{"id":"https://openalex.org/W4297314868","doi":"https://doi.org/10.1016/j.xpro.2022.101720","title":"Protocol to utilize fresh uncultured human lung tumor cells for personalized functional diagnostics","display_name":"Protocol to utilize fresh uncultured human lung tumor cells for personalized functional diagnostics","publication_year":2022,"publication_date":"2022-09-27","ids":{"openalex":"https://openalex.org/W4297314868","doi":"https://doi.org/10.1016/j.xpro.2022.101720","pmid":"https://pubmed.ncbi.nlm.nih.gov/36170112","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9520273"},"language":"en","primary_location":{"id":"doi:10.1016/j.xpro.2022.101720","doi":"https://doi.org/10.1016/j.xpro.2022.101720","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xpro.2022.101720","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2666166722006001/pdf","source":{"id":"https://openalex.org/S4210212477","display_name":"STAR Protocols","issn_l":"2666-1667","issn":["2666-1667"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"STAR Protocols","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2666166722006001/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077062276","display_name":"Sarang S. Talwelkar","orcid":"https://orcid.org/0000-0001-7047-4058","observed_orcids":["https://orcid.org/0000-0001-7047-4058"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Sarang S. Talwelkar","raw_affiliation_strings":["Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland; Institute of Biomedicine and MediCity Research Laboratories, University of Turku, Turku 20520, Finland","Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland","Institute of Biomedicine and MediCity Research Laboratories, University of Turku, Turku 20520, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland; Institute of Biomedicine and MediCity Research Laboratories, University of Turku, Turku 20520, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I155660961","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]},{"raw_affiliation_string":"Institute of Biomedicine and MediCity Research Laboratories, University of Turku, Turku 20520, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103677585","display_name":"Iris A.K. L\u00e4hdeniemi","orcid":"https://orcid.org/0000-0002-8868-8908","observed_orcids":["https://orcid.org/0000-0002-8868-8908"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Iris A.K. L\u00e4hdeniemi","raw_affiliation_strings":["Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003452123","display_name":"Mikko Ilari M\u00e4yr\u00e4np\u00e4\u00e4","orcid":"https://orcid.org/0000-0002-0877-9640","observed_orcids":["https://orcid.org/0000-0002-0877-9640"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mikko I. M\u00e4yr\u00e4np\u00e4\u00e4","raw_affiliation_strings":["Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069463210","display_name":"Annabrita Hemmes","orcid":"https://orcid.org/0009-0005-5051-9331","observed_orcids":["https://orcid.org/0009-0005-5051-9331"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Annabrita Hemmes","raw_affiliation_strings":["Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021371196","display_name":"Nora M Linnavirta","orcid":"https://orcid.org/0000-0001-9545-415X","observed_orcids":["https://orcid.org/0000-0001-9545-415X"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Nora Linnavirta","raw_affiliation_strings":["Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042344249","display_name":"Jari Veli R\u00e4s\u00e4nen","orcid":"https://orcid.org/0000-0002-7826-532X","observed_orcids":["https://orcid.org/0000-0002-7826-532X"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jari R\u00e4s\u00e4nen","raw_affiliation_strings":["Department of Thoracic Surgery, Heart and Lung Center, Helsinki University Hospital, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Heart and Lung Center, Helsinki University Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008969167","display_name":"Aija Knuuttila","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Aija Knuuttila","raw_affiliation_strings":["Department of Pulmonary Medicine, Heart and Lung Center and Cancer Center, Helsinki University Hospital, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Medicine, Heart and Lung Center and Cancer Center, Helsinki University Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067760174","display_name":"Krister Wennerberg","orcid":"https://orcid.org/0000-0002-1352-4220","observed_orcids":["https://orcid.org/0000-0002-1352-4220"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["DK","FI"],"is_corresponding":true,"raw_author_name":"Krister Wennerberg","raw_affiliation_strings":["Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland; BRIC - Biotech Research & Innovation Centre, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address: krister.wennerberg@bric.ku.dk","BRIC - Biotech Research & Innovation Centre, University of Copenhagen, 2200 Copenhagen, Denmark","Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland; BRIC - Biotech Research & Innovation Centre, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address: krister.wennerberg@bric.ku.dk","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]},{"raw_affiliation_string":"BRIC - Biotech Research & Innovation Centre, University of Copenhagen, 2200 Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018131963","display_name":"Emmy