{"id":"https://openalex.org/W4297546906","doi":"https://doi.org/10.3390/molecules27196374","title":"In Silico Evaluation of Natural Flavonoids as a Potential Inhibitor of Coronavirus Disease","display_name":"In Silico Evaluation of Natural Flavonoids as a Potential Inhibitor of Coronavirus Disease","publication_year":2022,"publication_date":"2022-09-27","ids":{"openalex":"https://openalex.org/W4297546906","doi":"https://doi.org/10.3390/molecules27196374","pmid":"https://pubmed.ncbi.nlm.nih.gov/36234910","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9572657"},"language":"en","primary_location":{"id":"doi:10.3390/molecules27196374","doi":"https://doi.org/10.3390/molecules27196374","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules27196374","pdf_url":"https://www.mdpi.com/1420-3049/27/19/6374/pdf?version=1664430486","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/27/19/6374/pdf?version=1664430486","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008864840","display_name":"Piyush Kashyap","orcid":"https://orcid.org/0000-0003-1650-082X","observed_orcids":["https://orcid.org/0000-0003-1650-082X"]},"institutions":[{"id":"https://openalex.org/I110360157","display_name":"Lovely Professional University","ror":"https://ror.org/00et6q107","country_code":"IN","type":"education","lineage":["https://openalex.org/I110360157"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Piyush Kashyap","raw_affiliation_strings":["Department of Food Technology and Nutrition, School of Agriculture, Lovely Professional University, Phagwara 144401, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Technology and Nutrition, School of Agriculture, Lovely Professional University, Phagwara 144401, India","institution_ids":["https://openalex.org/I110360157"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026704384","display_name":"Mamta Thakur","orcid":"https://orcid.org/0000-0002-6052-6819","observed_orcids":["https://orcid.org/0000-0002-6052-6819"]},"institutions":[{"id":"https://openalex.org/I191366470","display_name":"ITM University","ror":"https://ror.org/004pc5924","country_code":"IN","type":"education","lineage":["https://openalex.org/I191366470"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mamta Thakur","raw_affiliation_strings":["Department of Food Technology, School of Sciences, ITM University, Gwalior 474001, India"],"raw_orcid":"https://orcid.org/0000-0002-6052-6819","affiliations":[{"raw_affiliation_string":"Department of Food Technology, School of Sciences, ITM University, Gwalior 474001, India","institution_ids":["https://openalex.org/I191366470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100720001","display_name":"Nidhi Singh","orcid":"https://orcid.org/0000-0002-7408-7191","observed_orcids":["https://orcid.org/0000-0002-7408-7191"]},"institutions":[{"id":"https://openalex.org/I168893459","display_name":"University of Allahabad","ror":"https://ror.org/03vrx7m55","country_code":"IN","type":"education","lineage":["https://openalex.org/I168893459"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nidhi Singh","raw_affiliation_strings":["Centre of Bioinformatics, University of Allahabad, Prayraj 211002, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of Bioinformatics, University of Allahabad, Prayraj 211002, India","institution_ids":["https://openalex.org/I168893459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021897553","display_name":"Deep Shikha","orcid":"https://orcid.org/0009-0000-8434-9290","observed_orcids":["https://orcid.org/0009-0000-8434-9290","https://orcid.org/0000-0001-5766-341X","https://orcid.org/0000-0002-6822-5412","https://orcid.org/0009-0005-1795-3646"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deep Shikha","raw_affiliation_strings":["Department of Food Technology, Bhai Gurdas Institute of Engineering and Technology, Sangrur 148001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Technology, Bhai Gurdas Institute of Engineering and Technology, Sangrur 148001, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062791923","display_name":"Shiv Kumar","orcid":"https://orcid.org/0000-0003-0655-9561","observed_orcids":["https://orcid.org/0000-0003-0655-9561"]},"institutions":[{"id":"https://openalex.org/I155284866","display_name":"Maharishi Markandeshwar