{"id":"https://openalex.org/W4299867874","doi":"https://doi.org/10.17615/rprj-jx97","title":"Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence","display_name":"Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence","publication_year":2020,"publication_date":"2020-11-10","ids":{"openalex":"https://openalex.org/W4299867874","doi":"https://doi.org/10.17615/rprj-jx97"},"language":"en","primary_location":{"id":"doi:10.17615/rprj-jx97","doi":"https://doi.org/10.17615/rprj-jx97","is_oa":true,"landing_page_url":"https://doi.org/10.17615/rprj-jx97","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.17615/rprj-jx97","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023024313","display_name":"Mikael Land\u00e9n","orcid":"https://orcid.org/0000-0002-4496-6451","observed_orcids":["https://orcid.org/0000-0002-4496-6451"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Land\u00e9n, Mikael","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054867399","display_name":"Robert E. Handsaker","orcid":"https://orcid.org/0000-0002-3128-3547","observed_orcids":["https://orcid.org/0000-0002-3128-3547"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Handsaker, Robert E.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004083002","display_name":"Martin H\u00f6glund","orcid":"https://orcid.org/0000-0003-2468-0226","observed_orcids":["https://orcid.org/0000-0003-2468-0226"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H\u00f6glund, Martin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035972654","display_name":"Oscar Svantesson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Svantesson, Oscar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051946088","display_name":"Menachem Fromer","orcid":"https://orcid.org/0000-0003-3749-4342","observed_orcids":["https://orcid.org/0000-0003-3749-4342"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fromer, Menachem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074033554","display_name":"S\u00f6ren Lehmann","orcid":"https://orcid.org/0000-0001-8374-8978","observed_orcids":["https://orcid.org/0000-0001-8374-8978","https://orcid.org/0009-0009-3243-3947"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lehmann, S\u00f6ren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061030489","display_name":"Stacey Gabriel","orcid":"https://orcid.org/0000-0001-6939-2215","observed_orcids":["https://orcid.org/0000-0001-6939-2215"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriel, Stacey B.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113680625","display_name":"Kimberly Chambert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chambert, Kimberly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058482061","display_name":"Jennifer L. Moran","orcid":"https://orcid.org/0000-0002-5664-4716","observed_orcids":["https://orcid.org/0000-0002-5664-4716"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Moran, Jennifer L.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107835392","display_name":"Anna K. K\u00e4hler","orcid":"https://orcid.org/0000-0003-4047-4588","observed_orcids":["https://orcid.org/0000-0003-4047-4588"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K\u00e4hler, Anna K.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061802355","display_name":"Patrick F. Sullivan","orcid":"https://orcid.org/0000-0002-6619-873X","observed_orcids":["https://orcid.org/0000-0002-6619-873X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sullivan, Patrick F.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017147813","display_name":"Eran Mick","orcid":"https://orcid.org/0000-0002-7299-808X","observed_orcids":["https://orcid.org/0000-0002-7299-808X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mick, Eran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031466516","display_name":"Johan Lindberg","orcid":"https://orcid.org/0000-0003-3610-6774","observed_orcids":["https://orcid.org/0000-0003-3610-6774"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lindberg, Johan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062171528","display_name":"Samuel A. Rose","orcid":"https://orcid.org/0000-0001-9701-0050","observed_orcids":["https://orcid.org/0000-0001-9701-0050"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rose, Samuel A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053574652","display_name":"Christina M. Hultman","orcid":"https://orcid.org/0000-0002-0327-2410","observed_orcids":["https://orcid.org/0000-0002-0327-2410"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hultman, Christina M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021982213","display_name":"Henrik Gr\u00f6nberg","orcid":"https://orcid.org/0000-0002-1073-2753","observed_orcids":["https://orcid.org/0000-0002-1073-2753"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gr\u00f6nberg, Henrik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055970647","display_name":"Samuel F. Bakhoum","orcid":"https://orcid.org/0000-0002-0295-3564","observed_orcids":["https://orcid.org/0000-0002-0295-3564","https://orcid.org/0000-0002-4779-8422"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bakhoum, Samuel F.