{"id":"https://openalex.org/W4297900532","doi":"https://doi.org/10.3389/fendo.2022.903085","title":"Case Report: Composite pheochromocytoma with ganglioneuroma component: A report of three cases","display_name":"Case Report: Composite pheochromocytoma with ganglioneuroma component: A report of three cases","publication_year":2022,"publication_date":"2022-09-14","ids":{"openalex":"https://openalex.org/W4297900532","doi":"https://doi.org/10.3389/fendo.2022.903085","pmid":"https://pubmed.ncbi.nlm.nih.gov/36187102","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9515550"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2022.903085","doi":"https://doi.org/10.3389/fendo.2022.903085","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2022.903085","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2022.903085/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fendo.2022.903085/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112559455","display_name":"Paula Bruna Ara\u00fajo","orcid":"https://orcid.org/0000-0001-5393-9386","observed_orcids":["https://orcid.org/0000-0001-5393-9386"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]},{"id":"https://openalex.org/I4387156159","display_name":"DASA (Brazil)","ror":"https://ror.org/05ht9bp04","country_code":"BR","type":"company","lineage":["https://openalex.org/I4387156159"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Paula B. Araujo","raw_affiliation_strings":["Medical Board of Clinical Analysis Department, Dasa, Rio de Janeiro, Brazil","Medical School, Endocrine Service, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Board of Clinical Analysis Department, Dasa, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4387156159"]},{"raw_affiliation_string":"Medical School, Endocrine Service, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090812101","display_name":"Mirna Sanchez Carvallo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mirna S. Carvallo","raw_affiliation_strings":["Medical School, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109312367","display_name":"Ana Paula Vidal","orcid":"https://orcid.org/0009-0002-9724-8696","observed_orcids":["https://orcid.org/0009-0002-9724-8696"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]},{"id":"https://openalex.org/I4210138087","display_name":"Hospital Universit\u00e1rio Clementino Fraga Filho","ror":"https://ror.org/04pznag94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210138087"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana P. Vidal","raw_affiliation_strings":["Pathology Service Clementino Fraga Filho University Hospital, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Service Clementino Fraga Filho University Hospital, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I122140584","https://openalex.org/I4210138087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039010255","display_name":"Jo\u00e3o Bosco Nascimento","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o B. Nascimento","raw_affiliation_strings":["Medical School, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004007818","display_name":"Julia Mey Lin Wo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Julia M. Wo","raw_affiliation_strings":["Medical School, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078045756","display_name":"Erika O. Naliato","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erika O. Naliato","raw_affiliation_strings":["Ricardo Castilho Center of Studies Teresopolis Medical Association, Teresopolis, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ricardo Castilho Center of Studies Teresopolis Medical Association, Teresopolis, Rio de Janeiro, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082392343","display_name":"S\u00edlvio Henriques da Cunha Neto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]},{"id":"https://openalex.org/I4210138087","display_name":"Hospital Universit\u00e1rio Clementino Fraga Filho","ror":"https://ror.org/04pznag94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210138087"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Silvio H. Cunha Neto","raw_affiliation_strings":["Endocrine Surgery Service, Hospital Universitario Clementino Fraga Filho, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Surgery Service, Hospital Universitario Clementino Fraga Filho, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I122140584","https://openalex.org/I4210138087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050264575","display_name":"Fl\u00e1via L\u00facia Concei\u00e7\u00e3o","orcid":"https://orcid.org/0000-0002-4977-4379","observed_orcids":["https://orcid.org/0000-0002-4977-4379","https://orcid.org/0000-0002-8554-9830"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]},{"id":"https://openalex.org/I4210138087","display_name":"Hospital Universit\u00e1rio Clementino Fraga Filho","ror":"https://ror.org/04pznag94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210138087"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Flavia L. Concei\u00e7\u00e3o","raw_affiliation_strings":["Medical School, Endocrinology Unit, Hospital Universitario Clementino Fraga Filho, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School, Endocrinology Unit, Hospital Universitario Clementino Fraga Filho, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I122140584","https://openalex.org/I4210138087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044971915","display_name":"Rosita Gomes