{"id":"https://openalex.org/W4299815876","doi":null,"title":"miR-1297 inhibits osteosarcoma cell proliferation and growth by targeting CCND2.","display_name":"miR-1297 inhibits osteosarcoma cell proliferation and growth by targeting CCND2.","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4299815876","pmid":"https://pubmed.ncbi.nlm.nih.gov/35968334","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9360223"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9360223","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9360223","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9360223","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Pan Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111628","display_name":"Affiliated Hospital of Jiangsu University","ror":"https://ror.org/028pgd321","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111628"]},{"id":"https://openalex.org/I4405268066","display_name":"Xuzhou Rehabilitation Hospital","ror":"https://ror.org/05n8q7c16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405268066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pan Jiang","raw_affiliation_strings":["Affiliated Hospital of Jiangsu University Zhenjiang, China","Guizhou Orthopedics Hospital Guizhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Jiangsu University Zhenjiang, China","institution_ids":["https://openalex.org/I4210111628"]},{"raw_affiliation_string":"Guizhou Orthopedics Hospital Guizhou, China","institution_ids":["https://openalex.org/I4405268066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025746715","display_name":"Lianghao Mao","orcid":"https://orcid.org/0009-0007-0946-6420","observed_orcids":["https://orcid.org/0009-0007-0946-6420"]},"institutions":[{"id":"https://openalex.org/I4210111628","display_name":"Affiliated Hospital of Jiangsu University","ror":"https://ror.org/028pgd321","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lianghao Mao","raw_affiliation_strings":["Affiliated Hospital of Jiangsu University Zhenjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Jiangsu University Zhenjiang, China","institution_ids":["https://openalex.org/I4210111628"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xuan Lei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111628","display_name":"Affiliated Hospital of Jiangsu University","ror":"https://ror.org/028pgd321","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuan Lei","raw_affiliation_strings":["Affiliated Hospital of Jiangsu University Zhenjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Jiangsu University Zhenjiang, China","institution_ids":["https://openalex.org/I4210111628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102017019","display_name":"Chunshan Luo","orcid":"https://orcid.org/0000-0001-7286-9010","observed_orcids":["https://orcid.org/0000-0001-7286-9010"]},"institutions":[{"id":"https://openalex.org/I4405268066","display_name":"Xuzhou Rehabilitation Hospital","ror":"https://ror.org/05n8q7c16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405268066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunshan Luo","raw_affiliation_strings":["Guizhou Orthopedics Hospital Guizhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guizhou Orthopedics Hospital Guizhou, China","institution_ids":["https://openalex.org/I4405268066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100395350","display_name":"Yiming Zhang","orcid":"https://orcid.org/0000-0001-5959-0963","observed_orcids":["https://orcid.org/0000-0001-5959-0963"]},"institutions":[{"id":"https://openalex.org/I4210111628","display_name":"Affiliated Hospital of Jiangsu University","ror":"https://ror.org/028pgd321","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiming Zhang","raw_affiliation_strings":["Affiliated Hospital of Jiangsu University Zhenjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Jiangsu University Zhenjiang, China","institution_ids":["https://openalex.org/I4210111628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035988522","display_name":"Xinyu Zhong","orcid":"https://orcid.org/0009-0009-3182-8787","observed_orcids":["https://orcid.org/0009-0009-3182-8787"]},"institutions":[{"id":"https://openalex.org/I4210111628","display_name":"Affiliated Hospital of Jiangsu University","ror":"https://ror.org/028pgd321","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Zhong","raw_affiliation_strings":["Affiliated Hospital of Jiangsu University Zhenjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Jiangsu