{"id":"https://openalex.org/W4298077574","doi":"https://doi.org/10.17615/8yv6-mf67","title":"Association of HIV viral load with monocyte chemoattractant protein-1 and atherosclerosis burden measured by magnetic resonance imaging","display_name":"Association of HIV viral load with monocyte chemoattractant protein-1 and atherosclerosis burden measured by magnetic resonance imaging","publication_year":2020,"publication_date":"2020-10-30","ids":{"openalex":"https://openalex.org/W4298077574","doi":"https://doi.org/10.17615/8yv6-mf67"},"language":"en","primary_location":{"id":"pmh:cdr.lib.unc.edu:8910k118k","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/8yv6-mf67","pdf_url":"https://cdr.lib.unc.edu/downloads/d791sn944","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"AIDS (London, England), 23(8)","raw_type":"Article"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://cdr.lib.unc.edu/downloads/d791sn944","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078061422","display_name":"Robert S. Klein","orcid":"https://orcid.org/0000-0002-8816-0783","observed_orcids":["https://orcid.org/0000-0002-8816-0783"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Klein, Robert S.","raw_affiliation_strings":["School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070093206","display_name":"Venkatesh Mani","orcid":"https://orcid.org/0000-0002-0432-2918","observed_orcids":["https://orcid.org/0000-0002-0432-2918"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mani, Venkatesh","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074727212","display_name":"Valent\u0131\u0301n Fuster","orcid":"https://orcid.org/0000-0002-9043-9986","observed_orcids":["https://orcid.org/0000-0002-9043-9986","https://orcid.org/0009-0005-7344-8425"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fuster, Valentin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057650635","display_name":"Joan W. Berman","orcid":"https://orcid.org/0000-0003-0635-4072","observed_orcids":["https://orcid.org/0000-0003-0635-4072"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Berman, Joan W.","raw_affiliation_strings":["School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045303822","display_name":"Andrea A. Howard","orcid":"https://orcid.org/0000-0003-3248-1307","observed_orcids":["https://orcid.org/0000-0003-3248-1307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Howard, Andrea A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006056671","display_name":"Karen B Weinshelbaum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weinshelbaum, Karen B.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089434484","display_name":"Zahi Adel Fayad","orcid":"https://orcid.org/0000-0002-3439-7347","observed_orcids":["https://orcid.org/0000-0002-3439-7347"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fayad, Zahi A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059998338","display_name":"Alison D. Schecter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Schecter, Alison D.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086305989","display_name":"Ellie E. Schoenbaum","orcid":"https://orcid.org/0000-0002-0878-284X","observed_orcids":["https://orcid.org/0000-0002-0878-284X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Schoenbaum, Ellie E.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010371161","display_name":"Michelle Floris-Moore","orcid":"https://orcid.org/0009-0007-9515-2857","observed_orcids":["https://orcid.org/0009-0007-9515-2857"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"FIoris-Moore, Michelle","raw_affiliation_strings":["University of North Carolina at Chapel Hill"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086230340","display_name":"Yungtai Lo","orcid":"https://orcid.org/0000-0002-2694-4830","observed_orcids":["https://orcid.org/0000-0002-2694-4830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lo, Yungtai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39730311,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.8859999775886536},{"id":"https://openalex.org/keywords/hiv-1-viral-load","display_name":"HIV-1 viral load","score":0.9470000267028809},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8330000042915344},{"id":"https://openalex.org/keywords/thoracic-aorta","display_name":"thoracic aorta","score":0.906000018119812},{"id":"https://openalex.org/keywords/vessel-wall-area","display_name":"vessel wall area","score":0.8510000109672546},{"id":"https://openalex.org/keywords/vessel-wall-thickness","display_name":"vessel wall thickness","score":0.9950000047683716},{"id":"https://openalex.org/keywords/carotid-artery","display_name":"carotid artery","score":0.8949999809265137},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6439999938011169},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.7739999890327454},{"id":"https://openalex.org/keywords/undetectable-viral-load","display_name":"undetectable viral