{"id":"https://openalex.org/W4297977909","doi":"https://doi.org/10.24304/kjcp.2022.32.3.238","title":"Impact of ABCB1 C3435T Polymorphism on Treatment Response of Vitamin K Antagonists: A Systematic Review and Meta-analysis","display_name":"Impact of ABCB1 C3435T Polymorphism on Treatment Response of Vitamin K Antagonists: A Systematic Review and Meta-analysis","publication_year":2022,"publication_date":"2022-09-30","ids":{"openalex":"https://openalex.org/W4297977909","doi":"https://doi.org/10.24304/kjcp.2022.32.3.238"},"language":"en","primary_location":{"id":"doi:10.24304/kjcp.2022.32.3.238","doi":"https://doi.org/10.24304/kjcp.2022.32.3.238","is_oa":true,"landing_page_url":"https://doi.org/10.24304/kjcp.2022.32.3.238","pdf_url":"https://www.ekjcp.org/journal/download_pdf.php?doi=10.24304/kjcp.2022.32.3.238","source":{"id":"https://openalex.org/S4306517643","display_name":"Korean Journal of Clinical Pharmacy","issn_l":"1226-6051","issn":["1226-6051","1975-1869","2508-786X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean Journal of Clinical Pharmacy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.ekjcp.org/journal/download_pdf.php?doi=10.24304/kjcp.2022.32.3.238","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100610701","display_name":"So Yeon Lee","orcid":"https://orcid.org/0000-0002-0109-0998","observed_orcids":["https://orcid.org/0000-0002-0109-0998"]},"institutions":[{"id":"https://openalex.org/I77079311","display_name":"Wonkwang University","ror":"https://ror.org/006776986","country_code":"KR","type":"education","lineage":["https://openalex.org/I77079311"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"So Yeon Lee","raw_affiliation_strings":["College of Pharmacy, Wonkwang University, Iksan 54538, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Wonkwang University, Iksan 54538, Republic of Korea","institution_ids":["https://openalex.org/I77079311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055025410","display_name":"Sook Hee An","orcid":"https://orcid.org/0000-0002-7552-0233","observed_orcids":["https://orcid.org/0000-0002-7552-0233"]},"institutions":[{"id":"https://openalex.org/I77079311","display_name":"Wonkwang University","ror":"https://ror.org/006776986","country_code":"KR","type":"education","lineage":["https://openalex.org/I77079311"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sook Hee An","raw_affiliation_strings":["College of Pharmacy, Wonkwang University, Iksan 54538, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Wonkwang University, Iksan 54538, Republic of Korea","institution_ids":["https://openalex.org/I77079311"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055025410"],"corresponding_institution_ids":["https://openalex.org/I77079311"],"apc_list":null,"apc_paid":null,"fwci":0.0343,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.04041721,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"32","issue":"3","first_page":"238","last_page":"250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abcb1-c3435t-polymorphism","display_name":"ABCB1 C3435T polymorphism","score":0.8960000276565552},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.7950000166893005},{"id":"https://openalex.org/keywords/vitamin-k-antagonists","display_name":"vitamin K antagonists","score":0.9490000009536743},{"id":"https://openalex.org/keywords/warfarin","display_name":"warfarin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/acenocoumarol","display_name":"acenocoumarol","score":1.0},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.6880000233650208},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6159999966621399},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.671999990940094},{"id":"https://openalex.org/keywords/cyp2c9","display_name":"CYP2C9","score":0.699999988079071},{"id":"https://openalex.org/keywords/vkorc1","display_name":"VKORC1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cyp4f2","display_name":"CYP4F2","score":0.8899999856948853},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.5180000066757202},{"id":"https://openalex.org/keywords/international-normalized-ratio","display_name":"international normalized