{"id":"https://openalex.org/W4297946293","doi":"https://doi.org/10.1016/j.esmoop.2022.100589","title":"A phase I/II study of arfolitixorin and 5-fluorouracil in combination with oxaliplatin (plus or minus bevacizumab) or irinotecan in metastatic colorectal cancer","display_name":"A phase I/II study of arfolitixorin and 5-fluorouracil in combination with oxaliplatin (plus or minus bevacizumab) or irinotecan in metastatic colorectal cancer","publication_year":2022,"publication_date":"2022-09-29","ids":{"openalex":"https://openalex.org/W4297946293","doi":"https://doi.org/10.1016/j.esmoop.2022.100589","pmid":"https://pubmed.ncbi.nlm.nih.gov/36183444","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9588906"},"language":"en","primary_location":{"id":"doi:10.1016/j.esmoop.2022.100589","doi":"https://doi.org/10.1016/j.esmoop.2022.100589","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.esmoop.2022.100589","pdf_url":null,"source":{"id":"https://openalex.org/S4210217024","display_name":"ESMO Open","issn_l":"2059-7029","issn":["2059-7029"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO Open","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.esmoop.2022.100589","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109205336","display_name":"Goran Ulf Carlsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"G. Carlsson","raw_affiliation_strings":["Department of Surgery, University of Gothenburg, Sahlgrenska University Hospital/\u00d6stra Institute of Clinical Sciences, Gothenburg, Sweden. Electronic address: goran.u.carlsson@vgregion.se","Department of Surgery, University of Gothenburg, Sahlgrenska University Hospital/\u00d6stra Institute of Clinical Sciences, Gothenburg, Sweden;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Gothenburg, Sahlgrenska University Hospital/\u00d6stra Institute of Clinical Sciences, Gothenburg, Sweden. Electronic address: goran.u.carlsson@vgregion.se","institution_ids":["https://openalex.org/I2801112325","https://openalex.org/I881427289"]},{"raw_affiliation_string":"Department of Surgery, University of Gothenburg, Sahlgrenska University Hospital/\u00d6stra Institute of Clinical Sciences, Gothenburg, Sweden;","institution_ids":["https://openalex.org/I2801112325","https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086594420","display_name":"Anna A. Koumarianou","orcid":"https://orcid.org/0000-0002-4159-2511","observed_orcids":["https://orcid.org/0000-0002-4159-2511"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210140282","display_name":"University General Hospital Attikon","ror":"https://ror.org/03gb7n667","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140282"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"A. Koumarianou","raw_affiliation_strings":["Hematology Oncology Unit, Fourth Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Oncology Unit, Fourth Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210140282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071850607","display_name":"Tormod Kyrre Guren","orcid":"https://orcid.org/0000-0001-6471-2072","observed_orcids":["https://orcid.org/0000-0001-6471-2072"]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"T.K. Guren","raw_affiliation_strings":["Department of Oncology, Oslo University Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Oslo University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013842044","display_name":"Johan Haux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142379","display_name":"Skaraborg Hospital","ror":"https://ror.org/040m2wv49","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210142379"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"J. Haux","raw_affiliation_strings":["Department of Surgery, Skaraborg Hospital, Sk\u00f6vde, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Skaraborg Hospital, Sk\u00f6vde, Sweden","institution_ids":["https://openalex.org/I4210142379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057702347","display_name":"Panagiotis Katsaounis","orcid":"https://orcid.org/0000-0003-3778-5705","observed_orcids":["https://orcid.org/0000-0003-3778-5705"]},"institutions":[{"id":"https://openalex.org/I4210150697","display_name":"Metropolitan Hospital","ror":"https://ror.org/05a3efx98","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210150697"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"P. Katsaounis","raw_affiliation_strings":["Oncology Department, Metropolitan General Hospital, Athens, Greece","Oncology Department, Metropolitan General Hospital, Athens;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department, Metropolitan General Hospital, Athens, Greece","institution_ids":["https://openalex.org/I4210150697"]},{"raw_affiliation_string":"Oncology Department, Metropolitan General