{"id":"https://openalex.org/W4299940097","doi":null,"title":"Expression levels of the BAK1 and BCL2 genes highlight the role of apoptosis in age-related hearing impairment","display_name":"Expression levels of the BAK1 and BCL2 genes highlight the role of apoptosis in age-related hearing impairment","publication_year":2016,"publication_date":"2016-07-01","ids":{"openalex":"https://openalex.org/W4299940097"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:ffe87a3ed7d5411ba488e3ed45d47fac","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ffe87a3ed7d5411ba488e3ed45d47fac","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Interventions in Aging, Vol Volume 11, Pp 1003-1008 (2016)","raw_type":"article"},"volume":null,"type":"article","indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/ffe87a3ed7d5411ba488e3ed45d47fac","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069135202","display_name":"Muhammad Fajrul Falah","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Falah M","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021574398","display_name":"M Najafi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Najafi M","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079381099","display_name":"Houshm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Houshm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084646567","display_name":"M","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5085362618","display_name":"M Farhadi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Farhadi M","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.29348736,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-hearing-loss","display_name":"age-related hearing loss","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/bak1","display_name":"BAK1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.7979999780654907},{"id":"https://openalex.org/keywords/peripheral-blood-gene-expression","display_name":"peripheral blood gene expression","score":0.8790000081062317},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7289999723434448},{"id":"https://openalex.org/keywords/audiometric-outcomes","display_name":"audiometric outcomes","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.642210066318512},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5898647308349609},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4930674731731415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48478907346725464},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.44147101044654846},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4275232255458832},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3130732774734497},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.09557393193244934},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:doaj.org/article:ffe87a3ed7d5411ba488e3ed45d47fac","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ffe87a3ed7d5411ba488e3ed45d47fac","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Interventions in Aging, Vol Volume 11, Pp 1003-1008 (2016)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:ffe87a3ed7d5411ba488e3ed45d47fac","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ffe87a3ed7d5411ba488e3ed45d47fac","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Interventions in Aging, Vol Volume 11, Pp 1003-1008 (2016)","raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2049959604","https://openalex.org/W4403311636","https://openalex.org/W2560062982","https://openalex.org/W3029468813","https://openalex.org/W847239","https://openalex.org/W2057663429","https://openalex.org/W2745734762","https://openalex.org/W2021677864","https://openalex.org/W1554664283","https://openalex.org/W1980295286"],"abstract_inverted_index":{"Masoumeh":[0],"Falah,1,2":[1],"Mohammad":[2,6],"Najafi,2":[3],"Massoud":[4],"Houshmand,3":[5],"Farhadi1":[7],"1ENT":[8],"and":[9,15,25,47,59,67,113,127,141,145,158,169,183,247],"Head":[10],"&":[11],"Neck":[12],"Research":[13,27],"Center":[14],"Department,":[16,30],"Iran":[17,31,50],"University":[18,32],"of":[19,33,39,81,91,106,123,132,204,222,253],"Medical":[20,34,40],"Sciences,":[21,35],"Tehran,":[22,36,49],"Iran;":[23,37],"2Cellular":[24],"Molecular":[26],"Center,":[28],"Biochemistry":[29],"3Department":[38],"Genetics,":[41],"National":[42],"Institute":[43],"for":[44,250],"Genetic":[45],"Engineering":[46],"Biotechnology,":[48],"Abstract:":[51],"Age-related":[52],"hearing":[53,103,257],"impairment":[54,258],"(ARHI)":[55],"is":[56,84],"a":[57,60,216,245],"progressive":[58],"common":[61],"sensory":[62],"disorder":[63],"in":[64,88,191,219,224,229,237],"the":[65,76,121,124,133,184,192,202,205,220,233],"elderly":[66,78],"will":[68],"become":[69],"an":[70,85,151],"increasingly":[71],"important":[72,86],"clinical":[73],"problem":[74],"given":[75],"growing":[77],"population.":[79],"Apoptosis":[80],"cochlear":[82],"cells":[83,95],"factor":[87],"animal":[89,230],"models":[90],"ARHI.":[92,254],"As":[93],"these":[94],"cannot":[96],"regenerate,":[97],"their":[98],"loss":[99],"leads":[100],"to":[101,227],"irreversible":[102],"impairment.":[104],"Identification":[105],"molecular":[107],"mechanisms":[108],"can":[109],"facilitate":[110],"disease":[111],"prevention":[112],"effective":[114],"treatment.":[115],"In":[116],"this":[117],"study,":[118],"we":[119],"compared":[120],"expression":[122,172,235],"genes":[125],"BAK1":[126,182],"BCL2":[128],"as":[129,244],"two":[130],"arms":[131],"intrinsic":[134],"apoptosis":[135,213],"pathway":[136],"between":[137],"patients":[138],"with":[139,201],"ARHI":[140,144,193,223],"healthy":[142,146],"subjects.":[143,194],"subjects":[147],"were":[148,174,187],"selected":[149],"after":[150],"ear":[152],"nose":[153],"throat":[154],"examination,":[155],"otoscopic":[156],"investigation,":[157],"pure":[159],"tone":[160],"audiometry.":[161],"RNA":[162],"was":[163,198],"extracted":[164],"from":[165],"peripheral":[166,238],"blood":[167,239],"samples,":[168],"relative":[170],"gene":[171,234],"levels":[173],"measured":[175],"using":[176],"quantitative":[177],"real-time":[178],"polymerase":[179],"chain":[180],"reaction.":[181],"BAK1/BCL2":[185,196],"ratio":[186,197],"statistically":[188],"significantly":[189],"upregulated":[190],"The":[195],"positively":[199],"correlated":[200],"results":[203,209],"audiometric":[206],"tests.":[207],"Our":[208],"indicate":[210],"that":[211],"BAK-mediated":[212],"may":[214],"be":[215,242],"core":[217],"mechanism":[218],"progression":[221],"humans,":[225],"similar":[226],"finding":[228],"models.":[231],"Moreover,":[232],"changes":[236],"samples":[240],"could":[241],"used":[243],"rapid":[246],"simple":[248],"biomarker":[249],"early":[251],"detection":[252],"Keywords:":[255],"age-related":[256],"(ARHI),":[259],"presbycusis,":[260],"biomarker,":[261],"treatment":[262]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2022-10-03T00:00:00"}
