{"id":"https://openalex.org/W4298087216","doi":"https://doi.org/10.1002/term.3352","title":"Cartilage\u2010penetrating hyaluronic acid hydrogel preserves tissue content and reduces chondrocyte catabolism","display_name":"Cartilage\u2010penetrating hyaluronic acid hydrogel preserves tissue content and reduces chondrocyte catabolism","publication_year":2022,"publication_date":"2022-09-30","ids":{"openalex":"https://openalex.org/W4298087216","doi":"https://doi.org/10.1002/term.3352","pmid":"https://pubmed.ncbi.nlm.nih.gov/36178309"},"language":"en","primary_location":{"id":"doi:10.1002/term.3352","doi":"https://doi.org/10.1002/term.3352","is_oa":true,"landing_page_url":"https://doi.org/10.1002/term.3352","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/term.3352","source":{"id":"https://openalex.org/S68700368","display_name":"Journal of Tissue Engineering and Regenerative Medicine","issn_l":"1932-6254","issn":["1932-6254","1932-7005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Tissue Engineering and Regenerative Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/term.3352","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Michael A. Kowalski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Kowalski","raw_affiliation_strings":["Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA","Department of Veterans Affairs, Atlanta VA Medical Center, Decatur, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Department of Veterans Affairs, Atlanta VA Medical Center, Decatur, Georgia, USA","institution_ids":["https://openalex.org/I4210152539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045519111","display_name":"Lorenzo M. Fernandes","orcid":"https://orcid.org/0000-0001-5116-170X","observed_orcids":["https://orcid.org/0000-0001-5116-170X"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorenzo M. Fernandes","raw_affiliation_strings":["Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA","Department of Veterans Affairs, Atlanta VA Medical Center, Decatur, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Department of Veterans Affairs, Atlanta VA Medical Center, Decatur, Georgia, USA","institution_ids":["https://openalex.org/I4210152539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075900267","display_name":"Kyle E. Hammond","orcid":"https://orcid.org/0000-0002-3481-4921","observed_orcids":["https://orcid.org/0000-0002-3481-4921"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle E. Hammond","raw_affiliation_strings":["Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027790084","display_name":"Sameh A. Labib","orcid":"https://orcid.org/0000-0003-1593-2014","observed_orcids":["https://orcid.org/0000-0003-1593-2014"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sameh Labib","raw_affiliation_strings":["Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034940707","display_name":"Hicham Drissi","orcid":"https://orcid.org/0000-0002-3322-281X","observed_orcids":["https://orcid.org/0000-0002-3322-281X"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hicham Drissi","raw_affiliation_strings":["Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA","Department of Veterans Affairs, Atlanta VA Medical Center, Decatur, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Department of Veterans Affairs, Atlanta VA Medical Center, Decatur, Georgia, USA","institution_ids":["https://openalex.org/I4210152539"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057380357","display_name":"Jay Patel","orcid":"https://orcid.org/0000-0003-4889-0818","observed_orcids":["https://orcid.org/0000-0003-4889-0818"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jay M. Patel","raw_affiliation_strings":["Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA","Department of Veterans Affairs, Atlanta VA Medical Center, Decatur, Georgia, USA"],"raw_orcid":"https://orcid.org/0000-0003-4889-0818","affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Department of Veterans Affairs, Atlanta VA Medical Center, Decatur, Georgia, USA","institution_ids":["https://openalex.org/I4210152539"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057380357"],"corresponding_institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210152539"],"apc_list":{"value":4300,"currency":"USD","value_usd":4300},"apc_paid":null,"fwci":3.081,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.92916667,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"16","issue":"12","first_page":"1138","last_page":"1148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyaluronic-acid-hydrogel","display_name":"hyaluronic acid hydrogel","score":0.984000027179718},{"id":"https://openalex.org/keywords/articular-cartilage","display_name":"articular cartilage","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cartilage-degeneration","display_name":"cartilage