{"id":"https://openalex.org/W4297965441","doi":"https://doi.org/10.1007/s00204-022-03379-y","title":"Towards the mechanism of spermatotoxicity of p-tert-butyl-alpha-methylhydrocinnamic aldehyde: inhibition of late stage ex-vivo spermatogenesis in rat seminiferous tubule cultures by para-tert-butyl- benzoic acid","display_name":"Towards the mechanism of spermatotoxicity of p-tert-butyl-alpha-methylhydrocinnamic aldehyde: inhibition of late stage ex-vivo spermatogenesis in rat seminiferous tubule cultures by para-tert-butyl- benzoic acid","publication_year":2022,"publication_date":"2022-09-29","ids":{"openalex":"https://openalex.org/W4297965441","doi":"https://doi.org/10.1007/s00204-022-03379-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/36173422"},"language":"en","primary_location":{"id":"doi:10.1007/s00204-022-03379-y","doi":"https://doi.org/10.1007/s00204-022-03379-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00204-022-03379-y","pdf_url":null,"source":{"id":"https://openalex.org/S87018847","display_name":"Archives of Toxicology","issn_l":"0340-5761","issn":["0340-5761","1432-0738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072176743","display_name":"Lars Hareng","orcid":"https://orcid.org/0000-0002-8539-9035","observed_orcids":["https://orcid.org/0000-0002-8539-9035"]},"institutions":[{"id":"https://openalex.org/I4210107087","display_name":"BASF (Germany)","ror":"https://ror.org/01q8f6705","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107087"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Lars Hareng","raw_affiliation_strings":["Product Safety, Regulations, Toxicology and Ecology, BASF SE, Z470, 67056, Ludwigshafen, Germany. lars.hareng@basf.com","Product Safety, Regulations, Toxicology and Ecology, BASF SE, Z470, 67056, Ludwigshafen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8539-9035","affiliations":[{"raw_affiliation_string":"Product Safety, Regulations, Toxicology and Ecology, BASF SE, Z470, 67056, Ludwigshafen, Germany. lars.hareng@basf.com","institution_ids":["https://openalex.org/I4210107087"]},{"raw_affiliation_string":"Product Safety, Regulations, Toxicology and Ecology, BASF SE, Z470, 67056, Ludwigshafen, Germany","institution_ids":["https://openalex.org/I4210107087"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Paul Schuster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107087","display_name":"BASF (Germany)","ror":"https://ror.org/01q8f6705","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107087"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Paul Schuster","raw_affiliation_strings":["BASF SE, Lampertheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BASF SE, Lampertheim, Germany","institution_ids":["https://openalex.org/I4210107087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072109120","display_name":"Volker Haake","orcid":"https://orcid.org/0000-0001-7124-6727","observed_orcids":["https://orcid.org/0000-0001-7124-6727"]},"institutions":[{"id":"https://openalex.org/I4210107087","display_name":"BASF (Germany)","ror":"https://ror.org/01q8f6705","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107087"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Volker Haake","raw_affiliation_strings":["BASF Metabolome Solutions GmbH, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BASF Metabolome Solutions GmbH, Berlin, Germany","institution_ids":["https://openalex.org/I4210107087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077557407","display_name":"Tilman Walk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107087","display_name":"BASF (Germany)","ror":"https://ror.org/01q8f6705","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107087"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tilman Walk","raw_affiliation_strings":["BASF Metabolome Solutions GmbH, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BASF Metabolome Solutions GmbH, Berlin, Germany","institution_ids":["https://openalex.org/I4210107087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067184222","display_name":"Michael J. Herold","orcid":"https://orcid.org/0000-0001-7733-0196","observed_orcids":["https://orcid.org/0000-0001-7733-0196"]},"institutions":[{"id":"https://openalex.org/I4210107087","display_name":"BASF (Germany)","ror":"https://ror.org/01q8f6705","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107087"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Herold","raw_affiliation_strings":["BASF Metabolome Solutions GmbH, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BASF Metabolome Solutions GmbH, Berlin, Germany","institution_ids":["https://openalex.org/I4210107087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078520106","display_name":"Heike Laue","orcid":"https://orcid.org/0000-0001-8923-7802","observed_orcids":["https://orcid.org/0000-0001-8923-7802"]},"institutions":[{"id":"https://openalex.org/I2800326226","display_name":"Givaudan (Switzerland)","ror":"https://ror.org/012ddpd05","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800326226"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Heike Laue","raw_affiliation_strings":["Fragrances S&T, Ingredients Research, Givaudan Schweiz AG, 8310, Kemptthal, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fragrances