W. Verschuren","orcid":"https://orcid.org/0000-0001-5771-9129","observed_orcids":["https://orcid.org/0000-0001-5771-9129"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]},{"id":"https://openalex.org/I4391768107","display_name":"HiLIFE \u2013 El\u00e4m\u00e4ntieteiden Instituutti","ror":"https://ror.org/018bh0m68","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4391768107"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Emmy W. Verschuren","raw_affiliation_strings":["Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland. Electronic address: emmy.verschuren@helsinki.fi","Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland"],"raw_orcid":"https://orcid.org/0000-0001-5771-9129","affiliations":[{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland. Electronic address: emmy.verschuren@helsinki.fi","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, 00014 Helsinki, Finland","institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5018131963","https://openalex.org/A5067760174"],"corresponding_institution_ids":["https://openalex.org/I124055696","https://openalex.org/I133731052","https://openalex.org/I4210133586","https://openalex.org/I4391768107"],"apc_list":{"value":1500,"currency":"USD","value_usd":1500},"apc_paid":{"value":1500,"currency":"USD","value_usd":1500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18705167,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"4","first_page":"101720","last_page":"101720"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.4724000096321106,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.4724000096321106,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.45260000228881836,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.029999999329447746,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7049999833106995},{"id":"https://openalex.org/keywords/drug-susceptibility-testing","display_name":"drug susceptibility testing","score":0.6959999799728394},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.5809999704360962},{"id":"https://openalex.org/keywords/targeted-therapy-resistance","display_name":"targeted therapy resistance","score":0.8019999861717224},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.9179999828338623},{"id":"https://openalex.org/keywords/ex-vivo-drug-screening","display_name":"ex vivo drug testing","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.6900666952133179},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.6633644700050354},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5954971313476562},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4838344156742096},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.4624064266681671},{"id":"https://openalex.org/C176553487","wikidata":"https://www.wikidata.org/wiki/Q7855819","display_name":"Turnaround time","level":2,"score":0.430642306804657},{"id":"https://openalex.org/C2779744229","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Human lung","level":3,"score":0.4286736249923706},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39568135142326355},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3501385748386383},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3381838798522949},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.322101891040802},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.319574773311615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22772300243377686},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21943974494934082},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.20909690856933594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08896347880363464},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1016/j.xpro.2022.101720","doi":"https://doi.org/10.1016/j.xpro.2022.101720","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xpro.2022.101720","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2666166722006001/pdf","source":{"id":"https://openalex.org/S4210212477","display_name":"STAR Protocols","issn_l":"2666-1667","issn":["2666-1667"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"STAR Protocols","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9520273","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9520273","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"STAR Protoc","raw_type":"Text"},{"id":"pmid:36170112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36170112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"STAR protocols","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/c34e15c5-c875-4222-9815-0714d8dde3d4","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/c34e15c5-c875-4222-9815-0714d8dde3d4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Talwelkar, S S, L\u00e4hdeniemi, I A K, M\u00e4yr\u00e4np\u00e4\u00e4, M I, Hemmes, A, Linnavirta, N, R\u00e4s\u00e4nen, J, Knuuttila, A, Wennerberg, K & Verschuren, E W 2022, 'Protocol to utilize fresh uncultured human lung tumor cells for personalized functional diagnostics', STAR Protocols, vol. 3, no. 4, 101720. https://doi.org/10.1016/j.xpro.2022.101720","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:utupub.fi:11111/35081","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/35081","pdf_url":"https://www.utupub.fi/bitstreams/1809cf01-3445-4720-9ae6-a758bee3e9e8/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/173411","raw_type":null},{"id":"pmh:oai:www.utupub.fi:10024/173411","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/10024/173411","pdf_url":"https://www.utupub.fi/bitstream/10024/173411/1/1-s2.0-S2666166722006001-main.pdf","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:006c6459adf0456781a8ab0e155bc7a4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/006c6459adf0456781a8ab0e155bc7a4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"STAR