{"id":"https://openalex.org/W4297845837","doi":"https://doi.org/10.1055/s-0037-1616932","title":"Blood coagulation dynamics in haemostasis","display_name":"Blood coagulation dynamics in haemostasis","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W4297845837","doi":"https://doi.org/10.1055/s-0037-1616932","mag":"2122414794","pmid":"https://pubmed.ncbi.nlm.nih.gov/19151839","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3152749"},"language":"en","primary_location":{"id":"doi:10.1055/s-0037-1616932","doi":"https://doi.org/10.1055/s-0037-1616932","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0037-1616932","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1616932.pdf","source":{"id":"https://openalex.org/S60043848","display_name":"H\u00e4mostaseologie","issn_l":"0720-9355","issn":["0720-9355","2567-5761"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"H\u00e4mostaseologie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1616932.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004717464","display_name":"Thomas Orfeo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Orfeo","raw_affiliation_strings":["University of Vermont, Burlington, VT USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vermont, Burlington, VT USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020728232","display_name":"Saulius Butenas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Butenas","raw_affiliation_strings":["University of Vermont, Burlington, VT USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vermont, Burlington, VT USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047958060","display_name":"Anetta Undas","orcid":"https://orcid.org/0000-0003-3716-1724","observed_orcids":["https://orcid.org/0000-0003-3716-1724","https://orcid.org/0000-0002-0667-8109","https://orcid.org/0000-0002-0370-8739"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"A. Undas","raw_affiliation_strings":["Jagiellonian University, Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jagiellonian University, Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113585078","display_name":"Kathleen E. Brummel\u2010Ziedins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Brummel-Ziedins","raw_affiliation_strings":["University of Vermont, Burlington, VT USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vermont, Burlington, VT USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075389112","display_name":"Kenneth G. Mann","orcid":"https://orcid.org/0000-0003-1878-263X","observed_orcids":["https://orcid.org/0000-0003-1878-263X"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K. G. Mann","raw_affiliation_strings":["University of Vermont, Burlington, VT USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vermont, Burlington, VT USA","institution_ids":["https://openalex.org/I111236770"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075389112"],"corresponding_institution_ids":["https://openalex.org/I111236770"],"apc_list":null,"apc_paid":null,"fwci":4.3609,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.94781966,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"29","issue":"01","first_page":"7","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.890999972820282},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tissue-factor","display_name":"tissue factor","score":0.9449999928474426},{"id":"https://openalex.org/keywords/factor-viia","display_name":"factor VIIa","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tissue-factor-pathway-inhibitor","display_name":"tissue factor pathway inhibitor","score":0.9210000038146973},{"id":"https://openalex.org/keywords/antithrombin-iii","display_name":"antithrombin III","score":0.9919999837875366},{"id":"https://openalex.org/keywords/protein-c-pathway","display_name":"protein C pathway","score":0.8820000290870667},{"id":"https://openalex.org/keywords/procoagulant-activation","display_name":"procoagulant activation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/prothrombinase","display_name":"prothrombinase","score":0.8169999718666077},{"id":"https://openalex.org/keywords/anticoagulants","display_name":"anticoagulants","score":0.871999979019165},{"id":"https://openalex.org/keywords/venous-thrombosis","display_name":"venous thrombosis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/arterial-thrombosis","display_name":"arterial thrombosis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hemorrhagic-disease","display_name":"hemorrhagic disease","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C186738567","wikidata":"https://www.wikidata.org/wiki/Q412841","display_name":"Tissue factor","level":3,"score":0.7957963943481445},{"id":"https://openalex.org/C112516734","wikidata":"https://www.wikidata.org/wiki/Q423640","display_name":"Prothrombinase","level":4,"score":0.7914658784866333},{"id":"https://openalex.org/C2779026020","wikidata":"https://www.wikidata.org/wiki/Q416336","display_name":"Antithrombin","level":3,"score":0.6122424006462097},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5975335836410522},{"id":"https://openalex.org/C144594695","wikidata":"https://www.wikidata.org/wiki/Q6153218","display_name":"Thromboplastin","level":3,"score":0.5007486343383789},{"id":"https://openalex.org/C2777151630","wikidata":"https://www.wikidata.org/wiki/Q14878075","display_name":"Tissue factor pathway inhibitor","level":4,"score":0.4969666302204132},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.48195526003837585},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4802427589893341},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.4794924855232239},{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.4414517283439636},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.4320725202560425},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3582780957221985},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32968711853027344},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30499905347824097},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2808193564414978},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.22567099332809448},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19170895218849182},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13814228773117065}],"mesh":[{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001779","descriptor_name":"Blood