ratio","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.8574525117874146},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.46290549635887146},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44819512963294983},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.4455547332763672},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41769707202911377},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33333683013916016},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.33299678564071655},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2363232672214508},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23100325465202332},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20664876699447632},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.10817015171051025},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09580191969871521},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08845916390419006}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.24304/kjcp.2022.32.3.238","doi":"https://doi.org/10.24304/kjcp.2022.32.3.238","is_oa":true,"landing_page_url":"https://doi.org/10.24304/kjcp.2022.32.3.238","pdf_url":"https://www.ekjcp.org/journal/download_pdf.php?doi=10.24304/kjcp.2022.32.3.238","source":{"id":"https://openalex.org/S4306517643","display_name":"Korean Journal of Clinical Pharmacy","issn_l":"1226-6051","issn":["1226-6051","1975-1869","2508-786X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean Journal of Clinical Pharmacy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.24304/kjcp.2022.32.3.238","doi":"https://doi.org/10.24304/kjcp.2022.32.3.238","is_oa":true,"landing_page_url":"https://doi.org/10.24304/kjcp.2022.32.3.238","pdf_url":"https://www.ekjcp.org/journal/download_pdf.php?doi=10.24304/kjcp.2022.32.3.238","source":{"id":"https://openalex.org/S4306517643","display_name":"Korean Journal of Clinical Pharmacy","issn_l":"1226-6051","issn":["1226-6051","1975-1869","2508-786X"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Korean Journal of Clinical Pharmacy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321310","display_name":"Wonkwang University","ror":"https://ror.org/006776986"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4297977909.pdf","grobid_xml":"https://content.openalex.org/works/W4297977909.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1534181333","https://openalex.org/W1976848577","https://openalex.org/W1978892904","https://openalex.org/W2013047801","https://openalex.org/W2013683506","https://openalex.org/W2016290546","https://openalex.org/W2016318120","https://openalex.org/W2018143722","https://openalex.org/W2018517088","https://openalex.org/W2023052933","https://openalex.org/W2027504487","https://openalex.org/W2048536578","https://openalex.org/W2058864686","https://openalex.org/W2063280109","https://openalex.org/W2066731188","https://openalex.org/W2093626671","https://openalex.org/W2107892767","https://openalex.org/W2114701438","https://openalex.org/W2118654523","https://openalex.org/W2132505348","https://openalex.org/W2141889414","https://openalex.org/W2149454816","https://openalex.org/W2156098321","https://openalex.org/W2156687558","https://openalex.org/W2159907414","https://openalex.org/W2160120733","https://openalex.org/W2165311645","https://openalex.org/W2170892587","https://openalex.org/W2264995213","https://openalex.org/W2332269933","https://openalex.org/W2521448637","https://openalex.org/W2522236038","https://openalex.org/W2586263952","https://openalex.org/W2588108371","https://openalex.org/W2605198076","https://openalex.org/W2735887918","https://openalex.org/W2757691553","https://openalex.org/W2789161402","https://openalex.org/W2790932077","https://openalex.org/W2799550129","https://openalex.org/W2802152541","https://openalex.org/W2808897013","https://openalex.org/W2896426515","https://openalex.org/W2994976464","https://openalex.org/W3014241269","https://openalex.org/W3033261398","https://openalex.org/W4317926563"],"related_works":["https://openalex.org/W2368491491","https://openalex.org/W2245478593","https://openalex.org/W2274090030","https://openalex.org/W2940518457","https://openalex.org/W1686195124","https://openalex.org/W2142503768","https://openalex.org/W2278337446","https://openalex.org/W2772850148","https://openalex.org/W2049580796","https://openalex.org/W2254474753"],"abstract_inverted_index":{"In":[0,201,261],"the":[1,41,99,116,155,183,188,212,222,228,238,251,267,280,294,313,330,341,359,370,390,401,404,409],"United