{"id":"https://openalex.org/W4298368752","doi":"https://doi.org/10.17615/mbge-8h28","title":"Plasma Complement Components and Activation Fragments: Associations with Age-Related Macular Degeneration Genotypes and Phenotypes","display_name":"Plasma Complement Components and Activation Fragments: Associations with Age-Related Macular Degeneration Genotypes and Phenotypes","publication_year":2020,"publication_date":"2020-11-03","ids":{"openalex":"https://openalex.org/W4298368752","doi":"https://doi.org/10.17615/mbge-8h28"},"language":"en","primary_location":{"id":"pmh:cdr.lib.unc.edu:1544bw82x","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.17615/mbge-8h28","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology and Visual Science, 50(12)","raw_type":"Article"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.17615/mbge-8h28","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045710915","display_name":"Patricia C. Giclas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giclas, Patricia C.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104928419","display_name":"Johanna M. Seddon","orcid":"https://orcid.org/0000-0002-2494-7552","observed_orcids":["https://orcid.org/0000-0002-2494-7552"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seddon, Johanna M.","raw_affiliation_strings":["School of Medicine, Department of Ophthalmology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Department of Ophthalmology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075224562","display_name":"Robyn C Reynolds","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reynolds, Robyn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033811449","display_name":"M. Elizabeth Hartnett","orcid":"https://orcid.org/0000-0002-7270-5670","observed_orcids":["https://orcid.org/0000-0002-7270-5670"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hartnett, M. Elizabeth","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008114290","display_name":"John P. Atkinson","orcid":"https://orcid.org/0000-0002-2514-3441","observed_orcids":["https://orcid.org/0000-0002-2514-3441","https://orcid.org/0000-0003-2809-9308"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Atkinson, John P.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5089191285","display_name":"BERNARD A. ROSNER","orcid":"https://orcid.org/0000-0001-6907-0056","observed_orcids":["https://orcid.org/0000-0001-6907-0056"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosner, Bernard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37857701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.051600001752376556,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9950000047683716},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.9190000295639038},{"id":"https://openalex.org/keywords/complement-regulation","display_name":"complement regulation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/advanced-amd","display_name":"advanced AMD","score":0.6869999766349792},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6230000257492065},{"id":"https://openalex.org/keywords/genotypes","display_name":"genotypes","score":0.5099999904632568},{"id":"https://openalex.org/keywords/phenotypes","display_name":"phenotypes","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.8742818832397461},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7417129278182983},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6496680378913879},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.6035841107368469},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.41304126381874084},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40759843587875366},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3753989636898041},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3287855386734009},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.1974542737007141},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1651090383529663},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0700870156288147},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:cdr.lib.unc.edu:1544bw82x","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.17615/mbge-8h28","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology and Visual Science, 50(12)","raw_type":"Article"},{"id":"doi:10.17615/mbge-8h28","doi":"https://doi.org/10.17615/mbge-8h28","is_oa":true,"landing_page_url":"https://doi.org/10.17615/mbge-8h28","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.17615/mbge-8h28","doi":"https://doi.org/10.17615/mbge-8h28","is_oa":true,"landing_page_url":"https://doi.org/10.17615/mbge-8h28","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2028283509","https://openalex.org/W1964909530","https://openalex.org/W2117957387","https://openalex.org/W2468521850","https://openalex.org/W2127439967","https://openalex.org/W6964810438","https://openalex.org/W2994601225","https://openalex.org/W2035609834","https://openalex.org/W3215348782","https://openalex.org/W2001661375"],"abstract_inverted_index":{"Several":[0],"genes":[1],"encoding":[2],"complement":[3,30],"system":[4],"components":[5],"and":[6,32,41],"fragments":[7],"are":[8,34,44],"associated":[9,37],"with":[10,38],"age-related":[11],"macular":[12],"degeneration":[13],"(AMD).":[14],"This":[15],"study":[16],"was":[17],"conducted":[18],"to":[19,46],"determine":[20],"whether":[21,42],"alterations":[22],"in":[23],"circulating":[24],"levels":[25],"of":[26,29],"these":[27],"markers":[28],"activation":[31],"regulation":[33],"also":[35],"independently":[36],"advanced":[39],"AMD":[40,47],"they":[43],"related":[45],"genotypes.":[48]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2022-10-02T00:00:00"}