{"id":"https://openalex.org/W4298082365","doi":"https://doi.org/10.17615/av8b-vj41","title":"VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells","display_name":"VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells","publication_year":2021,"publication_date":"2021-01-14","ids":{"openalex":"https://openalex.org/W4298082365","doi":"https://doi.org/10.17615/av8b-vj41"},"language":"en","primary_location":{"id":"pmh:cdr.lib.unc.edu:xw42nh543","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/av8b-vj41","pdf_url":"https://cdr.lib.unc.edu/downloads/mg74qv69k","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Physiology, 590(Pt 3)","raw_type":"Article"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://cdr.lib.unc.edu/downloads/mg74qv69k","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056452771","display_name":"Elizabeth J. Hudson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4405259350","display_name":"Mucoviscidose et bronchopathies chroniques : biopathologie et ph\u00e9notype cliniques","ror":"https://ror.org/0240qt703","country_code":"FR","type":"facility","lineage":["https://openalex.org/I157536573","https://openalex.org/I204730241","https://openalex.org/I4405259350"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Hudson, Elizabeth J","raw_affiliation_strings":["University of North Carolina at Chapel Hill","School of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"School of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center","institution_ids":["https://openalex.org/I4405259350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110348890","display_name":"Lisa C. Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4405259350","display_name":"Mucoviscidose et bronchopathies chroniques : biopathologie et ph\u00e9notype cliniques","ror":"https://ror.org/0240qt703","country_code":"FR","type":"facility","lineage":["https://openalex.org/I157536573","https://openalex.org/I204730241","https://openalex.org/I4405259350"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Jones, Lisa C","raw_affiliation_strings":["University of North Carolina at Chapel Hill","School of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"School of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center","institution_ids":["https://openalex.org/I4405259350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016698020","display_name":"Lama Moussa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4405259350","display_name":"Mucoviscidose et bronchopathies chroniques : biopathologie et ph\u00e9notype cliniques","ror":"https://ror.org/0240qt703","country_code":"FR","type":"facility","lineage":["https://openalex.org/I157536573","https://openalex.org/I204730241","https://openalex.org/I4405259350"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Moussa, Lama","raw_affiliation_strings":["University of North Carolina at Chapel Hill","School of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"School of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center","institution_ids":["https://openalex.org/I4405259350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040257436","display_name":"Eduardo Rodolfo Lazarowski","orcid":"https://orcid.org/0000-0002-5419-351X","observed_orcids":["https://orcid.org/0000-0002-5419-351X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4405259350","display_name":"Mucoviscidose et bronchopathies chroniques : biopathologie et ph\u00e9notype cliniques","ror":"https://ror.org/0240qt703","country_code":"FR","type":"facility","lineage":["https://openalex.org/I157536573","https://openalex.org/I204730241","https://openalex.org/I4405259350"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Lazarowski, Eduardo R","raw_affiliation_strings":["University of North Carolina at Chapel Hill","School of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"School of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center","institution_ids":["https://openalex.org/I4405259350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072490028","display_name":"Silvia M. Kreda","orcid":"https://orcid.org/0000-0003-3137-573X","observed_orcids":["https://orcid.org/0000-0003-3137-573X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4405259350","display_name":"Mucoviscidose et bronchopathies chroniques : biopathologie et ph\u00e9notype cliniques","ror":"https://ror.org/0240qt703","country_code":"FR","type":"facility","lineage":["https://openalex.org/I157536573","https://openalex.org/I204730241","https://openalex.org/I4405259350"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Kreda, Silvia M","raw_affiliation_strings":["University of North Carolina at Chapel Hill","School of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"School of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center","institution_ids":["https://openalex.org/I4405259350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049641668","display_name":"Scott H. Randell","orcid":"https://orcid.org/0000-0001-5351-2841","observed_orcids":["https://orcid.org/0000-0001-5351-2841"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4405259350","display_name":"Mucoviscidose et bronchopathies chroniques : biopathologie et ph\u00e9notype cliniques","ror":"https://ror.org/0240qt703","country_code":"FR","type":"facility","lineage":["https://openalex.org/I157536573","https://openalex.org/I204730241","https://openalex.org/I4405259350"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Randell, Scott H","raw_affiliation_strings":["University of North Carolina at Chapel Hill","School of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"School of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center","institution_ids":["https://openalex.org/I4405259350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103509349","display_name":"Yunxiang Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4405259350","display_name":"Mucoviscidose et bronchopathies chroniques : biopathologie et ph\u00e9notype cliniques","ror":"https://ror.org/0240qt703","country_code":"FR","type":"facility","lineage":["https://openalex.org/I157536573","https://openalex.org/I204730241","https://openalex.org/I4405259350"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Zhu, Yunxiang","raw_affiliation_strings":["University of North Carolina at Chapel Hill","School of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"School of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center","institution_ids":["https://openalex.org/I4405259350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059803142","display_name":"W.K. O apos Neal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4405259350","display_name":"Mucoviscidose et bronchopathies chroniques : biopathologie et ph\u00e9notype