{"id":"https://openalex.org/W4297916829","doi":"https://doi.org/10.1161/hyp.79.suppl_1.p236","title":"Abstract P236: Role Of Axl In Target Organ Inflammation And Damage Due To Hypertensive Aortic Remodeling","display_name":"Abstract P236: Role Of Axl In Target Organ Inflammation And Damage Due To Hypertensive Aortic Remodeling","publication_year":2022,"publication_date":"2022-09-01","ids":{"openalex":"https://openalex.org/W4297916829","doi":"https://doi.org/10.1161/hyp.79.suppl_1.p236"},"language":"en","primary_location":{"id":"doi:10.1161/hyp.79.suppl_1.p236","doi":"https://doi.org/10.1161/hyp.79.suppl_1.p236","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hyp.79.suppl_1.p236","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100344323","display_name":"Wei Chen","orcid":"https://orcid.org/0000-0001-7196-8703","observed_orcids":["https://orcid.org/0000-0001-7196-8703"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Chen","raw_affiliation_strings":["Vanderbilt Univ Med Cntr, Nashville, TN","Wei Chen Vanderbilt Univ Med Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ Med Cntr, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Wei Chen Vanderbilt Univ Med Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027910137","display_name":"Justin Pieter Van Beusecum","orcid":"https://orcid.org/0000-0002-9265-9915","observed_orcids":["https://orcid.org/0000-0002-9265-9915"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin P Van Beusecum","raw_affiliation_strings":["MUSC, Charleston, SC","Justin P Van Beusecum MUSC, Charleston, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MUSC, Charleston, SC","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Justin P Van Beusecum MUSC, Charleston, SC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077190393","display_name":"Liang Xiao","orcid":"https://orcid.org/0000-0003-0312-7149","observed_orcids":["https://orcid.org/0000-0003-0312-7149"]},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Xiao","raw_affiliation_strings":["Kidney Disease Cntr, the First Affiliated Hosp, College of Medicine, Zhejiang Univ, Zhejiang Province, P.R.China, Zhejiang Province, China","Liang Xiao Kidney Disease Cntr, the First Affiliated Hosp, College of Medicine, Zhejiang Univ, Zhejiang Province, P.R.China, Zhejiang Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kidney Disease Cntr, the First Affiliated Hosp, College of Medicine, Zhejiang Univ, Zhejiang Province, P.R.China, Zhejiang Province, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Liang Xiao Kidney Disease Cntr, the First Affiliated Hosp, College of Medicine, Zhejiang Univ, Zhejiang Province, P.R.China, Zhejiang Province, China","institution_ids":["https://openalex.org/I4210166576","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066501041","display_name":"David M. Patrick","orcid":"https://orcid.org/0000-0002-3412-447X","observed_orcids":["https://orcid.org/0000-0002-3412-447X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Patrick","raw_affiliation_strings":["Nashville, TN","David Patrick Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nashville, TN","institution_ids":[]},{"raw_affiliation_string":"David Patrick Nashville, TN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042507935","display_name":"Mingfang Ao","orcid":"https://orcid.org/0000-0002-3639-8546","observed_orcids":["https://orcid.org/0000-0002-3639-8546"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mingfang Ao","raw_affiliation_strings":["Vanderbilt Univ medical Cente, Nashville, TN","Mingfang Ao Vanderbilt Univ medical Cente, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ medical Cente, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Mingfang Ao Vanderbilt Univ medical Cente, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084130453","display_name":"Shilin Zhao","orcid":"https://orcid.org/0000-0002-3921-3965","observed_orcids":["https://orcid.org/0000-0002-3921-3965"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shilin Zhao","raw_affiliation_strings":["VANDERBILT Univ Med Cntr, Nashville, TN","Shilin Zhao VANDERBILT Univ Med Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"VANDERBILT Univ Med Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]},{"raw_affiliation_string":"Shilin Zhao VANDERBILT Univ Med Cntr, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051546366","display_name":"Cristina Cavinato","orcid":"https://orcid.org/0000-0002-6021-8920","observed_orcids":["https://orcid.org/0000-0002-6021-8920"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina Cavinato","raw_affiliation_strings":["Yale Univ, New Haven, CT","Cristina Cavinato Yale Univ, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Univ, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Cristina Cavinato Yale Univ, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063840145","display_name":"Alexander W. Caulk","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander W Caulk","raw_affiliation_strings":["Medtronic, New Haven, CT","Alexander W Caulk Medtronic, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medtronic, New Haven, CT","institution_ids":[]},{"raw_affiliation_string":"Alexander W Caulk Medtronic, New Haven, CT","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014180482","display_name":"Jay D. Humphrey","orcid":"https://orcid.org/0000-0003-1011-2025","observed_orcids":["https://orcid.org/0000-0003-1011-2025"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay D Humphrey","raw_affiliation_strings":["Yale Univ, New Haven, CT","Jay D Humphrey Yale Univ, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Univ, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Jay D Humphrey Yale Univ, New Haven, CT","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011627807","display_name":"David Glenn Harrison","orcid":"https://orcid.org/0000-0001-9363-6451","observed_orcids":["https://orcid.org/0000-0001-9363-6451"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David