{"id":"https://openalex.org/W4300840767","doi":null,"title":"Preparation, characterization and targeting of micronized 10-hydroxycamptothecin-loaded folate-conjugated human serum albumin nanoparticles to cancer cells","display_name":"Preparation, characterization and targeting of micronized 10-hydroxycamptothecin-loaded folate-conjugated human serum albumin nanoparticles to cancer cells","publication_year":2011,"publication_date":"2011-02-01","ids":{"openalex":"https://openalex.org/W4300840767"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:750b5602c5a24f87a760d130e3d41e70","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/750b5602c5a24f87a760d130e3d41e70","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Nanomedicine, Vol 2011, Iss default, Pp 397-405 (2011)","raw_type":"article"},"volume":null,"type":"article","indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/750b5602c5a24f87a760d130e3d41e70","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"et al","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"et al","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102319325","display_name":"Xiuhua Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiuhua Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101433368","display_name":"Qingyong Li","orcid":"https://orcid.org/0000-0003-1492-3909","observed_orcids":["https://orcid.org/0000-0003-1492-3909"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qingyong Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100322216","display_name":"Chen Liu","orcid":"https://orcid.org/0009-0003-0430-6146","observed_orcids":["https://orcid.org/0009-0003-0430-6146","https://orcid.org/0009-0008-6552-1719"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chen Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39017121,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/10-hydroxycamptothecin","display_name":"10-hydroxycamptothecin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/human-serum-albumin-nanoparticles","display_name":"human serum albumin nanoparticles","score":0.8610000014305115},{"id":"https://openalex.org/keywords/folate-conjugation","display_name":"folate conjugation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.968999981880188},{"id":"https://openalex.org/keywords/anticancer-drug-delivery","display_name":"anticancer drug delivery","score":0.7889999747276306},{"id":"https://openalex.org/keywords/supercritical-antisolvent-process","display_name":"supercritical antisolvent process","score":0.8259999752044678},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.9269999861717224},{"id":"https://openalex.org/keywords/poorly-water-soluble-drugs","display_name":"poorly water-soluble drugs","score":0.8159999847412109},{"id":"https://openalex.org/keywords/nanoparticle-characterization","display_name":"nanoparticle characterization","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2778597219","wikidata":"https://www.wikidata.org/wiki/Q11721976","display_name":"Human serum albumin","level":2,"score":0.6151210069656372},{"id":"https://openalex.org/C112613896","wikidata":"https://www.wikidata.org/wiki/Q898370","display_name":"Conjugated system","level":3,"score":0.5935105681419373},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.5366840362548828},{"id":"https://openalex.org/C165616093","wikidata":"https://www.wikidata.org/wiki/Q424232","display_name":"Serum albumin","level":2,"score":0.5314491987228394},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5314421057701111},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.49536240100860596},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.39677852392196655},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.21378356218338013},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.20726093649864197},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18956106901168823},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.05424600839614868},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:doaj.org/article:750b5602c5a24f87a760d130e3d41e70","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/750b5602c5a24f87a760d130e3d41e70","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Nanomedicine, Vol 