{"id":"https://openalex.org/W4297965077","doi":"https://doi.org/10.1242/jcs.259900","title":"S. mediterranea ETS-1 regulates the function of cathepsin-positive cells and the epidermal lineage landscape via basement membrane remodeling","display_name":"S. mediterranea ETS-1 regulates the function of cathepsin-positive cells and the epidermal lineage landscape via basement membrane remodeling","publication_year":2022,"publication_date":"2022-09-29","ids":{"openalex":"https://openalex.org/W4297965077","doi":"https://doi.org/10.1242/jcs.259900","pmid":"https://pubmed.ncbi.nlm.nih.gov/36172824"},"language":"en","primary_location":{"id":"doi:10.1242/jcs.259900","doi":"https://doi.org/10.1242/jcs.259900","is_oa":true,"landing_page_url":"https://doi.org/10.1242/jcs.259900","pdf_url":"https://journals.biologists.com/jcs/article-pdf/135/20/jcs259900/2198996/jcs259900.pdf","source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://journals.biologists.com/jcs/article-pdf/135/20/jcs259900/2198996/jcs259900.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028524578","display_name":"Vinay Kumar Dubey","orcid":"https://orcid.org/0000-0001-9978-2126","observed_orcids":["https://orcid.org/0000-0001-9978-2126"]},"institutions":[{"id":"https://openalex.org/I164861460","display_name":"Manipal Academy of Higher Education","ror":"https://ror.org/02xzytt36","country_code":"IN","type":"education","lineage":["https://openalex.org/I164861460"]},{"id":"https://openalex.org/I4210087873","display_name":"Institute for Stem Cell Biology and Regenerative Medicine","ror":"https://ror.org/007wpch15","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I3141573830","https://openalex.org/I4210087873","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vinay Kumar Dubey","raw_affiliation_strings":["Integrative Chemical Biology (ICB), Institute for Stem Cell Science and Regenerative Medicine (inStem) 1 , Bengaluru 560065 , India","Manipal Academy of Higher Education 2 , Manipal 576104 , India"],"raw_orcid":"https://orcid.org/0000-0001-9978-2126","affiliations":[{"raw_affiliation_string":"Integrative Chemical Biology (ICB), Institute for Stem Cell Science and Regenerative Medicine (inStem) 1 , Bengaluru 560065 , India","institution_ids":["https://openalex.org/I4210087873"]},{"raw_affiliation_string":"Manipal Academy of Higher Education 2 , Manipal 576104 , India","institution_ids":["https://openalex.org/I164861460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060219187","display_name":"Souradeep R. Sarkar","orcid":"https://orcid.org/0000-0002-5037-855X","observed_orcids":["https://orcid.org/0000-0002-5037-855X"]},"institutions":[{"id":"https://openalex.org/I11947397","display_name":"Tata Institute of Fundamental Research","ror":"https://ror.org/03ht1xw27","country_code":"IN","type":"education","lineage":["https://openalex.org/I11947397","https://openalex.org/I2799351866","https://openalex.org/I3149292468"]},{"id":"https://openalex.org/I194223965","display_name":"National Centre for Biological Sciences","ror":"https://ror.org/03gf8rp76","country_code":"IN","type":"facility","lineage":["https://openalex.org/I11947397","https://openalex.org/I194223965","https://openalex.org/I2799351866","https://openalex.org/I3149292468"]},{"id":"https://openalex.org/I4210087873","display_name":"Institute for Stem Cell Biology and Regenerative Medicine","ror":"https://ror.org/007wpch15","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I3141573830","https://openalex.org/I4210087873","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Souradeep R. Sarkar","raw_affiliation_strings":["Integrative Chemical Biology (ICB), Institute for Stem Cell Science and Regenerative Medicine (inStem) 1 , Bengaluru 560065 , India","National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research (TIFR) 3 , Bengaluru 560065 , India"],"raw_orcid":"https://orcid.org/0000-0002-5037-855X","affiliations":[{"raw_affiliation_string":"Integrative Chemical Biology (ICB), Institute for Stem Cell Science and Regenerative Medicine (inStem) 1 , Bengaluru 560065 , India","institution_ids":["https://openalex.org/I4210087873"]},{"raw_affiliation_string":"National Centre for Biological Sciences (NCBS), Tata Institute of Fundamental Research (TIFR) 3 , Bengaluru 560065 , India","institution_ids":["https://openalex.org/I11947397","https://openalex.org/I194223965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017135196","display_name":"Vairavan