{"id":"https://openalex.org/W4300527062","doi":null,"title":"Role of Presepsin in Predicting ShortTerm Patient\u2019s Status Changes and Preventing Excessive Antimicrobial Therapy in Patients with Nosocomial Infections","display_name":"Role of Presepsin in Predicting ShortTerm Patient\u2019s Status Changes and Preventing Excessive Antimicrobial Therapy in Patients with Nosocomial Infections","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W4300527062"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:3f4060df63af4134b7a614e7463af36c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3f4060df63af4134b7a614e7463af36c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043c\u0438\u043a\u0440\u043e\u0431\u0438\u043e\u043b\u043e\u0433\u0438\u044f \u0438 \u0430\u043d\u0442\u0438\u043c\u0438\u043a\u0440\u043e\u0431\u043d\u0430\u044f \u0445\u0438\u043c\u0438\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f, Vol 17, Iss 3, Pp 235-240 (2015)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/3f4060df63af4134b7a614e7463af36c","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034729139","display_name":"\u0417\u0430\u0433\u043e\u0440\u043e\u0434\u043d\u0438\u043a\u043e\u0432\u0430 \u041a\u0441\u0435\u043d\u0438\u044f \u0410\u043b\u0435\u043a\u0441\u0430\u043d\u0434\u0440\u043e\u0432\u043d\u0430","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151936","display_name":"North-Western State Medical University named after I.I. Mechnikov","ror":"https://ror.org/04kayk232","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210151936"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Zagorodnikova K.A.","raw_affiliation_strings":["North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia","institution_ids":["https://openalex.org/I4210151936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109381220","display_name":"L. B. Gaykovaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151936","display_name":"North-Western State Medical University named after I.I. Mechnikov","ror":"https://ror.org/04kayk232","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210151936"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Gaykovaya L.B.","raw_affiliation_strings":["North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia","institution_ids":["https://openalex.org/I4210151936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016354154","display_name":"\u0411\u0443\u0440\u0431\u0435\u043b\u043b\u043e \u0410\u043b\u0435\u043a\u0441\u0430\u043d\u0434\u0440\u0430 \u0422\u0438\u043c\u043e\u0444\u0435\u0435\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0003-4097-4267","observed_orcids":["https://orcid.org/0000-0003-4097-4267"]},"institutions":[{"id":"https://openalex.org/I4210151936","display_name":"North-Western State Medical University named after I.I. Mechnikov","ror":"https://ror.org/04kayk232","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210151936"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Burbello A.T.","raw_affiliation_strings":["North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia","institution_ids":["https://openalex.org/I4210151936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086496650","display_name":"Kostitsyna M.A.","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151936","display_name":"North-Western State Medical University named after I.I. Mechnikov","ror":"https://ror.org/04kayk232","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210151936"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Kostitsyna M.A.","raw_affiliation_strings":["North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia","institution_ids":["https://openalex.org/I4210151936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028344597","display_name":"Maria Pokladova","orcid":"https://orcid.org/0000-0001-9458-450X","observed_orcids":["https://orcid.org/0000-0001-9458-450X"]},"institutions":[{"id":"https://openalex.org/I4210151936","display_name":"North-Western State Medical University named after I.I. Mechnikov","ror":"https://ror.org/04kayk232","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210151936"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Pokladova M.V.","raw_affiliation_strings":["North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia","institution_ids":["https://openalex.org/I4210151936"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000038907","display_name":"\u0410. \u0418. \u0415\u0440\u043c\u0430\u043a\u043e\u0432","orcid":"https://orcid.org/0000-0003-3435-5881","observed_orcids":["https://orcid.org/0000-0003-3435-5881"]},"institutions":[{"id":"https://openalex.org/I4210151936","display_name":"North-Western State Medical University named after I.I. Mechnikov","ror":"https://ror.org/04kayk232","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210151936"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ermakov A.I.","raw_affiliation_strings":["North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia","institution_ids":["https://openalex.org/I4210151936"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032011142","display_name":"\u041c. \u0412. \u041a\u043e\u043c\u043e\u043a","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151936","display_name":"North-Western State Medical University named after I.I. Mechnikov","ror":"https://ror.org/04kayk232","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210151936"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Komok