{"id":"https://openalex.org/W4300958013","doi":"https://doi.org/10.17615/0kzc-7948","title":"Simvastatin and Atorvastatin inhibit DNA replication licensing factor MCM7 and effectively suppress RB-deficient tumors growth","display_name":"Simvastatin and Atorvastatin inhibit DNA replication licensing factor MCM7 and effectively suppress RB-deficient tumors growth","publication_year":2020,"publication_date":"2020-04-15","ids":{"openalex":"https://openalex.org/W4300958013","doi":"https://doi.org/10.17615/0kzc-7948"},"language":"en","primary_location":{"id":"pmh:cdr.lib.unc.edu:k3569908r","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/0kzc-7948","pdf_url":"https://cdr.lib.unc.edu/downloads/fx719r806","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Death & Disease, 8(3)","raw_type":"Article"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://cdr.lib.unc.edu/downloads/fx719r806","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100999204","display_name":"Zhou Can","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhou, Can","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046474582","display_name":"Cyrus Vaziri","orcid":"https://orcid.org/0000-0002-3081-8685","observed_orcids":["https://orcid.org/0000-0002-3081-8685"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vaziri, Cyrus","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100666034","display_name":"Pingping Li","orcid":"https://orcid.org/0000-0002-6397-1643","observed_orcids":["https://orcid.org/0000-0002-6397-1643"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li, Pingping","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100420987","display_name":"Juan Li","orcid":"https://orcid.org/0000-0001-8320-2406","observed_orcids":["https://orcid.org/0000-0001-8320-2406"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li, Juan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101625363","display_name":"Peijun Liu","orcid":"https://orcid.org/0000-0002-0767-0774","observed_orcids":["https://orcid.org/0000-0002-0767-0774"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liu, Peijun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100444675","display_name":"Jianmin Zhang","orcid":"https://orcid.org/0000-0003-4765-0812","observed_orcids":["https://orcid.org/0000-0003-4765-0812"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhang, Jianmin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063446205","display_name":"Bo Wang","orcid":"https://orcid.org/0000-0001-9234-035X","observed_orcids":["https://orcid.org/0000-0001-9234-035X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wang, Bo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Ren, Yu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ren, Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jiang, Yina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiang, Yina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071918408","display_name":"Yaochun Wang","orcid":"https://orcid.org/0000-0002-1531-9378","observed_orcids":["https://orcid.org/0000-0002-1531-9378","https://orcid.org/0000-0003-3498-3407"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wang, Yaochun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061500565","display_name":"Zheyong Liang","orcid":"https://orcid.org/0000-0002-4418-306X","observed_orcids":["https://orcid.org/0000-0002-4418-306X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liang, Zheyong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100454257","display_name":"Lu Yang","orcid":"https://orcid.org/0000-0002-5428-7874","observed_orcids":["https://orcid.org/0000-0002-5428-7874","https://orcid.org/0000-0002-1308-9388"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang, Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100343816","display_name":"Jin Yang","orcid":"https://orcid.org/0000-0002-8357-9649","observed_orcids":["https://orcid.org/0000-0002-8357-9649"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang, Jin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043860726","display_name":"Zhijun Luo","orcid":"https://orcid.org/0000-0001-8105-5289","observed_orcids":["https://orcid.org/0000-0001-8105-5289"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luo, Zhijun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100454057","display_name":"Jie Liu","orcid":"https://orcid.org/0000-0002-1069-2384","observed_orcids":["https://orcid.org/0000-0002-1069-2384"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liu, Jie","raw_affiliation_strings":["School of Medicine, Department of Pathology and Laboratory Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Department of Pathology and Laboratory Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043624439","display_name":"Fang He","orcid":"https://orcid.org/0000-0002-0944-3364","observed_orcids":["https://orcid.org/0000-0002-0944-3364"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"He, Fang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6857,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.59835281,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.040300000458955765,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/atorvastatin","display_name":"atorvastatin","score":1.0},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mcm7","display_name":"MCM7","score":0.9559999704360962},{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.8040000200271606},{"id":"https://openalex.org/keywords/dna-replication-licensing","display_name":"DNA