{"id":"https://openalex.org/W4299869104","doi":"https://doi.org/10.1213/00000539-198202000-00004","title":"Plasma Levels of Ketamine and Two of Its Metabolites in Surgical Patients Using a Gas Chromatographic Mass Fragmentographic Assay","display_name":"Plasma Levels of Ketamine and Two of Its Metabolites in Surgical Patients Using a Gas Chromatographic Mass Fragmentographic Assay","publication_year":1982,"publication_date":"1982-02-01","ids":{"openalex":"https://openalex.org/W4299869104","doi":"https://doi.org/10.1213/00000539-198202000-00004","mag":"2062301264","pmid":"https://pubmed.ncbi.nlm.nih.gov/7198883"},"language":"en","primary_location":{"id":"doi:10.1213/00000539-198202000-00004","doi":"https://doi.org/10.1213/00000539-198202000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1213/00000539-198202000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia & Analgesia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104582094","display_name":"Edward F. Domino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Edward F. Domino","raw_affiliation_strings":["Professor, Department of Pharmacology, University of Michigan. Departments of Pharmacology and Anesthesiology, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor, Department of Pharmacology, University of Michigan. Departments of Pharmacology and Anesthesiology, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109089426","display_name":"Elem\u00e9r K. Zsigmond","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elemer K. Zsigmond","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113573874","display_name":"Laurence E. Domino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laurence E. Domino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033913471","display_name":"Kenneth E Domino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth E. Domino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038319466","display_name":"Sarla P. Kothary","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarla P. Kothary","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079232354","display_name":"Steven E. Dominof","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven E. Dominof","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5104582094"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":3.5081,"has_fulltext":false,"cited_by_count":176,"citation_normalized_percentile":{"value":0.92482034,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"61","issue":"2","first_page":"87???92","last_page":"87???92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12930","display_name":"Biomedical and Chemical Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ketamine","display_name":"ketamine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ketamine-metabolites","display_name":"ketamine metabolites","score":0.9819999933242798},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.7400000095367432},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.921999990940094},{"id":"https://openalex.org/keywords/three-compartment-model","display_name":"three-compartment model","score":0.8360000252723694},{"id":"https://openalex.org/keywords/anesthesia-recovery","display_name":"anesthesia recovery","score":0.5730000138282776},{"id":"https://openalex.org/keywords/surgical-patients","display_name":"surgical patients","score":0.5329999923706055},{"id":"https://openalex.org/keywords/intravenous-ketamine","display_name":"intravenous ketamine","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C2780795376","wikidata":"https://www.wikidata.org/wiki/Q243547","display_name":"Ketamine","level":2,"score":0.974151611328125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.684804379940033},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6313579082489014},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6134672164916992},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5763170123100281},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.5074908137321472},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2648722529411316},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15170326828956604}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003201","descriptor_name":"Computers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007649","descriptor_name":"Ketamine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013514","descriptor_name":"Surgical Procedures, Operative","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1213/00000539-198202000-00004","doi":"https://doi.org/10.1213/00000539-198202000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1213/00000539-198202000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia & Analgesia","raw_type":"journal-article"},{"id":"pmid:7198883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7198883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and analgesia","raw_type":"Journal Article"},{"id":"mag:2062301264","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7198883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309652","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2358228022","https://openalex.org/W2092318176","https://openalex.org/W2075619431","https://openalex.org/W2056528191","https://openalex.org/W2032819971","https://openalex.org/W2278146212","https://openalex.org/W3080908622","https://openalex.org/W1991698026","https://openalex.org/W2883782382","https://openalex.org/W3008874813"],"abstract_inverted_index":{"Ketamine":[0,97,113,141],"and":[1,15,40,100,204,214],"two":[2,173,185],"of":[3,26,51,111,121,150,175,178,183],"its":[4],"metabolites":[5,98,187],"were":[6,102,145,188],"determined":[7],"up":[8],"to":[9,56,63,71,123,132,157,159,170],"24":[10,77,138,162],"hours":[11,139,163],"by":[12],"a":[13,36,46,82,119,148,219,231],"sensitive":[14],"specific":[16],"gas":[17],"chromatographic":[18],"mass":[19],"fragmentographic":[20],"(GCMF)":[21],"assay":[22],"in":[23,35,105,153,239],"the":[24,68,75,79,106,171,184,224],"plasma":[25,107,181],"seven":[27],"premedicated":[28],"surgical":[29],"patients.":[30,241],"Each":[31],"patient":[32],"received":[33],"ketamine":[34,52,130,186,195,202,237],"dose":[37],"between":[38],"2.0":[39],"2.2":[41],"mg/kg":[42],"given":[43],"intravenously":[44],"over":[45,108],"30-second":[47],"period.":[48],"Plasma":[49],"levels":[50,116,144,182,200],"varied":[53],"from":[54,118,166,211],"9,000":[55],"25,800":[57],"ng/ml":[58,66,125,137,152,161],"1":[59],"minute":[60],"after":[61,86,129,194],"injection":[62],"approximately":[64,154,191],"1,000":[65],"when":[67],"patients":[69,80],"began":[70],"recover":[72],"consciousness.":[73],"Within":[74],"next":[76],"hours,":[78],"had":[81],"complex":[83,92],"logarithmic":[84],"decline":[85],"injection.":[87,196],"The":[88,180],"data":[89,225],"suggest":[90],"rather":[91],"pharmacokinetics":[93,238],"with":[94,147,209],"multiple":[95],"compartments.":[96],"I":[99,115],"II":[101,143],"also":[103],"found":[104],"comparable":[109],"periods":[110],"time.":[112],"metabolite":[114,142],"ranged":[117],"high":[120],"245":[122],"668":[124],"within":[126],"30":[127],"minutes":[128,156,193],"administration":[131],"as":[133,135],"low":[134,199],"15":[136],"later.":[140,164],"lower":[146],"peak":[149],"515":[151],"60":[155],"13":[158],"27":[160],"Recovery":[165],"anesthesia":[167,203],"was":[168],"related":[169],"first":[172,189],"phases":[174],"rapid":[176],"redistribution":[177],"ketamine.":[179],"detectable":[190],"5":[192],"Their":[197],"relatively":[198],"throughout":[201],"postanesthesia":[205],"do":[206],"not":[207],"correlate":[208],"recovery":[210],"anesthesia.":[212],"CSTRIP":[213],"NONLIN":[215],"analysis":[216],"indicated":[217],"that":[218,230],"three-exponential":[220],"equation":[221],"best":[222,235],"approximated":[223],"obtained.":[226],"It":[227],"is":[228],"concluded":[229],"three-compartment":[232],"open":[233],"model":[234],"approximates":[236],"these":[240]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2022-10-03T00:00:00"}