Lakshmanan","orcid":"https://orcid.org/0000-0001-9468-9571","observed_orcids":["https://orcid.org/0000-0001-9468-9571"]},"institutions":[{"id":"https://openalex.org/I4210087873","display_name":"Institute for Stem Cell Biology and Regenerative Medicine","ror":"https://ror.org/007wpch15","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I3141573830","https://openalex.org/I4210087873","https://openalex.org/I4210134808"]},{"id":"https://openalex.org/I932239252","display_name":"SASTRA University","ror":"https://ror.org/032jk8892","country_code":"IN","type":"education","lineage":["https://openalex.org/I932239252"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vairavan Lakshmanan","raw_affiliation_strings":["Integrative Chemical Biology (ICB), Institute for Stem Cell Science and Regenerative Medicine (inStem) 1 , Bengaluru 560065 , India","SASTRA University 4 , Thanjavur 613401 , India"],"raw_orcid":"https://orcid.org/0000-0001-9468-9571","affiliations":[{"raw_affiliation_string":"Integrative Chemical Biology (ICB), Institute for Stem Cell Science and Regenerative Medicine (inStem) 1 , Bengaluru 560065 , India","institution_ids":["https://openalex.org/I4210087873"]},{"raw_affiliation_string":"SASTRA University 4 , Thanjavur 613401 , India","institution_ids":["https://openalex.org/I932239252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014638845","display_name":"Rimple Dalmeida","orcid":"https://orcid.org/0009-0006-7614-9137","observed_orcids":["https://orcid.org/0009-0006-7614-9137"]},"institutions":[{"id":"https://openalex.org/I4210087873","display_name":"Institute for Stem Cell Biology and Regenerative Medicine","ror":"https://ror.org/007wpch15","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I3141573830","https://openalex.org/I4210087873","https://openalex.org/I4210134808"]},{"id":"https://openalex.org/I932239252","display_name":"SASTRA University","ror":"https://ror.org/032jk8892","country_code":"IN","type":"education","lineage":["https://openalex.org/I932239252"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rimple Dalmeida","raw_affiliation_strings":["Integrative Chemical Biology (ICB), Institute for Stem Cell Science and Regenerative Medicine (inStem) 1 , Bengaluru 560065 , India","SASTRA University 4 , Thanjavur 613401 , India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrative Chemical Biology (ICB), Institute for Stem Cell Science and Regenerative Medicine (inStem) 1 , Bengaluru 560065 , India","institution_ids":["https://openalex.org/I4210087873"]},{"raw_affiliation_string":"SASTRA University 4 , Thanjavur 613401 , India","institution_ids":["https://openalex.org/I932239252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018986182","display_name":"Akash Gulyani","orcid":"https://orcid.org/0000-0003-4130-4257","observed_orcids":["https://orcid.org/0000-0003-4130-4257"]},"institutions":[{"id":"https://openalex.org/I36893310","display_name":"University of Hyderabad","ror":"https://ror.org/04a7rxb17","country_code":"IN","type":"education","lineage":["https://openalex.org/I36893310"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Akash Gulyani","raw_affiliation_strings":["School of Life Sciences, University of Hyderabad 5 Department of Biochemistry , , Hyderabad , India"],"raw_orcid":"https://orcid.org/0000-0003-4130-4257","affiliations":[{"raw_affiliation_string":"School of Life Sciences, University of Hyderabad 5 Department of Biochemistry , , Hyderabad , India","institution_ids":["https://openalex.org/I36893310"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072304496","display_name":"Dasaradhi Palakodeti","orcid":"https://orcid.org/0000-0003-2219-4785","observed_orcids":["https://orcid.org/0000-0003-2219-4785"]},"institutions":[{"id":"https://openalex.org/I4210087873","display_name":"Institute for Stem Cell Biology and Regenerative Medicine","ror":"https://ror.org/007wpch15","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I3141573830","https://openalex.org/I4210087873","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Dasaradhi Palakodeti","raw_affiliation_strings":["Integrative Chemical Biology (ICB), Institute for Stem Cell Science and Regenerative Medicine (inStem) 1 , Bengaluru 560065 , India"],"raw_orcid":"https://orcid.org/0000-0003-2219-4785","affiliations":[{"raw_affiliation_string":"Integrative Chemical Biology (ICB), Institute for Stem Cell Science and Regenerative Medicine (inStem) 1 , Bengaluru 560065 , India","institution_ids":["https://openalex.org/I4210087873"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5072304496"],"corresponding_institution_ids":["https://openalex.org/I4210087873"],"apc_list":null,"apc_paid":null,"fwci":0.5841,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.55322066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"135","issue":"20","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12789","display_name":"Planarian Biology and Electrostimulation","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12789","display_name":"Planarian Biology and Electrostimulation","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ets-1-transcription-factor","display_name":"Ets-1 transcription factor","score":0.906000018119812},{"id":"https://openalex.org/keywords/schmidtea-mediterranea","display_name":"Schmidtea mediterranea","score":0.8389999866485596},{"id":"https://openalex.org/keywords/tricladida","display_name":"Tricladida","score":0.4779999852180481},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.8659999966621399},{"id":"https://openalex.org/keywords/basement-membrane-thickness","display_name":"basement membrane thickness","score":0.8379999995231628},{"id":"https://openalex.org/keywords/epidermal-progenitors","display_name":"epidermal progenitors","score":0.859000027179718},{"id":"https://openalex.org/keywords/stem-cell-niche","display_name":"stem cell niche","score":0.871999979019165},{"id":"https://openalex.org/keywords/stem-cell-migration","display_name":"stem cell migration","score":0.6079999804496765},{"id":"https://openalex.org/keywords/tissue-homeostasis","display_name":"tissue homeostasis","score":0.7540000081062317},{"id":"https://openalex.org/keywords/regeneration","display_name":"regeneration","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8695433139801025},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.8180787563323975},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.675032377243042},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6046682000160217},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5967670679092407},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.5762178301811218},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.4790026843547821}],"mesh":[{"descriptor_ui":"D000086222","descriptor_name":"Mediterranea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001485","descriptor_name":"Basement Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010932","descriptor_name":"Planarians","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020782","descriptor_name":"Matrix Metalloproteinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1242/jcs.259900","doi":"https://doi.org/10.1242/jcs.259900","is_oa":true,"landing_page_url":"https://doi.org/10.1242/jcs.259900","pdf_url":"https://journals.biologists.com/jcs/article-pdf/135/20/jcs259900/2198996/jcs259900.pdf","source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},{"id":"pmid:36172824","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36172824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cell science","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1242/jcs.259900","doi":"https://doi.org/10.1242/jcs.259900","is_oa":true,"landing_page_url":"https://doi.org/10.1242/jcs.259900","pdf_url":"https://journals.biologists.com/jcs/article-pdf/135/20/jcs259900/2198996/jcs259900.pdf","source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309507","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42"},{"id":"https://openalex.org/F4320312037","display_name":"Children's Investment Fund Foundation","ror":"https://ror.org/00jfgrn87"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320335065","display_name":"National Centre for Biological Sciences","ror":"https://ror.org/03gf8rp76"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4297965077.pdf","grobid_xml":"https://content.openalex.org/works/W4297965077.