{"id":"https://openalex.org/W4297986218","doi":"https://doi.org/10.1016/j.annonc.2022.08.037","title":"LBA39 Final 5-year results of the phase II, multicenter, randomized, open-label trial of talimogene laherparepvec (T-VEC) neoadjuvant treatment (Tx) plus surgery vs immediate surgery in patients (pts) with resectable stage IIIB-IVM1a melanoma (MEL)","display_name":"LBA39 Final 5-year results of the phase II, multicenter, randomized, open-label trial of talimogene laherparepvec (T-VEC) neoadjuvant treatment (Tx) plus surgery vs immediate surgery in patients (pts) with resectable stage IIIB-IVM1a melanoma (MEL)","publication_year":2022,"publication_date":"2022-09-01","ids":{"openalex":"https://openalex.org/W4297986218","doi":"https://doi.org/10.1016/j.annonc.2022.08.037"},"language":"en","primary_location":{"id":"doi:10.1016/j.annonc.2022.08.037","doi":"https://doi.org/10.1016/j.annonc.2022.08.037","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2022.08.037","pdf_url":"http://www.annalsofoncology.org/article/S0923753422039151/pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.annalsofoncology.org/article/S0923753422039151/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089297467","display_name":"Reinhard Dummer","orcid":"https://orcid.org/0000-0002-2279-6906","observed_orcids":["https://orcid.org/0000-0002-2279-6906"]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"R. Dummer","raw_affiliation_strings":["Dermatology Department, Universit\u00e4tsspital Z\u00fcrich - Klinik f\u00fcr Dermatologie, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology Department, Universit\u00e4tsspital Z\u00fcrich - Klinik f\u00fcr Dermatologie, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003976494","display_name":"David E. Gyorki","orcid":"https://orcid.org/0000-0002-3165-4694","observed_orcids":["https://orcid.org/0000-0002-3165-4694"]},"institutions":[{"id":"https://openalex.org/I4210158799","display_name":"Olivia Newton-John Cancer Wellness & Research Centre","ror":"https://ror.org/04t908e09","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210158799"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"D. Gyorki","raw_affiliation_strings":["Department of Surgery, Olivia Newton-John Cancer Centre, Heidelberg, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Olivia Newton-John Cancer Centre, Heidelberg, VIC, Australia","institution_ids":["https://openalex.org/I4210158799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002699089","display_name":"John Robert Hyngstrom","orcid":"https://orcid.org/0000-0002-4833-3838","observed_orcids":["https://orcid.org/0000-0002-4833-3838"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Hyngstrom","raw_affiliation_strings":["Department of Surgery, University of Utah Health - Huntsman Cancer Institute, Salt Lake City, UT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Utah Health - Huntsman Cancer Institute, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Berger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Berger","raw_affiliation_strings":["Surgical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA","institution_ids":["https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003787657","display_name":"R. Conry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Conry","raw_affiliation_strings":["Department of Medicine, University of Alabama at Birmingham - School of Medicine, Birmingham, AL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Alabama at Birmingham - School of Medicine, Birmingham, AL, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012502212","display_name":"\u041b\u0435\u0432 \u0412\u0430\u0434\u0438\u043c\u043e\u0432\u0438\u0447 \u0414\u0435\u043c\u0438\u0434\u043e\u0432","orcid":"https://orcid.org/0000-0002-8562-6082","observed_orcids":["https://orcid.org/0000-0002-8562-6082"]},"institutions":[{"id":"https://openalex.org/I4210090957","display_name":"Russian Cancer Research Center NN Blokhin","ror":"https://ror.org/00ab9fg88","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210090957"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"L. Demidov","raw_affiliation_strings":["Medical Oncology Dept., N.N. Blokhin Russian Cancer Research Center, Moscow, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Dept., N.N. Blokhin Russian Cancer Research Center, Moscow, Russian Federation","institution_ids":["https://openalex.org/I4210090957"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L. Ning","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. Ning","raw_affiliation_strings":["Biostatistics, Parexel China Co. Ltd., Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics, Parexel China Co. Ltd., Guangzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"T. Lawrence","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320553840","display_name":"Amgen (United States)","ror":"https://ror.org/03g03ge92","country_code":"US","type":"company","lineage":["https://openalex.org/I1320553840"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Lawrence","raw_affiliation_strings":["Clinical