{"id":"https://openalex.org/W4299564692","doi":"https://doi.org/10.1002/(sici)1098-2280(1998)31:4<340::aid-em6>3.0.co;2-m","title":"An automated method for discriminating aneugen- vs. clastogen-induced micronuclei","display_name":"An automated method for discriminating aneugen- vs. clastogen-induced micronuclei","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W4299564692","doi":"https://doi.org/10.1002/(sici)1098-2280(1998)31:4<340::aid-em6>3.0.co;2-m"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1098-2280(1998)31:4<340::aid-em6>3.0.co;2-m","doi":"https://doi.org/10.1002/(sici)1098-2280(1998)31:4<340::aid-em6>3.0.co;2-m","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1098-2280(1998)31:4<340::aid-em6>3.0.co;2-m","pdf_url":null,"source":{"id":"https://openalex.org/S204663187","display_name":"Environmental and Molecular Mutagenesis","issn_l":"0893-6692","issn":["0893-6692","1098-2280"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental and Molecular Mutagenesis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028450494","display_name":"Dorothea K. Torous","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086509","display_name":"Litron Laboratories (United States)","ror":"https://ror.org/003g7k569","country_code":"US","type":"company","lineage":["https://openalex.org/I4210086509"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dorothea K. Torous","raw_affiliation_strings":["Litron Laboratories, Rochester, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Litron Laboratories, Rochester, New York","institution_ids":["https://openalex.org/I4210086509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021440089","display_name":"Stephen D. Dertinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen D. Dertinger","raw_affiliation_strings":["Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, New York","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037986857","display_name":"Nikki E. Hall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086509","display_name":"Litron Laboratories (United States)","ror":"https://ror.org/003g7k569","country_code":"US","type":"company","lineage":["https://openalex.org/I4210086509"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikki E. Hall","raw_affiliation_strings":["Litron Laboratories, Rochester, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Litron Laboratories, Rochester, New York","institution_ids":["https://openalex.org/I4210086509"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046702241","display_name":"Carol R. Tometsko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086509","display_name":"Litron Laboratories (United States)","ror":"https://ror.org/003g7k569","country_code":"US","type":"company","lineage":["https://openalex.org/I4210086509"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol R. Tometsko","raw_affiliation_strings":["Litron Laboratories, Rochester, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Litron Laboratories, Rochester, New York","institution_ids":["https://openalex.org/I4210086509"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5028450494"],"corresponding_institution_ids":["https://openalex.org/I4210086509"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.273,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.56330275,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"31","issue":"4","first_page":"340","last_page":"344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/micronuclei","display_name":"micronuclei","score":0.8399999737739563},{"id":"https://openalex.org/keywords/aneugens","display_name":"aneugens","score":0.9229999780654907},{"id":"https://openalex.org/keywords/clastogens","display_name":"clastogens","score":0.996999979019165},{"id":"https://openalex.org/keywords/micronucleated-reticulocytes","display_name":"micronucleated reticulocytes","score":0.8980000019073486},{"id":"https://openalex.org/keywords/flow-cytometry","display_name":"flow cytometry","score":0.6759999990463257},{"id":"https://openalex.org/keywords/dna-content","display_name":"DNA content","score":0.6639999747276306},{"id":"https://openalex.org/keywords/methyl-methanesulfonate","display_name":"methyl methanesulfonate","score":0.8289999961853027},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/propidium-iodide","display_name":"propidium iodide","score":0.9409999847412109},{"id":"https://openalex.org/keywords/genotoxicity-testing","display_name":"genotoxicity testing","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C141710004","wikidata":"https://www.wikidata.org/wiki/Q744364","display_name":"Clastogen","level":4,"score":0.9659966230392456},{"id":"https://openalex.org/C45080847","wikidata":"https://www.wikidata.org/wiki/Q1658004","display_name":"Micronucleus