{"id":"https://openalex.org/W4297828222","doi":"https://doi.org/10.2174/9789815050622122010012","title":"Bioactive Compounds as Therapeutic Intervention in Neurodegenerative Diseases","display_name":"Bioactive Compounds as Therapeutic Intervention in Neurodegenerative Diseases","publication_year":2022,"publication_date":"2022-09-14","ids":{"openalex":"https://openalex.org/W4297828222","doi":"https://doi.org/10.2174/9789815050622122010012"},"language":"en","primary_location":{"id":"doi:10.2174/9789815050622122010012","doi":"https://doi.org/10.2174/9789815050622122010012","is_oa":false,"landing_page_url":"https://doi.org/10.2174/9789815050622122010012","pdf_url":null,"source":{"id":"https://openalex.org/S4306462908","display_name":"BENTHAM SCIENCE PUBLISHERS eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Use of Plant Secondary Metabolites","raw_type":"book-chapter"},"volume":null,"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001126650","display_name":"N. Suleiman","orcid":"https://orcid.org/0000-0003-2312-4439","observed_orcids":["https://orcid.org/0000-0003-2312-4439"]},"institutions":[{"id":"https://openalex.org/I55202024","display_name":"Usmanu Danfodiyo University","ror":"https://ror.org/006er0w72","country_code":"NG","type":"education","lineage":["https://openalex.org/I55202024"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"N. Suleiman","raw_affiliation_strings":["Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto,Department of Veterinary Physiology and Biochemistry,Nigeria,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto,Department of Veterinary Physiology and Biochemistry,Nigeria,","institution_ids":["https://openalex.org/I55202024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059724441","display_name":"Ibrahim Bulama","orcid":"https://orcid.org/0000-0002-2297-1663","observed_orcids":["https://orcid.org/0000-0002-2297-1663"]},"institutions":[{"id":"https://openalex.org/I64351976","display_name":"University of Maiduguri","ror":"https://ror.org/016na8197","country_code":"NG","type":"education","lineage":["https://openalex.org/I64351976"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"I. Bulama","raw_affiliation_strings":["University of Maiduguri,Department of Veterinary Physiology and Biochemistry,Maiduguri,Nigeria,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maiduguri,Department of Veterinary Physiology and Biochemistry,Maiduguri,Nigeria,","institution_ids":["https://openalex.org/I64351976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049475665","display_name":"Lawal Suleman Bilbis","orcid":"https://orcid.org/0000-0002-6917-4880","observed_orcids":["https://orcid.org/0000-0002-6917-4880","https://orcid.org/0000-0001-9583-0661"]},"institutions":[{"id":"https://openalex.org/I55202024","display_name":"Usmanu Danfodiyo University","ror":"https://ror.org/006er0w72","country_code":"NG","type":"education","lineage":["https://openalex.org/I55202024"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"L.S. Bilbis","raw_affiliation_strings":["Usmanu Danfodiyo University Sokoto,Department of Biochemistry,Nigeria,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Usmanu Danfodiyo University Sokoto,Department of Biochemistry,Nigeria,","institution_ids":["https://openalex.org/I55202024"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39380531,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"214","last_page":"237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bioactive-compounds","display_name":"bioactive compounds","score":0.9980000257492065},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.7229999899864197},{"id":"https://openalex.org/keywords/medicinal-plants","display_name":"medicinal plants","score":0.9509999752044678},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.9959999918937683},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9890000224113464},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.9990000128746033},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":1.0},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.718999981880188},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6152352690696716},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.44641104340553284},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.445800244808197},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4308410882949829},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.4142521619796753},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.40164151787757874},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.35241463780403137},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.24300172924995422},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.22286280989646912},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17821231484413147},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10702541470527649},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2174/9789815050622122010012","doi":"https://doi.org/10.2174/9789815050622122010012","is_oa":false,"landing_page_url":"https://doi.org/10.2174/9789815050622122010012","pdf_url":null,"source":{"id":"https://openalex.org/S4306462908","display_name":"BENTHAM SCIENCE PUBLISHERS eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Use of Plant Secondary Metabolites","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.4399999976158142,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3001724323","https://openalex.org/W4414057263","https://openalex.org/W3005885232","https://openalex.org/W4386812559","https://openalex.org/W4403687876","https://openalex.org/W7149956633","https://openalex.org/W3198336939","https://openalex.org/W4321787376","https://openalex.org/W4410792011","https://openalex.org/W4399436947"],"abstract_inverted_index":{"Neurodegenerative":[0],"disorders":[1,50,120],"have":[2,78,82],"been":[3,79],"implicated":[4],"as":[5,54,101],"the":[6,23,46,68,108,115,145,148],"cause":[7],"of":[8,17,25,51,70,117,125,135,140,147],"manydevastating":[9],"diseases":[10,27,142],"that":[11,43],"are":[12,32],"characterized":[13],"by":[14,49],"gradual":[15],"loss":[16],"susceptible":[18],"neurons,":[19],"thatare":[20],"increasingly":[21],"rising":[22],"prevalence":[24],"neurodegenerative":[26,52,131,141],"globally;":[28],"however,therapeutics":[29],"for":[30,67,97],"them":[31],"lacking.":[33],"There":[34],"is":[35],"an":[36,41],"urgent":[37],"need":[38],"to":[39,81,89],"develop":[40],"effectivetherapy":[42],"can":[44],"combat":[45],"menace":[47],"caused":[48],"originsuch":[53],"Alzheimer's":[55],"and":[56,60,121],"Parkinson\u2019s":[57],"diseases,":[58],"stroke,":[59],"traumatic":[61],"brain":[62],"injury.":[63],"Peerreviewedarticles":[64],"were":[65],"explored":[66],"purpose":[69],"this":[71],"review.":[72],"Several":[73],"natural":[74],"productsfrom":[75],"medicinal":[76],"plants":[77],"reported":[80],"phytochemical":[83],"components":[84],"withbioactive":[85],"effects":[86,129],"in":[87,107],"addition":[88],"nutritional":[90],"value.":[91],"An":[92],"appropriate":[93],"bioactive":[94,126,136],"component":[95],"isessential":[96],"a":[98,104],"healthy":[99],"lifestyle":[100],"it":[102],"plays":[103],"significant":[105],"role":[106],"modulation":[109],"ofneurodegenerative":[110,119],"diseases.":[111],"This":[112],"review":[113],"covers":[114],"mechanism":[116],"action":[118],"highlights":[122],"selected":[123],"classes":[124],"compoundsand":[127],"their":[128],"on":[130],"disorders.":[132],"The":[133],"use":[134],"compounds":[137],"inthe":[138],"management":[139],"could":[143],"solve":[144],"problem":[146],"nonavailabilityof":[149],"therapy.":[150]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2022-10-01T00:00:00"}