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1488829562","https://openalex.org/W1502528873","https://openalex.org/W1584346353","https://openalex.org/W1947892036","https://openalex.org/W1965498876","https://openalex.org/W1966846295","https://openalex.org/W1975244827","https://openalex.org/W1978053309","https://openalex.org/W1980325398","https://openalex.org/W1986260964","https://openalex.org/W2006628284","https://openalex.org/W2008124611","https://openalex.org/W2017874888","https://openalex.org/W2025404424","https://openalex.org/W2026300944","https://openalex.org/W2041871675","https://openalex.org/W2045295282","https://openalex.org/W2050991236","https://openalex.org/W2053002126","https://openalex.org/W2065269485","https://openalex.org/W2071359561","https://openalex.org/W2073612966","https://openalex.org/W2073663498","https://openalex.org/W2074658822","https://openalex.org/W2076186971","https://openalex.org/W2077265707","https://openalex.org/W2081165140","https://openalex.org/W2081453778","https://openalex.org/W2082516919","https://openalex.org/W2088711064","https://openalex.org/W2089083573","https://openalex.org/W2094784156","https://openalex.org/W2100305481","https://openalex.org/W2102278945","https://openalex.org/W2111086936","https://openalex.org/W2123106337","https://openalex.org/W2130255071","https://openalex.org/W2130410032","https://openalex.org/W2131271579","https://openalex.org/W2139320982","https://openalex.org/W2141458291","https://openalex.org/W2152773911","https://openalex.org/W2166820820","https://openalex.org/W2168056522","https://openalex.org/W2328310528","https://openalex.org/W2462053388","https://openalex.org/W2769811696","https://openalex.org/W2770845723","https://openalex.org/W2785060806","https://openalex.org/W2790536428","https://openalex.org/W2794480084","https://openalex.org/W2799796757","https://openalex.org/W2895493535","https://openalex.org/W2900048527","https://openalex.org/W2901453315","https://openalex.org/W2930367636","https://openalex.org/W2932319579","https://openalex.org/W2949177718","https://openalex.org/W2953909068","https://openalex.org/W3007940209","https://openalex.org/W3092007298","https://openalex.org/W3140182938","https://openalex.org/W3153804619","https://openalex.org/W4225408985","https://openalex.org/W4230096730","https://openalex.org/W6688101732"],"related_works":["https://openalex.org/W3007940209","https://openalex.org/W7055390430","https://openalex.org/W2471917135","https://openalex.org/W3109445906","https://openalex.org/W2905452871","https://openalex.org/W3153804619","https://openalex.org/W2794902534","https://openalex.org/W1975244827","https://openalex.org/W1964083927","https://openalex.org/W4415223732"],"abstract_inverted_index":{"Extracellular":[0],"matrix":[1,20],"(ECM)":[2],"is":[3,60,90],"an":[4,190],"important":[5],"component":[6],"of":[7,12,38,53,71,128,135,141,148,160,173,197,201],"stem":[8,28,43,99,142],"cell":[9,29,44,65,143,164],"niche.":[10],"Remodeling":[11],"ECM":[13,16,39,73,174],"mediated":[14],"by":[15],"regulators,":[17],"such":[18],"as":[19,94],"metalloproteinases":[21],"(MMPs)":[22],"plays":[23],"a":[24,95,152],"vital":[25],"role":[26,52,172],"in":[27,41,62,67,132,138,162,176,182],"function.":[30],"However,":[31],"the":[32,36,42,51,54,63,69,72,83,87,106,120,129,133,146,170,183,198,202],"mechanisms":[33],"that":[34,105,126],"modulate":[35],"function":[37],"regulators":[40],"niche":[45,96],"are":[46],"understudied.":[47],"Here,":[48],"we":[49],"explored":[50],"transcription":[55],"factor":[56],"(TF)":[57],"ETS-1,":[58],"which":[59],"expressed":[61],"cathepsin-positive":[64],"population,":[66],"regulating":[68,177],"expression":[70,161],"regulator,":[74],"mt-mmpA,":[75],"thereby":[76],"modulating":[77],"basement":[78,84,130],"membrane":[79,85,131],"thickness.":[80],"In":[81],"planarians,":[82],"around":[86],"gut/inner":[88],"parenchyma":[89],"thought":[91],"to":[92,118,151],"act":[93],"for":[97],"pluripotent":[98],"cells.":[100],"It":[101],"has":[102,189],"been":[103],"shown":[104],"early":[107],"epidermal":[108,154],"progenitors":[109],"migrate":[110],"outwards":[111],"from":[112],"this":[113],"region":[114],"and":[115,180],"progressively":[116],"differentiate":[117],"maintain":[119],"terminal":[121],"epidermis.":[122],"Our":[123],"data":[124],"shows":[125],"thickening":[127],"absence":[134,147],"ets-1":[136,149],"results":[137,168],"defective":[139,153],"migration":[140],"progeny.":[144],"Furthermore,":[145],"leads":[150],"progenitor":[155],"landscape,":[156],"despite":[157],"its":[158],"lack":[159],"those":[163],"types.":[165],"Together,":[166],"our":[167],"demonstrate":[169],"active":[171],"remodeling":[175],"tissue":[178],"homeostasis":[179],"regeneration":[181],"planarian":[184],"Schmidtea":[185],"mediterranea.":[186],"This":[187],"article":[188],"associated":[191],"First":[192],"Person":[193],"interview":[194],"with":[195],"one":[196],"co-first":[199],"authors":[200],"paper.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-10-01T00:00:00"}