Protocols, Vol 3, Iss 4, Pp 101720- (2022)","raw_type":"article"},{"id":"pmh:oai:helda.helsinki.fi:10138/355292","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/355292","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/j.xpro.2022.101720","doi":"https://doi.org/10.1016/j.xpro.2022.101720","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.xpro.2022.101720","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2666166722006001/pdf","source":{"id":"https://openalex.org/S4210212477","display_name":"STAR Protocols","issn_l":"2666-1667","issn":["2666-1667"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"STAR Protocols","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G155838707","display_name":null,"funder_award_id":"NNF21SA0073733","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G3589578894","display_name":null,"funder_award_id":"NNF17CC0027852","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G399059165","display_name":null,"funder_award_id":"307111","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4436625874","display_name":"Innovative strategies for cancer prevention with focus on sex hormone signaling and chronic inflammation","funder_award_id":"859860","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G54864864","display_name":"Development of new antimicrobial nanostructured durable coatings for fuel tanks","funder_award_id":"307111","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5967312566","display_name":"Innovative strategies for cancer prevention with focus on sex hormone signaling and chronic inflammation","funder_award_id":"859860","funder_id":"https://openalex.org/F4320338337","funder_display_name":"H2020 Marie Sk\u0142odowska-Curie Actions"},{"id":"https://openalex.org/G7044228676","display_name":null,"funder_award_id":"NNF17CC0027852","funder_id":"https://openalex.org/F4320322436","funder_display_name":"Novo Nordisk"},{"id":"https://openalex.org/G7940337353","display_name":null,"funder_award_id":"328473","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"}],"funders":[{"id":"https://openalex.org/F4320309952","display_name":"Ida Montinin S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/0269hs475"},{"id":"https://openalex.org/F4320310086","display_name":"Helsingin Yliopisto","ror":"https://ror.org/040af2s02"},{"id":"https://openalex.org/F4320310751","display_name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/0593mby10"},{"id":"https://openalex.org/F4320311797","display_name":"Medicinska Underst\u00f6dsf\u00f6reningen Liv och H\u00e4lsa","ror":"https://ror.org/00qx9g681"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320325172","display_name":"V\u00e4in\u00f6 ja Laina Kiven S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/00274wg63"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"},{"id":"https://openalex.org/F4320328139","display_name":"Biocenter Finland","ror":"https://ror.org/03aay6c48"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320333873","display_name":"Helsinki Institute of Life Science, Helsingin Yliopisto","ror":"https://ror.org/018bh0m68"},{"id":"https://openalex.org/F4320335254","display_name":"Horizon 2020","ror":null},{"id":"https://openalex.org/F4320338337","display_name":"H2020 Marie Sk\u0142odowska-Curie Actions","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4297314868.pdf","grobid_xml":"https://content.openalex.org/works/W4297314868.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W1849210920","https://openalex.org/W2002783575","https://openalex.org/W2106513086","https://openalex.org/W2751210758","https://openalex.org/W3010256878","https://openalex.org/W3124786886","https://openalex.org/W4200579603"],"related_works":["https://openalex.org/W3124786886","https://openalex.org/W2066119710","https://openalex.org/W7222338847","https://openalex.org/W7134902139","https://openalex.org/W6944132769","https://openalex.org/W4380302469","https://openalex.org/W2898520269","https://openalex.org/W7130585513","https://openalex.org/W4408326429","https://openalex.org/W4401824063"],"abstract_inverted_index":{"Drug":[0],"sensitivity":[1],"data":[2],"acquired":[3],"from":[4],"solid":[5],"tumor-derived":[6,37],"cultures":[7],"are":[8],"often":[9],"unsuitable":[10],"for":[11,26,46],"personalized":[12],"treatment":[13],"guidance":[14],"due":[15],"to":[16,51,72,77,94],"the":[17,85],"lengthy":[18],"turnaround":[19],"time.":[20],"Here,":[21],"we":[22],"present":[23],"a":[24],"protocol":[25],"determining":[27],"ex":[28],"vivo":[29,75],"drug":[30,47],"sensitivities":[31],"using":[32],"fresh":[33],"uncultured":[34],"human":[35],"lung":[36],"EpCAM":[38],"+":[39],"epithelial":[40],"cells":[41],"(FUTCs).":[42],"We":[43],"describe":[44],"steps":[45],"testing":[48],"in":[49,59,74],"FUTCs":[50],"identify":[52],"tumor":[53],"cell-selective":[54],"single":[55],"or":[56],"combination":[57],"therapy":[58],"72":[60],"h":[61],"of":[62,89],"sample":[63],"processing.":[64],"The":[65],"FUTC-based":[66],"approach":[67],"can":[68],"also":[69],"be":[70],"used":[71],"predict":[73],"resistance":[76],"known":[78],"targeted":[79],"therapies.":[80],"For":[81],"complete":[82],"details":[83],"on":[84],"use":[86],"and":[87],"execution":[88],"this":[90],"protocol,":[91],"please":[92],"refer":[93],"Talwelkar":[95],"et":[96],"al.":[97],"(2021)":[98],".":[99]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-09-28T00:00:00"}