degeneration","score":0.8289999961853027},{"id":"https://openalex.org/keywords/chondrocyte-catabolism","display_name":"chondrocyte catabolism","score":0.953000009059906},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8330000042915344},{"id":"https://openalex.org/keywords/cartilage-biomechanics","display_name":"cartilage biomechanics","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cartilage-repair","display_name":"cartilage repair","score":0.6240000128746033},{"id":"https://openalex.org/keywords/osteoarthritis-prevention","display_name":"osteoarthritis prevention","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7428678870201111},{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.7337083220481873},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.7151895761489868},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.6941309571266174},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.6110919117927551},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5442100763320923},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5125653743743896},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46087199449539185},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.441354364156723},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.4383859932422638},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.41743916273117065},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.41701480746269226},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3854968845844269},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3812935948371887},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3243284225463867},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2832639217376709},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.26728469133377075},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.22598659992218018},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19635912775993347},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1793988049030304},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.08565396070480347},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051457","descriptor_name":"Hyaline Cartilage","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/term.3352","doi":"https://doi.org/10.1002/term.3352","is_oa":true,"landing_page_url":"https://doi.org/10.1002/term.3352","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/term.3352","source":{"id":"https://openalex.org/S68700368","display_name":"Journal of Tissue Engineering and Regenerative Medicine","issn_l":"1932-6254","issn":["1932-6254","1932-7005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Tissue Engineering and Regenerative Medicine","raw_type":"journal-article"},{"id":"doi:10.1101/2022.05.17.492335","doi":"https://doi.org/10.1101/2022.05.17.492335","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.05.17.492335","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/05/19/2022.05.17.492335.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:36178309","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36178309","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of tissue engineering and regenerative medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/term.3352","doi":"https://doi.org/10.1002/term.3352","is_oa":true,"landing_page_url":"https://doi.org/10.1002/term.3352","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/term.3352","source":{"id":"https://openalex.org/S68700368","display_name":"Journal of Tissue Engineering and Regenerative Medicine","issn_l":"1932-6254","issn":["1932-6254","1932-7005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Tissue Engineering and Regenerative Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6952834413","display_name":null,"funder_award_id":"IK1 RX003208","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G8968134464","display_name":null,"funder_award_id":"IK2 RX003928","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320309381","display_name":"Emory University","ror":"https://ror.org/03czfpz43"},{"id":"https://openalex.org/F4320332554","display_name":"School of Medicine, Emory University","ror":"https://ror.org/03czfpz43"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4298087216.pdf","grobid_xml":"https://content.openalex.org/works/W4298087216.