{"id":"https://openalex.org/W4297724082","doi":"https://doi.org/10.1309/v8q9kdd5aj9lnbag","title":"Small Colonic Microsatellite Unstable Adenocarcinomas and High-Grade Epithelial Dysplasias in Sessile Serrated Adenoma Polypectomy Specimens","display_name":"Small Colonic Microsatellite Unstable Adenocarcinomas and High-Grade Epithelial Dysplasias in Sessile Serrated Adenoma Polypectomy Specimens","publication_year":2005,"publication_date":"2005-11-29","ids":{"openalex":"https://openalex.org/W4297724082","doi":"https://doi.org/10.1309/v8q9kdd5aj9lnbag","mag":"2099367190","pmid":"https://pubmed.ncbi.nlm.nih.gov/16483002"},"language":"en","primary_location":{"id":"doi:10.1309/v8q9kdd5aj9lnbag","doi":"https://doi.org/10.1309/v8q9kdd5aj9lnbag","is_oa":false,"landing_page_url":"https://doi.org/10.1309/v8q9kdd5aj9lnbag","pdf_url":null,"source":{"id":"https://openalex.org/S15871148","display_name":"American Journal of Clinical Pathology","issn_l":"0002-9173","issn":["0002-9173","1943-7722"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108393329","display_name":"Neal S. Goldstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128757","display_name":"Corewell Health William Beaumont University Hospital","ror":"https://ror.org/03artm726","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128757","https://openalex.org/I4392738273"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Neal S. Goldstein","raw_affiliation_strings":["Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomic Pathology, William Beaumont Hospital, Royal Oak, MI","institution_ids":["https://openalex.org/I4210128757"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108393329"],"corresponding_institution_ids":["https://openalex.org/I4210128757"],"apc_list":{"value":4660,"currency":"USD","value_usd":4660},"apc_paid":null,"fwci":6.6503,"has_fulltext":false,"cited_by_count":156,"citation_normalized_percentile":{"value":0.97138948,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"125","issue":"1","first_page":"132","last_page":"145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sessile-serrated-adenoma","display_name":"sessile serrated adenoma","score":0.9589999914169312},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.8460000157356262},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.5090000033378601},{"id":"https://openalex.org/keywords/proximal-colon","display_name":"proximal colon","score":0.4090000092983246},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.40400001406669617}],"concepts":[{"id":"https://openalex.org/C2775894508","wikidata":"https://www.wikidata.org/wiki/Q1128996","display_name":"Dysplasia","level":2,"score":0.8043038845062256},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.6610599160194397},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.6497852206230164},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6442272663116455},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.5606184601783752},{"id":"https://openalex.org/C2780581329","wikidata":"https://www.wikidata.org/wiki/Q7226727","display_name":"Polypectomy","level":5,"score":0.5569837093353271},{"id":"https://openalex.org/C2779534503","wikidata":"https://www.wikidata.org/wiki/Q6058399","display_name":"Intraepithelial neoplasia","level":4,"score":0.4995853900909424},{"id":"https://openalex.org/C2777936439","wikidata":"https://www.wikidata.org/wiki/Q2825480","display_name":"Tubular adenoma","level":5,"score":0.4981040954589844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4132775664329529},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3341415822505951},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23838010430335999},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22740131616592407},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.17005810141563416},{"id":"https://openalex.org/C2778435480","wikidata":"https://www.wikidata.org/wiki/Q840387","display_name":"Colonoscopy","level":4,"score":0.11353838443756104},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000070957","descriptor_name":"MutL Protein Homolog 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003111","descriptor_name":"Colonic Polyps","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018895","descriptor_name":"Microsatellite Repeats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043171","descriptor_name":"Chromosomal Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1309/v8q9kdd5aj9lnbag","doi":"https://doi.org/10.1309/v8q9kdd5aj9lnbag","is_oa":false,"landing_page_url":"https://doi.org/10.1309/v8q9kdd5aj9lnbag","pdf_url":null,"source":{"id":"https://openalex.org/S15871148","display_name":"American Journal of Clinical