{"id":"https://openalex.org/W4299521139","doi":"https://doi.org/10.2106/00004623-198567010-00014","title":"Calcium flux and endogenous calcium content in isolated mammalian growth-plate chondrocytes, hyaline-cartilage chondrocytes, and hepatocytes.","display_name":"Calcium flux and endogenous calcium content in isolated mammalian growth-plate chondrocytes, hyaline-cartilage chondrocytes, and hepatocytes.","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W4299521139","doi":"https://doi.org/10.2106/00004623-198567010-00014","mag":"2231255470","pmid":"https://pubmed.ncbi.nlm.nih.gov/2578468"},"language":"en","primary_location":{"id":"doi:10.2106/00004623-198567010-00014","doi":"https://doi.org/10.2106/00004623-198567010-00014","is_oa":false,"landing_page_url":"https://doi.org/10.2106/00004623-198567010-00014","pdf_url":null,"source":{"id":"https://openalex.org/S128848949","display_name":"Journal of Bone and Joint Surgery","issn_l":"0021-9355","issn":["0021-9355","1058-2436","1535-1386"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Bone & Joint Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024252310","display_name":"Joseph P. Iannotti","orcid":"https://orcid.org/0000-0001-7806-1872","observed_orcids":["https://orcid.org/0000-0001-7806-1872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J P Iannotti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043516951","display_name":"Carl T. Brighton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C T Brighton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046500243","display_name":"J L Stambough","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J L Stambough","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5002672104","display_name":"B T Storey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B T Storey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6051,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.67355688,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"67","issue":"1","first_page":"113","last_page":"120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.6845999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.6845999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.1145000010728836,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.04650000110268593,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-flux","display_name":"calcium flux","score":0.7239999771118164},{"id":"https://openalex.org/keywords/growth-plate-chondrocytes","display_name":"growth plate chondrocytes","score":0.9449999928474426},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.9190000295639038},{"id":"https://openalex.org/keywords/endochondral-ossification","display_name":"endochondral ossification","score":0.8410000205039978},{"id":"https://openalex.org/keywords/mitochondrial-calcium-accumulation","display_name":"mitochondrial calcium accumulation","score":0.6869999766349792},{"id":"https://openalex.org/keywords/calcium-release","display_name":"calcium release","score":0.7300000190734863},{"id":"https://openalex.org/keywords/extracellular-matrix-calcification","display_name":"extracellular matrix calcification","score":0.8830000162124634},{"id":"https://openalex.org/keywords/calcium-transport","display_name":"calcium transport","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.7591763734817505},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.7384225130081177},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6977708339691162},{"id":"https://openalex.org/C2780024818","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Hyaline cartilage","level":5,"score":0.5592068433761597},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.4854593873023987},{"id":"https://openalex.org/C17938293","wikidata":"https://www.wikidata.org/wiki/Q3312710","display_name":"Endochondral ossification","level":3,"score":0.4661098122596741},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4657455384731293},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.4604341387748718},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43499937653541565},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.41118499636650085},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.408282071352005},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3716946244239807},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.25236713886260986},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07048889994621277},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.062059640884399414},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05189239978790283},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002113","descriptor_name":"Calcification, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003580","descriptor_name":"Cytochromes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006132","descriptor_name":"Growth Plate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006818","descriptor_name":"Hyalin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2106/00004623-198567010-00014","doi":"https://doi.org/10.2106/00004623-198567010-00014","is_oa":false,"landing_page_url":"https://doi.org/10.2106/00004623-198567010-00014","pdf_url":null,"source":{"id":"https://openalex.org/S128848949","display_name":"Journal of Bone and Joint Surgery","issn_l":"0021-9355","issn":["0021-9355","1058-2436","1535-1386"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Bone & Joint Surgery","raw_type":"journal-article"},{"id":"pmid:2578468","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2578468","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of bone and joint surgery. American volume","raw_type":"Journal Article"},{"id":"mag:2231255470","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2578468","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2135243174","https://openalex.org/W1996294191","https://openalex.org/W4319689355","https://openalex.org/W1604084902","https://openalex.org/W2032353936","https://openalex.org/W2073672885","https://openalex.org/W2013812998","https://openalex.org/W2031339910","https://openalex.org/W175975416","https://openalex.org/W1987605489"],"abstract_inverted_index":{"The":[0,17,46,104,152],"role":[1],"of":[2,12,19,52,81,92,97,101,112,115,119,126,144,148,170,178,182,191,213,217],"chondrocyte":[3,200],"mitochondria":[4,51,80,86,106,125,169,173,187,201],"in":[5,38,156,167,210],"endochondral":[6],"ossification":[7],"has":[8],"been":[9],"the":[10,25,30,50,53,79,124,168,199,211,214,218],"subject":[11],"intensive":[13],"investigation":[14],"and":[15,29,36,43,56,71,84,94,134,141,159,207],"controversy.":[16],"purpose":[18],"this":[20],"study":[21],"was":[22,162],"to":[23],"quantitate":[24],"endogenous":[26,62,89],"calcium":[27,34,63,69,90,110,205],"content":[28,91,133],"maximum":[31,109,137],"capacity":[32,67,111],"for":[33,68,204],"accumulation":[35],"release":[37],"isolated":[39,54],"mammalian":[40],"growth-plate":[41,55,105,158],"chondrocytes":[42,58,161],"hyaline-cartilage":[44,57,85,160],"chondrocytes.":[45],"results":[47,196],"indicated":[48],"that":[49,166,198],"possess":[59],"a":[60,65,72,108,129,135],"greater":[61,66,164],"content,":[64],"accumulation,":[70],"larger":[73],"labile":[74],"Ca+2":[75,98,116,138,145,179,192],"pool":[76,155],"than":[77,165],"do":[78],"hepatocytes.":[82,171],"Growth-plate":[83],"had":[87,107,128],"an":[88],"908":[93],"142":[95],"nanomoles":[96,114,143,177,190],"per":[99,117,146,180,193],"milligram":[100,118,147,181],"mitochondrial":[102,120,149,153,183],"protein.":[103,121],"5249":[113],"In":[122],"comparison,":[123],"hepatocytes":[127],"much":[130],"smaller":[131,136],"endogenous-calcium":[132],"capacity:":[139],"twenty-one":[140],"3262":[142],"protein,":[150,184],"respectively.":[151],"labile-calcium":[154],"both":[157],"twofold":[163],"Chondrocyte":[172],"released":[174,188],"approximately":[175],"2400":[176],"whereas":[185],"hepatocyte":[186],"1200":[189],"milligram.":[194],"These":[195],"suggest":[197],"are":[202,208],"specialized":[203],"transport":[206],"important":[209],"calcification":[212],"extracellular":[215],"matrix":[216],"growth":[219],"plate.":[220]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-10-02T00:00:00"}