{"id":"https://openalex.org/W4300417817","doi":"https://doi.org/10.17615/8p36-9s38","title":"Molecular Analysis of Mutations Induced at the hisD3052 Allele of Salmonella by Single Chemicals and Complex Mixtures","display_name":"Molecular Analysis of Mutations Induced at the hisD3052 Allele of Salmonella by Single Chemicals and Complex Mixtures","publication_year":2020,"publication_date":"2020-11-02","ids":{"openalex":"https://openalex.org/W4300417817","doi":"https://doi.org/10.17615/8p36-9s38"},"language":"en","primary_location":{"id":"pmh:cdr.lib.unc.edu:kp78gp591","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/8p36-9s38","pdf_url":"https://doi.org/10.17615/8p36-9s38","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Environmental Health Perspectives, 101","raw_type":"Article"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.17615/8p36-9s38","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077994339","display_name":"Amal Abu\u2010Shakra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abu-Shakra, Amal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032808829","display_name":"Douglas A. Bell","orcid":"https://orcid.org/0000-0001-7700-0840","observed_orcids":["https://orcid.org/0000-0001-7700-0840","https://orcid.org/0000-0002-8456-3024"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bell, Douglas A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018593693","display_name":"Jessie G. Levine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Levine, Jessie G.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035667778","display_name":"David M. DeMarini","orcid":"https://orcid.org/0000-0001-8357-7988","observed_orcids":["https://orcid.org/0000-0001-8357-7988"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"DeMarini, David M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5082041864","display_name":"Melissa L. Shelton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shelton, Melissa L.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19558255,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salmonella","display_name":"Salmonella","score":0.7260000109672546},{"id":"https://openalex.org/keywords/mutagenicity","display_name":"mutagenicity","score":0.859000027179718},{"id":"https://openalex.org/keywords/environmental-mixtures","display_name":"environmental mixtures","score":0.75},{"id":"https://openalex.org/keywords/mutation-spectrum","display_name":"mutation spectrum","score":0.6209999918937683},{"id":"https://openalex.org/keywords/dna-secondary-structure","display_name":"DNA secondary structure","score":0.621999979019165},{"id":"https://openalex.org/keywords/base-substitutions","display_name":"base substitutions","score":0.5339999794960022},{"id":"https://openalex.org/keywords/deletions-and-duplications","display_name":"deletions and duplications","score":0.8259999752044678},{"id":"https://openalex.org/keywords/direct-dna-sequencing","display_name":"direct DNA sequencing","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2781065037","wikidata":"https://www.wikidata.org/wiki/Q150839","display_name":"Salmonella","level":3,"score":0.8699029684066772},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.741269052028656},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6047550439834595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43751439452171326},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29463696479797363},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.19899407029151917}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:cdr.lib.unc.edu:kp78gp591","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/8p36-9s38","pdf_url":"https://doi.org/10.17615/8p36-9s38","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Environmental Health Perspectives, 101","raw_type":"Article"},{"id":"doi:10.17615/8p36-9s38","doi":"https://doi.org/10.17615/8p36-9s38","is_oa":true,"landing_page_url":"https://doi.org/10.17615/8p36-9s38","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:cdr.lib.unc.edu:kp78gp591","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/8p36-9s38","pdf_url":"https://doi.org/10.17615/8p36-9s38","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Environmental Health Perspectives, 101","raw_type":"Article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306107","display_name":"U.S. Environmental Protection Agency","ror":"https://ror.org/03tns0030"},{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4300417817.pdf","grobid_xml":"https://content.openalex.org/works/W4300417817.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7099434935","https://openalex.org/W2093451477","https://openalex.org/W2044058902","https://openalex.org/W2020774888","https://openalex.org/W4298371902","https://openalex.org/W2078138768","https://openalex.org/W1990355239","https://openalex.org/W1983410267","https://openalex.org/W2093418457","https://openalex.org/W1982547422"],"abstract_inverted_index":{"More":[0],"single":[1],"chemicals":[2],"and":[3,35,43,59,74,137,150,158],"complex":[4,75,138],"environmental":[5,72],"mixtures":[6],"have":[7,65,102],"been":[8,66],"evaluated":[9],"for":[10,114,167],"mutagenicity":[11],"at":[12],"the":[13,36,39,60,88,93,111,117,147,168],"hisD3052":[14,118],"allele":[15],"of":[16,30,38,71,87,92,108,116,124,146,170],"Salmonella,":[17],"primarily":[18],"in":[19,23],"strain":[20],"TA98,":[21],"than":[22],"any":[24],"other":[25,106],"mutation":[26,62],"assay.":[27],"The":[28,143],"development":[29],"colony":[31],"probe":[32],"hybridization":[33],"procedures":[34],"application":[37],"polymerase":[40],"chain":[41],"reaction":[42],"direct":[44],"DNA":[45,155],"sequencing":[46],"has":[47],"permitted":[48],"rapid":[49],"molecular":[50],"access":[51],"to":[52,97,153,162],"this":[53,98,171],"allele.":[54,119,172],"We":[55],"discuss":[56],"these":[57],"techniques":[58],"resulting":[61],"spectra":[63],"that":[64],"induced":[67],"by":[68],"a":[69,84,122],"variety":[70,123],"mutagens":[73],"mixtures.":[76],"A":[77],"common":[78],"GC":[79],"or":[80],"CG":[81],"deletion":[82],"within":[83,110],"hot-spot":[85],"region":[86],"sequence":[89,149],"dominates":[90],"most":[91],"spectra.":[94],"In":[95],"addition":[96],"two-base":[99],"deletion,":[100],"we":[101],"recovered":[103],"about":[104],"200":[105],"types":[107],"mutations":[109,139],"72-base":[112],"target":[113,148],"reversion":[115],"These":[120],"include":[121],"deletions":[125],"(as":[126,132],"large":[127,133],"as":[128,134],"35":[129],"bases),":[130,136],"duplications":[131],"46":[135],"involving":[140],"base":[141],"substitutions.":[142],"quasipalindromic":[144],"nature":[145],"its":[151],"potential":[152],"form":[154],"secondary":[156],"structures":[157],"slippage":[159],"mismatches":[160],"appear":[161],"be":[163],"an":[164],"important":[165],"basis":[166],"mutability":[169]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2022-10-03T00:00:00"}