University, Mullana","ror":"https://ror.org/013qfkw58","country_code":"IN","type":"education","lineage":["https://openalex.org/I155284866"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Shiv Kumar","raw_affiliation_strings":["MMICT & BM (HM), Maharishi Markandeshwar Deemed to be University, Mullana, Ambala 133207, India"],"raw_orcid":"https://orcid.org/0000-0003-0655-9561","affiliations":[{"raw_affiliation_string":"MMICT & BM (HM), Maharishi Markandeshwar Deemed to be University, Mullana, Ambala 133207, India","institution_ids":["https://openalex.org/I155284866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008246727","display_name":"Poonam Baniwal","orcid":"https://orcid.org/0000-0003-2907-2537","observed_orcids":["https://orcid.org/0000-0003-2907-2537"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Poonam Baniwal","raw_affiliation_strings":["Department of Quality Control, Food Corporation of India, New Delhi 110001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Quality Control, Food Corporation of India, New Delhi 110001, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yogender Singh Yadav","orcid":"https://orcid.org/0000-0001-6638-9926","observed_orcids":["https://orcid.org/0000-0001-6638-9926"]},"institutions":[{"id":"https://openalex.org/I233492666","display_name":"Lala Lajpat Rai University of Veterinary and Animal Sciences","ror":"https://ror.org/02d10f818","country_code":"IN","type":"education","lineage":["https://openalex.org/I233492666"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Yogender Singh Yadav","raw_affiliation_strings":["Department of Dairy Engineering, College of Dairy Science and Technology, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar 125004, India"],"raw_orcid":"https://orcid.org/0000-0001-6638-9926","affiliations":[{"raw_affiliation_string":"Department of Dairy Engineering, College of Dairy Science and Technology, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar 125004, India","institution_ids":["https://openalex.org/I233492666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000015224","display_name":"Minaxi Sharma","orcid":"https://orcid.org/0000-0001-6493-5217","observed_orcids":["https://orcid.org/0000-0001-6493-5217"]},"institutions":[{"id":"https://openalex.org/I4210115096","display_name":"Haute \u00c9cole Provinciale de Hainaut Condorcet","ror":"https://ror.org/02a22tx41","country_code":"BE","type":"education","lineage":["https://openalex.org/I4210115096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Minaxi Sharma","raw_affiliation_strings":["Laboratoire de Chimieverte et Produits Biobas\u00e9s, D\u00e9partement AgroBioscience et Chimie, Haute Ecole Provinciale du Hainaut-Condorcet, 11, 7800 ATH Rue de la Sucrerie, Belgium"],"raw_orcid":"https://orcid.org/0000-0001-6493-5217","affiliations":[{"raw_affiliation_string":"Laboratoire de Chimieverte et Produits Biobas\u00e9s, D\u00e9partement AgroBioscience et Chimie, Haute Ecole Provinciale du Hainaut-Condorcet, 11, 7800 ATH Rue de la Sucrerie, Belgium","institution_ids":["https://openalex.org/I4210115096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049132883","display_name":"Kandi Sridhar","orcid":"https://orcid.org/0000-0002-6174-0024","observed_orcids":["https://orcid.org/0000-0002-6174-0024"]},"institutions":[{"id":"https://openalex.org/I2800285241","display_name":"Institut Agro Rennes-Angers","ror":"https://ror.org/01s3fs709","country_code":"FR","type":"education","lineage":["https://openalex.org/I2800285241","https://openalex.org/I4210117091","https://openalex.org/I4399657933"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210132287","display_name":"Science et Technologie du Lait et de l'Oeuf","ror":"https://ror.org/03whgj090","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210117091","https://openalex.org/I4210132287","https://openalex.org/I4399657933"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Kandi Sridhar","raw_affiliation_strings":["UMR1253, Science et Technologie du Lait et de l\u2019\u0153uf, INRAE, L\u2019InstitutAgro, Rennes-Angers, 65 Rue de Saint Brieuc, F-35042 Rennes, France"],"raw_orcid":"https://orcid.org/0000-0002-6174-0024","affiliations":[{"raw_affiliation_string":"UMR1253, Science et Technologie du Lait et de l\u2019\u0153uf, INRAE, L\u2019InstitutAgro, Rennes-Angers, 65 Rue de Saint Brieuc, F-35042 