Fontes","orcid":"https://orcid.org/0000-0002-2628-0886","observed_orcids":["https://orcid.org/0000-0002-2628-0886"]},"institutions":[{"id":"https://openalex.org/I4387156159","display_name":"DASA (Brazil)","ror":"https://ror.org/05ht9bp04","country_code":"BR","type":"company","lineage":["https://openalex.org/I4387156159"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rosita Fontes","raw_affiliation_strings":["Medical Board of Clinical Analysis Department, Dasa, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Board of Clinical Analysis Department, Dasa, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I4387156159"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026490228","display_name":"Vinicius V. de Lima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vinicius V. de Lima","raw_affiliation_strings":["Laboratorio de Fisiologia Endocrina Doris Rosenthal, Instituto de Biof\u00edsica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Fisiologia Endocrina Doris Rosenthal, Instituto de Biof\u00edsica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078141626","display_name":"Denise Pires de Carvalho","orcid":"https://orcid.org/0000-0001-6933-6424","observed_orcids":["https://orcid.org/0000-0001-6933-6424"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Denise P. Carvalho","raw_affiliation_strings":["Laboratorio de Fisiologia Endocrina Doris Rosenthal, Instituto de Biof\u00edsica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Fisiologia Endocrina Doris Rosenthal, Instituto de Biof\u00edsica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063696842","display_name":"Paula Soares","orcid":"https://orcid.org/0000-0001-9607-6998","observed_orcids":["https://orcid.org/0000-0001-9607-6998"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Paula Soares","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal","Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal","Institute of Research and Innovation in Health of the University do Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"Institute of Research and Innovation in Health of the University do Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042372238","display_name":"Jorge Pereira Lima","orcid":"https://orcid.org/0000-0001-7780-0901","observed_orcids":["https://orcid.org/0000-0001-7780-0901"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jorge Lima","raw_affiliation_strings":["Department of Medicine, Faculty of Medicine, University of Porto, Porto, Portugal","Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal","Institute of Research and Innovation in Health of the University do Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Faculty of Medicine, University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"Institute of Research and Innovation in Health of the University do Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088500248","display_name":"Delmar Muniz Louren\u00e7o","orcid":"https://orcid.org/0000-0003-1147-4159","observed_orcids":["https://orcid.org/0000-0003-1147-4159"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210088998","display_name":"Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo","ror":"https://ror.org/005vqqr19","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210088998"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Delmar M. Louren\u00e7o","raw_affiliation_strings":["Endocrine Genetic Unit, Endocrinology Division, Hospital das Cl\u00ednicas, University of Sao Paulo School of Medicine, University of Sao Paulo, S\u00e3o Paulo, Brazil","Endocrine Oncology Division, Institute of Cancer of the State of Sao Paulo, University of Sao Paulo School of Medicine, University of Sao Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Genetic Unit, Endocrinology Division, Hospital das Cl\u00ednicas, University of Sao Paulo School of Medicine, University of Sao Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]},{"raw_affiliation_string":"Endocrine Oncology Division, Institute of Cancer of the State of Sao Paulo, University of Sao Paulo School of Medicine, University of Sao Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210088998"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040978542","display_name":"A Violante","orcid":"https://orcid.org/0000-0001-8721-501X","observed_orcids":["https://orcid.org/0000-0001-8721-501X"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]},{"id":"https://openalex.org/I4210138087","display_name":"Hospital Universit\u00e1rio Clementino Fraga Filho","ror":"https://ror.org/04pznag94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210138087"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Alice Helena D. Violante","raw_affiliation_strings":["Medical School, Endocrinology Unit, Hospital Universitario Clementino Fraga Filho, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School, Endocrinology Unit, Hospital Universitario Clementino Fraga Filho, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I122140584","https://openalex.org/I4210138087"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5040978542"],"corresponding_institution_ids":["https://openalex.org/I122140584","https://openalex.org/I4210138087"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.053,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.72891595,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":null,"first_page":"903085","last_page":"903085"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ganglioneuroma","display_name":"ganglioneuroma","score":0.9570000171661377},{"id":"https://openalex.org/keywords/pheochromocytoma","display_name":"pheochromocytoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/chromaffin-cell-tumors","display_name":"chromaffin