{"id":"https://openalex.org/W4298058382","doi":null,"title":"[Osteoimmunology-overview].","display_name":"[Osteoimmunology-overview].","publication_year":2016,"publication_date":"2016-05-01","ids":{"openalex":"https://openalex.org/W4298058382","pmid":"https://pubmed.ncbi.nlm.nih.gov/27117610"},"language":"ja","primary_location":{"id":"pmid:27117610","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27117610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030763978","display_name":"T. Ono","orcid":"https://orcid.org/0000-0003-2445-4253","observed_orcids":["https://orcid.org/0000-0003-2445-4253"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takehito Ono","raw_affiliation_strings":["Department of Immunology, Graduate School of Medicine and Faculty of Medicine,The University of Tokyo, Japan\uff0eDepartment of Cell Signaling, Graduate School of Medical and Dental Sciences,Tokyo Medical and Dental UnivDepartment of Cell Signaling, Graduate School of Medical and Dental Sciences,Tokyo Medical and Dental University, Japan\uff0eersity, Japan\uff0e"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Graduate School of Medicine and Faculty of Medicine,The University of Tokyo, Japan\uff0eDepartment of Cell Signaling, Graduate School of Medical and Dental Sciences,Tokyo Medical and Dental UnivDepartment of Cell Signaling, Graduate School of Medical and Dental Sciences,Tokyo Medical and Dental University, Japan\uff0eersity, Japan\uff0e","institution_ids":["https://openalex.org/I125602781","https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005463265","display_name":"Hiroshi Takayanagi","orcid":"https://orcid.org/0000-0002-1462-4127","observed_orcids":["https://orcid.org/0000-0002-1462-4127"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Takayanagi","raw_affiliation_strings":["Department of Immunology, Graduate School of Medicine and Faculty of Medicine,The University of Tokyo, Japan\uff0e"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Graduate School of Medicine and Faculty of Medicine,The University of Tokyo, Japan\uff0e","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.128,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.50447644,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"26","issue":"5","first_page":"661","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13328","display_name":"Osteomyelitis and Bone Disorders Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoimmunology","display_name":"osteoimmunology","score":1.0},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.8339999914169312},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.9850000143051147},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8799999952316284},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.9860000014305115},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/inflammatory-bone-destruction","display_name":"inflammatory bone destruction","score":0.8339999914169312},{"id":"https://openalex.org/keywords/bone-disorders","display_name":"bone disease","score":0.421999990940094},{"id":"https://openalex.org/keywords/immune-disorders","display_name":"immune disorders","score":0.8949999809265137}],"concepts":[{"id":"https://openalex.org/C26374806","wikidata":"https://www.wikidata.org/wiki/Q7107616","display_name":"Osteoimmunology","level":5,"score":0.9938378930091858},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6755035519599915},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.6275748014450073},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5363655686378479},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4852421283721924},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.4692632555961609},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.4531385004520416},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.43991369009017944},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.43642663955688477},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.41259095072746277},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.36604803800582886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2714725136756897},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18303552269935608},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.09080031514167786},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06570300459861755},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.0},{"id":"https://openalex.org/C2779428903","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANKL","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:27117610","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27117610","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical calcium","raw_type":"English Abstract"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W41516964","https://openalex.org/W58690323","https://openalex.org/W93053989","https://openalex.org/W1501473386","https://openalex.org/W1547733031","https://openalex.org/W1594144334","https://openalex.org/W2008492357","https://openalex.org/W2014707628","https://openalex.org/W2045562495","https://openalex.org/W2066613071","https://openalex.org/W2098511755","https://openalex.org/W2100604852","https://openalex.org/W2101503666","https://openalex.org/W2105894548","https://openalex.org/W2142099365","https://openalex.org/W2144930991","https://openalex.org/W2150891147","https://openalex.org/W2172421250","https://openalex.org/W2337485820","https://openalex.org/W2409360547","https://openalex.org/W2409679560","https://openalex.org/W2414044484","https://openalex.org/W2508997451","https://openalex.org/W2520211681","https://openalex.org/W2542822064","https://openalex.org/W2769671204","https://openalex.org/W2791309620","https://openalex.org/W2895903821","https://openalex.org/W2909894833","https://openalex.org/W2981617674","https://openalex.org/W2990840371","https://openalex.org/W3016852213","https://openalex.org/W3016940380","https://openalex.org/W3025259451","https://openalex.org/W3028330817","https://openalex.org/W3034225365","https://openalex.org/W3035467903","https://openalex.org/W3036451283","https://openalex.org/W3092541624","https://openalex.org/W3147479802","https://openalex.org/W6776928405"],"related_works":["https://openalex.org/W7141622176","https://openalex.org/W2107540216","https://openalex.org/W7101176785","https://openalex.org/W2396675088","https://openalex.org/W2414098910","https://openalex.org/W2747893584","https://openalex.org/W2794998606","https://openalex.org/W2005350525","https://openalex.org/W3195299324","https://openalex.org/W1994650601"],"abstract_inverted_index":{"Bone":[0,32],"serves":[1],"not":[2],"only":[3],"as":[4,10,19,66],"a":[5,85],"locomotive":[6],"organ":[7,12],"but":[8],"also":[9],"an":[11],"instrumental":[13],"in":[14,80,91,100],"many":[15,39,62],"other":[16],"functions":[17],"such":[18,65,73],"hematopoiesis.":[20],"To":[21],"this":[22],"end,":[23],"bone":[24,78,101],"undergoes":[25],"renewal":[26],"by":[27,38],"sequential":[28],"resorption":[29,33],"and":[30,34,46,52,68,76,102],"formation.":[31],"formation":[35],"are":[36,56],"regulated":[37],"systems":[40,55],"including":[41],"the":[42,44,47,53,96],"endocrine,":[43],"nervous":[45],"immune":[48,54,103],"systems.":[49],"The":[50],"skeletal":[51],"closely":[57],"related":[58],"because":[59],"they":[60],"share":[61],"regulatory":[63],"molecules":[64,75],"cytokines":[67],"transcription":[69],"factors.":[70],"Studies":[71],"on":[72],"shared":[74],"inflammatory":[77],"destruction":[79],"rheumatoid":[81],"arthritis":[82],"have":[83],"fostered":[84],"novel":[86,97],"interdisciplinary":[87],"field,":[88],"\"osteoimmunology\".":[89],"Advances":[90],"osteoimmunology":[92],"may":[93],"lead":[94],"to":[95],"therapeutic":[98],"strategies":[99],"diseases.":[104]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2022-10-01T00:00:00"}