAR Protocols","issn_l":"2666-1667","issn":["2666-1667"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"STAR Protocols","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S266616672200630X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053252425","display_name":"Lori D. Dwyer\u2010Nield","orcid":"https://orcid.org/0000-0001-9224-3648","observed_orcids":["https://orcid.org/0000-0001-9224-3648"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lori Dwyer-Nield","raw_affiliation_strings":["University of Colorado School of Pharmacy, Aurora, CO 80045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado School of Pharmacy, Aurora, CO 80045, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072704172","display_name":"Robert L. Keith","orcid":"https://orcid.org/0000-0002-3275-2608","observed_orcids":["https://orcid.org/0000-0002-3275-2608"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert L. Keith","raw_affiliation_strings":["Rocky Mountain Regional VA Medical Center, Aurora, CO 80045, USA; University of Colorado School of Medicine, Aurora, CO 80045, USA","Rocky Mountain Regional VA Medical Center, Aurora, CO 80045, USA","University of Colorado School of Medicine, Aurora, CO 80045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rocky Mountain Regional VA Medical Center, Aurora, CO 80045, USA; University of Colorado School of Medicine, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Rocky Mountain Regional VA Medical Center, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I1322918889"]},{"raw_affiliation_string":"University of Colorado School of Medicine, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066678557","display_name":"Meredith A. Tennis","orcid":"https://orcid.org/0000-0002-0619-6732","observed_orcids":["https://orcid.org/0000-0002-0619-6732"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Meredith A. Tennis","raw_affiliation_strings":["University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: meredith.tennis@cuanschutz.edu","University of Colorado School of Medicine, Aurora, CO 80045, USA"],"raw_orcid":"https://orcid.org/0000-0002-0619-6732","affiliations":[{"raw_affiliation_string":"University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: meredith.tennis@cuanschutz.edu","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"University of Colorado School of Medicine, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I51713134"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5066678557"],"corresponding_institution_ids":["https://openalex.org/I51713134"],"apc_list":{"value":1500,"currency":"USD","value_usd":1500},"apc_paid":{"value":1500,"currency":"USD","value_usd":1500},"fwci":0.3224,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.5752789,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"3","issue":"4","first_page":"101750","last_page":"101750"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.5630000233650208,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.5630000233650208,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.08070000261068344,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.039000000804662704,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iloprost","display_name":"iloprost","score":0.7919999957084656},{"id":"https://openalex.org/keywords/lung-cancer-chemoprevention","display_name":"lung cancer chemoprevention","score":0.9129999876022339},{"id":"https://openalex.org/keywords/intranasal-drug-delivery","display_name":"intranasal drug delivery","score":0.972000002861023},{"id":"https://openalex.org/keywords/inhaled-iloprost","display_name":"inhaled iloprost","score":0.8090000152587891},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.6499999761581421},{"id":"https://openalex.org/keywords/lung-cancer-prevention","display_name":"lung cancer prevention","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C2781103887","wikidata":"https://www.wikidata.org/wiki/Q20817139","display_name":"Iloprost","level":3,"score":0.8192363977432251},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7361650466918945},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7085630297660828},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.6992076635360718},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.45892077684402466},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.4500999450683594},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3408067226409912},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2613377571105957},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.23292267322540283},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18300142884254456},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1291409134864807},{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014520","descriptor_name":"Urethane","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016285","descriptor_name":"Iloprost","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018890","descriptor_name":"Chemoprevention","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.xpro.2022.101750","doi":"https://doi.org/10.1016/j.xpro.2022.101750","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xpro.2022.101750","pdf_url":"https://www.sciencedirect.com/science/article/pii/S266616672200630X/pdf","source":{"id":"https://openalex.org/S4210212477","display_name":"STAR Protocols","issn_l":"2666-1667","issn":["2666-1667"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"STAR Protocols","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9535317","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9535317","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"STAR Protoc","raw_type":"Text"},{"id":"pmid:36201319","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36201319","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"STAR protocols","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c7c10e77f2c642ec88b0ad1040249963","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c7c10e77f2c642ec88b0ad1040249963","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"STAR Protocols, Vol 3, Iss 4, Pp 101750- (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.xpro.2022.101750","doi":"https://doi.org/10.1016/j.xpro.2022.101750","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xpro.2022.101750","pdf_url":"https://www.sciencedirect.com/science/article/pii/S266616672200630X/pdf","source":{"id":"https://openalex.org/S4210212477","display_name":"STAR Protocols","issn_l":"2666-1667","issn":["2666-1667"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"STAR Protocols","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8500000238418579}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1662437938","display_name":null,"funder_award_id":"I01 BX000382","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G2426738490","display_name":"Frizzled 9 loss and regulation in preventing the progression of pre-malignant lung lesions","funder_award_id":"R01CA214531","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320309842","display_name":"Biomedical Laboratory Research and Development, VA Office of Research and Development","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4301366336.pdf","grobid_xml":"https://content.openalex.org/works/W4301366336.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W2066859759","https://openalex.org/W2118578517","https://openalex.org/W2145328346","https://openalex.org/W2164233455","https://openalex.org/W3047736703","https://openalex.org/W3094055804","https://openalex.org/W3199613434","https://openalex.org/W4211130057","https://openalex.org/W4281391286","https://openalex.org/W4289544583","https://openalex.org/W4301381245"],"related_works":["https://openalex.org/W3199613434","https://openalex.org/W2159714432","https://openalex.org/W2300051455","https://openalex.org/W2319160279","https://openalex.org/W4295759461","https://openalex.org/W2752881180","https://openalex.org/W2319351211","https://openalex.org/W1611762702","https://openalex.org/W2129988491","https://openalex.org/W1994278280"],"abstract_inverted_index":{"Mouse":[0],"iloprost":[1,17,40,48,60],"lung":[2,22,62],"cancer":[3,63],"chemoprevention":[4,70],"studies":[5,71],"typically":[6],"use":[7,84],"oral":[8],"delivery.":[9],"Here,":[10],"we":[11],"present":[12],"a":[13,20,74],"protocol":[14,66],"for":[15,29,45,61,69],"intranasal":[16,39],"delivery":[18,49],"within":[19],"urethane":[21,31],"adenocarcinoma":[23],"mouse":[24],"model.":[25,78],"We":[26],"detail":[27],"steps":[28],"intraperitoneal":[30],"injection":[32],"in":[33],"mice,":[34],"followed":[35],"by":[36],"nine-week":[37],"monitoring,":[38],"treatment,":[41],"and":[42,72,76,85],"lungs":[43],"harvesting":[44],"analysis.":[46],"This":[47,65],"approach":[50],"parallels":[51],"an":[52],"ongoing":[53],"phase":[54],"II":[55],"clinical":[56],"trial":[57],"of":[58,87],"inhaled":[59],"chemoprevention.":[64],"diversifies":[67],"options":[68],"offers":[73],"relevant":[75],"translatable":[77],"For":[79],"complete":[80],"details":[81],"on":[82],"the":[83],"execution":[86],"this":[88],"protocol,":[89],"please":[90],"refer":[91],"to":[92],"Sompel":[93],"et":[94],"al.":[95],"(2022).":[96]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-10-05T00:00:00"}