G Harrison","raw_affiliation_strings":["Vanderbilt Univ Med Cntr, Nashville, TN","David G Harrison Vanderbilt Univ Med Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ Med Cntr, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"David G Harrison Vanderbilt Univ Med Cntr, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.46000000834465027,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.46000000834465027,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.35569998621940613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.09719999879598618,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/axl-receptor","display_name":"AXL receptor","score":0.7549999952316284},{"id":"https://openalex.org/keywords/gas6","display_name":"Gas6","score":0.7940000295639038},{"id":"https://openalex.org/keywords/aortic-remodeling","display_name":"aortic remodeling","score":0.8230000138282776},{"id":"https://openalex.org/keywords/renal-inflammation","display_name":"renal inflammation","score":0.621999979019165},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.7609999775886536},{"id":"https://openalex.org/keywords/r428","display_name":"R428","score":0.7820000052452087},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.8669999837875366},{"id":"https://openalex.org/keywords/monocyte-activation","display_name":"monocyte activation","score":0.6899999976158142},{"id":"https://openalex.org/keywords/t-cell-infiltration","display_name":"T cell infiltration","score":0.8320000171661377},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9409999847412109},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.47099998593330383},{"id":"https://openalex.org/keywords/windkessel-function","display_name":"Windkessel function","score":0.593999981880188},{"id":"https://openalex.org/keywords/target-organ-damage","display_name":"target organ damage","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6707342267036438},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6617839336395264},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5261832475662231},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49835729598999023},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.46692368388175964},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.4198509752750397},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2344350814819336}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/hyp.79.suppl_1.p236","doi":"https://doi.org/10.1161/hyp.79.suppl_1.p236","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hyp.79.suppl_1.p236","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4295076178","https://openalex.org/W3203413613","https://openalex.org/W3197921053","https://openalex.org/W2884251740","https://openalex.org/W2015404887","https://openalex.org/W2141221536","https://openalex.org/W1979753043","https://openalex.org/W2064050311","https://openalex.org/W3017730646","https://openalex.org/W2087167227"],"abstract_inverted_index":{"Background:":[0],"Aortic":[1],"remodeling":[2,137,204],"enhances":[3],"arterial":[4],"pulsatility":[5],"in":[6,108,183],"the":[7,72,122],"microcirculation":[8],"and":[9,33,40,43,52,71,79,110,144,153,172,191,209],"we":[10],"have":[11],"shown":[12],"that":[13,86,218],"excessive":[14],"endothelial":[15],"stretch":[16],"increases":[17,206],"release":[18],"of":[19,83,147,185,199,211,237],"Growth":[20],"Arrest":[21],"Specific":[22],"6":[23,89],"(GAS6),":[24],"which":[25,205],"activates":[26],"Axl":[27,123,207,222],"on":[28,135],"monocytes":[29,212],"causing":[30],"immune":[31],"activation":[32],"inflammation.":[34],"Hypothesis:":[35],"GAS6/Axl":[36],"blockade":[37,223],"reduces":[38],"renal":[39,45,145,164,174],"vascular":[41],"inflammation":[42],"lessens":[44],"dysfunction":[46],"caused":[47],"by":[48,115,157,194],"aortic":[49,136,143,203],"remodeling.":[50],"Methods":[51],"Results:":[53],"Three":[54],"month":[55],"old":[56],"male":[57],"C57Bl/6":[58],"mice":[59,186],"received":[60],"osmotic":[61],"minipumps":[62],"containing":[63],"vehicle":[64],"or":[65],"ang":[66,92,130],"II":[67,131],"for":[68,88],"2":[69,127,138],"weeks":[70],"pumps":[73],"removed.":[74],"Aortas":[75],"demonstrated":[76],"increased":[77],"collagen":[78],"an":[80,235],"80%":[81],"loss":[82],"Windkessel":[84],"function":[85,95],"persisted":[87],"months":[90,128,139],"following":[91],"II.":[93],"Renal":[94],"studies":[96],"showed":[97],"reduced":[98,142,170,193],"ability":[99],"to":[100,189,213,230],"excrete":[101],"a":[102,105,227],"volume":[103],"load,":[104],"progressive":[106],"increase":[107],"albuminuria":[109],"tubular":[111,175],"damage":[112,233],"as":[113,155,226],"estimated":[114],"Periodic":[116],"Acid":[117],"Schiff":[118],"staining.":[119],"Treatment":[120],"with":[121],"inhibitor":[124],"R428":[125,161],"beginning":[126],"after":[129,234],"had":[132],"minimal":[133],"effect":[134],"later,":[140],"but":[141],"infiltration":[146],"T":[148,151,220],"cells,":[149],"gamma/delta":[150],"cells":[152,217],"macrophages":[154],"measured":[156],"flow":[158],"cytometry":[159],"(Figure).":[160],"also":[162],"improved":[163],"excretory":[165],"capacity,":[166],"decreased":[167],"urinary":[168],"NGAL,":[169],"albuminuria,":[171],"attenuated":[173],"damage.":[176],"Interestingly,":[177],"macrophage/T":[178],"cell":[179],"complexes":[180],"were":[181,192],"present":[182],"aortas":[184],"previously":[187],"exposed":[188],"hypertension,":[190],"R428.":[195],"Conclusion:":[196],"Brief":[197],"episodes":[198],"hypertension":[200],"induce":[201],"chronic":[202],"signaling":[208],"transformation":[210],"inflammatory":[214],"antigen":[215],"presenting":[216],"activate":[219],"cells.":[221],"might":[224],"serve":[225],"therapeutic":[228],"option":[229],"improve":[231],"end-organ":[232],"episode":[236],"hypertension.":[238]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2022-10-01T00:00:00"}