":[2],"States,":[3],"approximately":[4,23],"2.7-6.1":[5],"million":[6,27],"patients":[7,69,74,255,328],"had":[8],"atrial":[9],"fibrillation":[10],"(AF)":[11],"in":[12,300,312,327,338],"2010,":[13],"and":[14,36,68,88,130,133,150,174,198,265,270,307,316,408],"this":[15,113,233,262,301],"number":[16],"is":[17,83,193,397],"expected":[18],"to":[19,22,25,77,92,154,181,203,236,256,283,290,293,356,379,399],"gradually":[20],"increase":[21,115],"5.6":[24],"12":[26],"by":[28,140,196],"2050.1,2)":[29],"The":[30,230,382],"vitamin":[31,166,257],"K":[32,167,258],"antagonists":[33,259],"(VKAs),":[34],"warfarin":[35,184,323],"acenocoumarol,":[37],"are":[38,75,123,138,179],"prescribed":[39,55],"for":[40,56,85,276,279],"treatment":[42,252,288],"or":[43,48,66,80,98,120,333],"prophylaxis":[44],"of":[45,64,118,136,191,225,232,240,254,305,322,363,394,412],"embolic":[46],"AF":[47],"deep":[49],"vein":[50],"thrombosis":[51],"(DVT).Warfarin":[52],"was":[53,235,324,365,386],"commonly":[54],"older":[57],"individuals,":[58],"those":[59,339],"with":[60,70,127,329,340,369,389],"a":[61,105],"high":[62],"risk":[63,117],"stroke":[65],"bleeding,":[67],"many":[71],"comorbidities.3)":[72],"These":[73],"likely":[76],"have":[78,104,209],"drugdisorder":[79],"drug-drug":[81],"interactions.It":[82],"necessary":[84],"patient":[86,141],"safety":[87],"personal":[89],"medication":[90],"therapy":[91],"regularly":[93],"monitor":[94],"prothrombin":[95],"time":[96],"(PT)":[97],"international":[100],"normalized":[101],"ratio":[102],"(INR).VKAs":[103],"narrow":[106],"therapeutic":[107],"range":[108,114],"and,":[109],"therefore,":[110],"levels":[111],"outside":[112],"thromboem-bolism":[119],"bleeding":[121,413],"incidences.VKAs":[122],"drugs":[124],"that":[125,211,286],"interact":[126],"various":[128],"medications":[129],"foods":[131],"[4][5][6]":[132],"maintenance":[134,189,223,320,361,392],"doses":[135],"VKAs":[137,291],"affected":[139,195],"age,":[142],"7)":[143],"body":[144],"weight,":[145],"8)":[146],"clinical":[147],"conditions,":[148],"9,10)":[149],"genetic":[151],"factors.8,11)":[152],"According":[153],"Clinical":[156],"Pharmacogenetics":[157],"Implementation":[158],"Consortium":[159],"(CPIC)":[160],"guidelines,":[161],"cytochrome":[162,175],"P450":[163,176],"2C9":[164],"(CYP2C9),":[165],"epoxide":[168],"reductase":[169],"complex":[170],"subunit":[171],"1":[172,218,246],"(VKORC1),":[173],"4F2":[177],"(CYP4F2)":[178],"known":[180],"influence":[182],"dosing":[185],"algorithm.11)":[186],"Similarly,":[187],"dose":[190,224,321,362,393],"acenocoumarol":[192,364],"also":[194],"VKORC1":[197],"CYP2C9":[199],"genes.12)":[200],"addition":[202],"these":[204],"well-known":[205],"genes,":[206],"recent":[207],"studies":[208],"suggested":[210],"ATP-binding":[213,241],"cassette":[214,242],"subfamily":[215,243],"B":[216,244],"member":[217,245],"(ABCB1)":[219,247],"gene":[220],"affects":[221],"VKAs;":[226],"however,":[227],"ABSTRACTObjective:":[229],"aim":[231],"study":[234],"examine":[237],"impact":[239],"C3435T":[248,296,372,384,406],"polymorphism":[249,297,335,373,385,407],"on":[250],"response":[253,289],"(VKAs).Methods:":[260],"systematic":[263,314],"review":[264,315],"metaanalysis,":[266],"PubMed/Medline,":[268],"Embase,":[269],"Cochrane":[271],"Library":[272],"databases":[273],"were":[274,298,310],"searched":[275],"eligible":[277],"articles":[278,309],"period":[281],"up":[282],"November":[284],"2020.Articles":[285],"reported":[287],"according":[292],"ABCB1":[295,331,342,371,383,405],"included":[299,311],"study.Results:":[302],"A":[303],"total":[304],"13":[306],"9":[308],"meta-analysis,":[317],"respectively.The":[318],"weekly":[319,360,391],"significantly":[325,367,387],"lower":[326],"3435CT":[332],"TT":[334],"type":[336,344],"than":[337],"3435CC":[343],"(weighted":[345],"mean":[346],"difference":[347],"[WMD],":[348],"-2.53":[349],"mg/week;":[350],"95%":[351,376],"confidence":[352],"interval":[353],"[CI],":[354],"-3.64":[355],"-1.43,":[357],"p<0.001).However,":[358],"not":[366],"associated":[368,388],"(WMD,":[374],"1.02;":[375],"CI,":[377],"-0.61":[378],"2.65,":[380],"p=0.22).Conclusion:":[381],"warfarin.Further":[395],"research":[396],"needed":[398],"confirm":[400],"association":[402],"between":[403],"incidence":[410],"rate":[411],"events.":[414]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-10-01T00:00:00"}