University Zhenjiang, China","institution_ids":["https://openalex.org/I4210111628"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhenyu Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111628","display_name":"Affiliated Hospital of Jiangsu University","ror":"https://ror.org/028pgd321","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenyu Yin","raw_affiliation_strings":["Affiliated Hospital of Jiangsu University Zhenjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Jiangsu University Zhenjiang, China","institution_ids":["https://openalex.org/I4210111628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101181839","display_name":"Xu Xiaofeng","orcid":"https://orcid.org/0000-0002-4090-902X","observed_orcids":["https://orcid.org/0000-0002-4090-902X"]},"institutions":[{"id":"https://openalex.org/I4210111628","display_name":"Affiliated Hospital of Jiangsu University","ror":"https://ror.org/028pgd321","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofeng Xu","raw_affiliation_strings":["Affiliated Hospital of Jiangsu University Zhenjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Jiangsu University Zhenjiang, China","institution_ids":["https://openalex.org/I4210111628"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100419597","display_name":"Dapeng Li","orcid":"https://orcid.org/0000-0002-8232-3094","observed_orcids":["https://orcid.org/0000-0002-8232-3094"]},"institutions":[{"id":"https://openalex.org/I4210111628","display_name":"Affiliated Hospital of Jiangsu University","ror":"https://ror.org/028pgd321","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111628"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dapeng Li","raw_affiliation_strings":["Affiliated Hospital of Jiangsu University Zhenjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Jiangsu University Zhenjiang, China","institution_ids":["https://openalex.org/I4210111628"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100557721","display_name":"Qiping Zheng","orcid":"https://orcid.org/0000-0002-9302-5885","observed_orcids":["https://orcid.org/0000-0002-9302-5885"]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiping Zheng","raw_affiliation_strings":["Department of Laboratory Science, School of Medicine, Jiangsu University Zhenjiang, China","Shenzhen Walgenron Bio-Pharm Co., Ltd. Shenzhen 518118, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Science, School of Medicine, Jiangsu University Zhenjiang, China","institution_ids":["https://openalex.org/I115592961"]},{"raw_affiliation_string":"Shenzhen Walgenron Bio-Pharm Co., Ltd. Shenzhen 518118, Guangdong, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7044,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.62524411,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"12","issue":"7","first_page":"3464","last_page":"3478"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-1297","display_name":"miR-1297","score":1.0},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cyclin-d2","display_name":"cyclin D2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/microrna-target-regulation","display_name":"microRNA target regulation","score":0.699999988079071},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7279999852180481},{"id":"https://openalex.org/keywords/g1-cell-cycle-arrest","display_name":"G1 cell cycle arrest","score":0.8989999890327454},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.8970000147819519},{"id":"https://openalex.org/keywords/bone-erosion","display_name":"bone erosion","score":0.5019999742507935},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C2780733254","wikidata":"https://www.wikidata.org/wiki/Q5198271","display_name":"Cyclin D2","level":5,"score":0.767662763595581},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.669959545135498},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5946544408798218},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5655328035354614},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5219166278839111},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41951513290405273},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.3323866128921509},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3174760937690735},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2805245518684387},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07330849766731262},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06074148416519165}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:9360223","