test","level":3,"score":0.8565575480461121},{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.8291146755218506},{"id":"https://openalex.org/C2778403015","wikidata":"https://www.wikidata.org/wiki/Q1404923","display_name":"Reticulocyte","level":4,"score":0.6331074833869934},{"id":"https://openalex.org/C2776639595","wikidata":"https://www.wikidata.org/wiki/Q221696","display_name":"Mutagen","level":3,"score":0.6024599671363831},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5759495496749878},{"id":"https://openalex.org/C36681516","wikidata":"https://www.wikidata.org/wiki/Q1700733","display_name":"Micronucleus","level":4,"score":0.5451487898826599},{"id":"https://openalex.org/C2776900477","wikidata":"https://www.wikidata.org/wiki/Q3077242","display_name":"Methyl methanesulfonate","level":4,"score":0.5227560997009277},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5173627734184265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48977231979370117},{"id":"https://openalex.org/C2778959862","wikidata":"https://www.wikidata.org/wiki/Q1009245","display_name":"Genotoxicity","level":3,"score":0.4210277497768402},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37218427658081055},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2474917471408844},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.201075941324234},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.1899750530719757},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.12500464916229248},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.09839880466461182},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/(sici)1098-2280(1998)31:4<340::aid-em6>3.0.co;2-m","doi":"https://doi.org/10.1002/(sici)1098-2280(1998)31:4<340::aid-em6>3.0.co;2-m","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1098-2280(1998)31:4<340::aid-em6>3.0.co;2-m","pdf_url":null,"source":{"id":"https://openalex.org/S204663187","display_name":"Environmental and Molecular Mutagenesis","issn_l":"0893-6692","issn":["0893-6692","1098-2280"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental and Molecular Mutagenesis","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4723300462","display_name":null,"funder_award_id":"1R43ES07707-02","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2004642777","https://openalex.org/W2078012986","https://openalex.org/W3092766834","https://openalex.org/W2052064846","https://openalex.org/W2161477415","https://openalex.org/W2060258936","https://openalex.org/W2033785453","https://openalex.org/W2353633846","https://openalex.org/W2084830219","https://openalex.org/W1974970143"],"abstract_inverted_index":{"A":[0,111],"flow":[1,68,168,203],"cytometric":[2,69,204],"(FCM)":[3],"procedure":[4],"for":[5,16,67,144],"quantitating":[6],"micronucleated":[7,99],"reticulocytes":[8,100,107],"in":[9],"mouse":[10],"peripheral":[11],"blood":[12,53,109],"samples":[13,54],"was":[14,101,114,142],"evaluated":[15],"its":[17],"ability":[18],"to":[19,77,88,156,173],"discriminate":[20],"between":[21],"aneugen-":[22],"and":[23,61,65,81,93,131,147,185],"clastogen-induced":[24],"micronuclei":[25],"(MN).":[26],"In":[27],"this":[28,163],"experiment,":[29],"BALB/c":[30],"mice":[31],"were":[32,55,62,129],"injected":[33],"with":[34,92],"0.9%":[35],"saline,":[36],"the":[37,46,82,120,160,175],"model":[38],"clastogen":[39,199],"methyl":[40],"methanesulfonate":[41],"(100":[42],"mg/kg":[43,50],"bw)":[44],"or":[45,182,197],"aneugen":[47],"vincristine":[48],"(0.2":[49],"bw).":[51],"Peripheral":[52],"collected":[56,130],"48":[57],"hr":[58],"after":[59],"injection":[60],"subsequently":[63],"fixed":[64],"stained":[66],"analysis.":[70],"The":[71,96,137],"staining":[72],"method":[73],"utilized":[74],"FITC-conjugated":[75],"anti-CD71":[76],"differentially":[78],"label":[79],"reticulocytes,":[80],"nucleic":[83],"acid":[84],"dye":[85],"propidium":[86,121],"iodide":[87,122],"resolve":[89],"erythrocyte":[90],"populations":[91],"without":[94],"micronuclei.":[95],"frequency":[97],"of":[98,126,152,162,177,206],"determined":[102],"by":[103],"analyzing":[104],"10,000":[105],"total":[106],"per":[108],"sample.":[110],"second":[112],"analysis":[113,205],"performed":[115],"on":[116,202],"each":[117,145],"sample":[118,146],"whereby":[119],"associated":[123],"fluorescent":[124],"signals":[125],"250":[127],"MN":[128,153,178,187],"graphed":[132],"as":[133],"a":[134,149],"single-parameter":[135],"histogram.":[136],"histogram":[138],"statistic":[139],"\u201cmedian":[140],"channel\u201d":[141],"recorded":[143],"provided":[148],"quantitative":[150],"description":[151],"distribution":[154],"according":[155],"DNA":[157,207],"content.":[158,208],"Cumulatively,":[159],"results":[161],"study":[164],"suggest":[165],"that":[166],"1)":[167],"cytometry":[169],"can":[170],"be":[171,191],"employed":[172],"measure":[174],"incidence":[176],"resulting":[179,188],"from":[180,189,193,198],"clastogenic":[181],"aneugenic":[183],"activity,":[184],"2)":[186],"aneugenscan":[190],"discriminated":[192],"those":[194],"arising":[195],"spontaneously":[196],"treatment":[200],"based":[201],"Environ.":[209],"Mol.":[210],"Mutagen.":[211],"31:340\u2013344,":[212],"1998.":[213],"\u00a9":[214],"1998":[215],"Wiley-Liss,":[216],"Inc.":[217]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2022-10-02T00:00:00"}
