{"id":"https://openalex.org/W429770655","doi":null,"title":"Radioprotective effect of melatonin on the cervical spinal cord in irradiated rats.","display_name":"Radioprotective effect of melatonin on the cervical spinal cord in irradiated rats.","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W429770655","mag":"429770655","pmid":"https://pubmed.ncbi.nlm.nih.gov/23577303","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3593928"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2616832","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3593928","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3593928","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013240849","display_name":"Gholamhassan Haddadi","orcid":"https://orcid.org/0000-0002-1401-4951","observed_orcids":["https://orcid.org/0000-0002-1401-4951"]},"institutions":[{"id":"https://openalex.org/I4210161235","display_name":"Fasa University of Medical Sciences","ror":"https://ror.org/05bh0zx16","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210161235"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Gholamhassan Haddadi","raw_affiliation_strings":["1. Department of Medical Physics, Faculty of Medicine, Fassa University of Medical Sciences, Fassa, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1. Department of Medical Physics, Faculty of Medicine, Fassa University of Medical Sciences, Fassa, Iran","institution_ids":["https://openalex.org/I4210161235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101993938","display_name":"Alireza Shirazi","orcid":"https://orcid.org/0000-0002-7579-1797","observed_orcids":["https://orcid.org/0000-0002-7579-1797"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alireza Shirazi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003226443","display_name":"Zargham Sepehrizadeh","orcid":"https://orcid.org/0000-0003-0169-166X","observed_orcids":["https://orcid.org/0000-0003-0169-166X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zargham Sepehrizadeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012690210","display_name":"Seied Rabi Mahdavi","orcid":"https://orcid.org/0000-0003-1973-2140","observed_orcids":["https://orcid.org/0000-0003-1973-2140"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seied Rabie Mahdavi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023380649","display_name":"Maryam Haddadi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maryam Haddadi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5317,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.79004917,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"14","issue":"4","first_page":"246","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/radiation-protection","display_name":"radiation protection","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cervical-spinal-cord","display_name":"cervical spinal cord","score":0.9290000200271606},{"id":"https://openalex.org/keywords/radiation-myelopathy","display_name":"radiation myelopathy","score":0.8209999799728394},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9819999933242798},{"id":"https://openalex.org/keywords/vegf-expression","display_name":"VEGF expression","score":0.8180000185966492},{"id":"https://openalex.org/keywords/gamma-irradiation","display_name":"gamma irradiation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.8645138740539551},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.7224847674369812},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.5748887062072754},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.545894980430603},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5167507529258728},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4890912175178528},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.4528903663158417},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.42735984921455383},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40053799748420715},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37917518615722656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3329737186431885},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2332962155342102},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.18868550658226013},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.06190541386604309}],"mesh":[],"locations_count":6,"locations":[{"id":"pmh:oai:europepmc.org:2616832","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3593928","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3593928","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3593928","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell J","raw_type":"Text"},{"id":"pmid:23577303","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23577303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell journal","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.785.1674","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.785.1674","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/1c/85/Cell-J-14-246.PMC3593928.