{"id":"https://openalex.org/W4297980993","doi":"https://doi.org/10.1021/acsfoodscitech.2c00205","title":"Effect of Carotenes against Oxidative Stress Induced Age-Related Macular Degeneration in Human Retinal Pigment Cells","display_name":"Effect of Carotenes against Oxidative Stress Induced Age-Related Macular Degeneration in Human Retinal Pigment Cells","publication_year":2022,"publication_date":"2022-09-29","ids":{"openalex":"https://openalex.org/W4297980993","doi":"https://doi.org/10.1021/acsfoodscitech.2c00205"},"language":"en","primary_location":{"id":"doi:10.1021/acsfoodscitech.2c00205","doi":"https://doi.org/10.1021/acsfoodscitech.2c00205","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsfoodscitech.2c00205","pdf_url":null,"source":{"id":"https://openalex.org/S4210220491","display_name":"ACS Food Science & Technology","issn_l":"2692-1944","issn":["2692-1944"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Food Science & Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082415312","display_name":"Puvaneswari Meganathan","orcid":"https://orcid.org/0000-0003-3176-4866","observed_orcids":["https://orcid.org/0000-0003-3176-4866"]},"institutions":[{"id":"https://openalex.org/I1322209998","display_name":"Malaysian Palm Oil Board","ror":"https://ror.org/008gwdp12","country_code":"MY","type":"government","lineage":["https://openalex.org/I1322209998"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Puvaneswari Meganathan","raw_affiliation_strings":["Nutrition Unit, Product Development and Advisory Services Division, Malaysian Palm Oil Board, 6, Persiaran Institusi, Bandar Baru Bangi, Kajang, 43000 Selangor, Malaysia"],"raw_orcid":"https://orcid.org/0000-0003-3176-4866","affiliations":[{"raw_affiliation_string":"Nutrition Unit, Product Development and Advisory Services Division, Malaysian Palm Oil Board, 6, Persiaran Institusi, Bandar Baru Bangi, Kajang, 43000 Selangor, Malaysia","institution_ids":["https://openalex.org/I1322209998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034469290","display_name":"Chun\u2010Wai Mai","orcid":"https://orcid.org/0000-0001-6532-184X","observed_orcids":["https://orcid.org/0000-0001-6532-184X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210138900","display_name":"State Key Laboratory of Oncogene and Related Genes","ror":"https://ror.org/03xt1x768","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210138900"]},{"id":"https://openalex.org/I62370553","display_name":"IMU University","ror":"https://ror.org/04d4wjw61","country_code":"MY","type":"education","lineage":["https://openalex.org/I62370553"]}],"countries":["CN","MY"],"is_corresponding":false,"raw_author_name":"Chun-Wai Mai","raw_affiliation_strings":["School of Pharmacy, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Malaysia","State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cells Research Center, Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, International Medical University, 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur 57000, Malaysia","institution_ids":["https://openalex.org/I62370553"]},{"raw_affiliation_string":"State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cells Research Center, Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210138900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050390042","display_name":"Kanga Rani Selvaduray","orcid":"https://orcid.org/0000-0003-1832-3118","observed_orcids":["https://orcid.org/0000-0003-1832-3118"]},"institutions":[{"id":"https://openalex.org/I1322209998","display_name":"Malaysian Palm Oil Board","ror":"https://ror.org/008gwdp12","country_code":"MY","type":"government","lineage":["https://openalex.org/I1322209998"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Kanga Rani Selvaduray","raw_affiliation_strings":["Nutrition Unit, Product Development and Advisory Services Division, Malaysian Palm Oil Board, 6, Persiaran Institusi, Bandar Baru Bangi, Kajang, 43000 Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition Unit, Product Development and Advisory Services Division, Malaysian Palm Oil Board, 6, Persiaran Institusi, Bandar Baru Bangi, Kajang, 43000 Selangor, Malaysia","institution_ids":["https://openalex.org/I1322209998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019389868","display_name":"Zaida Zainal","orcid":"https://orcid.org/0000-0002-4665-8620","observed_orcids":["https://orcid.org/0000-0002-4665-8620"]},"institutions":[{"id":"https://openalex.org/I1322209998","display_name":"Malaysian Palm Oil Board","ror":"https://ror.org/008gwdp12","country_code":"MY","type":"government","lineage":["https://openalex.org/I1322209998"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Zaida Zainal","raw_affiliation_strings":["Nutrition Unit, Product Development and Advisory Services Division, Malaysian Palm Oil Board, 6, Persiaran Institusi, Bandar Baru Bangi, Kajang, 43000 Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition Unit, Product Development