{"id":"https://openalex.org/W4300960244","doi":"https://doi.org/10.1002/adfm.202209239","title":"Brain\u2010Targeting Metastatic Tumor Cell Membrane Cloaked Biomimetic Nanomedicines Mediate Potent Chemodynamic and RNAi Combinational Therapy of Glioblastoma","display_name":"Brain\u2010Targeting Metastatic Tumor Cell Membrane Cloaked Biomimetic Nanomedicines Mediate Potent Chemodynamic and RNAi Combinational Therapy of Glioblastoma","publication_year":2022,"publication_date":"2022-10-03","ids":{"openalex":"https://openalex.org/W4300960244","doi":"https://doi.org/10.1002/adfm.202209239"},"language":"en","primary_location":{"id":"doi:10.1002/adfm.202209239","doi":"https://doi.org/10.1002/adfm.202209239","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adfm.202209239","pdf_url":null,"source":{"id":"https://openalex.org/S135204980","display_name":"Advanced Functional Materials","issn_l":"1616-301X","issn":["1616-301X","1616-3028"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-3","ki-jl-3","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Functional Materials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1002/adfm.202209239","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115593019","display_name":"Dongya Zhang","orcid":"https://orcid.org/0009-0003-3900-1756","observed_orcids":["https://orcid.org/0009-0003-3900-1756"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongya Zhang","raw_affiliation_strings":["Henan Key Laboratory of Brain Targeted Bio\u2010nanomedicine School of Life Sciences Henan University  Kaifeng Henan 475004 China","Henan\u2010Macquarie Uni Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henan Key Laboratory of Brain Targeted Bio\u2010nanomedicine School of Life Sciences Henan University  Kaifeng Henan 475004 China","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"Henan\u2010Macquarie Uni Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103223721","display_name":"Yajing Sun","orcid":"https://orcid.org/0000-0002-6292-7798","observed_orcids":["https://orcid.org/0000-0002-6292-7798"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yajing Sun","raw_affiliation_strings":["Henan Key Laboratory of Brain Targeted Bio\u2010nanomedicine School of Life Sciences Henan University  Kaifeng Henan 475004 China","Henan\u2010Macquarie Uni Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henan Key Laboratory of Brain Targeted Bio\u2010nanomedicine School of Life Sciences Henan University  Kaifeng Henan 475004 China","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"Henan\u2010Macquarie Uni Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100437642","display_name":"Shiyu Wang","orcid":"https://orcid.org/0009-0005-5358-4278","observed_orcids":["https://orcid.org/0009-0005-5358-4278"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiyu Wang","raw_affiliation_strings":["Henan Key Laboratory of Brain Targeted Bio\u2010nanomedicine School of Life Sciences Henan University  Kaifeng Henan 475004 China","Henan\u2010Macquarie Uni Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henan Key Laboratory of Brain Targeted Bio\u2010nanomedicine School of Life Sciences Henan University  Kaifeng Henan 475004 China","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"Henan\u2010Macquarie Uni Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101553544","display_name":"Yan Zou","orcid":"https://orcid.org/0000-0002-2307-1376","observed_orcids":["https://orcid.org/0000-0002-2307-1376","https://orcid.org/0000-0002-9238-9249","https://orcid.org/0009-0002-3872-6176"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]},{"id":"https://openalex.org/I99043593","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89","country_code":"AU","type":"education","lineage":["https://openalex.org/I99043593"]}],"countries":["AU","CN"],"is_corresponding":false,"raw_author_name":"Yan Zou","raw_affiliation_strings":["Henan Key Laboratory of Brain Targeted Bio\u2010nanomedicine School of Life Sciences Henan University  Kaifeng Henan 475004 China","Henan\u2010Macquarie Uni Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China","Maquarie Medical School Faculty of Medicine, Health and Human Sciences Macquarie University  Sydney NSW 2109 Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henan Key Laboratory of Brain Targeted Bio\u2010nanomedicine School of Life Sciences Henan University  Kaifeng Henan 475004 China","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"Henan\u2010Macquarie Uni Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"Maquarie Medical School Faculty of Medicine, Health and Human Sciences Macquarie University  Sydney NSW 2109 Australia","institution_ids":["https://openalex.org/I99043593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078088290","display_name":"Meng Zheng","orcid":"https://orcid.org/0000-0003-2932-1062","observed_orcids":["https://orcid.org/0000-0003-2932-1062"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Zheng","raw_affiliation_strings":["Henan Key Laboratory of Brain Targeted Bio\u2010nanomedicine School of Life Sciences Henan University  Kaifeng Henan 475004 China","Henan\u2010Macquarie Uni Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henan Key Laboratory of Brain Targeted Bio\u2010nanomedicine