{"id":"https://openalex.org/W4300716355","doi":"https://doi.org/10.14423/smj.0000000000001453","title":"Safety of Nonvitamin K Antagonists Compared with Warfarin in Patients with Atrial Fibrillation and End-Stage Kidney Disease","display_name":"Safety of Nonvitamin K Antagonists Compared with Warfarin in Patients with Atrial Fibrillation and End-Stage Kidney Disease","publication_year":2022,"publication_date":"2022-10-01","ids":{"openalex":"https://openalex.org/W4300716355","doi":"https://doi.org/10.14423/smj.0000000000001453","pmid":"https://pubmed.ncbi.nlm.nih.gov/36191918"},"language":"en","primary_location":{"id":"doi:10.14423/smj.0000000000001453","doi":"https://doi.org/10.14423/smj.0000000000001453","is_oa":false,"landing_page_url":"https://doi.org/10.14423/smj.0000000000001453","pdf_url":null,"source":{"id":"https://openalex.org/S89143414","display_name":"Southern Medical Journal","issn_l":"0038-4348","issn":["0038-4348","1541-8243"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Southern Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062909961","display_name":"Nathan A. Pinner","orcid":"https://orcid.org/0000-0003-1938-5951","observed_orcids":["https://orcid.org/0000-0003-1938-5951"]},"institutions":[{"id":"https://openalex.org/I4210118201","display_name":"Princeton Baptist Medical Center","ror":"https://ror.org/02hvk4n65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210118201"]},{"id":"https://openalex.org/I82497590","display_name":"Auburn University","ror":"https://ror.org/02v80fc35","country_code":"US","type":"education","lineage":["https://openalex.org/I82497590"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan A. Pinner","raw_affiliation_strings":["From the Department of Pharmacy Practice, Auburn University Harrison School of Pharmacy, Auburn, Alabama, and the Department of Pharmacy, Princeton Baptist Medical Center, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacy Practice, Auburn University Harrison School of Pharmacy, Auburn, Alabama, and the Department of Pharmacy, Princeton Baptist Medical Center, Birmingham, Alabama","institution_ids":["https://openalex.org/I4210118201","https://openalex.org/I82497590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031520631","display_name":"Alyssa J. Osmonson","orcid":"https://orcid.org/0000-0001-9420-3076","observed_orcids":["https://orcid.org/0000-0001-9420-3076"]},"institutions":[{"id":"https://openalex.org/I4210118201","display_name":"Princeton Baptist Medical Center","ror":"https://ror.org/02hvk4n65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210118201"]},{"id":"https://openalex.org/I82497590","display_name":"Auburn University","ror":"https://ror.org/02v80fc35","country_code":"US","type":"education","lineage":["https://openalex.org/I82497590"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alyssa J. Osmonson","raw_affiliation_strings":["From the Department of Pharmacy Practice, Auburn University Harrison School of Pharmacy, Auburn, Alabama, and the Department of Pharmacy, Princeton Baptist Medical Center, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacy Practice, Auburn University Harrison School of Pharmacy, Auburn, Alabama, and the Department of Pharmacy, Princeton Baptist Medical Center, Birmingham, Alabama","institution_ids":["https://openalex.org/I4210118201","https://openalex.org/I82497590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060893585","display_name":"Jessica A. Starr","orcid":"https://orcid.org/0000-0003-2704-4372","observed_orcids":["https://orcid.org/0000-0003-2704-4372"]},"institutions":[{"id":"https://openalex.org/I4210118201","display_name":"Princeton Baptist Medical Center","ror":"https://ror.org/02hvk4n65","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210118201"]},{"id":"https://openalex.org/I82497590","display_name":"Auburn University","ror":"https://ror.org/02v80fc35","country_code":"US","type":"education","lineage":["https://openalex.org/I82497590"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica A. Starr","raw_affiliation_strings":["From the Department of Pharmacy Practice, Auburn University Harrison School of Pharmacy, Auburn, Alabama, and the Department of Pharmacy, Princeton Baptist Medical Center, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacy Practice, Auburn University Harrison School of Pharmacy, Auburn, Alabama, and the Department of Pharmacy, Princeton Baptist Medical Center, Birmingham, Alabama","institution_ids":["https://openalex.org/I4210118201","https://openalex.org/I82497590"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3497,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.54814187,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"115","issue":"10","first_page":"794","last_page":"798"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/direct-oral-anticoagulants","display_name":"direct oral