and Advisory Services Division, Malaysian Palm Oil Board, 6, Persiaran Institusi, Bandar Baru Bangi, Kajang, 43000 Selangor, Malaysia","institution_ids":["https://openalex.org/I1322209998"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082578606","display_name":"Ju\u2010Yen Fu","orcid":"https://orcid.org/0000-0002-4398-4471","observed_orcids":["https://orcid.org/0000-0002-4398-4471"]},"institutions":[{"id":"https://openalex.org/I1322209998","display_name":"Malaysian Palm Oil Board","ror":"https://ror.org/008gwdp12","country_code":"MY","type":"government","lineage":["https://openalex.org/I1322209998"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Ju-Yen Fu","raw_affiliation_strings":["Nutrition Unit, Product Development and Advisory Services Division, Malaysian Palm Oil Board, 6, Persiaran Institusi, Bandar Baru Bangi, Kajang, 43000 Selangor, Malaysia"],"raw_orcid":"https://orcid.org/0000-0002-4398-4471","affiliations":[{"raw_affiliation_string":"Nutrition Unit, Product Development and Advisory Services Division, Malaysian Palm Oil Board, 6, Persiaran Institusi, Bandar Baru Bangi, Kajang, 43000 Selangor, Malaysia","institution_ids":["https://openalex.org/I1322209998"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5082415312"],"corresponding_institution_ids":["https://openalex.org/I1322209998"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.4328,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.52102213,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"2","issue":"11","first_page":"1719","last_page":"1727"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.030899999663233757,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carotenoids","display_name":"carotenoids","score":0.972000002861023},{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9909999966621399},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9959999918937683},{"id":"https://openalex.org/keywords/retinal-pigment-epithelial-cells","display_name":"retinal pigment epithelial cells","score":0.8650000095367432},{"id":"https://openalex.org/keywords/arpe-19","display_name":"ARPE-19","score":0.875},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.9610000252723694},{"id":"https://openalex.org/keywords/liver-x-receptor","display_name":"liver X receptor","score":0.7310000061988831},{"id":"https://openalex.org/keywords/tissue-inhibitors-of-metalloproteinases","display_name":"tissue inhibitors of metalloproteinases","score":0.7689999938011169},{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.8270000219345093},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5419999957084656},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.6899999976158142},{"id":"https://openalex.org/keywords/gw3965","display_name":"GW3965","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.842955470085144},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6475005149841309},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.5406453609466553},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.46335768699645996},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.43196630477905273},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.42040324211120605},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4037741720676422},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39846014976501465},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3936825096607208},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38460221886634827},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34384506940841675},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29610833525657654},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22051748633384705},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21046647429466248},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acsfoodscitech.2c00205","doi":"https://doi.org/10.1021/acsfoodscitech.2c00205","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsfoodscitech.2c00205","pdf_url":null,"source":{"id":"https://openalex.org/S4210220491","display_name":"ACS Food Science & Technology","issn_l":"2692-1944","issn":["2692-1944"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Food Science & Technology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7911380010","display_name":null,"funder_award_id":"PD 220/16","funder_id":"https://openalex.org/F4320328606","funder_display_name":"Malaysian Palm Oil Board"}],"funders":[{"id":"https://openalex.org/F4320328606","display_name":"Malaysian Palm Oil