{"id":"https://openalex.org/W4297980262","doi":"https://doi.org/10.1007/978-1-0716-2724-2_16","title":"A Split CRISPR\u2013Cpf1 Platform for Inducible Gene Activation","display_name":"A Split CRISPR\u2013Cpf1 Platform for Inducible Gene Activation","publication_year":2022,"publication_date":"2022-09-29","ids":{"openalex":"https://openalex.org/W4297980262","doi":"https://doi.org/10.1007/978-1-0716-2724-2_16","pmid":"https://pubmed.ncbi.nlm.nih.gov/36173577"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-0716-2724-2_16","doi":"https://doi.org/10.1007/978-1-0716-2724-2_16","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-0716-2724-2_16","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4297969028","display_name":"Epigenomics"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023035803","display_name":"Takahiro Otabe","orcid":"https://orcid.org/0000-0001-7029-1913","observed_orcids":["https://orcid.org/0000-0001-7029-1913"]},"institutions":[{"id":"https://openalex.org/I4405256897","display_name":"Kanagawa Institute of Industrial Science and Technology","ror":"https://ror.org/04n160k30","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405256897"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Otabe","raw_affiliation_strings":["Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan","Kanagawa Institute of Industrial Science and Technology, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Kanagawa Institute of Industrial Science and Technology, Kanagawa, Japan","institution_ids":["https://openalex.org/I4405256897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014528389","display_name":"Yuta Nihongaki","orcid":"https://orcid.org/0000-0002-9818-9344","observed_orcids":["https://orcid.org/0000-0002-9818-9344"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Yuta Nihongaki","raw_affiliation_strings":["Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA","Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan","Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013172910","display_name":"Moritoshi Sato","orcid":"https://orcid.org/0000-0002-3095-5831","observed_orcids":["https://orcid.org/0000-0002-3095-5831"]},"institutions":[{"id":"https://openalex.org/I4405256897","display_name":"Kanagawa Institute of Industrial Science and Technology","ror":"https://ror.org/04n160k30","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405256897"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Moritoshi Sato","raw_affiliation_strings":["Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan. moritoshisato@g.ecc.u-tokyo.ac.jp","Kanagawa Institute of Industrial Science and Technology, Kanagawa, Japan. moritoshisato@g.ecc.u-tokyo.ac.jp","Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan","Kanagawa Institute of Industrial Science and Technology, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan. moritoshisato@g.ecc.u-tokyo.ac.jp","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Kanagawa Institute of Industrial Science and Technology, Kanagawa, Japan. moritoshisato@g.ecc.u-tokyo.ac.jp","institution_ids":["https://openalex.org/I4405256897"]},{"raw_affiliation_string":"Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Kanagawa Institute of Industrial Science and Technology, Kanagawa, Japan","institution_ids":["https://openalex.org/I4405256897"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5013172910"],"corresponding_institution_ids":["https://openalex.org/I4405256897","https://openalex.org/I74801974"],"apc_list":null,"apc_paid":null,"fwci":1.1859,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.72482014,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"2577","issue":null,"first_page":"229","last_page":"240"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crispr-cas12a","display_name":"CRISPR/Cas12a","score":0.9879999756813049},{"id":"https://openalex.org/keywords/optogenetics","display_name":"optogenetics","score":0.8339999914169312},{"id":"https://openalex.org/keywords/rna-guided-endonuclease","display_name":"RNA-guided endonuclease","score":0.8320000171661377},{"id":"https://openalex.org/keywords/mammalian-cells","display_name":"mammalian cells","score":0.7710000276565552},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.924225926399231},{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.693861186504364},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.6900976896286011},{"id":"https://openalex.org/C132455925","wikidata":"https://www.wikidata.org/wiki/Q16965677","display_name":"Cas9","level":4,"score":0.6382502317428589},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5941226482391357},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.5873057246208191},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5671147704124451},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5304445624351501},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5238744616508484},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.49481791257858276},{"id":"https://openalex.org/C2777028655","wikidata":"https://www.wikidata.org/wiki/Q415601","display_name":"Endonuclease","level":3,"score":0.48855432868003845},{"id":"https://openalex.org/C97702854","wikidata":"https://www.wikidata.org/wiki/Q4039747","display_name":"Guide RNA","level":5,"score":0.4462239146232605},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.42245811223983765},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3447113633155823},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.10982620716094971},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05161622166633606}],"mesh":[{"descriptor_ui":"D000072669","descriptor_name":"Gene Editing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004720","descriptor_name":"Endonucleases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004720","descriptor_name":"Endonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008322","descriptor_name":"Mammals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-0716-2724-2_16","doi":"https://doi.org/10.1007/978-1-0716-2724-2_16","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-0716-2724-2_16","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},{"id":"pmid:36173577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36173577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular biology (Clifton, N.J.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1977709885","https://openalex.org/W2063408699","https://openalex.org/W2165869860","https://openalex.org/W2560230043","https://openalex.org/W2765257165","https://openalex.org/W2947574057","https://openalex.org/W2947777875","https://openalex.org/W2968519502","https://openalex.org/W3005113480","https://openalex.org/W3015892555"],"related_works":["https://openalex.org/W2968519502","https://openalex.org/W4394929340","https://openalex.org/W2134288637","https://openalex.org/W2769708729","https://openalex.org/W7162730833","https://openalex.org/W3185424385","https://openalex.org/W3183040693","https://openalex.org/W3046859470","https://openalex.org/W2952898285","https://openalex.org/W2810940962"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-10-01T00:00:00"}