load","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.74575275182724},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6729350090026855},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6127319931983948},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4683346748352051},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.46407392621040344},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4214276671409607},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.36009275913238525},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24079221487045288},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:cdr.lib.unc.edu:8910k118k","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/8yv6-mf67","pdf_url":"https://cdr.lib.unc.edu/downloads/d791sn944","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"AIDS (London, England), 23(8)","raw_type":"Article"},{"id":"doi:10.17615/8yv6-mf67","doi":"https://doi.org/10.17615/8yv6-mf67","is_oa":true,"landing_page_url":"https://doi.org/10.17615/8yv6-mf67","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:cdr.lib.unc.edu:8910k118k","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/8yv6-mf67","pdf_url":"https://cdr.lib.unc.edu/downloads/d791sn944","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"AIDS (London, England), 23(8)","raw_type":"Article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1665807352","display_name":null,"funder_award_id":"MH 070297","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2914726324","display_name":null,"funder_award_id":"MH075679","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6721914976","display_name":"MR/PET Imaging of coronary atherosclerosis","funder_award_id":"R01HL071021","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320309686","display_name":"Yeshiva University","ror":"https://ror.org/045x93337"},{"id":"https://openalex.org/F4320332522","display_name":"Albert Einstein College of Medicine, Yeshiva University","ror":"https://ror.org/045x93337"},{"id":"https://openalex.org/F4320332582","display_name":"Center for AIDS Research, University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4298077574.pdf","grobid_xml":"https://content.openalex.org/works/W4298077574.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2083875667","https://openalex.org/W2043509121","https://openalex.org/W2090899436","https://openalex.org/W3082720449","https://openalex.org/W2091797632","https://openalex.org/W2260432300","https://openalex.org/W2046102184","https://openalex.org/W2142748172","https://openalex.org/W3134923773","https://openalex.org/W251920225"],"abstract_inverted_index":{"BACKGROUND:":[0],"HIV-infected":[1,62,99,107,206],"individuals":[2],"may":[3,20],"be":[4],"at":[5],"increased":[6],"risk":[7],"for":[8,111,131],"atherosclerosis.":[9],"Although":[10],"this":[11],"is":[12,251],"partially":[13],"attributable":[14],"to":[15,80],"metabolic":[16],"factors,":[17],"HIV-associated":[18],"inflammation":[19],"play":[21],"a":[22],"role.":[23],"OBJECTIVE:":[24],"To":[25],"investigate":[26],"associations":[27],"of":[28,73,233,257],"HIV":[29,150],"disease":[30],"with":[31,123,154,176,181,190,207,213,235,253,260],"serum":[32,255],"monocyte":[33],"chemoattractant":[34],"protein-1/chemokine":[35],"(C-C":[36],"motif)":[37],"ligand":[38],"2":[39],"(MCP-1/CCL2)":[40],"levels":[41,94,256],"and":[42,55,63,77,100,114,144,166,199,242,259,269],"atherosclerosis":[43,82,261],"burden.":[44,83],"DESIGN:":[45],"A":[46],"cross-sectional":[47],"analysis.":[48],"METHODS:":[49],":":[50],"Serum":[51],"MCP-1/CCL2,":[52,143],"fasting":[53],"lipids,":[54],"glucose":[56],"tolerance":[57],"were":[58,86],"measured":[59],"in":[60],"98":[61],"79":[64],"demographically":[65],"similar":[66],"uninfected":[67,101],"adults.":[68],"Eighty-four":[69],"participants":[70,102],"had":[71],"MRI":[72],"the":[74],"carotid":[75,177],"arteries":[76],"thoracic":[78,157,193,215,236,266],"aorta":[79,158,194,216,237,267],"measure":[81],"Multivariate":[84,128],"analyses":[85,129],"performed":[87],"using":[88],"linear":[89],"regression.":[90],"RESULTS:":[91],"Mean":[92],"MCP-1/CCL2":[93,124,234,258],"did":[95],"not":[96,175,222],"differ":[97],"between":[98],"(P":[103,125,196,201,218,224,239,244],"=":[104,126,172,202,219,225,240,245],"0.65).":[105],"Among":[106],"participants,":[108],"after":[109],"adjusting":[110,130],"age,":[112],"BMI,":[113],"cigarette":[115,141],"smoking,":[116,142],"HIV-1":[117,186,248],"viral":[118,209,249],"load":[119,210],"was":[120,152,188,211,228],"positively":[121],"associated":[122,153,189,212,252],"0.02).":[127],"sex,":[132],"low-density":[133],"lipoprotein":[134,138],"cholesterol,":[135],"total":[136],"cholesterol:high-density":[137],"cholesterol":[139],"ratio,":[140],"protease":[145],"inhibitor":[146],"use":[147],"found":[148],"that":[149],"infection":[151],"greater":[155,191,214],"mean":[156,192],"vessel":[159,167],"wall":[160,168],"area":[161],"(VWA,":[162],"P":[163,171],"<":[164,197],"0.01)":[165,198,241],"thickness":[169],"(VWT,":[170],"0.03),":[173,203],"but":[174,221],"artery":[178],"parameters.":[179],"Compared":[180],"being":[182,205],"uninfected,":[183],"having":[184],"detectable":[185],"viremia":[187],"VWA":[195,217,238,268],"VWT":[200,223,243],"whereas":[204],"undetectable":[208],"0.02)":[220],"0.15).":[226],"There":[227],"an":[229],"independent":[230],"positive":[231],"association":[232],"0.01).":[246],"CONCLUSION:":[247],"burden":[250],"higher":[254],"burden,":[262],"as":[263],"assessed":[264],"by":[265],"VWT.":[270]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2022-10-01T00:00:00"}
