{"id":"https://openalex.org/W4300935402","doi":"https://doi.org/10.1093/oxfordjournals.alcalc.a045778","title":"THE THYROTROPIN RELEASING HORMONE STIMULATION TEST IN ALCOHOLISM","display_name":"THE THYROTROPIN RELEASING HORMONE STIMULATION TEST IN ALCOHOLISM","publication_year":1995,"publication_date":"1995-09-01","ids":{"openalex":"https://openalex.org/W4300935402","doi":"https://doi.org/10.1093/oxfordjournals.alcalc.a045778","mag":"2115068716","pmid":"https://pubmed.ncbi.nlm.nih.gov/8554651"},"language":"en","primary_location":{"id":"doi:10.1093/oxfordjournals.alcalc.a045778","doi":"https://doi.org/10.1093/oxfordjournals.alcalc.a045778","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.alcalc.a045778","pdf_url":null,"source":{"id":"https://openalex.org/S102424854","display_name":"Alcohol and Alcoholism","issn_l":"0735-0414","issn":["0735-0414","1464-3502"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcohol and Alcoholism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025720995","display_name":"Pienaar Wp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"WILLEM P. PIENAAR","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110152384","display_name":"Mimi C. Roberts","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MIMI C. ROBERTS","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012421719","display_name":"Robin Alexander Emsley","orcid":"https://orcid.org/0000-0003-1250-6888","observed_orcids":["https://orcid.org/0000-0003-1250-6888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ROBIN A. EMSLEY","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000966130","display_name":"Cor Aalbers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"COR AALBERS","raw_affiliation_strings":["Medical Research Council Unit for the Neurochemistry of Mental Disorders PO Box 19113, Tygerberg 7505, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Unit for the Neurochemistry of Mental Disorders PO Box 19113, Tygerberg 7505, South Africa","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056597863","display_name":"Frans J. J. Taljaard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"FRANS J. J. TALJAARD","raw_affiliation_strings":["Medical Research Council Unit for the Neurochemistry of Mental Disorders PO Box 19113, Tygerberg 7505, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Unit for the Neurochemistry of Mental Disorders PO Box 19113, Tygerberg 7505, South Africa","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5025720995"],"corresponding_institution_ids":[],"apc_list":{"value":3250,"currency":"GBP","value_usd":4286},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"30","issue":"5","first_page":"661","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.44429999589920044,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.44429999589920044,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12494","display_name":"Alcoholism and Thiamine Deficiency","score":0.38940000534057617,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.12460000067949295,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trh-test","display_name":"TRH stimulation test","score":0.9509999752044678},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.949999988079071},{"id":"https://openalex.org/keywords/alcohol-withdrawal-syndrome","display_name":"alcohol withdrawal","score":0.6100000143051147},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone-response","display_name":"thyroid-stimulating hormone response","score":0.8989999890327454},{"id":"https://openalex.org/keywords/gonadotropin-releasing-hormone","display_name":"gonadotropin-releasing hormone","score":0.7820000052452087},{"id":"https://openalex.org/keywords/alcohol-abstinence","display_name":"alcohol abstinence","score":0.7680000066757202},{"id":"https://openalex.org/keywords/serum-magnesium","display_name":"serum magnesium","score":0.9150000214576721},{"id":"https://openalex.org/keywords/family-history-of-alcoholism","display_name":"family history of alcoholism","score":0.9589999914169312},{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.7639999985694885},{"id":"https://openalex.org/keywords/genetic-factors","display_name":"genetic factors","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C2776216936","wikidata":"https://www.wikidata.org/wiki/Q24726011","display_name":"Thyrotropin-releasing