Hospital, Athens;","institution_ids":["https://openalex.org/I4210150697"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087963010","display_name":"Nikolaos K. Kentepozidis","orcid":"https://orcid.org/0000-0002-6037-5707","observed_orcids":["https://orcid.org/0000-0002-6037-5707"]},"institutions":[{"id":"https://openalex.org/I2802113776","display_name":"Hellenic Air Force","ror":"https://ror.org/044xk2674","country_code":"GR","type":"government","lineage":["https://openalex.org/I2802113776"]},{"id":"https://openalex.org/I4210102619","display_name":"Hellenic Airforce General Hospital","ror":"https://ror.org/0169n7f49","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210102619"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"N. Kentepozidis","raw_affiliation_strings":["Department of Medical Oncology, 251 General Air Force Hospital, Athens, Greece","Department of Medical Oncology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, 251 General Air Force Hospital, Athens, Greece","institution_ids":["https://openalex.org/I2802113776","https://openalex.org/I4210102619"]},{"raw_affiliation_string":"Department of Medical Oncology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068848511","display_name":"Per Pfeiffer","orcid":"https://orcid.org/0000-0002-2925-0586","observed_orcids":["https://orcid.org/0000-0002-2925-0586"]},"institutions":[{"id":"https://openalex.org/I2801498763","display_name":"Odense University Hospital","ror":"https://ror.org/00ey0ed83","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801498763"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"P. Pfeiffer","raw_affiliation_strings":["Experimental Research in Medical Cancer Therapy, Odense University Hospital, Odense, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Research in Medical Cancer Therapy, Odense University Hospital, Odense, Denmark","institution_ids":["https://openalex.org/I2801498763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068135845","display_name":"Morten Br\u00e6ndengen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"M. Br\u00e6ndengen","raw_affiliation_strings":["Department of Oncology, Oslo University Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Oslo University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113317981","display_name":"D. Mavroudis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138654","display_name":"University Hospital of Heraklion","ror":"https://ror.org/0312m2266","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210138654"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"D. Mavroudis","raw_affiliation_strings":["Department of Medical Oncology, University Hospital of Heraklion, Heraklion, Crete, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, University Hospital of Heraklion, Heraklion, Crete, Greece","institution_ids":["https://openalex.org/I4210138654"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013118398","display_name":"Helena Anna Taflin","orcid":"https://orcid.org/0000-0002-8795-5250","observed_orcids":["https://orcid.org/0000-0002-8795-5250"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"H. Taflin","raw_affiliation_strings":["Department of Transplant Surgery, The Institute of Clinical Sciences, The Sahlgrenska Academy At University of Gothenburg, Gothenburg, Sweden","Department of Transplant Surgery, The Institute of Clinical Sciences, The Sahlgrenska Academy At University of Gothenburg, Gothenburg;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Transplant Surgery, The Institute of Clinical Sciences, The Sahlgrenska Academy At University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"Department of Transplant Surgery, The Institute of Clinical Sciences, The Sahlgrenska Academy At University of Gothenburg, Gothenburg;","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028974841","display_name":"L. Skintemo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097377","display_name":"Isofol (Sweden)","ror":"https://ror.org/00v70n302","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210097377"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"L. Skintemo","raw_affiliation_strings":["Isofol Medical AB, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Isofol Medical AB, Gothenburg, Sweden","institution_ids":["https://openalex.org/I4210097377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063054956","display_name":"Roger Tell","orcid":"https://orcid.org/0009-0005-6723-8499","observed_orcids":["https://orcid.org/0009-0005-6723-8499"]},"institutions":[{"id":"https://openalex.org/I4210097377","display_name":"Isofol (Sweden)","ror":"https://ror.org/00v70n302","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210097377"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"R. Tell","raw_affiliation_strings":["Isofol Medical AB, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Isofol Medical