S&T, Ingredients Research, Givaudan Schweiz AG, 8310, Kemptthal, Switzerland","institution_ids":["https://openalex.org/I2800326226"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023479712","display_name":"Andreas Natsch","orcid":"https://orcid.org/0000-0003-2231-2489","observed_orcids":["https://orcid.org/0000-0003-2231-2489"]},"institutions":[{"id":"https://openalex.org/I2800326226","display_name":"Givaudan (Switzerland)","ror":"https://ror.org/012ddpd05","country_code":"CH","type":"company","lineage":["https://openalex.org/I2800326226"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Andreas Natsch","raw_affiliation_strings":["Fragrances S&T, Ingredients Research, Givaudan Schweiz AG, 8310, Kemptthal, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fragrances S&T, Ingredients Research, Givaudan Schweiz AG, 8310, Kemptthal, Switzerland","institution_ids":["https://openalex.org/I2800326226"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5072176743"],"corresponding_institution_ids":["https://openalex.org/I4210107087"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.788,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.66294095,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":96},"biblio":{"volume":"97","issue":"1","first_page":"279","last_page":"294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.010300000198185444,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spermatotoxicity","display_name":"spermatotoxicity","score":0.9179999828338623},{"id":"https://openalex.org/keywords/spermatogenesis-suppression","display_name":"spermatogenesis inhibition","score":0.7889999747276306},{"id":"https://openalex.org/keywords/blood-testis-barrier","display_name":"blood-testis barrier","score":0.8519999980926514},{"id":"https://openalex.org/keywords/metabolomics","display_name":"metabolomics","score":0.6660000085830688},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.6840000152587891},{"id":"https://openalex.org/keywords/redox-metabolism","display_name":"redox metabolism","score":0.6769999861717224},{"id":"https://openalex.org/keywords/male-reproductive-toxicity","display_name":"male reproductive toxicity","score":0.7689999938011169},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5695468783378601},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5165780782699585},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.49880051612854004},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.496069997549057},{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.49042651057243347},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4267335534095764},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.42026567459106445},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.4120102524757385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35187047719955444},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3360673785209656},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2449110746383667},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2344111204147339},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06319946050643921}],"mesh":[{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012671","descriptor_name":"Seminiferous Tubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013091","descriptor_name":"Spermatogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019817","descriptor_name":"Benzoic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019817","descriptor_name":"Benzoic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00204-022-03379-y","doi":"https://doi.org/10.1007/s00204-022-03379-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00204-022-03379-y","pdf_url":null,"source":{"id":"https://openalex.org/S87018847","display_name":"Archives of Toxicology","issn_l":"0340-5761","issn":["0340-5761","1432-0738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Toxicology","raw_type":"journal-article"},{"id":"pmid:36173422","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36173422","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307790","display_name":"BASF","ror":"https://ror.org/01q8f6705"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1967081895","https://openalex.org/W1968942294","https://openalex.org/W1990531193","https://openalex.org/W2006667778","https://openalex.org/W2030295813","https://openalex.org/W2055890190","https://openalex.org/W2060932321","https://openalex.org/W2093103082","https://openalex.org/W2121561326","https://openalex.org/W2136702712","https://openalex.org/W2289657943","https://openalex.org/W2319811175","https://openalex.org/W2520519965","https://openalex.org/W2620615807","https://openalex.org/W2751613048","https://openalex.org/W2759884959","https://openalex.org/W2883396602","https://openalex.org/W3093353405","https://openalex.org/W3185197933"],"related_works":["https://openalex.org/W2078975791","https://openalex.org/W3093353405","https://openalex.org/W2751613048","https://openalex.org/W1987730602","https://openalex.org/W2043565175","https://openalex.org/W4214647004","https://openalex.org/W2072097036","https://openalex.org/W3159031703","https://openalex.org/W2987708549","https://openalex.org/W7097700137"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-10-01T00:00:00"}