hormone","level":3,"score":0.6880448460578918},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.6450967788696289},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5316406488418579},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5203297138214111},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4761781096458435},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4465567171573639},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3690037131309509}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000430","descriptor_name":"Alcohol Withdrawal Delirium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000430","descriptor_name":"Alcohol Withdrawal Delirium","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000430","descriptor_name":"Alcohol Withdrawal Delirium","qualifier_ui":"Q000534","qualifier_name":"rehabilitation","is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000534","qualifier_name":"rehabilitation","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013973","descriptor_name":"Thyrotropin-Releasing Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/oxfordjournals.alcalc.a045778","doi":"https://doi.org/10.1093/oxfordjournals.alcalc.a045778","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oxfordjournals.alcalc.a045778","pdf_url":null,"source":{"id":"https://openalex.org/S102424854","display_name":"Alcohol and Alcoholism","issn_l":"0735-0414","issn":["0735-0414","1464-3502"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcohol and Alcoholism","raw_type":"journal-article"},{"id":"pmid:8554651","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8554651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcohol and alcoholism (Oxford, Oxfordshire)","raw_type":"Journal Article"},{"id":"mag:2115068716","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8554651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1978721303","https://openalex.org/W2027229855","https://openalex.org/W1990955321","https://openalex.org/W2404222064","https://openalex.org/W1970245598","https://openalex.org/W2055355157","https://openalex.org/W2059993339","https://openalex.org/W2091685422","https://openalex.org/W2136344137","https://openalex.org/W2154818923"],"abstract_inverted_index":{"The":[0],"mechanism":[1],"for":[2,52,66,79],"a":[3,22,107,118,131,146],"blunted":[4,82],"thyroid":[5,174],"stimulating":[6],"hormone":[7,13,175],"(TSH)":[8],"response":[9,84],"to":[10,85,155,185,188,210],"thyrotropin":[11],"releasing":[12],"(TRH)":[14],"in":[15,94,191],"alcoholics":[16],"is":[17],"not":[18,151,164],"known.":[19],"We":[20,177],"performed":[21],"combined":[23],"TRH":[24,86,180],"and":[25,58,98,117,157,160,195,206],"gonadoliberin":[26],"stimulation":[27,181],"test":[28,182],"on":[29],"three":[30],"well-defined":[31],"groups":[32,95],"of":[33,114,134,203],"nondepressed":[34],"alcoholic":[35],"men.":[36],"Group":[37],"A":[38,81,96,103,200],"comprised":[39],"patients":[40,50,61,129],"with":[41,111,122,130,153,167,197],"acute":[42],"withdrawal":[43,115,193],"symptoms":[44,116],"(n":[45,55,70],"=":[46,56,71],"28),":[47],"group":[48,59,102,127],"B":[49,99],"abstinent":[51,65],"5-8":[53],"weeks":[54],"29)":[57],"C":[60],"who":[62],"had":[63,136],"been":[64],">":[67],"2":[68],"years":[69],"16).":[72],"Twenty-two":[73],"healthy":[74],"male":[75],"volunteers":[76],"were":[77,163],"used":[78],"comparison.":[80],"TSH":[83,88,105,140,161],"(delta":[87],"<":[89],"5":[90],"microU/l)":[91],"occurred":[92],"only":[93],"(39%)":[97],"(17%).":[100],"In":[101,126],"delta":[104,139,158],"showed":[106],"significant":[108,119],"negative":[109],"correlation":[110,121],"the":[112,192],"severity":[113],"positive":[120],"serum":[123,207],"magnesium":[124,208],"levels.":[125,176],"B,":[128],"family":[132,147],"history":[133],"alcoholism":[135],"significantly":[137,165],"lower":[138],"levels":[141,171],"than":[142],"those":[143],"without":[144],"such":[145],"history.":[148],"Groups":[149],"did":[150],"differ":[152],"respect":[154],"basal":[156],"prolactin,":[159],"responses":[162],"associated":[166],"vitamin":[168],"deficiency,":[169],"cortisol":[170],"or":[172],"free":[173],"conclude":[178],"that":[179],"blunting":[183],"appears":[184],"be":[186,211],"related":[187],"factors":[189,205],"operating":[190],"state":[194],"improves":[196],"continued":[198],"abstinence.":[199],"possible":[201],"role":[202],"genetic":[204],"needs":[209],"further":[212],"explored.":[213]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-10-04T00:00:00"}