{"id":"https://openalex.org/W4298326953","doi":"https://doi.org/10.1167/tvst.11.10.6","title":"A Framework for Automating Psychiatric Distress Screening in Ophthalmology Clinics Using an EHR-Derived AI Algorithm","display_name":"A Framework for Automating Psychiatric Distress Screening in Ophthalmology Clinics Using an EHR-Derived AI Algorithm","publication_year":2022,"publication_date":"2022-10-03","ids":{"openalex":"https://openalex.org/W4298326953","doi":"https://doi.org/10.1167/tvst.11.10.6","pmid":"https://pubmed.ncbi.nlm.nih.gov/36180026","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9547354"},"language":"en","primary_location":{"id":"doi:10.1167/tvst.11.10.6","doi":"https://doi.org/10.1167/tvst.11.10.6","is_oa":true,"landing_page_url":"https://doi.org/10.1167/tvst.11.10.6","pdf_url":null,"source":{"id":"https://openalex.org/S2764591444","display_name":"Translational Vision Science & Technology","issn_l":"2164-2591","issn":["2164-2591"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315919","host_organization_name":"Association for Research in Vision and Ophthalmology","host_organization_lineage":["https://openalex.org/P4310315919"],"host_organization_lineage_names":["Association for Research in Vision and Ophthalmology"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Vision Science &amp; Technology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1167/tvst.11.10.6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021086139","display_name":"Samuel I. Berchuck","orcid":"https://orcid.org/0000-0001-5705-3144","observed_orcids":["https://orcid.org/0000-0001-5705-3144"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel I. Berchuck","raw_affiliation_strings":["Department of Statistical Science, Duke University, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistical Science, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013584197","display_name":"Alessandro A. Jammal","orcid":"https://orcid.org/0000-0001-5341-8353","observed_orcids":["https://orcid.org/0000-0001-5341-8353"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alessandro A. Jammal","raw_affiliation_strings":["Duke Eye Center and Department of Ophthalmology, Duke University, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Eye Center and Department of Ophthalmology, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029755575","display_name":"David I. Page","orcid":"https://orcid.org/0000-0003-0524-0516","observed_orcids":["https://orcid.org/0000-0003-0524-0516"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Page","raw_affiliation_strings":["Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055252656","display_name":"Tamara J. Somers","orcid":"https://orcid.org/0000-0002-8809-2979","observed_orcids":["https://orcid.org/0000-0002-8809-2979"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamara J. Somers","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075198015","display_name":"Felipe Andrade Medeiros","orcid":"https://orcid.org/0000-0003-3924-2720","observed_orcids":["https://orcid.org/0000-0003-3924-2720"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Felipe A. Medeiros","raw_affiliation_strings":["Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA","Duke Eye Center and Department of Ophthalmology, Duke University, Durham, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Duke Eye Center and Department of Ophthalmology, Duke University, Durham, NC, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075198015"],"corresponding_institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.329,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.55211149,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"11","issue":"10","first_page":"6","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.6675000190734863,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.6675000190734863,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.13349999487400055,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11396","display_name":"Artificial Intelligence in Healthcare","score":0.07760000228881836,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ophthalmology-patients","display_name":"ophthalmology patients","score":0.906000018119812},{"id":"https://openalex.org/keywords/automated-screening","display_name":"automated screening","score":0.6790000200271606},{"id":"https://openalex.org/keywords/computable-phenotypes","display_name":"computable phenotypes","score":0.7910000085830688},{"id":"https://openalex.org/keywords/psychosocial-risk-factors","display_name":"psychosocial risk factors","score":0.8989999890327454},{"id":"https://openalex.org/keywords/central-pain","display_name":"central