{"id":"https://openalex.org/W4297347299","doi":"https://doi.org/10.1155/2022/8141443","title":"Exploring the Molecular Mechanism of Tong Xie Yao Fang in Treating Ulcerative Colitis Using Network Pharmacology and Molecular Docking","display_name":"Exploring the Molecular Mechanism of Tong Xie Yao Fang in Treating Ulcerative Colitis Using Network Pharmacology and Molecular Docking","publication_year":2022,"publication_date":"2022-09-27","ids":{"openalex":"https://openalex.org/W4297347299","doi":"https://doi.org/10.1155/2022/8141443","pmid":"https://pubmed.ncbi.nlm.nih.gov/36204124","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9532093"},"language":"en","primary_location":{"id":"doi:10.1155/2022/8141443","doi":"https://doi.org/10.1155/2022/8141443","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/8141443","pdf_url":"https://downloads.hindawi.com/journals/ecam/2022/8141443.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/ecam/2022/8141443.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074946685","display_name":"Menglong Zou","orcid":"https://orcid.org/0000-0002-8927-503X","observed_orcids":["https://orcid.org/0000-0002-8927-503X"]},"institutions":[{"id":"https://openalex.org/I4210104845","display_name":"First Affiliated Hospital of Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/01ffek432","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104845"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Menglong Zou","raw_affiliation_strings":["The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China"],"raw_orcid":"https://orcid.org/0000-0002-8927-503X","affiliations":[{"raw_affiliation_string":"The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China","institution_ids":["https://openalex.org/I4210104845"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039574991","display_name":"Ying Zhu","orcid":"https://orcid.org/0000-0002-7160-2477","observed_orcids":["https://orcid.org/0000-0002-7160-2477"]},"institutions":[{"id":"https://openalex.org/I4210104845","display_name":"First Affiliated Hospital of Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/01ffek432","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104845"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying Zhu","raw_affiliation_strings":["The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China"],"raw_orcid":"https://orcid.org/0000-0002-7160-2477","affiliations":[{"raw_affiliation_string":"The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China","institution_ids":["https://openalex.org/I4210104845"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039574991"],"corresponding_institution_ids":["https://openalex.org/I4210104845"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":0.6774,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.61231498,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"2022","issue":null,"first_page":"1","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.05090000107884407,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.02070000022649765,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.9240000247955322},{"id":"https://openalex.org/keywords/active-ingredients","display_name":"active ingredients","score":0.6179999709129333},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.8130000233650208},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9440000057220459},{"id":"https://openalex.org/keywords/il-17-signaling","display_name":"IL-17 signaling","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tnf-signaling","display_name":"TNF signaling","score":1.0},{"id":"https://openalex.org/keywords/kaempferol","display_name":"kaempferol","score":0.949999988079071},{"id":"https://openalex.org/keywords/beta-sitosterol","display_name":"\u03b2-sitosterol","score":0.9509999752044678},{"id":"https://openalex.org/keywords/wogonin","display_name":"wogonin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/naringenin","display_name":"naringenin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.7699999809265137},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C45904493","wikidata":"https://www.wikidata.org/wiki/Q912807","display_name":"Active ingredient","level":2,"score":0.7650579214096069},{"id":"https://openalex.org/C2778559982","wikidata":"https://www.wikidata.org/wiki/Q409606","display_name":"Wogonin","level":5,"score":0.5883554220199585},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5036846995353699},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.47158873081207275},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46943071484565735},{"id":"https://openalex.org/C2779655422","wikidata":"https://www.wikidata.org/wiki/Q1196166","display_name":"Glycyrrhiza