cliniques","ror":"https://ror.org/0240qt703","country_code":"FR","type":"facility","lineage":["https://openalex.org/I157536573","https://openalex.org/I204730241","https://openalex.org/I4405259350"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"O'Neal, Wanda K","raw_affiliation_strings":["University of North Carolina at Chapel Hill","School of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"School of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center","institution_ids":["https://openalex.org/I4405259350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078499329","display_name":"M. Leslie Fulcher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4405259350","display_name":"Mucoviscidose et bronchopathies chroniques : biopathologie et ph\u00e9notype cliniques","ror":"https://ror.org/0240qt703","country_code":"FR","type":"facility","lineage":["https://openalex.org/I157536573","https://openalex.org/I204730241","https://openalex.org/I4405259350"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Fulcher, M Leslie","raw_affiliation_strings":["University of North Carolina at Chapel Hill","School of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"School of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center","institution_ids":["https://openalex.org/I4405259350"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001166056","display_name":"Richard C. Boucher","orcid":"https://orcid.org/0000-0002-5745-3989","observed_orcids":["https://orcid.org/0000-0002-5745-3989"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4405259350","display_name":"Mucoviscidose et bronchopathies chroniques : biopathologie et ph\u00e9notype cliniques","ror":"https://ror.org/0240qt703","country_code":"FR","type":"facility","lineage":["https://openalex.org/I157536573","https://openalex.org/I204730241","https://openalex.org/I4405259350"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Boucher, Richard C","raw_affiliation_strings":["University of North Carolina at Chapel Hill","School of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"School of Medicine, Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center","institution_ids":["https://openalex.org/I4405259350"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22010144,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vamp8","display_name":"VAMP8","score":1.0},{"id":"https://openalex.org/keywords/snare-proteins","display_name":"SNARE proteins","score":0.8320000171661377},{"id":"https://openalex.org/keywords/mucin-secretion","display_name":"mucin secretion","score":0.9810000061988831},{"id":"https://openalex.org/keywords/airway-epithelium","display_name":"airway epithelium","score":0.8190000057220459},{"id":"https://openalex.org/keywords/neutrophil-elastase","display_name":"neutrophil elastase","score":0.996999979019165},{"id":"https://openalex.org/keywords/atp","display_name":"ATP","score":0.9150000214576721},{"id":"https://openalex.org/keywords/lung-disease","display_name":"lung disease","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.7738697528839111},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.7575571537017822},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6782264113426208},{"id":"https://openalex.org/C2775941134","wikidata":"https://www.wikidata.org/wiki/Q813622","display_name":"Goblet cell","level":3,"score":0.6181226372718811},{"id":"https://openalex.org/C2909863526","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretory Vesicle","level":4,"score":0.4881022870540619},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4740210175514221},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.45741671323776245},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.437500536441803},{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.31163057684898376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3058337867259979},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1603051722049713},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.13234952092170715},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.09934741258621216},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0833103358745575},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:cdr.lib.unc.edu:xw42nh543","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/av8b-vj41","pdf_url":"https://cdr.lib.unc.edu/downloads/mg74qv69k","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Physiology, 590(Pt 3)","raw_type":"Article"},{"id":"doi:10.17615/av8b-vj41","doi":"https://doi.org/10.17615/av8b-vj41","is_oa":true,"landing_page_url":"https://doi.org/10.17615/av8b-vj41","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:cdr.lib.unc.edu:xw42nh543","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/av8b-vj41","pdf_url":"https://cdr.lib.unc.edu/downloads/mg74qv69k","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Physiology, 590(Pt 3)","raw_type":"Article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4298082365.pdf","grobid_xml":"https://content.openalex.org/works/W4298082365.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2335603082","https://openalex.org/W7025475114","https://openalex.org/W7165534962","https://openalex.org/W2317656902","https://openalex.org/W3041000048","https://openalex.org/W2134634219","https://openalex.org/W2049097275","https://openalex.org/W7006220429","https://openalex.org/W2970280147","https://openalex.org/W2013160041"],"abstract_inverted_index":{"Mucin":[0],"secretion":[1,58,71,83],"in":[2,23,42,86,106,126],"the":[3,8,30,87],"lung":[4,127],"is":[5,102],"regulated":[6],"by":[7,50,60],"soluble":[9],"N-ethylmaleimide-sensitive":[10],"factor":[11],"attachment":[12],"protein":[13,34],"receptor":[14],"(SNARE)":[15],"exocytotic":[16],"core,":[17],"which":[18],"has":[19],"not":[20],"been":[21],"defined":[22],"airway":[24,44,55,107,123],"goblet":[25,46],"cells.":[26,47],"In":[27],"this":[28],"study,":[29],"SNARE":[31,105],"vesicle-associated":[32],"membrane":[33],"8":[35],"(VAMP8)":[36],"was":[37,72,84],"found":[38],"to":[39,94,121],"be":[40],"expressed":[41],"human":[43],"epithelial":[45,56],"VAMP8":[48,79,90,101,113],"knockdown":[49],"RNA":[51],"interference":[52],"techniques":[53],"reduced":[54,74,85],"mucin":[57,70,82,108],"induced":[59],"PAR":[61],"agonists,":[62],"neutrophil":[63],"elastase":[64],"and":[65],"ATP.":[66],"Basal":[67],"(non-agonist":[68],"elicited)":[69],"also":[73],"as":[75],"a":[76,117],"result":[77],"of":[78,89,112],"knockdown.":[80],"Importantly,":[81],"lungs":[88],"knockout":[91],"mice":[92],"compared":[93],"wild-type":[95],"littermates.":[96],"Our":[97],"data":[98],"suggest":[99],"that":[100],"an":[103],"essential":[104],"granule":[109],"exocytosis.":[110],"Reduction":[111],"activity/expression":[114],"may":[115],"provide":[116],"novel":[118],"therapeutic":[119],"target":[120],"ameliorate":[122],"mucus":[124],"obstruction":[125],"diseases.":[128]},"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2022-10-01T00:00:00"}