Rennes, France","institution_ids":["https://openalex.org/I2800285241","https://openalex.org/I4210088668","https://openalex.org/I4210132287"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052886955","display_name":"Baskaran Stephen Inbaraj","orcid":"https://orcid.org/0000-0003-4301-7614","observed_orcids":["https://orcid.org/0000-0003-4301-7614"]},"institutions":[{"id":"https://openalex.org/I114150738","display_name":"Fu Jen Catholic University","ror":"https://ror.org/04je98850","country_code":"TW","type":"education","lineage":["https://openalex.org/I114150738"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Baskaran Stephen Inbaraj","raw_affiliation_strings":["Department of Food Science, Fu Jen Catholic University, New Taipei City 242 05, Taiwan"],"raw_orcid":"https://orcid.org/0000-0003-4301-7614","affiliations":[{"raw_affiliation_string":"Department of Food Science, Fu Jen Catholic University, New Taipei City 242 05, Taiwan","institution_ids":["https://openalex.org/I114150738"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5049132883","https://openalex.org/A5052886955","https://openalex.org/A5062791923"],"corresponding_institution_ids":["https://openalex.org/I114150738","https://openalex.org/I155284866","https://openalex.org/I2800285241","https://openalex.org/I4210088668","https://openalex.org/I4210132287"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2408},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2408},"fwci":0.6359,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.57575758,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"27","issue":"19","first_page":"6374","last_page":"6374"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8798999786376953,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8798999786376953,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0333000011742115,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.878000020980835},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9900000095367432},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9599999785423279},{"id":"https://openalex.org/keywords/natural-plant-compounds","display_name":"natural plant compounds","score":0.6510000228881836},{"id":"https://openalex.org/keywords/mpro-inhibitors","display_name":"Mpro inhibitors","score":0.531000018119812},{"id":"https://openalex.org/keywords/viral-entry-mechanism","display_name":"viral entry mechanism","score":0.6520000100135803},{"id":"https://openalex.org/keywords/hesperidin","display_name":"hesperidin","score":0.8679999709129333},{"id":"https://openalex.org/keywords/amentoflavone","display_name":"amentoflavone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/rutin","display_name":"rutin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/diosmin","display_name":"diosmin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/apiin","display_name":"apiin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6159999966621399},{"id":"https://openalex.org/keywords/antiviral-drug-discovery","display_name":"antiviral drug discovery","score":0.8970000147819519}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8931281566619873},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.535257875919342},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5027830600738525},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46160903573036194},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.42879927158355713},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3856857717037201},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3247329294681549},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2518850564956665},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14355769753456116},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.13193175196647644},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1080784797668457},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07137471437454224}],"mesh":[{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004145","descriptor_name":"Diosmin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006569","descriptor_name":"Hesperidin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012431","descriptor_name":"Rutin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019438","descriptor_name":"Ritonavir","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