Research, Amgen (Headquarters) - USA, Thousand Oaks, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research, Amgen (Headquarters) - USA, Thousand Oaks, CA, USA","institution_ids":["https://openalex.org/I1320553840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080404941","display_name":"Mark B. Faries","orcid":"https://orcid.org/0000-0003-1752-7282","observed_orcids":["https://orcid.org/0000-0003-1752-7282"]},"institutions":[{"id":"https://openalex.org/I4210104507","display_name":"Angeles Clinic and Research Institute","ror":"https://ror.org/01ct2ab72","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834","https://openalex.org/I4210104507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Faries","raw_affiliation_strings":["Surgical Oncology, The Angeles Clinic and Research Institute, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Oncology, The Angeles Clinic and Research Institute, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I4210104507"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033985974","display_name":"Merrick I. Ross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Ross","raw_affiliation_strings":["Surgical Oncology, MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Oncology, MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4230,"currency":"USD","value_usd":4230},"apc_paid":null,"fwci":0.3109,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.54443294,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":96},"biblio":{"volume":"33","issue":null,"first_page":"S1406","last_page":"S1406"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/talimogene-laherparepvec","display_name":"talimogene laherparepvec","score":0.9959999918937683},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.7020000219345093},{"id":"https://openalex.org/keywords/neoadjuvant-therapy","display_name":"neoadjuvant therapy","score":0.9610000252723694},{"id":"https://openalex.org/keywords/recurrence-free-survival","display_name":"recurrence-free survival","score":0.9679999947547913}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9793792963027954},{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.6099042892456055},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.583797812461853},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5393381714820862},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.5212322473526001},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.5203925371170044},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4744585454463959},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4495670199394226},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.43940412998199463},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4218006730079651},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3662835359573364},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26526033878326416},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.23768579959869385},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.07126972079277039}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.annonc.2022.08.037","doi":"https://doi.org/10.1016/j.annonc.2022.08.037","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2022.08.037","pdf_url":"http://www.annalsofoncology.org/article/S0923753422039151/pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.annonc.2022.08.037","doi":"https://doi.org/10.1016/j.annonc.2022.08.037","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2022.08.037","pdf_url":"http://www.annalsofoncology.org/article/S0923753422039151/pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320308982","display_name":"American Society of Clinical Oncology","ror":"https://ror.org/04fy6j421"},{"id":"https://openalex.org/F4320312902","display_name":"Society for Immunotherapy of Cancer","ror":"https://ror.org/0481e3r23"},{"id":"https://openalex.org/F4320314128","display_name":"Les Laboratories Pierre Fabre","ror":"https://ror.org/04hdhz511"},{"id":"https://openalex.org/F4320322148","display_name":"Eisai","ror":"https://ror.org/04vvh7p27"},{"id":"https://openalex.org/F4320324142","display_name":"European Society for Medical Oncology","ror":"https://ror.org/03xtz2n86"},{"id":"https://openalex.org/F4320328455","display_name":"Ipsen","ror":"https://ror.org/00d801g55"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4297986218.pdf","grobid_xml":"https://content.openalex.org/works/W4297986218.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3201686202","https://openalex.org/W3104348248","https://openalex.org/W1554562956","https://openalex.org/W2588153689","https://openalex.org/W2978452266","https://openalex.org/W2947117185","https://openalex.org/W2891670268","https://openalex.org/W3206505643","https://openalex.org/W4385716123","https://openalex.org/W3088230839"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2022-10-01T00:00:00"}