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9360223","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"pmid:35968334","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35968334","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9360223","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9360223","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1715359867","https://openalex.org/W1779581060","https://openalex.org/W1965904918","https://openalex.org/W1988805027","https://openalex.org/W2009362185","https://openalex.org/W2020356496","https://openalex.org/W2026570544","https://openalex.org/W2052465225","https://openalex.org/W2075174542","https://openalex.org/W2079616505","https://openalex.org/W2083381199","https://openalex.org/W2090427824","https://openalex.org/W2099966324","https://openalex.org/W2102428449","https://openalex.org/W2104073489","https://openalex.org/W2109303819","https://openalex.org/W2116071996","https://openalex.org/W2123780208","https://openalex.org/W2126255656","https://openalex.org/W2143939772","https://openalex.org/W2146642335","https://openalex.org/W2150883469","https://openalex.org/W2151692524","https://openalex.org/W2350153786","https://openalex.org/W2461910056","https://openalex.org/W2531856586","https://openalex.org/W2588432900","https://openalex.org/W2604499837","https://openalex.org/W2760323384","https://openalex.org/W2805571235","https://openalex.org/W2808343666","https://openalex.org/W2809797501","https://openalex.org/W2892900345","https://openalex.org/W2896584957","https://openalex.org/W2913276036","https://openalex.org/W2920632090","https://openalex.org/W2967220881","https://openalex.org/W2972396522","https://openalex.org/W2982034498","https://openalex.org/W3006004337","https://openalex.org/W3094159415","https://openalex.org/W4237011200"],"related_works":["https://openalex.org/W2967448688","https://openalex.org/W2793370744","https://openalex.org/W2106016477","https://openalex.org/W3008672032","https://openalex.org/W3149220525","https://openalex.org/W4200552285","https://openalex.org/W2985813858","https://openalex.org/W2811155609","https://openalex.org/W2936625148","https://openalex.org/W3141689583"],"abstract_inverted_index":{"Cyclin":[0],"D2":[1],"(CCND2)":[2],"is":[3,24],"abnormally":[4],"overexpressed":[5],"in":[6,34,51,61,73,121,154,164,187],"many":[7],"tumor":[8,15,146,172,185],"types":[9],"and":[10,32,54,112,145,158,184],"has":[11,37],"been":[12,39],"associated":[13],"with":[14,103],"cell":[16,58,64],"proliferation.":[17],"Although":[18],"the":[19,27,42,114,165],"important":[20],"role":[21],"of":[22,88],"miR-1297":[23,33,69,100,105,125,139,166,169,180,196],"well":[25],"established,":[26],"molecular":[28],"mechanism":[29],"between":[30],"CCND2":[31,47,84,109,119],"osteosarcoma":[35],"(OS)":[36],"not":[38],"determined.":[40],"In":[41,67],"present":[43],"study,":[44],"we":[45],"found":[46],"was":[48,70,85,91],"highly":[49],"expressed":[50,72],"OS":[52,74,122,140,171,188],"cells,":[53],"its":[55],"downregulation":[56,120],"suppressed":[57],"proliferation,":[59],"resulting":[60],"G1":[62],"phase":[63],"cycle":[65],"arrest.":[66],"contrast,":[68],"lowly":[71],"compared":[75],"to":[76],"normal":[77],"tissue.":[78],"Several":[79],"data":[80],"platforms":[81],"predicted":[82],"that":[83,98,179,195],"a":[86,94,199],"target":[87,202],"miR-1297,":[89],"which":[90,193],"validated":[92],"by":[93,131,153,162,189],"dual-luciferase":[95],"reporter":[96],"assay":[97],"revealed":[99,161],"could":[101,127],"bind":[102],"CCND2-3'UTR.":[104],"overexpression":[106],"greatly":[107],"inhibited":[108,170],"protein":[110],"expression":[111],"exerted":[113],"same":[115],"phenotypic":[116],"effect":[117],"as":[118],"cells.":[123],"Furthermore,":[124],"inhibition":[126],"also":[128],"be":[129],"rescued":[130],"CCND2.":[132,175],"Nude":[133],"mice":[134],"injected":[135],"cells":[136,141],"stable":[137],"overexpressing":[138],"showed":[142],"lower":[143,149],"size":[144],"weight.":[147],"Moreover,":[148],"fluorescence":[150],"activity":[151],"recorded":[152],"vivo":[155],"imaging":[156],"system":[157],"bone":[159],"erosion":[160],"microCT":[163],"group":[167],"demonstrated":[168,178],"growth":[173,186],"via":[174],"Our":[176],"findings":[177],"can":[181],"inhibit":[182],"proliferation":[183],"directly":[190],"targeting":[191],"CCND2,":[192],"indicates":[194],"may":[197],"represent":[198],"novel":[200],"therapeutic":[201],"for":[203],"OS.":[204]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-10-03T00:00:00"}