uralensis","level":3,"score":0.44466227293014526},{"id":"https://openalex.org/C2780113650","wikidata":"https://www.wikidata.org/wiki/Q2879368","display_name":"Baicalin","level":3,"score":0.44323301315307617},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44101932644844055},{"id":"https://openalex.org/C2780589914","wikidata":"https://www.wikidata.org/wiki/Q10675206","display_name":"Ingredient","level":2,"score":0.43833646178245544},{"id":"https://openalex.org/C2779446555","wikidata":"https://www.wikidata.org/wiki/Q7663877","display_name":"Systems pharmacology","level":3,"score":0.4332258999347687},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4274660348892212},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.4127645492553711},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3970435559749603},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.288414865732193},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2250240445137024},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.2226141393184662},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2210865318775177},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19422179460525513},{"id":"https://openalex.org/C2778153525","wikidata":"https://www.wikidata.org/wiki/Q803769","display_name":"Scutellaria baicalensis","level":4,"score":0.18716630339622498},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1155/2022/8141443","doi":"https://doi.org/10.1155/2022/8141443","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/8141443","pdf_url":"https://downloads.hindawi.com/journals/ecam/2022/8141443.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},{"id":"pmid:36204124","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36204124","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-based complementary and alternative medicine : eCAM","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9532093","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9532093/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evid Based Complement Alternat Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e667ed162a454b29810ef5dfbba28f21","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/e667ed162a454b29810ef5dfbba28f21","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine, Vol 2022 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2022/8141443","doi":"https://doi.org/10.1155/2022/8141443","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/8141443","pdf_url":"https://downloads.hindawi.com/journals/ecam/2022/8141443.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5153907069","display_name":null,"funder_award_id":"2021JJ30531","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6068948749","display_name":null,"funder_award_id":"2021JJ30531","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"},{"id":"https://openalex.org/G6187799107","display_name":null,"funder_award_id":"81874466","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"},{"id":"https://openalex.org/G7842912440","display_name":null,"funder_award_id":"81874466","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322843","display_name":"Natural Science Foundation of\u00a0Hunan Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4297347299.pdf","grobid_xml":"https://content.openalex.org/works/W4297347299.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W5795428","https://openalex.org/W571375525","https://openalex.org/W1515437203","https://openalex.org/W1534854079","https://openalex.org/W1542330291","https://openalex.org/W1964209960","https://openalex.org/W1965437709","https://openalex.org/W1984217145","https://openalex.org/W1991084006","https://openalex.org/W1995105553","https://openalex.org/W2019405125","https://openalex.org/W2024346860","https://openalex.org/W2054206661","https://openalex.org/W2059921491","https://openalex.org/W2079479624","https://openalex.org/W2086704402","https://openalex.org/W2096846494","https://openalex.org/W2103607874","https://openalex.org/W2118258530","https://openalex.org/W2124679671","https://openalex.org/W2126131092","https://openalex.org/W2130479394","https://openalex.org/W2150199771","https://openalex.org/W2158103815","https://openalex.org/W2180954358","https://openalex.org/W2391061120","https://openalex.org/W2395403721","https://openalex.org/W2511018