{"id":"https://openalex.org/W4297259366","doi":"https://doi.org/10.13345/j.cjb.220061","title":"[Industrial development and biomedical application prospect of recombinant collagen].","display_name":"[Industrial development and biomedical application prospect of recombinant collagen].","publication_year":2022,"publication_date":"2022-09-25","ids":{"openalex":"https://openalex.org/W4297259366","doi":"https://doi.org/10.13345/j.cjb.220061","pmid":"https://pubmed.ncbi.nlm.nih.gov/36151795"},"language":"zh","primary_location":{"id":"pmid:36151795","doi":"https://doi.org/10.13345/j.cjb.220061","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36151795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng wu gong cheng xue bao = Chinese journal of biotechnology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114859017","display_name":"Rongzhan Fu","orcid":"https://orcid.org/0000-0003-1517-6431","observed_orcids":["https://orcid.org/0000-0003-1517-6431"]},"institutions":[{"id":"https://openalex.org/I37802460","display_name":"Northwest University","ror":"https://ror.org/00z3td547","country_code":"CN","type":"education","lineage":["https://openalex.org/I37802460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rongzhan Fu","raw_affiliation_strings":["School of Chemical Engineering, Northwest University, Xi'an 710069, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical Engineering, Northwest University, Xi'an 710069, Shaanxi, China","institution_ids":["https://openalex.org/I37802460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043935829","display_name":"Daidi Fan","orcid":"https://orcid.org/0000-0001-9798-1674","observed_orcids":["https://orcid.org/0000-0001-9798-1674"]},"institutions":[{"id":"https://openalex.org/I37802460","display_name":"Northwest University","ror":"https://ror.org/00z3td547","country_code":"CN","type":"education","lineage":["https://openalex.org/I37802460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Daidi Fan","raw_affiliation_strings":["School of Chemical Engineering, Northwest University, Xi'an 710069, Shaanxi, China","Shaanxi Giant Biotechnology Co. Ltd., Xi'an 710077, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical Engineering, Northwest University, Xi'an 710069, Shaanxi, China","institution_ids":["https://openalex.org/I37802460"]},{"raw_affiliation_string":"Shaanxi Giant Biotechnology Co. Ltd., Xi'an 710077, Shaanxi, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066108468","display_name":"Wanjuan Yang","orcid":"https://orcid.org/0009-0005-3432-6070","observed_orcids":["https://orcid.org/0009-0005-3432-6070"]},"institutions":[{"id":"https://openalex.org/I4210136676","display_name":"National Institutes for Food and Drug Control","ror":"https://ror.org/041rdq190","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210136676"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wanjuan Yang","raw_affiliation_strings":["National Institutes for Food and Drug Control, Beijing 102629, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes for Food and Drug Control, Beijing 102629, China","institution_ids":["https://openalex.org/I4210136676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100334617","display_name":"Liang Chen","orcid":"https://orcid.org/0000-0002-6397-0931","observed_orcids":["https://orcid.org/0000-0002-6397-0931"]},"institutions":[{"id":"https://openalex.org/I4210136676","display_name":"National Institutes for Food and Drug Control","ror":"https://ror.org/041rdq190","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210136676"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Chen","raw_affiliation_strings":["National Institutes for Food and Drug Control, Beijing 102629, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes for Food and Drug Control, Beijing 102629, China","institution_ids":["https://openalex.org/I4210136676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058927736","display_name":"Ci Qu","orcid":"https://orcid.org/0009-0003-2133-2573","observed_orcids":["https://orcid.org/0009-0003-2133-2573"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ci Qu","raw_affiliation_strings":["Hebei Collagen Biotechnology Co. Ltd., Handan 057450, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hebei Collagen Biotechnology Co. Ltd., Handan 057450, Hebei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104108295","display_name":"Shulin Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36399199","display_name":"Nanjing University of Science and Technology","ror":"https://ror.org/00xp9wg62","country_code":"CN","type":"education","lineage":["https://openalex.org/I36399199"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shulin Yang","raw_affiliation_strings":["School