School of Life Sciences Henan University  Kaifeng Henan 475004 China","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"Henan\u2010Macquarie Uni Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022804352","display_name":"Bingyang Shi","orcid":"https://orcid.org/0000-0002-1043-3163","observed_orcids":["https://orcid.org/0000-0002-1043-3163"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]},{"id":"https://openalex.org/I99043593","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89","country_code":"AU","type":"education","lineage":["https://openalex.org/I99043593"]}],"countries":["AU","CN"],"is_corresponding":false,"raw_author_name":"Bingyang Shi","raw_affiliation_strings":["Henan Key Laboratory of Brain Targeted Bio\u2010nanomedicine School of Life Sciences Henan University  Kaifeng Henan 475004 China","Henan\u2010Macquarie Uni Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China","Maquarie Medical School Faculty of Medicine, Health and Human Sciences Macquarie University  Sydney NSW 2109 Australia"],"raw_orcid":"https://orcid.org/0000-0002-1043-3163","affiliations":[{"raw_affiliation_string":"Henan Key Laboratory of Brain Targeted Bio\u2010nanomedicine School of Life Sciences Henan University  Kaifeng Henan 475004 China","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"Henan\u2010Macquarie Uni Joint Centre for Biomedical Innovation School of Life Sciences Henan University  Kaifeng Henan 475004 China","institution_ids":["https://openalex.org/I173899330"]},{"raw_affiliation_string":"Maquarie Medical School Faculty of Medicine, Health and Human Sciences Macquarie University  Sydney NSW 2109 Australia","institution_ids":["https://openalex.org/I99043593"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5100,"currency":"USD","value_usd":5100},"apc_paid":{"value":5100,"currency":"USD","value_usd":5100},"fwci":2.7373,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.91555174,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"32","issue":"51","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.08290000259876251,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":1.0},{"id":"https://openalex.org/keywords/biomimetic-nanomedicine","display_name":"biomimetic nanomedicine","score":0.7519999742507935},{"id":"https://openalex.org/keywords/chemodynamic-therapy","display_name":"chemodynamic therapy","score":0.8550000190734863},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.7770000100135803},{"id":"https://openalex.org/keywords/sirna-delivery","display_name":"siRNA delivery","score":0.7789999842643738},{"id":"https://openalex.org/keywords/glutathione-depletion","display_name":"glutathione depletion","score":0.9110000133514404},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/blood-brain-barrier-penetration","display_name":"blood-brain barrier penetration","score":0.9430000185966492},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6363511085510254},{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.5536454916000366},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.46445274353027344},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.42018574476242065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3591321110725403},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35461682081222534},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.34442687034606934},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31672680377960205},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.1842394769191742},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1654070019721985},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1517033874988556},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12542468309402466},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.0985422432422638}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/adfm.202209239","doi":"https://doi.org/10.1002/adfm.202209239","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adfm.202209239","pdf_url":null,"source":{"id":"https://openalex.org/S135204980","display_name":"Advanced Functional Materials","issn_l":"1616-301X","issn":["1616-301X","1616-3028"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-3","ki-jl-3","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Functional Materials","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/adfm.202209239","doi":"https://doi.org/10.1002/adfm.202209239","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adfm.202209239","pdf_url":null,"source":{"id":"https://openalex.org/S135204980","display_name":"Advanced Functional Materials","issn_l":"1616-301X","issn":["1616-301X","1616-3028"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-3","ki-jl-3","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Functional Materials","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1257815923","display_name":null,"funder_award_id":"21HASTIT033","funder_id":"https://openalex.org/F4320336613","funder_display_name":"Science and Technology Innovation Talents in Universities of Henan