replication licensing","score":0.9660000205039978},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/chromosome-breakage","display_name":"chromosome breakage","score":0.7730000019073486},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.7649999856948853},{"id":"https://openalex.org/keywords/mouse-xenograft-model","display_name":"xenograft mouse model","score":0.7170000076293945},{"id":"https://openalex.org/keywords/lipid-lowering-drugs","display_name":"lipid-lowering drugs","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C2777482532","wikidata":"https://www.wikidata.org/wiki/Q668093","display_name":"Atorvastatin","level":2,"score":0.8956385254859924},{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.7959644794464111},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.5820384621620178},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5676180720329285},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.5469458699226379},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5039622187614441},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4984004497528076},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3741976022720337},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3319675028324127},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2802276611328125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26452216506004333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20323148369789124},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.10877647995948792}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:cdr.lib.unc.edu:k3569908r","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/0kzc-7948","pdf_url":"https://cdr.lib.unc.edu/downloads/fx719r806","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Death & Disease, 8(3)","raw_type":"Article"},{"id":"doi:10.17615/0kzc-7948","doi":"https://doi.org/10.17615/0kzc-7948","is_oa":true,"landing_page_url":"https://doi.org/10.17615/0kzc-7948","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:cdr.lib.unc.edu:k3569908r","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/0kzc-7948","pdf_url":"https://cdr.lib.unc.edu/downloads/fx719r806","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Death & Disease, 8(3)","raw_type":"Article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.41999998688697815,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2106239457","display_name":null,"funder_award_id":"NCET-10","funder_id":"https://openalex.org/F4320334924","funder_display_name":"Program for New Century Excellent Talents in University"},{"id":"https://openalex.org/G4732363153","display_name":"\u80bf\u7624\u751f\u7269\u6cbb\u7597\u7684\u65b0\u9776\u6807\uff1a\u5fae\u5c0f\u67d3\u8272\u8d28\u7ef4\u6301\u86cb\u767d\uff08MCMs)","funder_award_id":"81071876","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G476927142","display_name":null,"funder_award_id":"81272342","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334924","display_name":"Program for New Century Excellent Talents in University","ror":"https://ror.org/01mv9t934"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4300958013.pdf","grobid_xml":"https://content.openalex.org/works/W4300958013.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1985694774","https://openalex.org/W2739639727","https://openalex.org/W2405075276","https://openalex.org/W1996375823","https://openalex.org/W3015902538","https://openalex.org/W2040289803","https://openalex.org/W3083723312","https://openalex.org/W7020780330","https://openalex.org/W2337895243","https://openalex.org/W2913273819"],"abstract_inverted_index":{"Loss":[0],"or":[1,32],"dysfunction":[2],"of":[3,48,103],"tumor":[4,35,59,64,105,109,122],"suppressor":[5],"retinoblastoma":[6],"(RB)":[7],"is":[8],"a":[9,68],"common":[10],"feature":[11],"in":[12,57,62,126],"various":[13],"tumors,":[14],"and":[15,21,71,80,87,95,101,117],"contributes":[16],"to":[17,24,30,84,146],"cancer":[18,25],"cell":[19],"stemness":[20],"drug":[22,69,78],"resistance":[23],"therapy.":[26],"However,":[27],"the":[28,40],"strategy":[29],"suppress":[31],"eliminate":[33],"Rb-deficient":[34,104,121],"cells":[36,60,106],"remains":[37],"unclear.":[38],"In":[39,111],"present":[41,131],"study,":[42],"we":[43,74],"accidentally":[44],"found":[45],"that":[46,76,93,115,134],"reduction":[47],"DNA":[49],"replication":[50],"licensing":[51],"factor":[52],"MCM7":[53,86,151],"induced":[54,97],"more":[55,98],"apoptosis":[56],"RB-deficient":[58,143],"than":[61,107,124],"control":[63,108,125],"cells.":[65,110],"Moreover,":[66],"after":[67],"screening":[70],"further":[72],"studies,":[73],"demonstrated":[75],"statin":[77],"Simvastatin":[79,94,116],"Atorvastatin":[81,96,118],"were":[82],"able":[83],"inhibit":[85],"RB":[88],"expressions.":[89],"Further":[90],"study":[91],"showed":[92,114],"chromosome":[99],"breaks":[100],"gaps":[102],"vivo":[112],"results":[113],"significantly":[119],"suppressed":[120],"growth":[123],"xenograft":[127],"mouse":[128],"models.":[129],"The":[130],"work":[132],"demonstrates":[133],"\u2018old'":[135],"lipid-lowering":[136],"drugs":[137],"statins":[138],"are":[139],"novel":[140],"weapons":[141],"against":[142],"tumors":[144],"due":[145],"their":[147],"effects":[148],"on":[149],"suppressing":[150],"protein":[152],"levels.":[153]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2022-10-04T00:00:00"}