{"id":"https://openalex.org/W4299823360","doi":"https://doi.org/10.17615/xtwv-gg14","title":"Time to Rethink Antiviral Treatment for Hepatitis C in Patients with Coexisting Mental Health/Substance Abuse Issues","display_name":"Time to Rethink Antiviral Treatment for Hepatitis C in Patients with Coexisting Mental Health/Substance Abuse Issues","publication_year":2020,"publication_date":"2020-11-02","ids":{"openalex":"https://openalex.org/W4299823360","doi":"https://doi.org/10.17615/xtwv-gg14"},"language":"en","primary_location":{"id":"pmh:cdr.lib.unc.edu:nk322m80d","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/xtwv-gg14","pdf_url":"https://cdr.lib.unc.edu/downloads/ns064d075","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Digestive Diseases and Sciences, 57(6)","raw_type":"Article"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://cdr.lib.unc.edu/downloads/ns064d075","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003922079","display_name":"Jason E. Bonner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bonner, Jason E.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037987218","display_name":"Donna M. Evon","orcid":"https://orcid.org/0000-0002-1414-1846","observed_orcids":["https://orcid.org/0000-0002-1414-1846"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Evon, Donna M.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Fried, Michael W.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fried, Michael W.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040206411","display_name":"Alfred Sidney Barritt","orcid":"https://orcid.org/0000-0002-4200-3256","observed_orcids":["https://orcid.org/0000-0002-4200-3256"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barritt, A. Sidney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3515035,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.8769999742507935},{"id":"https://openalex.org/keywords/direct-acting-antivirals","display_name":"direct-acting antivirals","score":0.9539999961853027},{"id":"https://openalex.org/keywords/combination-antiviral-therapy","display_name":"combination antiviral therapy","score":0.7889999747276306},{"id":"https://openalex.org/keywords/psychiatric-comorbidity","display_name":"psychiatric comorbidity","score":0.8209999799728394},{"id":"https://openalex.org/keywords/substance-use-disorders","display_name":"substance use disorders","score":0.8389999866485596},{"id":"https://openalex.org/keywords/barriers-to-treatment","display_name":"barriers to treatment","score":0.7170000076293945},{"id":"https://openalex.org/keywords/treatment-access","display_name":"treatment access","score":0.5730000138282776},{"id":"https://openalex.org/keywords/deferred-treatment","display_name":"deferred treatment","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C40010229","wikidata":"https://www.wikidata.org/wiki/Q3184856","display_name":"Substance abuse","level":2,"score":0.700463593006134},{"id":"https://openalex.org/C134362201","wikidata":"https://www.wikidata.org/wiki/Q317309","display_name":"Mental health","level":2,"score":0.6606754064559937},{"id":"https://openalex.org/C2992025106","wikidata":"https://www.wikidata.org/wiki/Q1260022","display_name":"Substance abuse treatment","level":3,"score":0.6259955763816833},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.5029465556144714},{"id":"https://openalex.org/C2991912374","wikidata":"https://www.wikidata.org/wiki/Q400711","display_name":"Substance use","level":2,"score":0.4989800453186035},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.4961305558681488},{"id":"https://openalex.org/C3018481051","wikidata":"https://www.wikidata.org/wiki/Q3184856","display_name":"Drugs of abuse","level":3,"score":0.44133085012435913},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4282170534133911},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.418559730052948},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.34343528747558594},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.340969979763031}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:cdr.lib.unc.edu:nk322m80d","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/xtwv-gg14","pdf_url":"https://cdr.lib.unc.edu/downloads/ns064d075","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Digestive Diseases and Sciences, 57(6)","raw_type":"Article"},{"id":"doi:10.17615/xtwv-gg14","doi":"https://doi.org/10.17615/xtwv-gg14","is_oa":true,"landing_page_url":"https://doi.org/10.17615/xtwv-gg14","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:cdr.lib.unc.edu:nk322m80d","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/xtwv-gg14","pdf_url":"https://cdr.lib.unc.edu/downloads/ns064d075","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Digestive Diseases and Sciences, 57(6)","raw_type":"Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1505263124","display_name":"Mentoring Junior Faculty:  Viral hepatitis Clinical Research","funder_award_id":"K24DK066144","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5286718702","display_name":"UNC Clinical Translation Science Award-K12 Scholars Program (KL2)","funder_award_id":"KL2RR025746","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6602935441","display_name":"UNC Clinical and Translational Science Award","funder_award_id":"UL1RR025747","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7516741315","display_name":"An Adherence and Depression Intervention for Patients During Hepatitis C Therapy","funder_award_id":"K23DK089004","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320312517","display_name":"Vertex Pharmaceuticals","ror":"https://ror.org/00anb1726"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4299823360.pdf","grobid_xml":"https://content.openalex.org/works/W4299823360.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2017039225","https://openalex.org/W3072702025","https://openalex.org/W2930186252","https://openalex.org/W2883551899","https://openalex.org/W2903522797","https://openalex.org/W2131590660","https://openalex.org/W2136136441","https://openalex.org/W2600141067","https://openalex.org/W7138047179","https://openalex.org/W2114635652"],"abstract_inverted_index":{"A":[0],"new":[1],"era":[2],"has":[3],"dawned":[4],"in":[5],"the":[6,15,25],"treatment":[7,36],"of":[8,17,28,45,48],"chronic":[9],"hepatitis":[10],"C":[11],"(HCV)":[12],"virus":[13],"with":[14],"use":[16],"direct-acting":[18],"antiviral":[19,35],"medications":[20],"augmenting":[21],"combination":[22],"therapy.":[23],"Unfortunately,":[24],"significant":[26],"impact":[27],"improvements":[29],"may":[30],"not":[31,38],"be":[32],"realized":[33],"if":[34],"is":[37],"expanded":[39],"to":[40],"include":[41],"a":[42],"larger":[43],"proportion":[44],"patients,":[46],"many":[47],"whom":[49],"have":[50,59],"coexisting":[51],"mental":[52],"health":[53],"and/or":[54],"substance":[55],"abuse":[56],"issues":[57],"and":[58],"been":[60],"historically":[61],"deferred":[62],"from":[63],"treatment.":[64]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-10-03T00:00:00"}