{"id":"https://openalex.org/W4300977606","doi":null,"title":"Method to determine transcriptional regulation pathways in organisms","display_name":"Method to determine transcriptional regulation pathways in organisms","publication_year":2023,"publication_date":"2023-01-23","ids":{"openalex":"https://openalex.org/W4300977606"},"language":"en","primary_location":{"id":"pmh:oai:osti.gov:1080438","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1080438","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.osti.gov/biblio/1080438","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023845697","display_name":"Timothy S. Gardner","orcid":"https://orcid.org/0000-0001-5465-5828","observed_orcids":["https://orcid.org/0000-0001-5465-5828"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gardner, Timothy S.; Collins, James J.; Hayete, Boris; Faith, Jeremiah","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5023845697"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00274832,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.01850000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.9850000143051147},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.906000018119812},{"id":"https://openalex.org/keywords/gene-targets","display_name":"gene targets","score":0.7770000100135803},{"id":"https://openalex.org/keywords/regulatory-interactions","display_name":"regulatory interactions","score":0.8230000138282776},{"id":"https://openalex.org/keywords/regulatory-networks","display_name":"regulatory networks","score":0.3659999966621399},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5623274445533752},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.44400039315223694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39240095019340515},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3230409026145935},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2409592568874359},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16691595315933228},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.16208255290985107}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:osti.gov:1080438","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1080438","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:osti.gov:1080438","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1080438","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2159310376","https://openalex.org/W2163731693","https://openalex.org/W1531038186","https://openalex.org/W2104708941","https://openalex.org/W4391095456","https://openalex.org/W4399122978","https://openalex.org/W7070762803","https://openalex.org/W2415743350","https://openalex.org/W3187085884","https://openalex.org/W784962653"],"abstract_inverted_index":{"The":[0],"invention":[1,29],"relates":[2],"to":[3],"computer-implemented":[4,49],"methods":[5,50,87],"and":[6,16,60,73,98],"systems":[7],"for":[8,34,51,88],"identifying":[9,35,52],"regulatory":[10,20,36,54,90],"relationships":[11],"between":[12,38,56,69,92],"expressed":[13],"regulating":[14,24],"polypeptides":[15],"targets":[17,78],"of":[18,22,64,76,79,95,102],"the":[19,28,65,80],"activities":[21],"such":[23],"polypeptides.":[25],"More":[26],"specifically,":[27],"provides":[30],"a":[31,42,53,57,61,70,74,93,99],"new":[32],"method":[33],"dependencies":[37],"biochemical":[39],"species":[40],"in":[41],"cell.":[43],"In":[44],"particular":[45],"embodiments,":[46],"provided":[47,84],"are":[48,85],"interaction":[55],"transcription":[58,66,71,81,96],"factor":[59,72],"gene":[62,77],"target":[63,104],"factor,":[67],"or":[68],"set":[75,94,101],"factor.":[82],"Further":[83],"genome-scale":[86],"predicting":[89],"interactions":[91],"factors":[97],"corresponding":[100],"transcriptional":[103],"substrates":[105],"thereof.":[106]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2022-10-04T00:00:00"}