{"id":"https://openalex.org/W4300637178","doi":"https://doi.org/10.1093/jnci/65.3.603","title":"Effect of 5-Fluoro-2\u2032-deoxyuridine on Deoxyribonucleotide Pools In Vivo 2","display_name":"Effect of 5-Fluoro-2\u2032-deoxyuridine on Deoxyribonucleotide Pools In Vivo 2","publication_year":1980,"publication_date":"1980-09-01","ids":{"openalex":"https://openalex.org/W4300637178","doi":"https://doi.org/10.1093/jnci/65.3.603"},"language":"en","primary_location":{"id":"doi:10.1093/jnci/65.3.603","doi":"https://doi.org/10.1093/jnci/65.3.603","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/65.3.603","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI: Journal of the National Cancer Institute","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047072426","display_name":"Edmond J. Ritter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edmond J. Ritter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103548077","display_name":"William J. Scott","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William J. Scott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101867739","display_name":"James G. Wilson","orcid":"https://orcid.org/0000-0001-8503-2041","observed_orcids":["https://orcid.org/0000-0001-8503-2041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James G. Wilson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111536644","display_name":"Beatrice C. Lampkin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beatrice C. Lampkin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109222067","display_name":"John E. Neely","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John E. Neely","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5436,"currency":"USD","value_usd":5436},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34377155,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-fluorodeoxyuridine","display_name":"5-fluorodeoxyuridine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/deoxyribonucleotide-pools","display_name":"deoxyribonucleotide pools","score":0.9330000281333923},{"id":"https://openalex.org/keywords/dttp","display_name":"dTTP","score":0.8230000138282776},{"id":"https://openalex.org/keywords/dgtp","display_name":"dGTP","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nucleotide-metabolism","display_name":"nucleotide metabolism","score":0.5410000085830688},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9129999876022339},{"id":"https://openalex.org/keywords/rat-embryo","display_name":"rat embryo","score":0.6759999990463257},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.878000020980835},{"id":"https://openalex.org/keywords/nude-mice","display_name":"nude mice","score":0.7670000195503235},{"id":"https://openalex.org/keywords/fixation-artifacts","display_name":"fixation artifacts","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4149150550365448},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3504452705383301},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32776033878326416}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/jnci/65.3.603","doi":"https://doi.org/10.1093/jnci/65.3.603","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/65.3.603","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI: Journal of the National Cancer Institute","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2096416079","https://openalex.org/W7095708907","https://openalex.org/W2341007540","https://openalex.org/W2419638754","https://openalex.org/W1599809449","https://openalex.org/W1489609688","https://openalex.org/W2004724058","https://openalex.org/W1968400447","https://openalex.org/W1603376393","https://openalex.org/W2155353643"],"abstract_inverted_index":{"5-Fluoro-2\u2032-deoxyuridine":[0],"(FdUrd)":[1],"lowered":[2],"the":[3,48,54],"dTTP":[4],"levels":[5,37,42],"in":[6,14,19],"rapidly":[7],"frozen":[8],"12-day":[9],"W":[10],"rat":[11],"embryos":[12],"and":[13,38],"a":[15],"human":[16],"neuroblastoma":[17],"grown":[18],"nude":[20],"N:NIH(S)":[21],"mice":[22],"to":[23,44,65],"about":[24],"20%":[25],"of":[26,40,47,56,61],"control":[27],"values.":[28,71],"This":[29],"effect":[30],"was":[31,63],"associated":[32],"with":[33,53],"greatly":[34],"increased":[35],"dGTP":[36,41,49],"reduction":[39],"essentially":[43],"zero.":[45],"Elimination":[46],"pool":[50],"correlated":[51],"temporally":[52],"cytotoxicity":[55],"FdUrd.":[57],"Extremely":[58],"rapid":[59],"fixation":[60],"tissue":[62],"required":[64],"avoid":[66],"artifactually":[67],"high":[68],"deoxyribonucleoside":[69],"triphosphate":[70]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2022-10-03T00:00:00"}