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008886933","display_name":"Giulio Genovese","orcid":"https://orcid.org/0000-0003-3066-5575","observed_orcids":["https://orcid.org/0000-0003-3066-5575"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Genovese, Giulio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015235673","display_name":"Benjamin M. Neale","orcid":"https://orcid.org/0000-0003-1513-6077","observed_orcids":["https://orcid.org/0000-0003-1513-6077"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neale, Benjamin M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062214008","display_name":"Pamela B. Sklar","orcid":"https://orcid.org/0000-0001-9715-4943","observed_orcids":["https://orcid.org/0000-0001-9715-4943"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sklar, Pamela","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051460895","display_name":"Shaun Purcell","orcid":"https://orcid.org/0000-0002-7402-5812","observed_orcids":["https://orcid.org/0000-0002-7402-5812"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Purcell, Shaun M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020748592","display_name":"Eric S. Lander","orcid":"https://orcid.org/0000-0003-2662-4631","observed_orcids":["https://orcid.org/0000-0003-2662-4631"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lander, Eric S.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072347906","display_name":"Steven A. McCarroll","orcid":"https://orcid.org/0000-0002-6954-8184","observed_orcids":["https://orcid.org/0000-0002-6954-8184"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"McCarroll, Steven A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20400642,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.86080002784729,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.11169999837875366,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clonal-hematopoiesis","display_name":"clonal hematopoiesis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.5730000138282776},{"id":"https://openalex.org/keywords/germline-mutations","display_name":"germline mutations","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5324355959892273},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5283414125442505},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.4872945547103882},{"id":"https://openalex.org/C2992972558","wikidata":"https://www.wikidata.org/wiki/Q2509220","display_name":"Blood cancer","level":3,"score":0.47775426506996155},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4720001220703125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45619282126426697},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.4146585762500763},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3804997205734253},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3476789891719818},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.346652090549469},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34637826681137085},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.06270340085029602}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.17615/rprj-jx97","doi":"https://doi.org/10.17615/rprj-jx97","is_oa":true,"landing_page_url":"https://doi.org/10.17615/rprj-jx97","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.17615/rprj-jx97","doi":"https://doi.org/10.17615/rprj-jx97","is_oa":true,"landing_page_url":"https://doi.org/10.17615/rprj-jx97","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1712912693","display_name":"1/2 A Large-Scale Schizophrenia Association Study in Sweden","funder_award_id":"R01MH077139","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G190992208","display_name":"Structurally complex genome loci in human populations and human phenotypes","funder_award_id":"R01HG006855","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G1995292980","display_name":"Large Scale Sequencing and Analysis of Genomes","funder_award_id":"U54HG003067","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G4961161989","display_name":"Whole genome sequencing of bipolar disorder and schizophrenia","funder_award_id":"RC2MH089905","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8163607674","display_name":null,"funder_award_id":"HG006855","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320306523","display_name":"Alexander and Margaret Stewart Trust","ror":"https://ror.org/03nsgj842"},{"id":"https://openalex.org/F4320316574","display_name":"Sylvan C. Herman Foundation","ror":"https://ror.org/01x5mat36"},{"id":"https://openalex.org/F4320333423","display_name":"Stanley Center for Psychiatric Research, Broad Institute","ror":"https://ror.org/01tm9b530"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2934827496","https://openalex.org/W2075773745","https://openalex.org/W4247401063","https://openalex.org/W4252499673","https://openalex.org/W4400580407","https://openalex.org/W3213311103","https://openalex.org/W4412647422","https://openalex.org/W4245458426","https://openalex.org/W1992826811","https://openalex.org/W6887925468"],"abstract_inverted_index":{"Cancers":[0],"arise":[1],"from":[2],"multiple":[3],"acquired":[4],"mutations,":[5],"which":[6],"presumably":[7],"occur":[8],"over":[9],"many":[10],"years.":[11],"Early":[12],"stages":[13],"in":[14],"cancer":[15],"development":[16],"might":[17],"be":[18],"present":[19],"years":[20],"before":[21],"cancers":[22],"become":[23],"clinically":[24],"apparent.":[25]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2022-10-03T00:00:00"}