anticoagulants","score":0.824999988079071},{"id":"https://openalex.org/keywords/warfarin","display_name":"warfarin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.9390000104904175},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/major-bleeding","display_name":"major bleeding","score":0.8640000224113464},{"id":"https://openalex.org/keywords/oral-anticoagulation","display_name":"oral anticoagulation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/thromboembolic-events","display_name":"thromboembolic events","score":0.7279999852180481},{"id":"https://openalex.org/keywords/bleeding-risk","display_name":"bleeding risk","score":0.5360000133514404},{"id":"https://openalex.org/keywords/low-dose-anticoagulation","display_name":"low-dose anticoagulation","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9733730554580688},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.9119245409965515},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.701931357383728},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5496637225151062},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5280136466026306},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.4994387626647949},{"id":"https://openalex.org/C3017811039","wikidata":"https://www.wikidata.org/wiki/Q166019","display_name":"Major bleeding","level":3,"score":0.4800351858139038},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.4695100486278534},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.46936681866645813},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37003418803215027},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.15275681018829346}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D007676","descriptor_name":"Kidney Failure, Chronic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.14423/smj.0000000000001453","doi":"https://doi.org/10.14423/smj.0000000000001453","is_oa":false,"landing_page_url":"https://doi.org/10.14423/smj.0000000000001453","pdf_url":null,"source":{"id":"https://openalex.org/S89143414","display_name":"Southern Medical Journal","issn_l":"0038-4348","issn":["0038-4348","1541-8243"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Southern Medical Journal","raw_type":"journal-article"},{"id":"pmid:36191918","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36191918","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Southern medical journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1913544684","https://openalex.org/W2050178600","https://openalex.org/W2073789348","https://openalex.org/W2161038071","https://openalex.org/W2216123836","https://openalex.org/W2225937646","https://openalex.org/W2337007159","https://openalex.org/W2442448576","https://openalex.org/W2528808870","https://openalex.org/W2534290193","https://openalex.org/W2588182624","https://openalex.org/W2589662789","https://openalex.org/W2735710351","https://openalex.org/W2790801037","https://openalex.org/W2792857103","https://openalex.org/W2888082174","https://openalex.org/W2897495391","https://openalex.org/W2957544571","https://openalex.org/W3004050106","https://openalex.org/W3014494431","https://openalex.org/W3126268935"],"related_works":["https://openalex.org/W3213762078","https://openalex.org/W2984886106","https://openalex.org/W7119519782","https://openalex.org/W4388595375","https://openalex.org/W2764301312","https://openalex.org/W3083339919","https://openalex.org/W7117960392","https://openalex.org/W2889066936","https://openalex.org/W2939256306","https://openalex.org/W4281742092"],"abstract_inverted_index":{"OBJECTIVES:":[0],"This":[1,29],"study":[2,34,41],"evaluated":[3],"the":[4,10,40,61,97,106,111,127],"occurrence":[5,62,77],"of":[6,12,63,78,86,94,113,129],"major":[7,64,114],"bleeding":[8,65,87,115],"following":[9],"initiation":[11],"oral":[13,48,54,71],"anticoagulation":[14,49],"therapy":[15],"in":[16,23,96,116],"patients":[17,37,95,117],"with":[18,43,118,121],"end-stage":[19],"kidney":[20],"disease":[21],"(ESKD)":[22],"a":[24,31,102],"community":[25],"teaching":[26],"hospital.":[27],"METHODS:":[28],"was":[30,60],"single-center":[32],"retrospective":[33],"that":[35],"enrolled":[36],"admitted":[38],"to":[39],"hospital":[42],"ESKD":[44,119],"and":[45,83,123],"who":[46],"received":[47,101],"(warfarin":[50],"or":[51,88],"nonvitamin":[52],"K":[53],"antagonists":[55],"[NOACs]).":[56],"The":[57,92],"primary":[58],"endpoint":[59],"at":[66],"any":[67],"time":[68],"while":[69],"taking":[70],"anticoagulation.":[72],"Key":[73],"secondary":[74],"endpoints":[75],"included":[76],"minor":[79],"bleeding,":[80],"thrombotic":[81,130],"events,":[82],"hospitalizations":[84],"because":[85],"thrombosis.":[89],"RESULTS:":[90],"0.026).":[91],"majority":[93],"NOAC":[98],"group":[99],"(69%)":[100],"reduced":[103],"dose":[104],"for":[105],"indication.":[107],"CONCLUSIONS:":[108],"Warfarin":[109],"increased":[110],"risk":[112,128],"compared":[120],"NOACs":[122],"did":[124],"not":[125],"reduce":[126],"events.":[131]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-10-04T00:00:00"}