Province"},{"id":"https://openalex.org/G2093449833","display_name":null,"funder_award_id":"52073079","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2314869570","display_name":null,"funder_award_id":"32071388","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5174924172","display_name":null,"funder_award_id":"U2004171","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8248668026","display_name":null,"funder_award_id":"2018YFA0209800","funder_id":"https://openalex.org/F4320335774","funder_display_name":"Key Technologies Research and Development Program"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335774","display_name":"Key Technologies Research and Development Program","ror":null},{"id":"https://openalex.org/F4320336613","display_name":"Science and Technology Innovation Talents in Universities of Henan Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1522580276","https://openalex.org/W2035982498","https://openalex.org/W2579781948","https://openalex.org/W2586113539","https://openalex.org/W2735901092","https://openalex.org/W2778283729","https://openalex.org/W2796584001","https://openalex.org/W2802896169","https://openalex.org/W2830175972","https://openalex.org/W2902762607","https://openalex.org/W2903314645","https://openalex.org/W2906999196","https://openalex.org/W2910046601","https://openalex.org/W2918621718","https://openalex.org/W2949845037","https://openalex.org/W2951319864","https://openalex.org/W2967167596","https://openalex.org/W2967873149","https://openalex.org/W2972005444","https://openalex.org/W2972884644","https://openalex.org/W2995313504","https://openalex.org/W2995423159","https://openalex.org/W3005618687","https://openalex.org/W3017196622","https://openalex.org/W3031224726","https://openalex.org/W3033581122","https://openalex.org/W3035092570","https://openalex.org/W3035242014","https://openalex.org/W3044613732","https://openalex.org/W3048510814","https://openalex.org/W3091213026","https://openalex.org/W3092527046","https://openalex.org/W3094033349","https://openalex.org/W3094352410","https://openalex.org/W3135372736","https://openalex.org/W3170594552","https://openalex.org/W3202827870","https://openalex.org/W3210823829","https://openalex.org/W3213850471","https://openalex.org/W4205892996","https://openalex.org/W4206902167","https://openalex.org/W4213340657","https://openalex.org/W4221012755","https://openalex.org/W4224278741","https://openalex.org/W4243716084"],"related_works":["https://openalex.org/W2895971888","https://openalex.org/W4383198714","https://openalex.org/W4296270278","https://openalex.org/W4408251734","https://openalex.org/W3005618687","https://openalex.org/W4380078657","https://openalex.org/W3004596160","https://openalex.org/W4385349878","https://openalex.org/W4307771704","https://openalex.org/W7166728825"],"abstract_inverted_index":{"Abstract":[0],"The":[1,48,136],"complex":[2],"genetic":[3],"heterogeneity":[4],"of":[5,12,90,118],"glioblastoma":[6],"(GBM)":[7],"together":[8],"with":[9,79,97,153,165],"the":[10,69,88,106,119,149,154,182,190],"existence":[11],"blood":[13],"brain":[14,200],"barrier":[15],"(BBB)":[16],"renders":[17],"GBM":[18,46,133,177,198],"essentially":[19],"incurable.":[20],"In":[21],"this":[22,141],"paper,":[23],"a":[24],"brain\u2010targeting":[25],"metastatic":[26,54],"tumor":[27,74,178],"cell":[28,56,134],"membrane":[29],"cloaked":[30],"biomimetic":[31,191],"nanomedicine":[32,142],"that":[33,130,140,181],"potently":[34],"induces":[35,132],"cascade":[36],"chemodynamic":[37,183],"and":[38,61,76,87,99,151,175,184,199],"RNA":[39],"interference":[40],"(RNAi)":[41],"is":[42],"developed":[43],"for":[44],"combinational":[45],"therapy.":[47],"designed":[49],"nanomedicines":[50,192],"are":[51,169],"constructed":[52],"from":[53],"melanoma":[55,174],"membrane,":[57],"charge\u2010conversional":[58],"middle":[59],"layer,":[60],"siRNA":[62,112],"complexed":[63],"polyethyleneimine":[64],"xanthate":[65],"(PEX).":[66],"PEX":[67],"chelates":[68],"abundant":[70],"copper":[71],"ions":[72],"in":[73,84,109,157,171,196],"cells":[75],"then":[77],"reacts":[78],"intracellular":[80],"glutathione":[81],"(GSH),":[82],"resulting":[83],"GSH":[85],"depletion":[86],"reduction":[89],"Cu2+":[91],"to":[92,126],"Cu+,":[93],"followed":[94],"by":[95,189],"reacting":[96],"H2O2":[98],"producing":[100],"\u2022OH":[101],"via":[102,147],"Fenton\u2010like":[103],"reaction.":[104],"Interestingly,":[105],"acidic":[107],"conditions":[108],"endo/lysosomes":[110],"accelerate":[111],"release,":[113],"inducing":[114],"potent":[115],"gene":[116,185],"silencing":[117],"anti\u2010apoptotic":[120],"B\u2010cell":[121],"lymphoma":[122],"2":[123],"(Bcl\u20102),":[124],"lead":[125],"multiple":[127],"molecular":[128],"cascades":[129],"readily":[131],"apoptosis.":[135],"results":[137],"also":[138],"demonstrate":[139],"exhibits":[143],"efficient":[144],"BBB":[145],"penetration":[146],"decreasing":[148],"tightness":[150],"interacting":[152],"adhesion":[155],"molecules":[156],"endothelial":[158],"cells.":[159],"More":[160],"importantly,":[161],"improved":[162],"therapeutic":[163],"efficacy":[164],"extended":[166],"survival":[167],"rates":[168],"achieved":[170],"both":[172],"local":[173],"orthotopic":[176],"models,":[179],"suggesting":[180],"combinatorial":[186],"therapy":[187],"mediated":[188],"shows":[193],"promising":[194],"potential":[195],"treating":[197],"metastases.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":7}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-10-04T00:00:00"}