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:9f6071f6d68f4c038cbd348548823329","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9f6071f6d68f4c038cbd348548823329","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Journal, Vol 14, Iss 4, Pp 246-253 (2013)","raw_type":"article"},{"id":"mag:429770655","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23577303","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2616832","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3593928","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1738645460","https://openalex.org/W1981636067","https://openalex.org/W1981789917","https://openalex.org/W1986534326","https://openalex.org/W1991967763","https://openalex.org/W2000847452","https://openalex.org/W2001500938","https://openalex.org/W2002510503","https://openalex.org/W2021330248","https://openalex.org/W2030966861","https://openalex.org/W2037573897","https://openalex.org/W2063176993","https://openalex.org/W2080931388","https://openalex.org/W2082352153","https://openalex.org/W2085484338","https://openalex.org/W2101529296","https://openalex.org/W2107277218","https://openalex.org/W2109726055","https://openalex.org/W2122010571","https://openalex.org/W2127286809","https://openalex.org/W2130725042","https://openalex.org/W2132534755","https://openalex.org/W2136367179","https://openalex.org/W2160352643","https://openalex.org/W2164029304","https://openalex.org/W2165477627","https://openalex.org/W2170330790"],"related_works":["https://openalex.org/W7098899653","https://openalex.org/W92683273","https://openalex.org/W7099699373","https://openalex.org/W2136367179","https://openalex.org/W2050001481","https://openalex.org/W2169889456","https://openalex.org/W2000847452","https://openalex.org/W2028367095","https://openalex.org/W1962346823","https://openalex.org/W7129423939"],"abstract_inverted_index":{"OBJECTIVE:":[0],"It":[1],"has":[2],"been":[3],"suggested":[4],"that":[5,68,79,102,215],"the":[6,22,28,44,143,148,190,197,206,213,225],"vascular":[7],"endothelial":[8],"growth":[9],"factor":[10],"(VEGF)":[11],"gene":[12],"expression":[13,39,119,164,188,219],"plays":[14],"an":[15,70,81,104],"important":[16],"role":[17],"in":[18,117,189,196],"radiation-induced":[19,178],"injury":[20],"to":[21,89,110,169,205],"spinal":[23,46,91,111],"cord.":[24,47],"This":[25],"study":[26],"assesses":[27],"radioprotective":[29],"effects":[30],"of":[31,37,43,74,84,107,150,162,217,228],"N-acetyl-5-methoxytryptamine":[32],"(melatonin)":[33],"through":[34],"its":[35],"modulation":[36,216],"VEGF":[38,118,163,187,218],"after":[40,172,185,202],"localized":[41],"irradiation":[42,94,113,173,203],"cervical":[45,90],"MATERIALS":[48],"AND":[49],"METHODS:":[50],"In":[51],"this":[52],"experimental":[53],"study,":[54],"we":[55],"divided":[56],"192":[57],"male":[58],"rats":[59,67,78,101],"into":[60],"four":[61],"groups:":[62],"1.":[63],"control":[64],"(n=48);":[65,76],"2.":[66],"received":[69,80,103],"intraperitoneal":[71],"(IP)":[72],"injection":[73,83,106],"melatonin":[75,85,191,221],"3.":[77],"IP":[82,105],"30":[86],"minutes":[87],"prior":[88,109],"cord":[92,112],"gamma":[93],"[dose:":[95],"22":[96,170,183],"Gy;":[97],"(n=48)];":[98],"and":[99,125,137,176,199],"4.":[100],"vehicle":[108],"(n=48).":[114],"The":[115,140,210],"changes":[116],"were":[120,133,145],"assessed":[121],"using":[122,147],"real-time":[123],"RT-PCR":[124],"enzyme-linked":[126],"immunosorbent":[127],"assays.":[128],"Samples":[129],"for":[130],"light":[131],"microscopy":[132],"stained":[134],"with":[135],"hematoxylin":[136],"eosin":[138],"(H&E).":[139],"differences":[141],"among":[142],"groups":[144],"analyzed":[146],"analysis":[149],"variance":[151],"(ANOVA)":[152],"test":[153],"followed":[154],"by":[155,220],"Tukey's":[156],"multiple":[157],"comparisons":[158],"test.":[159],"RESULTS:":[160],"Up-regulation":[161],"was":[165],"observed":[166],"from":[167],"8":[168],"weeks":[171,184,201],"(p<0.05).":[174],"Paralysis":[175],"other":[177],"myelopathy":[179],"manifestations":[180],"developed":[181],"within":[182],"irradiation.":[186],"pre-treatment":[192],"group":[193],"significantly":[194],"down-regulated":[195],"20(th)":[198],"22(nd)":[200],"compared":[204],"radiation-only":[207],"group.":[208],"CONCLUSION:":[209],"results":[211],"support":[212],"hypothesis":[214],"administration":[222],"may":[223],"increase":[224],"survival":[226],"rate":[227],"irradiated":[229],"animals.":[230]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}