AB, Gothenburg, Sweden","institution_ids":["https://openalex.org/I4210097377"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056643910","display_name":"CHRISTOS A. PAPADIMITRIOU","orcid":"https://orcid.org/0000-0001-8084-0445","observed_orcids":["https://orcid.org/0000-0001-8084-0445"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210119545","display_name":"Aretaeio Hospital","ror":"https://ror.org/02qvqb543","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210119545"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"C. Papadimitriou","raw_affiliation_strings":["Oncology Unit, 'Aretaieion' University Hospital, National and Kapodistrian University of Athens, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Unit, 'Aretaieion' University Hospital, National and Kapodistrian University of Athens, Athens, Greece","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210119545"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5109205336"],"corresponding_institution_ids":["https://openalex.org/I2801112325","https://openalex.org/I881427289"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.2244,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.44948263,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"7","issue":"5","first_page":"100589","last_page":"100589"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9660000205039978},{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":0.9330000281333923},{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":0.9440000057220459},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/folate-pathway","display_name":"folate pathway","score":0.6470000147819519},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7739999890327454},{"id":"https://openalex.org/keywords/drug-accumulation","display_name":"drug accumulation","score":0.5320000052452087},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.4580000042915344},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.9431171417236328},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.931729793548584},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.9294625520706177},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.8174740672111511},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7921866178512573},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7120552659034729},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5601476430892944},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.503600537776947},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4431106448173523},{"id":"https://openalex.org/C2779682216","wikidata":"https://www.wikidata.org/wiki/Q419964","display_name":"Camptothecin","level":2,"score":0.41684022545814514},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.28434425592422485},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2787132263183594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08218541741371155},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000077146","descriptor_name":"Irinotecan","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.esmoop.2022.100589","doi":"https://doi.org/10.1016/j.esmoop.2022.100589","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.esmoop.2022.100589","pdf_url":null,"source":{"id":"https://openalex.org/S4210217024","display_name":"ESMO Open","issn_l":"2059-7029","issn":["2059-7029"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO Open","raw_type":"journal-article"},{"id":"pmid:36183444","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36183444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO open","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:pubmedcentral.nih.gov:9588906","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9588906/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO Open","raw_type":"Text"},{"id":"pmh:oai:sdu.dk:openaire/010d37fe-8ce8-43bb-ba27-a68b0fa53cdf","doi":null,"is_oa":true,"landing_page_url":"https://portal.findresearcher.sdu.dk/da/publications/010d37fe-8ce8-43bb-ba27-a68b0fa53cdf","pdf_url":"https://findresearcher.sdu.dk/ws/files/211347124/PIIS2059702922002198.pdf","source":{"id":"https://openalex.org/S4306400423","display_name":"University of Southern Denmark Research Portal (University of Southern Denmark)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177969490","host_organization_name":"University of Southern Denmark","host_organization_lineage":["https://openalex.org/I177969490"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Carlsson, G, Koumarianou, A, Guren, T K, Haux, J, Katsaounis, P, Kentepozidis, N, Pfeiffer, P, Br\u00e6ndengen, M, Mavroudis, D, Taflin, H, Skintemo, L, Tell, R & Papadimitriou, C 2022, 'A phase I/II study of arfolitixorin and 5-fluorouracil in combination with oxaliplatin (plus or minus bevacizumab) or irinotecan in metastatic colorectal cancer', ESMO Open, vol. 7, no. 5, 100589. https://doi.org/10.1016/j.esmoop.2022.100589","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.esmoop.2022.100589","doi":"https://doi.org/10.1016/j.esmoop.2022.100589","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.esmoop.2022.100589","pdf_url":null,"source":{"id":"https://openalex.org/S4210217024","display_name":"ESMO Open","issn_l":"2059-7029","issn":["2059-7029"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ESMO Open","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320328455","display_name":"Ipsen","ror":"https://ror.org/00d801g55"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4297946293.pdf","grobid_xml":"https://content.openalex.org/works/W4297946293.