pain","score":0.6510000228881836},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.37299999594688416},{"id":"https://openalex.org/keywords/esophageal-diseases","display_name":"esophageal diseases","score":0.9639999866485596},{"id":"https://openalex.org/keywords/headache","display_name":"headache","score":0.9430000185966492}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7694438695907593},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.624278724193573},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.6023126840591431},{"id":"https://openalex.org/C2776135927","wikidata":"https://www.wikidata.org/wiki/Q5242559","display_name":"Referral","level":2,"score":0.5284909009933472},{"id":"https://openalex.org/C150966472","wikidata":"https://www.wikidata.org/wiki/Q3410145","display_name":"Psychosocial","level":2,"score":0.4878578186035156},{"id":"https://openalex.org/C139265228","wikidata":"https://www.wikidata.org/wiki/Q5283089","display_name":"Distress","level":2,"score":0.47236162424087524},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4269052743911743},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.40399688482284546},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3303315341472626},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.2339617908000946},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.208303302526474},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.1293310821056366},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.10129651427268982}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009885","descriptor_name":"Ophthalmology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1167/tvst.11.10.6","doi":"https://doi.org/10.1167/tvst.11.10.6","is_oa":true,"landing_page_url":"https://doi.org/10.1167/tvst.11.10.6","pdf_url":null,"source":{"id":"https://openalex.org/S2764591444","display_name":"Translational Vision Science & Technology","issn_l":"2164-2591","issn":["2164-2591"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315919","host_organization_name":"Association for Research in Vision and Ophthalmology","host_organization_lineage":["https://openalex.org/P4310315919"],"host_organization_lineage_names":["Association for Research in Vision and Ophthalmology"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Vision Science &amp; Technology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9547354","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9547354","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Vis Sci Technol","raw_type":"Text"},{"id":"pmid:36180026","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36180026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational vision science & technology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1167/tvst.11.10.6","doi":"https://doi.org/10.1167/tvst.11.10.6","is_oa":true,"landing_page_url":"https://doi.org/10.1167/tvst.11.10.6","pdf_url":null,"source":{"id":"https://openalex.org/S2764591444","display_name":"Translational Vision Science & Technology","issn_l":"2164-2591","issn":["2164-2591"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315919","host_organization_name":"Association for Research in Vision and Ophthalmology","host_organization_lineage":["https://openalex.org/P4310315919"],"host_organization_lineage_names":["Association for Research in Vision and Ophthalmology"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Vision Science &amp; Technology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1889567339","display_name":"Objective Quantification of Neural Damage for Screening, Diagnosis and Monitoring of Glaucoma with Fundus Photographs","funder_award_id":"R21EY031898","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G4486636314","display_name":"Development of a program to assess and treat distress in glaucoma patients using an automated EHR-derived AI algorithm","funder_award_id":"K99EY033027","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G8187636677","display_name":"The BCI (Brain Computer Interface) Glaucoma Study: Objective Home-Based Detection of Progressive Visual Function Loss in