cell tumors","score":0.8080000281333923},{"id":"https://openalex.org/keywords/neurofibromatosis-type-1","display_name":"neurofibromatosis type 1","score":0.8799999952316284},{"id":"https://openalex.org/keywords/germline-mutation-testing","display_name":"germline mutation testing","score":0.6079999804496765},{"id":"https://openalex.org/keywords/vhl","display_name":"VHL","score":0.7070000171661377},{"id":"https://openalex.org/keywords/catecholamine-excess","display_name":"catecholamine excess","score":0.859000027179718},{"id":"https://openalex.org/keywords/adrenalectomy","display_name":"adrenalectomy","score":0.9869999885559082},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.7699999809265137},{"id":"https://openalex.org/keywords/rare-adrenal-tumor","display_name":"rare adrenal tumor","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C2779102060","wikidata":"https://www.wikidata.org/wiki/Q1124606","display_name":"Ganglioneuroma","level":4,"score":0.9573289155960083},{"id":"https://openalex.org/C2779512018","wikidata":"https://www.wikidata.org/wiki/Q536269","display_name":"Pheochromocytoma","level":2,"score":0.8707811832427979},{"id":"https://openalex.org/C2778984943","wikidata":"https://www.wikidata.org/wiki/Q847605","display_name":"Neurofibromatosis","level":2,"score":0.7516547441482544},{"id":"https://openalex.org/C126749454","wikidata":"https://www.wikidata.org/wiki/Q1348455","display_name":"Neural crest","level":3,"score":0.668285608291626},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6475368738174438},{"id":"https://openalex.org/C2780582931","wikidata":"https://www.wikidata.org/wiki/Q5521151","display_name":"Ganglioneuroblastoma","level":5,"score":0.6366604566574097},{"id":"https://openalex.org/C2780744430","wikidata":"https://www.wikidata.org/wiki/Q14916125","display_name":"SDHB","level":5,"score":0.5466710329055786},{"id":"https://openalex.org/C2777597313","wikidata":"https://www.wikidata.org/wiki/Q934888","display_name":"Adrenal medulla","level":3,"score":0.44967132806777954},{"id":"https://openalex.org/C2781334511","wikidata":"https://www.wikidata.org/wiki/Q108158","display_name":"Ganglion","level":2,"score":0.43641209602355957},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3774801790714264},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3519744277000427},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3480539321899414},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.3028898537158966},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.2746448218822479},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25379669666290283},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.24389085173606873},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.1478513479232788},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10655534267425537},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09153276681900024},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.0784311294555664},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000310","descriptor_name":"Adrenal Gland Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000310","descriptor_name":"Adrenal Gland Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000310","descriptor_name":"Adrenal Gland Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D001938","descriptor_name":"Brazil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005729","descriptor_name":"Ganglioneuroma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005729","descriptor_name":"Ganglioneuroma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005729","descriptor_name":"Ganglioneuroma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010235","descriptor_name":"Paraganglioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010673","descriptor_name":"Pheochromocytoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D010673","descriptor_name":"Pheochromocytoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010673","descriptor_name":"Pheochromocytoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fendo.2022.903085","doi":"https://doi.org/10.3389/fendo.2022.903085","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2022.903085","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2022.903085/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmid:36187102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36187102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in endocrinology","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:9515550","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9515550/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Endocrinol (Lausanne)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d4f54fad152e4ea69f9f9102ddb27fb2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d4f54fad152e4ea69f9f9102ddb27fb2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 13 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2022.903085","doi":"https://doi.org/10.3389/fendo.2022.903085","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2022.903085","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2022.903085/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[{"id":"https://openalex.org/G5458307886","display_name":"Clinical impact of the use of genetic panels based on next generation sequencing in the differential diagnosis of multiple endocrine neoplasia type 1 and analysis of potential genotype-phenotype correlations.","funder_award_id":"16/07504-2","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320322749","display_name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","ror":"https://ror.org/03kk0s825"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4297900532.pdf","grobid_xml":"https://content.openalex.org/works/W4297900532.