019438","descriptor_name":"Ritonavir","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019888","descriptor_name":"Nelfinavir","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061466","descriptor_name":"Lopinavir","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/molecules27196374","doi":"https://doi.org/10.3390/molecules27196374","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules27196374","pdf_url":"https://www.mdpi.com/1420-3049/27/19/6374/pdf?version=1664430486","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmid:36234910","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36234910","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9572657","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9572657/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:accbc9bccc5c42e28180d3818ddb849c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/accbc9bccc5c42e28180d3818ddb849c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 27, Iss 19, p 6374 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules27196374","doi":"https://doi.org/10.3390/molecules27196374","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules27196374","pdf_url":"https://www.mdpi.com/1420-3049/27/19/6374/pdf?version=1664430486","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4297546906.pdf","grobid_xml":"https://content.openalex.org/works/W4297546906.grobid-xml"},"referenced_works_count":123,"referenced_works":["https://openalex.org/W34328406","https://openalex.org/W1811783050","https://openalex.org/W1899472707","https://openalex.org/W1970651561","https://openalex.org/W1973395347","https://openalex.org/W1978897742","https://openalex.org/W1986240377","https://openalex.org/W2004746107","https://openalex.org/W2010903641","https://openalex.org/W2024634150","https://openalex.org/W2025170735","https://openalex.org/W2034368227","https://openalex.org/W2038459954","https://openalex.org/W2041378377","https://openalex.org/W2044549602","https://openalex.org/W2046153984","https://openalex.org/W2050273205","https://openalex.org/W2058755751","https://openalex.org/W2068214187","https://openalex.org/W2087973684","https://openalex.org/W2094875270","https://openalex.org/W2096544521","https://openalex.org/W2135721230","https://openalex.org/W2138657506","https://openalex.org/W2141877163","https://openalex.org/W2161435378","https://openalex.org/W2162166897","https://openalex.org/W2166189758","https://openalex.org/W2187293886","https://openalex.org/W2255243349","https://openalex.org/W2273547594","https://openalex.org/W2319555837","https://openalex.org/W2412032263","https://openalex.org/W2513547424","https://openalex.org/W2581823548","https://openalex.org/W2602216890","https://openalex.org/W2612692728","https://openalex.org/W2752981360","https://openalex.org/W2766931063","https://openalex.org/W2786695043","https://openalex.org/W2914037739","https://openalex.org/W2922600520","https://openalex.org/W2947642275","https://openalex.org/W2954970984","https://openalex.org/W2969718472","https://openalex.org/W2972493228","https://openalex.org/W2985346127","https://openalex.org/W2989182144","https://openalex.org/W2990101603","https://openalex.org/W3001456238","https://openalex.org/W3002812395","https://openalex.org/W3003154936","https://openalex.org/W3003322996","https://openalex.org/W3004071935","https://openalex.org/W3004202398","https://openalex.org/W3004280078","https://openalex.org/W3004318991","https://openalex.org/W3007386177","https://openalex.org/W3008627212","https://openalex.org/W3008827533","https://openalex.org/W3008869844","https://openalex.org/W3009375178","https://openalex.org/W3009906937","https://openalex.org/W3009912996","https://openalex.org/W3010096538","https://openalex.org/W3010149441","https://openalex.org/W3010955108","https://openalex.org/W3011176674","https://openalex.org/W3011379523","https://openalex.org/W3011537081","https://openalex.org/W3011701533","https://openalex.org/W3011848620","https://openalex.org/W3012171780","https://openalex.org/W3012237619","https://openalex.org/W3012352458","https://openalex.org/W3012440244","https://openalex.org/W3013093478","https://openalex.org/W3013821194","https://openalex.org/W3013867929","https://openalex.org/W3015463909","https://openalex.org/W3015701509","https://openalex.org/W3