Glaucoma","funder_award_id":"R01EY029885","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1165566466","https://openalex.org/W1789824814","https://openalex.org/W1859717416","https://openalex.org/W1956509155","https://openalex.org/W1980235398","https://openalex.org/W1981198734","https://openalex.org/W1995921825","https://openalex.org/W2005078500","https://openalex.org/W2058187333","https://openalex.org/W2058994551","https://openalex.org/W2073064013","https://openalex.org/W2084612794","https://openalex.org/W2101421486","https://openalex.org/W2101875245","https://openalex.org/W2113952938","https://openalex.org/W2120561451","https://openalex.org/W2131060185","https://openalex.org/W2154603673","https://openalex.org/W2157395790","https://openalex.org/W2170915407","https://openalex.org/W2280770517","https://openalex.org/W2285695094","https://openalex.org/W2330820318","https://openalex.org/W2343299680","https://openalex.org/W2492579539","https://openalex.org/W2570244741","https://openalex.org/W2595582532","https://openalex.org/W2606534641","https://openalex.org/W2742009585","https://openalex.org/W2790272042","https://openalex.org/W2798476254","https://openalex.org/W2804266670","https://openalex.org/W2898227265","https://openalex.org/W2911964244","https://openalex.org/W2913148669","https://openalex.org/W2917446798","https://openalex.org/W2964022491","https://openalex.org/W3007055256","https://openalex.org/W3012640291","https://openalex.org/W3027668648","https://openalex.org/W3082098373","https://openalex.org/W4214557538","https://openalex.org/W4225079996","https://openalex.org/W4235476200","https://openalex.org/W4241310110","https://openalex.org/W4242608705","https://openalex.org/W4251342068","https://openalex.org/W4294541781"],"related_works":["https://openalex.org/W4391726737","https://openalex.org/W4400257992","https://openalex.org/W2916364889","https://openalex.org/W4400912440","https://openalex.org/W4414994522","https://openalex.org/W3030502712","https://openalex.org/W3097006173","https://openalex.org/W7125590853","https://openalex.org/W3038849564","https://openalex.org/W3006961624"],"abstract_inverted_index":{"Purpose:":[0],"In":[1],"patients":[2,152,217],"with":[3,153,235],"ophthalmic":[4],"disorders,":[5],"psychosocial":[6],"risk":[7,107],"factors":[8,99,108],"play":[9],"an":[10,44,154,223,236],"important":[11],"role":[12],"in":[13,24,215,248],"morbidity":[14],"and":[15,18,27,77,128,166,171,207,239],"mortality.":[16],"Proper":[17],"early":[19],"psychiatric":[20,113],"screening":[21,32,42],"can":[22,218],"result":[23],"prompt":[25],"intervention":[26],"mitigate":[28],"its":[29],"impact.":[30],"Because":[31],"is":[33],"resource":[34],"intensive,":[35],"we":[36],"developed":[37],"a":[38,61,78,95],"framework":[39],"for":[40,65],"automating":[41],"using":[43,94,119,140,222],"electronic":[45],"health":[46,246],"record":[47],"(EHR)-derived":[48],"artificial":[49],"intelligence":[50],"(AI)":[51],"algorithm.":[52],"Methods:":[53],"Subjects":[54],"came":[55],"from":[56,150],"the":[57,66,91,122,131,175,179],"Duke":[58,67],"Ophthalmic":[59],"Registry,":[60],"retrospective":[62],"EHR":[63,102,229],"database":[64],"Eye":[68],"Center.":[69],"Inclusion":[70],"criteria":[71],"included":[72,100,147],"at":[73,90],"least":[74],"two":[75],"encounters":[76,149,158],"minimum":[79],"of":[80,83,86,156],"1":[81],"year":[82],"follow-up.":[84],"Presence":[85],"distress":[87,214],"was":[88,117,138],"defined":[89],"encounter":[92],"level":[93],"computable":[96],"phenotype.":[97],"Risk":[98],"available":[101],"history.":[103],"At":[104],"each":[105],"encounter,":[106],"were":[109,169,181],"used":[110],"to":[111,183],"discriminate":[112],"status.":[114],"Model":[115],"performance":[116],"evaluated":[118],"area":[120,129],"under":[121,130],"receiver":[123],"operating":[124],"characteristic":[125],"(ROC)":[126],"curve":[127,133],"precision-recall":[132],"(PR":[134],"AUC).":[135],"Variable":[136],"importance":[137],"presented":[139],"odds":[141],"ratios":[142],"(ORs).":[143],"Results:":[144],"Our":[145],"cohort":[146],"358,135":[148],"40,326":[151],"average":[155],"nine":[157],"per":[159],"patient":[160],"over":[161],"4":[162],"years.":[163],"The":[164],"ROC":[165],"PR":[167],"AUC":[168],"0.91":[170],"0.55,":[172],"respectively.":[173],"Of":[174],"top":[176],"25":[177],"predictors,":[178],"majority":[180],"related":[182],"existing":[184,228],"distress,":[185],"but":[186],"some":[187],"indicated":[188],"stressful":[189],"conditions,":[190],"including":[191],"chemotherapy":[192],"(OR":[193,198,204,209],"=":[194,199,205,210],"1.36),":[195],"esophageal":[196],"disorders":[197],"1.31),":[200],"central":[201],"pain":[202],"syndrome":[203],"1.25),":[206],"headaches":[208],"1.24).":[211],"Conclusions:":[212],"Psychiatric":[213],"ophthalmology":[216],"be":[219],"monitored":[220],"passively":[221],"AI":[224],"algorithm":[225],"trained":[226],"on":[227],"data.":[230],"Translational":[231],"Relevance:":[232],"When":[233],"paired":[234],"effective":[237],"referral":[238],"treatment":[240],"program,":[241],"such":[242],"algorithms":[243],"may":[244],"improve":[245],"outcomes":[247],"ophthalmology.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2022-10-02T00:00:00"}