of Environment and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Environment and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, Jiangsu, China","institution_ids":["https://openalex.org/I36399199"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101776774","display_name":"Liming Xu","orcid":"https://orcid.org/0000-0002-3577-0959","observed_orcids":["https://orcid.org/0000-0002-3577-0959","https://orcid.org/0009-0003-6600-3458"]},"institutions":[{"id":"https://openalex.org/I4210136676","display_name":"National Institutes for Food and Drug Control","ror":"https://ror.org/041rdq190","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210136676"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liming Xu","raw_affiliation_strings":["National Institutes for Food and Drug Control, Beijing 102629, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes for Food and Drug Control, Beijing 102629, China","institution_ids":["https://openalex.org/I4210136676"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5756,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.47973337,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"38","issue":"9","first_page":"3228","last_page":"3242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11966","display_name":"Silk-based biomaterials and applications","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recombinant-collagen","display_name":"recombinant collagen","score":1.0},{"id":"https://openalex.org/keywords/prokaryotic-expression","display_name":"prokaryotic expression","score":0.8560000061988831},{"id":"https://openalex.org/keywords/yeast-expression-system","display_name":"yeast expression system","score":0.8859999775886536},{"id":"https://openalex.org/keywords/plant-expression","display_name":"plant expression","score":0.5809999704360962},{"id":"https://openalex.org/keywords/mammalian-expression","display_name":"mammalian expression","score":0.8199999928474426},{"id":"https://openalex.org/keywords/biomaterials","display_name":"biomaterials","score":0.828000009059906},{"id":"https://openalex.org/keywords/biomedical-applications","display_name":"biomedical applications","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.9300318360328674},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.428524374961853},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4111173450946808},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3828836679458618},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21578919887542725},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09561246633529663}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006900","descriptor_name":"Hydroxylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:36151795","doi":"https://doi.org/10.13345/j.cjb.220061","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36151795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng wu gong cheng xue bao = Chinese journal of biotechnology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4383058934","https://openalex.org/W4415536109","https://openalex.org/W7212128633","https://openalex.org/W2101889508","https://openalex.org/W3109266820","https://openalex.org/W24552279","https://openalex.org/W7134905095","https://openalex.org/W4211207973","https://openalex.org/W4404850889","https://openalex.org/W4391885092"],"abstract_inverted_index":{"Recombinant":[0],"collagen,":[1,7,110],"as":[2,58,65,67],"an":[3],"alternative":[4],"to":[5,11],"natural":[6],"has":[8],"the":[9,43,78,92,96,113],"potential":[10,80],"be":[12,26],"widely":[13],"used":[14],"in":[15,29,95],"biomaterials,":[16],"biomedicine,":[17],"etc.":[18],"Diverse":[19],"recombinant":[20,47,55,85,97,101,109,118],"collagens":[21],"and":[22,41,71,76,82,105,111],"their":[23],"variants":[24],"can":[25],"industrially":[27],"produced":[28],"a":[30,37],"variety":[31],"of":[32,46,84,108,117],"expression":[33,52,60,63,74,102],"systems,":[34,61,64,75],"which":[35],"lays":[36],"foundation":[38],"for":[39,54],"exploring":[40],"expanding":[42],"clinical":[44],"application":[45],"collagens.":[48],"We":[49],"reviewed":[50],"different":[51],"systems":[53],"collagens,":[56],"such":[57],"prokaryotic":[59],"yeast":[62],"well":[66],"plant,":[68],"insect,":[69],"mammal,":[70],"human":[72],"cell":[73],"introduced":[77],"advantages,":[79],"applications,":[81],"limitations":[83],"collagen.":[86,119],"In":[87],"particularly,":[88],"we":[89],"focused":[90],"on":[91],"current":[93,114],"progress":[94],"collagen":[98],"production,":[99],"including":[100],"system":[103],"construction":[104],"hydroxylation":[106],"strategies":[107],"summarized":[112],"biomedical":[115],"applications":[116]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2022-09-28T00:00:00"}