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1485761504","https://openalex.org/W1804618116","https://openalex.org/W1902204700","https://openalex.org/W1934629777","https://openalex.org/W1968847972","https://openalex.org/W1978418591","https://openalex.org/W1989199493","https://openalex.org/W1991758957","https://openalex.org/W1992696273","https://openalex.org/W1996058009","https://openalex.org/W2000287184","https://openalex.org/W2010531086","https://openalex.org/W2011068803","https://openalex.org/W2011720064","https://openalex.org/W2016771878","https://openalex.org/W2022836746","https://openalex.org/W2023669928","https://openalex.org/W2036395758","https://openalex.org/W2048183424","https://openalex.org/W2052989524","https://openalex.org/W2058232580","https://openalex.org/W2072087534","https://openalex.org/W2075079425","https://openalex.org/W2106229831","https://openalex.org/W2107277218","https://openalex.org/W2110609533","https://openalex.org/W2143461769","https://openalex.org/W2148870463","https://openalex.org/W2150669575","https://openalex.org/W2164993228","https://openalex.org/W2167279371","https://openalex.org/W2290858121","https://openalex.org/W2294078678","https://openalex.org/W2343137005","https://openalex.org/W2396069820","https://openalex.org/W2400170731","https://openalex.org/W2465375521","https://openalex.org/W2485342379","https://openalex.org/W2512546469","https://openalex.org/W2600319591","https://openalex.org/W2783008859","https://openalex.org/W2801856460","https://openalex.org/W2806134382","https://openalex.org/W2908560042","https://openalex.org/W2914603303","https://openalex.org/W2948013203","https://openalex.org/W2967621635","https://openalex.org/W2972593257","https://openalex.org/W2993782230","https://openalex.org/W3013381570","https://openalex.org/W3014577661","https://openalex.org/W3024605243","https://openalex.org/W3049758648","https://openalex.org/W3137523727","https://openalex.org/W3139096903","https://openalex.org/W4200324094","https://openalex.org/W4243518260"],"related_works":["https://openalex.org/W4386222755","https://openalex.org/W3139096903","https://openalex.org/W2997685113","https://openalex.org/W4309303471","https://openalex.org/W2080183138","https://openalex.org/W4376309456","https://openalex.org/W4404553073","https://openalex.org/W7212431854","https://openalex.org/W2379814906","https://openalex.org/W4311951447"],"abstract_inverted_index":{"Articular":[0],"cartilage":[1,34,54,91,204],"injuries":[2],"have":[3],"a":[4,83,104,111,124,206],"limited":[5],"healing":[6],"capacity":[7],"and,":[8],"due":[9],"to":[10,47,52,65,79,88,136,145,191,209],"inflammatory":[11],"and":[12,42,61,81,93,110,148,180,214,220],"catabolic":[13,194],"activities,":[14],"often":[15],"experience":[16],"progressive":[17],"degeneration":[18,117],"towards":[19],"osteoarthritis.":[20],"Current":[21],"repair":[22,40],"techniques":[23],"generally":[24],"provide":[25],"short-term":[26],"symptomatic":[27],"relief;":[28],"however,":[29],"the":[30,39,70,100,140,172,185,188,199],"regeneration":[31],"of":[32,75,118,157,174,187,201],"hyaline":[33],"remains":[35],"elusive,":[36],"leaving":[37],"both":[38,210],"tissue":[41,45,95,212],"surrounding":[43],"healthy":[44],"susceptible":[46],"long-term":[48],"wear.":[49],"Therefore,":[50],"methods":[51],"preserve":[53,211],"following":[55],"injury,":[56],"especially":[57],"from":[58],"matrix":[59,175],"loss":[60,156],"catabolism,":[62],"are":[63],"needed":[64],"delay,":[66],"or":[67,137],"even":[68],"prevent,":[69],"deteriorative":[71],"process.":[72],"The":[73],"goal":[74],"this":[76],"study":[77],"was":[78,159],"develop":[80],"evaluate":[82],"cartilage-penetrating":[84],"hyaluronic-acid":[85],"(HA)":[86],"hydrogel":[87,102,133,168],"improve":[89],"damaged":[90,203],"biomechanics":[92],"prevent":[94],"degeneration.":[96],"At":[97],"time":[98],"zero,":[99],"HA-based":[101],"provided":[103],"46.5%":[105],"increase":[106],"in":[107,113,123,151,161],"compressive":[108,146],"modulus":[109,147],"decrease":[112,192],"permeability":[114,149],"after":[115],"simulated":[116],"explants":[119],"(collagenase":[120],"application).":[121],"Next,":[122],"degenerative":[125,162],"culture":[126,141,163],"model":[127],"(interleukin-1\u03b2":[128],"[IL-1\u03b2]":[129],"for":[130],"2":[131],"weeks),":[132],"application":[134],"prior":[135],"midway":[138],"through":[139],"mitigated":[142],"detrimental":[143],"changes":[144],"observed":[150,160],"non-treated":[152],"explants.":[153],"Furthermore,":[154],"localized":[155],"proteoglycan":[158],"conditions":[164],"alone":[165],"(non-treated),":[166],"but":[167],"administration":[169],"significantly":[170],"improved":[171],"retention":[173],"elements.":[176],"Finally,":[177],"NITEGE":[178],"staining":[179],"gene":[181],"expression":[182],"analysis":[183],"showed":[184],"ability":[186],"HA":[189],"gel":[190],"chondrocyte":[193],"activity.":[195],"These":[196],"results":[197],"highlight":[198],"importance":[200],"reinforcing":[202],"with":[205,218],"biomaterial":[207],"system":[208],"content":[213],"reduce":[215],"catabolism":[216],"associated":[217],"injury":[219],"inflammation.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2022-10-01T00:00:00"}