M.V.","raw_affiliation_strings":["North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg, Russia","institution_ids":["https://openalex.org/I4210151936"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210151936"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/presepsin","display_name":"presepsin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nosocomial-infections","display_name":"nosocomial infections","score":0.9769999980926514},{"id":"https://openalex.org/keywords/procalcitonin","display_name":"procalcitonin","score":0.8109999895095825},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8859999775886536},{"id":"https://openalex.org/keywords/systemic-inflammatory-response","display_name":"systemic inflammatory response","score":0.8889999985694885},{"id":"https://openalex.org/keywords/antibiotic-duration","display_name":"antibiotic duration","score":0.5839999914169312},{"id":"https://openalex.org/keywords/infection-related-mortality","display_name":"infection-related mortality","score":0.6510000228881836},{"id":"https://openalex.org/keywords/white-blood-cell-count","display_name":"white blood cell count","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.8167382478713989},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6126856207847595},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5537209510803223},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33606481552124023},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.1499236524105072},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0937495231628418}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:doaj.org/article:3f4060df63af4134b7a614e7463af36c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3f4060df63af4134b7a614e7463af36c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043c\u0438\u043a\u0440\u043e\u0431\u0438\u043e\u043b\u043e\u0433\u0438\u044f \u0438 \u0430\u043d\u0442\u0438\u043c\u0438\u043a\u0440\u043e\u0431\u043d\u0430\u044f \u0445\u0438\u043c\u0438\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f, Vol 17, Iss 3, Pp 235-240 (2015)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:3f4060df63af4134b7a614e7463af36c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3f4060df63af4134b7a614e7463af36c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043c\u0438\u043a\u0440\u043e\u0431\u0438\u043e\u043b\u043e\u0433\u0438\u044f \u0438 \u0430\u043d\u0442\u0438\u043c\u0438\u043a\u0440\u043e\u0431\u043d\u0430\u044f \u0445\u0438\u043c\u0438\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f, Vol 17, Iss 3, Pp 235-240 (2015)","raw_type":"article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2316760646","https://openalex.org/W2460106257","https://openalex.org/W3202924714","https://openalex.org/W3030856702","https://openalex.org/W2115622314","https://openalex.org/W3035247036","https://openalex.org/W2972397314","https://openalex.org/W4387477451","https://openalex.org/W2918796397","https://openalex.org/W4309629731"],"abstract_inverted_index":{"Relationship":[0],"between":[1],"presepsin":[2,17,67],"values":[3,50,63,125,182],"and":[4,19,80,97,175,180],"shortterm":[5],"status":[6,89,199],"of":[7,16,22,40,48,59,83,134,200],"patients":[8,36,139,151,165,201],"with":[9,37,152,202],"infections,":[10],"as":[11,13,114],"well":[12],"a":[14],"correlation":[15,117,186],"levels":[18,143,171,193],"other":[20],"markers":[21],"systemic":[23],"inflammatory":[24],"response":[25],"were":[26,64,108,112,126,140,147,172],"analyzed":[27,113],"in":[28,86,90,102,150,155,164,198,205],"this":[29],"prospective":[30],"observational":[31],"study.":[32],"The":[33],"study":[34],"included":[35],"different":[38,54],"types":[39],"nosocomial":[41,203],"infections":[42,101,204],"receiving":[43],"empiric":[44],"antimicrobial":[45],"therapy.":[46],"Analysis":[47],"laboratory":[49],"was":[51,119],"performed":[52,120],"at":[53,56],"time-points":[55],"the":[57,65,91,103,129,156,206],"discretion":[58],"treating":[60],"physician.":[61],"Laboratory":[62],"following:":[66],"(using":[68],"\u00abPathfast\u00ae":[69],"presepsin\u00bb":[70],"assay),":[71],"procalcitonin,":[72],"C-reactive":[73],"protein,":[74],"total":[75,133],"white":[76],"blood":[77],"cells,":[78],"neutrophils,":[79],"band":[81],"forms":[82],"neutrophils.":[84],"Changes":[85],"patient\u2019s":[87],"clinical":[88,153],"first":[92,104,157],"3":[93,158],"days":[94,159],"after":[95,106],"analysis":[96,107,118],"patient":[98],"deaths":[99],"from":[100,137],"week":[105],"evaluated":[109],"retrospectively.":[110],"Data":[111],"nonparametric":[115],"values;":[116],"using":[121,128],"Spearman":[122],"test;":[123],"mean":[124],"compared":[127,160],"Mann-Whitney":[130],"test.":[131],"A":[132],"71":[135],"measurements":[136],"38":[138],"analyzed.":[141],"Presepsin":[142,179,192],"(1365":[144],"pg/":[145],"ml)":[146],"significantly":[148],"increased":[149],"worsening":[154,167],"to":[161],"440":[162],"pg/ml":[163],"without":[166],"(p<0.0001).":[168],"Corresponding":[169],"procalcitonin":[170,181],"2.67":[173],"ng/ml":[174,177],"0.43":[176],"(p<0.001).":[178],"had":[183],"significant":[184],"moderate":[185],"(Spearman":[187],"r":[188],"=":[189],"0.43,":[190],"p=0.002).":[191],"promptly":[194],"predicted":[195],"short-term":[196],"changes":[197],"majority":[207],"cases.":[208]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-10-03T00:00:00"}