{"id":"https://openalex.org/W4299615917","doi":"https://doi.org/10.1093/clinchem/35.1.102","title":"Direct and indirect techniques for free thyroxin compared in patients with nonthyroidal illness. I. Effect of free fatty acids.","display_name":"Direct and indirect techniques for free thyroxin compared in patients with nonthyroidal illness. I. Effect of free fatty acids.","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W4299615917","doi":"https://doi.org/10.1093/clinchem/35.1.102","mag":"1952806310","pmid":"https://pubmed.ncbi.nlm.nih.gov/2491973"},"language":"en","primary_location":{"id":"doi:10.1093/clinchem/35.1.102","doi":"https://doi.org/10.1093/clinchem/35.1.102","is_oa":false,"landing_page_url":"https://doi.org/10.1093/clinchem/35.1.102","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027032991","display_name":"Gy\u00f6rgy Cs\u00e1k\u00f3","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Csako","raw_affiliation_strings":["Clinical Pathology Department, Warren G. Magnuson Clinical Center, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pathology Department, Warren G. Magnuson Clinical Center, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046689484","display_name":"MARK H. ZWEIG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M H Zweig","raw_affiliation_strings":["Clinical Pathology Department, Warren G. Magnuson Clinical Center, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pathology Department, Warren G. Magnuson Clinical Center, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017474191","display_name":"J Glickman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Glickman","raw_affiliation_strings":["Clinical Pathology Department, Warren G. Magnuson Clinical Center, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pathology Department, Warren G. Magnuson Clinical Center, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018832368","display_name":"Jane Kestner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Kestner","raw_affiliation_strings":["Clinical Pathology Department, Warren G. Magnuson Clinical Center, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pathology Department, Warren G. Magnuson Clinical Center, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015575563","display_name":"Mark E. Ruddel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210155647","display_name":"National Institutes of Health Clinical Center","ror":"https://ror.org/04vfsmv21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Ruddel","raw_affiliation_strings":["Clinical Pathology Department, Warren G. Magnuson Clinical Center, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pathology Department, Warren G. Magnuson Clinical Center, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210155647"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4636,"currency":"USD","value_usd":4636},"apc_paid":null,"fwci":2.0342,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.87171278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"35","issue":"1","first_page":"102","last_page":"109"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.04490000009536743,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/free-thyroxine","display_name":"free thyroxine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.9190000295639038},{"id":"https://openalex.org/keywords/non-thyroidal-illness","display_name":"low T3 syndrome","score":0.984000027179718},{"id":"https://openalex.org/keywords/equilibrium-dialysis","display_name":"equilibrium dialysis","score":0.7680000066757202},{"id":"https://openalex.org/keywords/assay-interference","display_name":"assay interference","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6389573812484741},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6210959553718567},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.5927354097366333},{"id":"https://openalex.org/C2994067411","wikidata":"https://www.wikidata.org/wiki/Q125264","display_name":"Molar ratio","level":3,"score":0.5856027603149414},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5782695412635803},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.5104779005050659},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5027756690979004},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.35114526748657227},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20293575525283813},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17630428075790405},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003956","descriptor_name":"Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013975","descriptor_name":"Thyroxine-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/clinchem/35.1.102","doi":"https://doi.org/10.1093/clinchem/35.1.102","is_oa":false,"landing_page_url":"https://doi.org/10.1093/clinchem/35.1.102","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},{"id":"pmid:2491973","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2491973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical chemistry","raw_type":"Comparative Study"},{"id":"mag:1952806310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2491973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7095448667","https://openalex.org/W2107060975","https://openalex.org/W1857690925","https://openalex.org/W1801162136","https://openalex.org/W1818796228","https://openalex.org/W2033422534","https://openalex.org/W1963324156","https://openalex.org/W1952077050","https://openalex.org/W7097299493","https://openalex.org/W2123158805"],"abstract_inverted_index":{"We":[0,85,114],"examined":[1],"the":[2,11,57,88,109,129,138,149,157,168,198,206,212],"effect":[3],"of":[4,13,30,61,108,132,140,208],"endogenous":[5],"free":[6,14],"fatty":[7],"acids":[8],"(FFA)":[9],"on":[10,74,126],"measurement":[12],"thyroxin":[15],"(FT4)":[16],"by":[17,97],"five":[18],"different":[19,24],"methodologies":[20],"represented":[21],"in":[22,26,135,148,179],"16":[23],"assays":[25],"a":[27,67,92],"large":[28],"number":[29],"patients":[31],"with":[32,46,91,101,156,192,211],"nonthyroidal":[33],"illness":[34],"(NTI).":[35],"Some,":[36],"but":[37,205],"not":[38,83,202],"all,":[39],"one-step":[40],"(analog)":[41],"FT4":[42,51,69,71,118,123,180],"RIAs":[43],"negatively":[44],"correlated":[45,155],"FFA":[47,162,185],"concentration.":[48],"All":[49],"two-step":[50],"RIAs,":[52,119],"equilibrium":[53,120,136],"dialysis":[54,121],"FT4,":[55,122],"and":[56,79,152,171],"dialyzable":[58,130],"(free)":[59],"fraction":[60,131,139],"T4":[62,134,142],"positively":[63],"correlated.":[64],"In":[65],"contrast,":[66],"binding-rate-based":[68,150],"RIA,":[70,151],"indices":[72,124],"based":[73,125],"T3":[75,127,153],"macroaggregated":[76],"albumin":[77],"uptake,":[78,128],"T4/TBG":[80,199],"ratios":[81],"did":[82,201],"correlate.":[84],"also":[86],"analyzed":[87],"FT4-FFA":[89],"relationship":[90],"second,":[93],"more":[94],"sensitive":[95],"approach":[96],"correlating":[98],"test":[99],"results":[100,181],"FFA/albumin":[102,158],"molar":[103,159],"ratio":[104,200],"as":[105],"an":[106],"estimate":[107],"\"excess\"":[110,213],"(nonalbumin":[111],"bound)":[112],"FFA.":[113,214],"found":[115],"that":[116],"all":[117,167],"labeled":[133,141],"dialysis,":[137],"bound":[143],"to":[144,183],"solid":[145],"phase":[146],"antibody":[147],"uptake":[154],"ratio.":[160],"This":[161],"dependency":[163],"was":[164,172],"comparable":[165],"among":[166],"various":[169],"techniques":[170],"relatively":[173],"small.":[174],"Thus,":[175],"increases":[176],"or":[177],"decreases":[178],"due":[182],"varying":[184],"(and":[186],"albumin)":[187],"concentrations":[188],"are":[189],"highly":[190],"likely":[191],"most":[193],"currently":[194],"available":[195],"methods":[196],"(only":[197],"reveal":[203],"FFA-dependency),":[204],"magnitude":[207],"changes":[209],"varies":[210]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-10-02T00:00:00"}