226","https://openalex.org/W2594486950","https://openalex.org/W2598864494","https://openalex.org/W2624858653","https://openalex.org/W2732834761","https://openalex.org/W2746698428","https://openalex.org/W2800354113","https://openalex.org/W2885818963","https://openalex.org/W2898468989","https://openalex.org/W2899291554","https://openalex.org/W2906864388","https://openalex.org/W2999636890","https://openalex.org/W3010363316","https://openalex.org/W3034449940","https://openalex.org/W3035822871","https://openalex.org/W3040643851","https://openalex.org/W3043919229","https://openalex.org/W3045561650","https://openalex.org/W3080821063","https://openalex.org/W3095929420","https://openalex.org/W3096174315","https://openalex.org/W3097145107","https://openalex.org/W3107527779","https://openalex.org/W3111851774","https://openalex.org/W3126894920","https://openalex.org/W3132161667","https://openalex.org/W3135397674","https://openalex.org/W3166962861","https://openalex.org/W3171295963","https://openalex.org/W3171734336","https://openalex.org/W3184283177","https://openalex.org/W4200080102","https://openalex.org/W4200139355","https://openalex.org/W4200211224","https://openalex.org/W4200400901","https://openalex.org/W4205156151","https://openalex.org/W4210972027","https://openalex.org/W4220924965","https://openalex.org/W4220993766","https://openalex.org/W4282971501","https://openalex.org/W4284878926","https://openalex.org/W4288054456"],"related_works":["https://openalex.org/W4402428733","https://openalex.org/W4386109888","https://openalex.org/W4391175934","https://openalex.org/W4392854567","https://openalex.org/W4312693556","https://openalex.org/W4402506054","https://openalex.org/W3031159977","https://openalex.org/W4327849875","https://openalex.org/W3216214905","https://openalex.org/W4391444913"],"abstract_inverted_index":{"Objective.":[0],"The":[1,30,91],"purpose":[2],"of":[3,11,13,36,43,71,84,93,133,141,165,187,189],"this":[4],"study":[5],"was":[6,65,124],"to":[7,67],"investigate":[8],"the":[9,37,44,49,53,69,94,99,105,116,125,170,174,184,199],"mechanisms":[10,70],"action":[12],"Tong":[14],"Xie":[15],"Yao":[16],"Fang":[17],"(TXYF)":[18],"against":[19,73,217],"ulcerative":[20],"colitis":[21],"(UC)":[22],"by":[23,193],"employing":[24],"a":[25],"network":[26,31,107],"pharmacology":[27,32],"approach.":[28],"Methods.":[29],"approach,":[33],"including":[34],"screening":[35],"active":[38,45,50,77,95,100],"ingredients":[39,78,118,172],"and":[40,62,79,81,86,104,113,119,137,154,173,211,219,226],"targets,":[41,210],"construction":[42],"ingredient-drug":[46,96],"target":[47,97,102,175],"network,":[48,52,57,98,103],"ingredient-diseasetarget":[51],"protein\u2013protein":[54],"interaction":[55],"(PPI)":[56],"enrichment":[58],"analyses,":[59],"molecular":[60,166],"docking,":[61],"targets":[63,83],"validation,":[64],"used":[66],"explore":[68],"TXYF":[72,85],"UC.":[74],"Results.":[75],"34":[76],"129":[80],"772":[82],"UC,":[87,218],"respectively,":[88],"were":[89,115,140,161],"identified.":[90],"intersection":[92],"ingredient-disease":[101],"PPI":[106],"suggested":[108],"that":[109,131,169],"kaempferol,":[110],"beta-sitosterol,":[111],"wogonin,":[112],"naringenin":[114],"core":[117,126,171],"prostaglandin-endoperoxide":[120],"synthase":[121],"2":[122],"(PTGS2)":[123],"target.":[127],"Enrichment":[128],"analyses":[129],"showed":[130],"regulation":[132],"exogenous":[134],"protein":[135],"binding":[136,179],"other":[138],"functions":[139],"great":[142],"significance.":[143],"Nuclear":[144],"factor-kappa":[145],"B":[146],"(NF-\u03baB)":[147],"signaling":[148,152,159],"pathway,":[149,153],"interleukin-17":[150],"(IL-17)":[151],"tumor":[155],"necrosis":[156],"factor":[157],"(TNF)":[158],"pathway":[160],"important":[162],"pathways.":[163],"Results":[164],"docking":[167],"indicated":[168],"molecule":[176],"had":[177],"strong":[178],"affinities.":[180],"We":[181],"have":[182],"validated":[183],"high":[185],"levels":[186],"expression":[188],"PTGS2":[190],"in":[191,214],"UC":[192],"analyzing":[194],"three":[195],"additional":[196],"datasets":[197],"from":[198],"Gene":[200],"Expression":[201],"Omnibus":[202],"(GEO)":[203],"database.":[204],"Conclusions.":[205],"There":[206],"are":[207],"multiple":[208],"ingredients,":[209],"pathways":[212],"involved":[213],"TXYF\u2019s":[215],"effectiveness":[216],"these":[220],"findings":[221],"will":[222],"promote":[223],"further":[224],"research":[225],"clinical":[227],"applications.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-09-28T00:00:00"}