Coagulation Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006487","descriptor_name":"Hemostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1055/s-0037-1616932","doi":"https://doi.org/10.1055/s-0037-1616932","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0037-1616932","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1616932.pdf","source":{"id":"https://openalex.org/S60043848","display_name":"H\u00e4mostaseologie","issn_l":"0720-9355","issn":["0720-9355","2567-5761"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"H\u00e4mostaseologie","raw_type":"journal-article"},{"id":"pmid:19151839","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19151839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hamostaseologie","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2159716","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3152749","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3152749","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3152749","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Hamostaseologie","raw_type":"Text"},{"id":"mag:2122414794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19151839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.1055/s-0037-1616932","doi":"https://doi.org/10.1055/s-0037-1616932","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0037-1616932","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1616932.pdf","source":{"id":"https://openalex.org/S60043848","display_name":"H\u00e4mostaseologie","issn_l":"0720-9355","issn":["0720-9355","2567-5761"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"H\u00e4mostaseologie","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4443462810","display_name":"Primary Structure of Prothrombin","funder_award_id":"R01HL034575","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5820286168","display_name":"Surface Dependent Reactions in Thrombosis and Thrombolysis","funder_award_id":"P01HL046703","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000315678","display_name":null,"funder_award_id":"HL46703","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4297845837.pdf","grobid_xml":"https://content.openalex.org/works/W4297845837.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W62994428","https://openalex.org/W110545565","https://openalex.org/W187459506","https://openalex.org/W194949005","https://openalex.org/W1489758714","https://openalex.org/W1511802802","https://openalex.org/W1540403899","https://openalex.org/W1575456191","https://openalex.org/W1588254032","https://openalex.org/W1961597147","https://openalex.org/W1966875441","https://openalex.org/W1967698766","https://openalex.org/W1979862980","https://openalex.org/W1980096532","https://openalex.org/W1982913199","https://openalex.org/W1995899417","https://openalex.org/W2001052209","https://openalex.org/W2003987097","https://openalex.org/W2010286614","https://openalex.org/W2011332991","https://openalex.org/W2023412739","https://openalex.org/W2031424136","https://openalex.org/W2038123291","https://openalex.org/W2048491412","https://openalex.org/W2051039082","https://openalex.org/W2058161894","https://openalex.org/W2093457400","https://openalex.org/W2095489676","https://openalex.org/W2098560324","https://openalex.org/W2141200852","https://openalex.org/W2151938814","https://openalex.org/W2168273167","https://openalex.org/W2168806739","https://openalex.org/W2737586143","https://openalex.org/W4242838016","https://openalex.org/W4246050607"],"related_works":["https://openalex.org/W4253436283","https://openalex.org/W2318133989","https://openalex.org/W2397967807","https://openalex.org/W7170260724","https://openalex.org/W2059526832","https://openalex.org/W2122833219","https://openalex.org/W2040245197","https://openalex.org/W2912550297","https://openalex.org/W2058161894","https://openalex.org/W2560369848"],"abstract_inverted_index":{"Our":[0,226],"studies":[1,20,246],"involve":[2],"computational":[3],"simulations,":[4],"a":[5,77,82,223],"reconstructed":[6],"plasma/platelet":[7],"proteome,":[8],"whole":[9],"blood":[10,14,190,217],"in":[11,23,41,60,80,244],"vitro":[12],"and":[13,65,110,120,138,182,210,213,237,240,243,249,252],"exuding":[15],"from":[16],"microvascular":[17],"wounds.":[18],"All":[19],"indicate":[21],"that":[22],"normal":[24],"haemostasis,":[25],"the":[26,42,46,66,93,98,108,116,126,139,145,153,161,165,171,187,194,200,203,208,214,220,233],"binding":[27],"of":[28,45,84,92,115,132,164,202,216,222,235,247],"tissue":[29,55],"factor":[30,34,56],"(TF)":[31],"with":[32,62],"plasma":[33],"(F)":[35],"VIIa":[36],"(extrinsic":[37],"FXase":[38,118,155],"complex)":[39],"results":[40],"initiation":[43,162],"phase":[44,50,147,163,173,179],"procoagulant":[47],"response.":[48],"This":[49,104],"is":[51,134,148,158,191,205],"negatively":[52],"regulated":[53],"by":[54,136,152,197,207],"pathway":[57],"inhibitor":[58],"(TFPI)":[59],"combination":[61],"antithrombin":[63],"(AT)":[64],"protein":[67],"C":[68],"(PC)":[69],"pathway.":[70],"The":[71,177],"synergy":[72],"between":[73],"these":[74],"inhibitors":[75],"provides":[76],"threshold-limited":[78],"reaction":[79,166,188,204],"which":[81,124,133],"stimulus":[83],"sufficient":[85,96],"magnitude":[86],"must":[87],"be":[88],"provided":[89,135,151],"for":[90,113,160],"continuation":[91],"reaction.":[94],"With":[95],"stimulus,":[97],"FXa":[99,142],"produced":[100],"activates":[101,107],"some":[102],"prothrombin.":[103],"initial":[105],"thrombin":[106],"procofactors":[109],"platelets":[111],"required":[112,159],"presentation":[114],"intrinsic":[117,154],"(FVIIIa-FIXa)":[119],"prothrombinase":[121],"(FVa-FXa)":[122],"complexes":[123],"drive":[125,186],"subsequent":[127],"propagation":[128,146,172,178],"phase;":[129],"continuous":[130],"downregulation":[131],"AT":[137],"thrombin-thrombomodulin-PC":[140],"complex.":[141,156],"generation":[143],"during":[144],"largely":[149],"(>90%)":[150],"TF":[157],"but":[167],"becomes":[168],"non-essential":[169],"once":[170],"has":[174],"been":[175,229],"achieved.":[176],"catalysts":[180],"(FVIIIa-FIXa":[181],"FVa-FXa)":[183],"continue":[184],"to":[185,193,219,231],"as":[189],"resupplied":[192],"wound":[195],"site":[196,221],"flow.":[198],"Ultimately,":[199],"control":[201],"governed":[206],"pro-":[209],"anticoagulant":[211],"dynamics":[212],"supply":[215],"reactants":[218],"perforating":[224],"injury.":[225],"systems":[227],"have":[228],"utilized":[230],"examine":[232],"qualities":[234],"hypothetical":[236],"novel":[238],"antihaemorrhagic":[239],"anticoagulation":[241],"agents":[242],"epidemiologic":[245],"venous":[248],"arterial":[250],"thrombosis":[251],"haemorrhagic":[253],"pathology.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2022-10-01T00:00:00"}