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1559760638","https://openalex.org/W1594241115","https://openalex.org/W1613453239","https://openalex.org/W1658179324","https://openalex.org/W1988222100","https://openalex.org/W1992804184","https://openalex.org/W2028225091","https://openalex.org/W2044111809","https://openalex.org/W2084516205","https://openalex.org/W2092512495","https://openalex.org/W2094705622","https://openalex.org/W2417549245","https://openalex.org/W2556416067","https://openalex.org/W2738485436","https://openalex.org/W2742030245","https://openalex.org/W2803781874","https://openalex.org/W2891428694","https://openalex.org/W2904853498","https://openalex.org/W2912849254","https://openalex.org/W2998815410","https://openalex.org/W3000251887","https://openalex.org/W3026160706","https://openalex.org/W3133661950","https://openalex.org/W3181444452","https://openalex.org/W4206743630","https://openalex.org/W4212919313","https://openalex.org/W4220716887","https://openalex.org/W4220820959"],"related_works":["https://openalex.org/W2944500222","https://openalex.org/W4316664645","https://openalex.org/W2084209512","https://openalex.org/W4382862597","https://openalex.org/W2094705622","https://openalex.org/W2014186160","https://openalex.org/W4285491305","https://openalex.org/W4322500211","https://openalex.org/W4403152815","https://openalex.org/W4391274541"],"abstract_inverted_index":{"Composite":[0],"pheochromocytoma":[1,16,50],"(CP)":[2],"is":[3,51,272],"a":[4,18,28,201,266,295,314],"very":[5],"rare":[6,322],"tumor":[7,21,29,253],"originating":[8],"from":[9,31,205],"neural":[10],"crest":[11],"cells,":[12],"predominantly":[13],"composed":[14],"of":[15,35,48,77,80,92,101,148,185,251,269,283,320],"(PCC),":[17],"chromaffin":[19],"cell":[20],"arising":[22],"in":[23,44,122,196,286,298,303,308,317,324],"adrenal":[24],"medulla,":[25],"and":[26,60,68,75,83,115,136,154,161,166,173,212,231],"ganglioneuroma,":[27],"derived":[30],"autonomic":[32],"ganglion":[33],"cells":[34],"the":[36,45,73,89,93,140,192,281,287,304,309,318],"nervous":[37],"system.":[38],"Moreover,":[39],"CP":[40,81,178,263,288,302],"may":[41],"be":[42],"present":[43,195],"hereditary":[46],"syndromes":[47],"which":[49],"part.":[52],"Literature":[53],"offers":[54],"scarce":[55],"data":[56],"on":[57],"this":[58,321],"subject,":[59],"particularly":[61],"about":[62],"its":[63],"biological":[64],"behavior,":[65],"clinical":[66,146,325],"evolution,":[67],"molecular":[69],"profile.":[70],"We":[71],"report":[72],"phenotype":[74],"outcome":[76],"three":[78,198],"cases":[79,181,242,285,299],"(PCC":[82],"ganglioneuroma":[84],"components),":[85],"followed":[86,168],"up":[87,169],"at":[88,158],"Endocrine":[90],"Service":[91],"Clementino":[94],"Fraga":[95],"Filho":[96],"University":[97,100],"Hospital,":[98],"Federal":[99],"Rio":[102,106],"de":[103,107],"Janeiro,":[104,108],"UFRJ,":[105],"Brazil.":[109],"Two":[110],"nonsyndromic":[111],"patients":[112],"(cases":[113],"1":[114],"2)":[116],"were":[117,156,167,210],"negative":[118],"to":[119,207,262],"germline":[120],"mutations":[121],"genes":[123],"VHL":[124],",":[125,127,129,131,133,135,138],"SDHB":[126],"SDHC":[128],"SDHD":[130],"SDHAF2":[132],"TMEM127":[134],"MAX":[137],"while":[139],"third":[141],"case":[142],"(case":[143],"3)":[144],"had":[145,182,200],"diagnosis":[147,319],"neurofibromatosis":[149],"syndrome.":[150],"Cases":[151],"1,":[152],"2,":[153],"3":[155,311],"diagnosed":[157],"29,":[159],"39,":[160],"47":[162],"years":[163,175],"old,":[164],"respectively,":[165],"for":[170],"3,":[171],"17,":[172],"9":[174],"without":[176],"no":[177,246],"recurrence.":[179],"All":[180,241],"apparent":[183],"symptoms":[184],"catecholaminergic":[186],"excess":[187],"secreted":[188],"by":[189,280],"PCC.":[190],"Ganglioneuroma,":[191],"neurogenic":[193],"component":[194],"all":[197],"cases,":[199],"percentage":[202],"representation":[203],"ranging":[204],"5%":[206],"15%.":[208],"Tumors":[209],"unilateral":[211],"large,":[213],"measuring":[214],"7.0":[215],"cm":[216,219,224,227,233,236],"\u00d7":[217,220,225,228,234,237],"6.0":[218,221,223,235],"cm,":[222,230,239],"4.0":[226],"3.2":[229],"7.5":[232],"4.5":[238],"respectively.":[240],"underwent":[243],"adrenalectomy":[244],"with":[245,276,301],"recurrence,":[247],"metastasis,":[248],"or":[249],"development":[250],"contralateral":[252],"during":[254],"follow-up.":[255],"Genetic":[256],"testing":[257],"has":[258],"been":[259],"scarcely":[260],"offered":[261],"cases.":[264],"However,":[265],"similar":[267],"frequency":[268],"genetic":[270],"background":[271],"found":[273],"when":[274],"compared":[275],"classic":[277],"PCC,":[278],"mainly":[279],"overrepresentation":[282],"NF1":[284],"subset.":[289],"By":[290],"literature":[291],"review,":[292],"we":[293],"identified":[294],"notorious":[296],"increase":[297],"reported":[300],"last":[305,310],"decade,":[306],"especially":[307],"years,":[312],"indicating":[313],"recent":[315],"improvement":[316],"disorder":[323],"practice.":[326]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-10-01T00:00:00"}