016885747","https://openalex.org/W3016955027","https://openalex.org/W3019322471","https://openalex.org/W3023594261","https://openalex.org/W3025917451","https://openalex.org/W3027002382","https://openalex.org/W3027898214","https://openalex.org/W3034907915","https://openalex.org/W3035876959","https://openalex.org/W3043002108","https://openalex.org/W3045339903","https://openalex.org/W3045563643","https://openalex.org/W3045668730","https://openalex.org/W3047100065","https://openalex.org/W3047180201","https://openalex.org/W3061336354","https://openalex.org/W3081909485","https://openalex.org/W3092948466","https://openalex.org/W3093345512","https://openalex.org/W3108127937","https://openalex.org/W3108980364","https://openalex.org/W3116827289","https://openalex.org/W3118874595","https://openalex.org/W3121803215","https://openalex.org/W3124182362","https://openalex.org/W3131183760","https://openalex.org/W3131809164","https://openalex.org/W3138770808","https://openalex.org/W3140346797","https://openalex.org/W3157595130","https://openalex.org/W3166824233","https://openalex.org/W3201570839","https://openalex.org/W4220916418","https://openalex.org/W4232814565","https://openalex.org/W4242120683","https://openalex.org/W4247555443","https://openalex.org/W4249636517","https://openalex.org/W4284704417","https://openalex.org/W4366825477","https://openalex.org/W6601382927","https://openalex.org/W6775285204","https://openalex.org/W7221178142"],"related_works":["https://openalex.org/W3215063941","https://openalex.org/W4376870799","https://openalex.org/W3045668730","https://openalex.org/W3134023886","https://openalex.org/W3110830513","https://openalex.org/W7169143063","https://openalex.org/W3091843196","https://openalex.org/W4285131879","https://openalex.org/W7221178142","https://openalex.org/W3126690804"],"abstract_inverted_index":{"The":[0,88],"recent":[1],"coronavirus":[2,85],"disease":[3],"(COVID-19)":[4],"outbreak":[5],"in":[6,57,83,190,193],"Wuhan,":[7],"China,":[8],"has":[9],"led":[10],"to":[11,117,196],"millions":[12],"of":[13,18,77,90,94,99,121],"infections":[14],"and":[15,29,65,96,129,150,160,173,192,200],"the":[16,75,84,92,97,103,119,202],"death":[17],"approximately":[19],"one":[20],"million":[21],"people.":[22],"No":[23],"targeted":[24],"therapeutics":[25],"are":[26,36,40,54,66],"currently":[27,165],"available,":[28],"only":[30],"a":[31,155],"few":[32],"efficient":[33],"treatment":[34],"options":[35],"accessible.":[37],"Many":[38],"researchers":[39],"investigating":[41],"active":[42],"compounds":[43,177,199],"from":[44],"natural":[45],"plant":[46],"sources":[47],"that":[48,140],"may":[49],"inhibit":[50],"COVID-19":[51,124],"proliferation.":[52],"Flavonoids":[53],"generally":[55],"present":[56],"our":[58],"diet,":[59],"as":[60,62,144,169,181],"well":[61],"traditional":[63],"medicines":[64],"effective":[67],"against":[68,79,123,185],"various":[69],"diseases.":[70],"Thus,":[71,175],"here,":[72],"we":[73],"reviewed":[74],"potential":[76],"flavonoids":[78,122,142,153],"crucial":[80],"proteins":[81],"involved":[82],"infectious":[86],"cycle.":[87],"fundamentals":[89],"coronaviruses,":[91],"structures":[93],"SARS-CoV-2,":[95],"mechanism":[98],"its":[100,134],"entry":[101],"into":[102],"host\u2019s":[104],"body":[105],"have":[106,113,154],"also":[107],"been":[108,114],"discussed.":[109],"In":[110],"silico":[111],"studies":[112,138,195],"successfully":[115],"employed":[116],"study":[118],"interaction":[120],"Mpro,":[125],"spike":[126],"protein":[127],"PLpro,":[128],"other":[130,152],"interactive":[131],"sites":[132],"for":[133,204],"possible":[135],"inhibition.":[136],"Recent":[137],"showed":[139],"many":[141,151],"such":[143,168],"hesperidin,":[145],"amentoflavone,":[146],"rutin,":[147],"diosmin,":[148],"apiin,":[149],"higher":[156],"affinity":[157],"with":[158],"Mpro":[159],"lower":[161],"binding":[162],"energy":[163],"than":[164],"used":[166],"drugs":[167],"hydroxylchloroquine,":[170],"nelfinavir,":[171],"ritonavir,":[172],"lopinavir.":[174],"these":[176,198],"can":[178],"be":[179],"developed":[180],"specific":[182],"therapeutic":[183],"agents":[184],"COVID-19,":[186],"but":[187],"need":[188],"further":[189],"vitro":[191],"vivo":[194],"validate":[197],"pave":[201],"way":[203],"drug":[205],"discovery.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-09-29T00:00:00"}