{"id":"https://openalex.org/W4298050817","doi":null,"title":"Expanding the diversity of unnatural cell surface sialic acids","display_name":"Expanding the diversity of unnatural cell surface sialic acids","publication_year":2003,"publication_date":"2003-10-30","ids":{"openalex":"https://openalex.org/W4298050817"},"language":"en","primary_location":{"id":"pmh:oai:osti.gov:839230","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/839230","pdf_url":"https://www.osti.gov/servlets/purl/839230","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.osti.gov/servlets/purl/839230","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038592299","display_name":"Sarah J. Luchansky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luchansky, Sarah J.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057260817","display_name":"Scarlett Goon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Goon, Scarlett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088409133","display_name":"Carolyn Ruth Bertozzi","orcid":"https://orcid.org/0000-0003-4482-2754","observed_orcids":["https://orcid.org/0000-0003-4482-2754"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bertozzi, Carolyn R.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33132022,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.6991999745368958,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.6991999745368958,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.21230000257492065,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.08399999886751175,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolic-oligosaccharide-engineering","display_name":"metabolic oligosaccharide engineering","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cell-surface-glycans","display_name":"cell surface glycans","score":0.7319999933242798},{"id":"https://openalex.org/keywords/n-acetylmannosamine","display_name":"N-acetylmannosamine","score":0.8629999756813049},{"id":"https://openalex.org/keywords/azide-alkyne-cycloaddition","display_name":"azide-alkyne cycloaddition","score":0.6000000238418579},{"id":"https://openalex.org/keywords/staudinger-ligation","display_name":"Staudinger ligation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hydrazide-condensation","display_name":"hydrazide condensation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/sialic-acid-binding-protein","display_name":"sialic acid-binding protein","score":0.8930000066757202}],"concepts":[{"id":"https://openalex.org/C2780115458","wikidata":"https://www.wikidata.org/wiki/Q419311","display_name":"Sialic acid","level":2,"score":0.6749032735824585},{"id":"https://openalex.org/C2781316041","wikidata":"https://www.wikidata.org/wiki/Q1230584","display_name":"Diversity (politics)","level":2,"score":0.6147825121879578},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44285157322883606},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3692786693572998},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3603626489639282},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3348158299922943},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3264056146144867},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2747052311897278},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.10086175799369812},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.08845147490501404}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:osti.gov:839230","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/839230","pdf_url":"https://www.osti.gov/servlets/purl/839230","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:info:ark/67531/metadc779351","doi":null,"is_oa":false,"landing_page_url":"https://digital.library.unt.edu/ark:/67531/metadc779351/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400792","display_name":"University of North Texas Digital Library (University of North Texas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123534392","host_organization_name":"University of North Texas","host_organization_lineage":["https://openalex.org/I123534392"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Submitted to ChemBioChem: Volume 5, No.3; Journal Publication Date: 03/05/2004","raw_type":"Article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt0vr0q6rp","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/0vr0q6rp","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:qt0vr0q6rp","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/0vr0q6rp","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Luchansky, Sarah J.; Goon, Scarlett; &amp; Bertozzi, Carolyn R.(2003). Expanding the diversity of unnatural cell surface sialic acids. Lawrence Berkeley National Laboratory. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/0vr0q6rp","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:osti.gov:839230","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/839230","pdf_url":"https://www.osti.gov/servlets/purl/839230","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320314571","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4298050817.pdf","grobid_xml":"https://content.openalex.org/works/W4298050817.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2110731978","https://openalex.org/W2922766726","https://openalex.org/W1987966136","https://openalex.org/W3103160258","https://openalex.org/W2094284515","https://openalex.org/W2036630880","https://openalex.org/W1974938963","https://openalex.org/W2111007380","https://openalex.org/W2037400245","https://openalex.org/W2061903157"],"abstract_inverted_index":{"Novel":[0],"chemical":[1],"reactivity":[2],"can":[3,93,126],"be":[4,94,127],"introduced":[5],"onto":[6,147],"cell":[7,57,77,165,188,214],"surfaces":[8,166],"through":[9,81],"metabolic":[10],"oligosaccharide":[11],"engineering.":[12],"This":[13],"technique":[14],"exploits":[15],"the":[16,43,48,56,60,82,119,148,180,202],"substrate":[17],"promiscuity":[18],"of":[19,37,62,65,101,160,169,183,204],"cellular":[20,32,44,175],"biosynthetic":[21,45],"enzymes":[22],"to":[23,55,109,164],"deliver":[24],"unnatural":[25],"monosaccharides":[26],"bearing":[27],"bioorthogonal":[28],"functional":[29,124,162],"groups":[30,125,163,172],"into":[31,47,76,96,118,187],"glycans.":[33],"For":[34],"example,":[35],"derivatives":[36,154],"N-acetylmannosamine":[38],"(ManNAc)":[39],"are":[40,71,155],"converted":[41],"by":[42,134,139],"machinery":[46],"corresponding":[49],"sialic":[50,83,152,197,205],"acids":[51],"and":[52,68,74,85,116,138,167,177,200,213],"subsequently":[53],"delivered":[54],"surface":[58,78,189],"in":[59,99,130,207],"form":[61],"sialoglycoconjugates.":[63],"Analogs":[64],"N-acetylglucosamine":[66],"(GlcNAc)":[67],"N-acetylgalactosamine":[69],"(GalNAc)":[70],"also":[72],"metabolized":[73],"incorporated":[75,95],"glycans,":[79],"likely":[80],"acid":[84,153,206],"GalNAc":[86],"salvage":[87],"pathways,":[88],"respectively.":[89],"Furthermore,":[90,179],"GlcNAc":[91],"analogs":[92],"nucleocytoplasmic":[97],"proteins":[98,199],"place":[100],"{beta}-O-GlcNAc":[102],"residues.":[103],"These":[104,123],"pathways":[105],"have":[106],"been":[107],"exploited":[108],"integrate":[110],"unique":[111],"electrophiles":[112],"such":[113,210],"as":[114,211],"ketones":[115],"azides":[117,186],"target":[120],"glycoconjugate":[121],"class.":[122],"further":[128],"elaborated":[129],"a":[131],"chemoselective":[132],"fashion":[133],"condensation":[135],"with":[136],"hydrazides":[137],"Staudinger":[140],"ligation,":[141],"respectively,":[142],"thereby":[143],"introducing":[144],"detectable":[145],"probes":[146],"cell.":[149],"In":[150],"conclusion,":[151],"efficient":[156],"vehicles":[157],"for":[158,195],"delivery":[159],"bulky":[161],"masking":[168],"their":[170,174],"hydroxyl":[171],"improves":[173],"uptake":[176],"utilization.":[178],"successful":[181],"introduction":[182],"photoactivatable":[184],"aryl":[185],"glycans":[190],"opens":[191],"up":[192],"new":[193],"avenues":[194],"studying":[196],"acid-binding":[198],"elucidating":[201],"role":[203],"essential":[208],"processes":[209],"signaling":[212],"adhesion.":[215]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2022-10-01T00:00:00"}