2011, Iss default, Pp 397-405 (2011)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:750b5602c5a24f87a760d130e3d41e70","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/750b5602c5a24f87a760d130e3d41e70","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Nanomedicine, Vol 2011, Iss default, Pp 397-405 (2011)","raw_type":"article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2344617060","https://openalex.org/W1994747657","https://openalex.org/W2385646201","https://openalex.org/W2040366245","https://openalex.org/W2074228324","https://openalex.org/W2038507014","https://openalex.org/W2914454399","https://openalex.org/W2062526575","https://openalex.org/W2522067040","https://openalex.org/W2165391945"],"abstract_inverted_index":{"Qingyong":[0],"Li,":[1],"Chen":[2],"Liu,":[3],"Xiuhua":[4],"Zhao,":[5,13,15],"Yuangang":[6],"Zu,":[7],"Ying":[8],"Wang,":[9],"Baoyou":[10],"Zhang,":[11],"Dongmei":[12],"Qi":[14],"Lin":[16],"Su,":[17],"Yang":[18],"Gao,":[19],"Baihe":[20],"SunKey":[21],"Laboratory":[22],"of":[23,28,37,41,52,95,107,124,152,183,189,253],"Forest":[24],"Plant":[25],"Ecology,":[26],"Ministry":[27],"Education,":[29],"Northeast":[30],"Forestry":[31],"University,":[32],"Harbin,":[33],"Heilongjiang,":[34],"People's":[35],"Republic":[36],"ChinaBackground:":[38],"The":[39,93,104,118,138,169,191],"purpose":[40],"this":[42],"study":[43],"was":[44,98,113],"to":[45,57,67],"develop":[46],"a":[47,63,85,90,141,145,165,180,210,215,242],"method":[48,87,212],"for":[49,174,197,220,250],"targeted":[50,251,264],"delivery":[51,195,244,252,265],"10-hydroxycamptothecin":[53],"(HCPT)-loaded":[54],"nanoparticles":[55],"(NPs)":[56],"cancer":[58],"cells.Methods:":[59],"We":[60],"first":[61],"used":[62],"supercritical":[64],"antisolvent":[65],"process":[66],"prepare":[68],"micronized":[69],"HCPT":[70],"(nHCPT),":[71],"and":[72,121,132,144,149,156,185,230,246],"then":[73],"folate-conjugated":[74],"human":[75,260],"serum":[76,261],"albumin":[77,235],"(HSA)":[78],"nHCPT-loaded":[79],"NPs":[80,222],"(FA-HSA-nHCPT-NPs)":[81],"were":[82,127,193],"prepared":[83],"using":[84,234],"NP-coated":[86,211],"combined":[88,213],"with":[89,179,203,214,223],"desolvation":[91,216,257],"technique.":[92],"amount":[94],"folate":[96],"conjugation":[97],"16":[99],"\u00b5g":[100],"\u00b7":[101],"mg-1":[102],"HSA.Results:":[103],"particle":[105,119],"size":[106,120],"the":[108,125,150,161,237,248],"spherical":[109,147],"nHCPT":[110],"microparticles":[111],"obtained":[112],"118.5":[114],"\u00b1":[115,129,134],"6.6":[116],"nm.":[117],"zeta":[122],"potential":[123,249],"FA-HSA-nHCPT-NPs":[126,139,162,170],"233.9":[128],"1.2":[130],"nm":[131],"-25.23":[133],"2.98":[135],"mV,":[136],"respectively.":[137],"exhibited":[140],"smooth":[142],"surface":[143],"distinct":[146],"shape,":[148],"results":[151,207],"differential":[153],"scanning":[154],"calorimetry":[155],"X-ray":[157],"diffraction":[158],"indicated":[159],"that":[160,209],"presented":[163],"in":[164,177,228],"nanostructured":[166],"amorphous":[167],"state.":[168],"showed":[171],"sustained-release":[172],"characteristics":[173],"120":[175],"hours":[176],"vitro,":[178],"drug-loading":[181],"content":[182],"7.3%":[184],"an":[186],"encapsulating":[187],"efficiency":[188],"79.1%.Conclusion:":[190],"FA-NPs":[192],"effective":[194,219],"systems":[196],"uptake":[198],"by":[199],"SGC7901":[200],"cells":[201],"compared":[202],"folate-free":[204],"NPs.":[205],"These":[206],"suggest":[208],"technique":[217],"is":[218],"preparing":[221],"drugs":[224],"having":[225],"poor":[226],"solubility":[227],"water":[229],"most":[231],"organic":[232],"solvents,":[233],"as":[236],"wall":[238],"material.":[239],"FA-HSA-NPs":[240],"are":[241],"stable":[243],"system":[245],"have":[247],"anticancer":[254],"drugs.Keywords:":[255],"nanoparticle-coated,":[256],"technique,":[258],"10-hydroxycamptothecin,":[259],"albumin,":[262],"folate,":[263]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-10-04T00:00:00"}