Pathology","issn_l":"0002-9173","issn":["0002-9173","1943-7722"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Pathology","raw_type":"journal-article"},{"id":"doi:10.1309/v8q9-kdd5-aj9l-nbag","doi":"https://doi.org/10.1309/v8q9-kdd5-aj9l-nbag","is_oa":false,"landing_page_url":"https://doi.org/10.1309/v8q9-kdd5-aj9l-nbag","pdf_url":null,"source":{"id":"https://openalex.org/S15871148","display_name":"American Journal of Clinical Pathology","issn_l":"0002-9173","issn":["0002-9173","1943-7722"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Pathology","raw_type":"journal-article"},{"id":"pmid:16483002","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16483002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of clinical pathology","raw_type":"Journal Article"},{"id":"mag:2099367190","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16483002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W69746513","https://openalex.org/W74919851","https://openalex.org/W624674342","https://openalex.org/W1964020724","https://openalex.org/W1973422511","https://openalex.org/W1975895074","https://openalex.org/W1982295513","https://openalex.org/W1994523314","https://openalex.org/W2003562316","https://openalex.org/W2019354420","https://openalex.org/W2025927784","https://openalex.org/W2030862171","https://openalex.org/W2031526548","https://openalex.org/W2033282924","https://openalex.org/W2037201529","https://openalex.org/W2043921067","https://openalex.org/W2047757804","https://openalex.org/W2048399566","https://openalex.org/W2052530261","https://openalex.org/W2057279358","https://openalex.org/W2059881380","https://openalex.org/W2061440944","https://openalex.org/W2069581121","https://openalex.org/W2073533714","https://openalex.org/W2081865235","https://openalex.org/W2092292137","https://openalex.org/W2096682473","https://openalex.org/W2114858558","https://openalex.org/W2120099188","https://openalex.org/W2128793721","https://openalex.org/W2133768293","https://openalex.org/W2145541762","https://openalex.org/W2154546296","https://openalex.org/W2331118586","https://openalex.org/W2425814120","https://openalex.org/W2512906422","https://openalex.org/W2985951973"],"related_works":["https://openalex.org/W2099367190","https://openalex.org/W2054440099","https://openalex.org/W4253262748","https://openalex.org/W2005995785","https://openalex.org/W1973257865","https://openalex.org/W2075789014","https://openalex.org/W2781139522","https://openalex.org/W2042270540","https://openalex.org/W2124585880","https://openalex.org/W2462990812"],"abstract_inverted_index":{"Eight":[0],"sessile":[1],"serrated":[2,32],"adenoma":[3],"(SSA),":[4],"right":[5],"colon":[6],"polypectomies":[7],"with":[8],"focal":[9],"invasive":[10,37,98,103,123],"adenocarcinoma":[11,124,191],"or":[12,97],"high-grade":[13,41,94,135],"dysplasia":[14],"were":[15,40,45,165],"studied":[16],"to":[17,93,150],"identify":[18],"features":[19,30],"indicating":[20],"a":[21,168,193],"high":[22],"risk":[23],"of":[24,31,78,121,144,170,178,195],"transformation":[25],"and":[26,48,159],"characterize":[27],"the":[28,101,105,111,122,145],"morphologic":[29],"dysplasia;":[33],"6":[34,102],"cases":[35,86,133],"had":[36,49,87,134,141,152,181],"adenocarcinoma;":[38],"2":[39],"dysplasia.":[42,137,197],"All":[43,84,131],"8":[44,85,132],"microsatellite":[46],"unstable-high":[47],"absent":[50],"hMLH1":[51],"nuclear":[52,157],"immunoreactivity.":[53],"The":[54,76,117,138],"mean":[55,118],"patient":[56],"age":[57],"at":[58],"polypectomy":[59],"was":[60,70,81,125],"69.5":[61],"years":[62],"(range,":[63,73,128],"57.1-83.9":[64],"years).":[65],"Mean":[66],"polyp":[67,80],"maximum":[68,119],"dimension":[69,120],"8.5":[71],"mm":[72,127],"6-12":[74],"mm).":[75,130],"majority":[77],"each":[79],"nonmalignant":[82,139],"SSA.":[83],"an":[88],"abrupt":[89],"transition":[90],"from":[91],"benign":[92],"in":[95],"situ":[96],"malignancy.":[99],"In":[100],"adenocarcinomas,":[104],"neoplasm":[106],"extended":[107],"directly":[108],"down":[109],"into":[110,190],"submucosa":[112],"without":[113,192],"lateral":[114],"intramucosal":[115],"spread.":[116],"2.9":[126],"2-4":[129],"serrated-type":[136],"SSAs":[140,187],"marked":[142],"expansion":[143],"proliferative":[146],"zone.":[147],"Crypts":[148],"adjacent":[149,179],"malignancy":[151],"moderately":[153],"enlarged":[154],"nuclei,":[155],"irregular":[156],"membranes,":[158],"overly":[160],"prominent":[161],"nucleoli.":[162],"SSA":[163],"crypts":[164,180],"lined":[166],"by":[167],"variety":[169],"gastric-type":[171],"cells;":[172],"no":[173],"cell":[174],"type":[175],"predominated.":[176],"Foci":[177],"similar":[182],"cytologic":[183],"features.":[184],"Small":[185],"proximal":[186],"can":[188],"transform":[189],"component":[194],"adenomatous":[196]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-09-30T00:00:00"}