Board","ror":"https://ror.org/008gwdp12"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1900216307","https://openalex.org/W1965635843","https://openalex.org/W1969187957","https://openalex.org/W1989169565","https://openalex.org/W2003993240","https://openalex.org/W2007973129","https://openalex.org/W2016472313","https://openalex.org/W2037546321","https://openalex.org/W2037555724","https://openalex.org/W2063954678","https://openalex.org/W2077132537","https://openalex.org/W2121824583","https://openalex.org/W2124451840","https://openalex.org/W2154864949","https://openalex.org/W2264799392","https://openalex.org/W2338221729","https://openalex.org/W2419255724","https://openalex.org/W2440667295","https://openalex.org/W2506002793","https://openalex.org/W2518819051","https://openalex.org/W2594844287","https://openalex.org/W2597267452","https://openalex.org/W2598520882","https://openalex.org/W2618328620","https://openalex.org/W2718321691","https://openalex.org/W2740695644","https://openalex.org/W2773213163","https://openalex.org/W2775048539","https://openalex.org/W2781977913","https://openalex.org/W2911730809","https://openalex.org/W2914528331","https://openalex.org/W2922457896","https://openalex.org/W2943995462","https://openalex.org/W2966394869","https://openalex.org/W2977417454","https://openalex.org/W2995438397","https://openalex.org/W2998152569","https://openalex.org/W2999122995","https://openalex.org/W3039077710","https://openalex.org/W3064226249","https://openalex.org/W4205810268","https://openalex.org/W4233698560"],"related_works":["https://openalex.org/W2082892358","https://openalex.org/W3166384928","https://openalex.org/W2130433046","https://openalex.org/W2599273932","https://openalex.org/W2083112901","https://openalex.org/W2682776232","https://openalex.org/W2775048539","https://openalex.org/W2638345336","https://openalex.org/W4298119655","https://openalex.org/W4241240235"],"abstract_inverted_index":{"Oxidative":[0],"stress":[1,292],"is":[2,37],"caused":[3],"by":[4,213,286],"an":[5,42],"imbalance":[6],"between":[7],"accumulation":[8,18],"of":[9,19,67,92,122,172,179,185,259,290],"reactive":[10],"oxygen":[11],"species":[12],"(ROS)":[13],"and":[14,29,97,128,143,170,221,266,293],"their":[15,129,249],"elimination.":[16],"Excessive":[17],"ROS":[20],"leads":[21],"to":[22,118,153,160,163,255],"inflammation":[23],"that":[24,54,227,248,274],"causes":[25],"many":[26],"chronic":[27],"diseases":[28],"accelerates":[30],"the":[31,48,65,120,201,288],"aging":[32],"process.":[33],"A":[34,109],"well-established":[35],"example":[36],"age-related":[38],"macular":[39],"degeneration":[40],"(AMD),":[41],"irreversible":[43],"eye":[44],"condition":[45],"commonly":[46],"affecting":[47],"aged":[49],"population.":[50],"Carotenoids":[51],"are":[52],"antioxidants":[53],"have":[55],"demonstrated":[56],"protective":[57,177,250],"effect":[58,169,178,251],"in":[59,69,73,84,124,188,241,283],"managing":[60,284],"AMD.":[61],"This":[62],"study":[63,115],"determined":[64],"efficacy":[66,121],"carotenes":[68,123,180,204,228,275],"modulating":[70,125,214],"molecular":[71,131],"targets":[72,132],"a":[74,90,235,242,281],"hydrogen":[75],"peroxide":[76],"(H":[77],"2":[78,80,196,198,208,210],"O":[79,197,209],")":[81],"induced":[82,211],"AMD":[83,285],"vitro":[85],"model.":[86],"To":[87],"evaluate":[88,119],"cytotoxicity,":[89],"panel":[91],"17":[93],"human":[94,99],"cancer":[95,156],"cells":[96,103,190],"noncancerous":[98],"retinal":[100],"pigment":[101],"epithelial":[102],"(ARPE-19)":[104],"were":[105,133],"treated":[106],"with":[107,192],"carotenes.":[108],"polymerase":[110],"chain":[111],"reaction":[112],"(PCR)":[113],"array":[114],"was":[116,150,181],"conducted":[117],"oxidative":[126,291],"stress,":[127],"underlying":[130],"also":[134,229],"studied":[135],"using":[136],"bioinformatic":[137],"analyses":[138],"through":[139],"Reactome":[140],"Pathway":[141],"Analysis":[142],"targeted":[144,243],"cell-based":[145,244],"reporter":[146,245],"assays.":[147],"Carotene":[148],"treatment":[149],"found":[151],"neither":[152],"induce":[154],"significant":[155],"cell":[157],"proliferation":[158],"nor":[159],"be":[161,253,277],"cytotoxic":[162],"ARPE-19,":[164],"suggesting":[165,247],"no":[166],"potent":[167],"anticancer":[168],"likelihood":[171],"safe":[173],"therapeutic":[174],"intervention.":[175],"The":[176],"observed":[182],"at":[183],"concentrations":[184],"1.56\u201325":[186],"\u03bcg/mL":[187],"ARPE-19":[189],"challenged":[191],"500":[193],"\u03bcM":[194],"H":[195,207],".":[199,223],"In":[200],"PCR":[202],"array,":[203],"significantly":[205],"reversed":[206],"damage":[212],"several":[215],"key":[216],"genes":[217],"such":[218],"as":[219,233,280],"TIMP":[220],"C5":[222],"We":[224],"further":[225,279],"confirmed":[226],"showed":[230],"similar":[231],"activation":[232],"GW3965,":[234],"synthetic":[236],"agonist":[237],"for":[238],"liver-X-receptor":[239],"(LXR)":[240],"assay,":[246],"could":[252],"related":[254],"LXR":[256],"but":[257],"independent":[258],"p53,":[260],"nuclear":[261],"factor":[262],"kappa":[263],"B":[264],"(NF-\u03baB),":[265],"peroxisome":[267],"proliferator-activated":[268],"receptor-gamma":[269],"(PPAR\u03b3).":[270],"These":[271],"findings":[272],"indicated":[273],"should":[276],"explored":[278],"nutraceutical":[282],"mitigating":[287],"ill-effects":[289],"inflammation.":[294]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-10-01T00:00:00"}