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1847455118","https://openalex.org/W1870066362","https://openalex.org/W1878265365","https://openalex.org/W2015445088","https://openalex.org/W2019659352","https://openalex.org/W2021009641","https://openalex.org/W2024506932","https://openalex.org/W2024835273","https://openalex.org/W2038325346","https://openalex.org/W2049266649","https://openalex.org/W2060189595","https://openalex.org/W2069218108","https://openalex.org/W2095317176","https://openalex.org/W2103789431","https://openalex.org/W2116781863","https://openalex.org/W2121368761","https://openalex.org/W2123133140","https://openalex.org/W2128447158","https://openalex.org/W2129255527","https://openalex.org/W2135521008","https://openalex.org/W2139002359","https://openalex.org/W2150985317","https://openalex.org/W2162313061","https://openalex.org/W2165385913","https://openalex.org/W2171232394","https://openalex.org/W2274948752","https://openalex.org/W2314927739","https://openalex.org/W2406010272","https://openalex.org/W2408898492","https://openalex.org/W2470575266","https://openalex.org/W2487599183","https://openalex.org/W2712978371","https://openalex.org/W2749315192","https://openalex.org/W2797024694","https://openalex.org/W2891768209","https://openalex.org/W2938918172","https://openalex.org/W2953093090","https://openalex.org/W2954841318","https://openalex.org/W2980963825","https://openalex.org/W3009139795","https://openalex.org/W3009963727","https://openalex.org/W3035470988","https://openalex.org/W3094350544","https://openalex.org/W3130224122","https://openalex.org/W6714214455"],"related_works":["https://openalex.org/W2977476690","https://openalex.org/W3004551912","https://openalex.org/W7154734371","https://openalex.org/W7122502437","https://openalex.org/W3125419748","https://openalex.org/W2898297936","https://openalex.org/W4389436951","https://openalex.org/W4412479946","https://openalex.org/W3158549255","https://openalex.org/W4404536312"],"abstract_inverted_index":{"BACKGROUND:":[0],"5-fluorouracil":[1],"(5-FU)":[2],"combined":[3],"with":[4,42,66,72,152],"a":[5,29,128],"folate":[6,20,44,154],"remains":[7],"an":[8,50],"essential":[9],"treatment":[10,148],"component":[11],"for":[12,104,137],"metastatic":[13],"colorectal":[14],"cancer":[15],"(mCRC).":[16],"Leucovorin":[17],"is":[18,49,127,135],"the":[19,144],"most":[21],"often":[22],"used,":[23],"but":[24],"requires":[25],"intracellular":[26],"conversion":[27],"to":[28,146,171],"reduced":[30],"folate,":[31,55],"and":[32,37,58,85,90,109,119,142],"has":[33,143],"high":[34],"pharmacokinetic":[35,114],"variability":[36],"limited":[38],"bioavailability":[39],"in":[40,70,140,150],"patients":[41,151],"low":[43,153],"pathway":[45,155],"gene":[46,156],"expression.":[47,157],"Arfolitixorin":[48,126,158],"immediately":[51],"active":[52],"form":[53],"of":[54,96,131,166],"[6R]-5,10-methylenetetrahydrofolate":[56],"([6R]-MTHF),":[57],"may":[59],"improve":[60,147],"outcomes.":[61],"PATIENTS":[62],"AND":[63],"METHODS:":[64],"intravenous)":[65],"5-FU":[67,132],"alone,":[68],"or":[69,75,78],"combination":[71],"oxaliplatin":[73],"(plus":[74],"minus":[76],"bevacizumab)":[77],"irinotecan,":[79],"every":[80],"14":[81],"days.":[82],"Safety,":[83],"efficacy,":[84],"pharmacokinetics":[86],"were":[87,111],"assessed":[88],"before":[89],"after":[91],"four":[92],"cycles":[93],"(8":[94],"weeks)":[95],"treatment.":[97],"RESULTS:":[98],".":[99],"No":[100],"accumulation":[101],"was":[102],"observed":[103],"[6R]-MTHF":[105],"following":[106],"repeated":[107],"administration,":[108],"there":[110],"no":[112],"major":[113],"differences":[115],"between":[116],"cycle":[117,120],"1":[118],"4":[121],"at":[122],"any":[123],"dose.":[124],"CONCLUSIONS:":[125],"well-tolerated":[129],"moderator":[130],"activity.":[133],"It":[134],"suitable":[136],"further":[138],"investigation":[139],"mCRC":[141],"potential":[145],"outcomes":[149],"can":[159],"easily":[160],"be":[161],"incorporated":[162],"into":[163],"current":[164],"standard":[165],"care,":[167],"requiring":[168],"minimal":[169],"changes":[170],"chemotherapy":[172],"regimens.":[173]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-10-01T00:00:00"}
